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聚合酶链反应在恶性疟疾普查中的应用

中国人兽共患病杂志 1998年第1期14卷 33-36页

作者：罗恩杰 J.Yuri Uchida 太田伸生川端真人大前广吕志熊田三由 J.Leafasia 石井明中国医科大学寄生虫学教研室沈阳110001 名古屋市立大学医学部医动物学教室 InternationalCenterforMedicalesearchSchoolofMedicine KobeUniversityKobeJapan 国际医疗中心国立健康研究所寄生虫部 SolomonIslandsMedicalTrainingandResearchInstituteHoniara

作者应用滤纸片干血液分离恶性疟原虫DNA进行聚合酶链反应的方法对所罗门群岛的489份血样品进行检查。结果表明此方法具有1）用血量少，经自然干燥后，易于保存和运输。2）DNA分离的方法简便、快捷。3）PCR的检测极限为1．5个原虫／μl... 详细信息

作者应用滤纸片干血液分离恶性疟原虫DNA进行聚合酶链反应的方法对所罗门群岛的489份血样品进行检查。结果表明此方法具有1）用血量少，经自然干燥后，易于保存和运输。2）DNA分离的方法简便、快捷。3）PCR的检测极限为1．5个原虫／μl血。其次，其结果与姬姆萨染色方法的结果进行了比较。结果提示姬姆萨染色方法的结果与其检查者的技术水平密切相关。在大面积普查时容易出现漏诊及误诊、此外，也证明单片段基因扩增同样容易出现漏诊及误诊。

关键词：恶性疟原虫聚合酶链反应所罗门群岛

Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

Prophylactic lateral pelvic lymph node dissection in stage Ⅳ low rectal cancer

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World Journal of Clinical Oncology 2017年第5期8卷 412-419页

作者： Hiroshi Tamura Yoshifumi Shimada Hitoshi Kameyama Ryoma Yagi Yosuke Tajima Takuma Okamura Mae Nakano masato Nakano Masayuki Nagahashi Jun Sakata Takashi Kobayashi Shin-ichi Kosugi Hitoshi Nogami Satoshi Maruyama Yasumasa Takii Toshifumi Wakai Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Department of Digestive and General Surgery Uonuma Institute of Community MedicineNiigata University Medical and Dental Hospital Department of Surgery Niigata Cancer Center Hospital

AIM To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage Ⅳ low rectal *** We selected 71 consecutive stage Ⅳ low rectal cancer patients who underwent primary tumor resection,and enrolled 50 of these 71 patients without clinical LPLN *** patients had distant metastasis such as liver,lung,peritoneum,and paraaortic *** LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography *** patients underwent primary tumor resection,27 patients underwent total mesorectal excision(TME) with LPLND(LPLND group),and 23 patients underwent only TME(TME group).Bilateral LPLND was performed simultaneously with primary tumor resection in LPLND group.R0 resection of both primary and metastatic sites was achieved in 20 of 50 *** evaluated possible prognostic factors for 5-year overall survival (OS),and compared 5-year cumulative local recurrence between the LPLND and TME *** For OS,univariate analyses revealed no significant benefit in the LPLND compared with the TME group (28.7% vs 17.0%,P = 0.523); multivariate analysis revealed that R0 resection was an independent prognostic *** cumulative local recurrence,the LPLND group showed no significant benefit compared with TME group (21.4% vs 14.8%,P = 0.833).CONCLUSION Prophylactic LPLND shows no oncological benefits in patients with Stage Ⅳ low rectal cancer without clinical LPLN metastasis.

关键词： Prophylactic lateral pelvic lymph node dissection StageⅣ Low rectal cancer

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皮肤老化相关的关键成分与结构特征概述

香料香精化妆品 2020年第3期 82-86页

作者：周荷益岑晓娟王颖张梦尧范春晖于淼北垣雅人资生堂(中国)研究开发有限公司北京100176

皮肤内在成分和结构的变化是皮肤老化的主要原因,这些变化最终导致了肉眼可见皱纹、松弛等皮肤老化特征。本文详细介绍了与老化相关的皮肤内在成分的变化,包括透明质酸和胶原蛋白含量或密度的变化,皮肤内在结构的变化,包括真皮乳头和真... 详细信息

皮肤内在成分和结构的变化是皮肤老化的主要原因,这些变化最终导致了肉眼可见皱纹、松弛等皮肤老化特征。本文详细介绍了与老化相关的皮肤内在成分的变化,包括透明质酸和胶原蛋白含量或密度的变化,皮肤内在结构的变化,包括真皮乳头和真皮毛细血管的密度变化,以及"真皮空洞"。在此基础上,探讨了皮肤内在关键成分和结构量的变化与皮肤外在特征的关系。

关键词：皮肤老化透明质酸胶原蛋白真皮乳头毛细血管 “真皮空洞”

Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy

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World Journal of Gastrointestinal Endoscopy 2015年第14期7卷 1142-1149页

作者： Hisatomo Ikehara Zhaoliang Li Jiro Watari masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Toshihiko Tomita Tadayuki Oshima Hirokazu Fukui Ikuo Matsuda Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Surgical Pathology Hyogo College of Medicine

AIM: To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy(EUS-FNAB) without cytology and mucosal cutting biopsy(MCB) in the histological diagnosis of gastric submucosal tumor(SMT).METHODS: We prospectively compared the diagnostic yield, feasibility, and safety of EUS-FNAB and those of MCB based on endoscopic submucosal dissection. The cases of 20 consecutive patients with gastric SMT ≥1 cm in diameter. who underwent both EUS-FNAB and MCB were ***: The histological diagnoses were gastrointestinal stromal tumors(n = 7), leiomyoma(n =6), schwannoma(n = 2), aberrant pancreas(n = 2), and one case each of glomus tumor, metastatic hepatocellular carcinoma, and no-diagnosis. The tumors' mean size was 23.6 mm. Histological diagnosis was made in 65.0% of the EUS-FNABs and 60.0% of the MCBs, a nonsignificant difference. There were no significant differences in the diagnostic yield concerning the tumor location or tumor size between the two methods. However, diagnostic specimens were significantly more frequently obtained in lesions with intraluminal growth than in those with extraluminal growth by the MCB method(P = 0.01). All four SMTs with extraluminal growth were diagnosed only by EUSFNAB(P = 0.03). No complications were found in either ***: MCB may be chosen as an alternative diagnostic modality in tumors showing the intraluminal growth pattern regardless of tumor size, whereas EUSFNAB should be performed for SMTs with extraluminal growth.

关键词： Submucosal tumor Endoscopic ultrasonography-guided

Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

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World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

采用Ni-Cr合金热喷涂延长连铸结晶器寿命

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连铸 2001年第4期26卷 13-14,46页

作者：久保田昭高田正人掘胜广梅山佑登山本圭祐大迫清一三岛光产(株)

三岛光产所开发的Ni-Cr合金热喷涂结晶器,是通过对连铸结晶器表面喷涂Ni-Cr合金涂层,使其寿命达到原来镀Ni结晶器的3～6倍。本文介绍Ni-Cr合金热喷涂结晶器的特性、使用效果和使用上的注意点。

关键词：连铸机结晶器使用寿命热喷涂镍铬合金

Hematogenous umbilical metastasis from colon cancer treated by palliative single-incision laparoscopic surgery

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World Journal of Gastrointestinal Surgery 2013年第10期5卷 272-277页

作者： Tomohide Hori Noriyuki Okada Masaya Nakauchi Shuji Hiramoto Ayako Kikuchi-Mizota Masahisa Kyogoku Fumitaka Oike Hidemitsu Sugimoto Junya Tanaka Yoshiki Morikami Kaori Shigemoto Toyotsugu Ota Masanobu Kaneko masato Nakatsuji Shunji Okae Takahiro Tanaka Daigo Gunji Akira Yoshioka Department of Surgery Mitsubishi Kyoto Hospital Department of Medical Oncology Mitsubishi Kyoto Hospital Department of Histopathology Mitsubishi Kyoto Hospital Department of Gastroenterology Mitsubishi Kyoto Hospital Department of Radiology Mitsubishi Kyoto Hospital Department of Internal Medicine Mitsubishi Kyoto Hospital

Sister Mary Joseph’s nodule(SMJN)is a rare umbilical nodule that develops secondary to metastatic *** malignancies are located in the abdomen or *** with SMJN have a poor *** 83-year-old woman presented to our hospital with a1-month history of a rapidly enlarging umbilical *** findings revealed advanced transverse colon *** tomography and fluorodeoxyglucose-positron emission tomography revealed tumors of the transverse colon,umbilicus,right inguinal lymph nodes,and left *** feeding arteries and drainage veins for the SMJN were the inferior epigastric *** findings of the left lung tumor allowed for identification of the primary lung cancer,and a diagnosis of advanced transverse colon cancer with SMJN and primary lung cancer was *** patient underwent local resection of the SMNJ and subsequent single-site laparoscopic surgery involving right hemicolectomy and paracolic lymph node ***-abdominal dissemination to the mesocolon was confirmed during ***,the transverse colon cancer was confirmed to be moderately differentiated tubular *** suspect that SMJN may occur via a hematogenous *** chemotherapy for colon cancer and thoracoscopic surgery for the primary lung cancer were scheduled,the patient and her family desired home *** months after surgery,she died of rapidly growing lung cancer.

关键词： Umbilicus Sister Mary Joseph Singleincision laparoscopic surgery Palliative operation Hematogenous metastasis

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皮肤中基底膜的结构与功能

中国美容医学 2016年第10期25卷 113-117页

作者：张丽丽李贤玉穆荣范春晖北垣雅人高须惠美子资生堂(中国)研究开发中心有限公司北京100176

基底膜是一类细胞外基质,存在于人体中所有的器官组织中,承担着重要的功能。皮肤的基底膜是表皮与真皮间重要的承接结构,主要成分有Ⅳ型和Ⅶ型胶原蛋白、层粘连蛋白、巢蛋白、串珠素等,通过它们交互形成的网状结构,构成了基底膜丰富多... 详细信息

基底膜是一类细胞外基质,存在于人体中所有的器官组织中,承担着重要的功能。皮肤的基底膜是表皮与真皮间重要的承接结构,主要成分有Ⅳ型和Ⅶ型胶原蛋白、层粘连蛋白、巢蛋白、串珠素等,通过它们交互形成的网状结构,构成了基底膜丰富多样的生物学功能,主要为表皮-真皮的连接功能、信号传导功能及渗透屏障功能等。健康的基底膜发挥多样生物学功能,使表皮-基底膜-真皮三者之间能够顺畅循环,保持皮肤的健康完整性。暴露于阳光下可引起基底膜的改变,可以引发多种肌肤烦恼,例如晒伤、光老化、皮肤癌等。研究发现一些植物提取物可以保护基底膜,如何运用这些活性成分对研究开发功能性化妆品可以提供更多的发展途径。

关键词：皮肤基底膜胶原蛋白层粘连蛋白多样生物学功能光老化活性植物提取物