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BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

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Bone Research 2020年第3期8卷 365-378页

作者： Yuhei Yahiro Shingo Maeda masato morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi Department of Orthopaedic Surgery Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Medical Joint Materials Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Bone and Joint Medicine Kagoshima UniversityKagoshimaKagoshima 890-8520Japan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoBunkyo-kuTokyo 113-0033Japan Institute for Frontier Life and Medical Sciences Kyoto UniversitySakyo-kuKyoto 606-8507Japan

Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone *** or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,*** morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of ***,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains *** the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in *** vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult *** global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult ***8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow ***8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ***,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression *** results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption.

关键词： Runx2 osteoclast BMP

Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： masato Kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

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未来气候条件下蒙古草原植被的预测分布

Journal of Plant Ecology 2024年第3期17卷 16-27页

作者： Kohei Suzuki Ikutaro Tsuyama Radnaakhand Tungalag Amartuvshin Narantsetseg Tsagaanbandi Tsendeekhuu masato Shinoda Norikazu Yamanaka Takashi Kamijo Department of Regional Regeneration Science Faculty of Regional Environment ScienceTokyo University of AgricultureTokyo 156-8502Japan Hokkaido Research Center Forestry and Forest Products Research InstituteHokkaido 062-8516Japan Department ofBiology School of Arts and SciencesNational University of MongoliaUlaanbaatar 210646Mongolia Botanic Garden and ResearchInstitute Mongolian Academy of ScienceUlaanbaatar 51Mongolia Department of Earth and Environmental Sciences GraduateSchool of Environmental StudiesNagoya UniversityNagoya 464-8601Japan Arid Land Research Center Tottori UniversityTottori680-0001Japan Faculty of Life and Environmental Sciences University of TsukubaIbaraki 305-8572Japan

蒙古牧民家庭通过适应当地植被分布的特点来维持牲畜的健康状况。因此,预测未来植被变化对于稳定的牲畜放牧和可持续的草原利用至关重要。本研究基于前期研究获得的植被数据预测了2081年至2100年间草原植被,尤其是沙漠草原、草原和草甸... 详细信息

蒙古牧民家庭通过适应当地植被分布的特点来维持牲畜的健康状况。因此,预测未来植被变化对于稳定的牲畜放牧和可持续的草原利用至关重要。本研究基于前期研究获得的植被数据预测了2081年至2100年间草原植被,尤其是沙漠草原、草原和草甸草原的分布范围。我们首先基于在蒙古(43–50°N,87–119°E)收集的草原植被数据(2012至2016年,278个样地)划分了不同的群落类型。其次,采用最大熵(MaxEnt)模型进行物种分布建模,其中以荒漠草原、草原和草甸草原的分布数据作为目标变量,使用WorldClim的生物气候数据作为解释变量。最后,采用WorldClim提供的CMIP6下缩放的未来气候预测数据进行未来预测。结果发现,荒漠草原、草原和草甸草原模型的曲线下面积值分别为0.850、0.847和0.873。根据所有情景和所有群落的气候变化,适宜栖息地预计将缩小。潜在适宜区域减少的程度在草甸草原群落中最为显著。上述结果表明,未来气候变化情景下草甸草原群落将转变为草原群落。

关键词：气候变化群落最大熵物种分布建模草原 WorldClim

Perihilar cholangiocarcinoma:a surgeon's perspective

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iLIVER 2022年第1期1卷 12-24页

作者： masato Nagino Department of Gastroenterological Surgery Aichi Cancer Center1-1 KanokodenChikusa-kuNagoya464-8681Japan

Perihilar cholangiocarcinoma(PHC)is defined anatomically as tumors located in the extrahepatic biliary tree proximal to the origin of the cystic ***,as the boundary between the extrahepatic and intrahepatic bile ducts is not well defined,PHC potentially includes two types of tumors:one is the extrahepatic type,which arises from the large hilar bile duct,and the other is the intrahepatic type,which has an intrahepatic component with invasion of the hepatic *** new American Joint Commission on Cancer tumor-node-metastasis staging system for PHC was well revised;an important revision is that the Bismuth type IV was removed from T4 stage *** patients with PHC present with obstructive jaundice,and preoperative biliary drainage is ***,percutaneous transhepatic biliary drainage was used in many centers;however,it has been accepted that endoscopic nasobiliary drainage is the most suitable method for ***,inside-stents have also been adopted for biliary drainage,with favorable *** vein embolization is widely performed as presurgical treatment for patients undergoing extended hepatectomy to minimize postoperative liver *** resection of PHC is technically demanding and continues to be the most difficult challenge for hepatobiliary *** of advances in diagnostic and surgical techniques,surgical outcomes and survival rates after resection have steadily ***,survival rates,especially for patients with lymph node metastasis,are unsatisfactory,and establishing a protocol for effective adjuvant chemotherapy is an urgent *** synergy of endoscopists,radiologists,oncologists,and surgeons is required to conquer this intractable disease.

关键词： Perihilar cholangiocarcinoma Biliary drainage Portal vein embolization Extended surgery

Vertical impedance functions of pile groups under low-to-high loading amplitudes:numerical simulations and experimental validation

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 647-666页

作者： Usama Zafar Chandra Shekhar Goit masato Saitoh Riku Fukuda School of Science and Engineering Saitama University255 Shimo-OkuboSaitamaJapan

Piles in a group experience additional displacements in soil due to pile-to-pile interactions apart from those resulting from the external *** effect of these interactions determined assuming soil as an elastic and/or viscoelastic material on pile head impedance functions of the pile group is studied by relating the group stiffness to the static stiffness of a single ***,the prevailing elastic solutions may misestimate the resulting pile group response due to the lack of consideration for either soil(material)and/or soil-pile interface *** is well established that soil behaves nonlinearly under moderate-to-high loading amplitudes,and besides,the soil-pile interface nonlinearity can exist even at small loading *** study addresses the effects of these nonlinearities on the vertical impedance functions of a 3×3-pile group using numerical methods by direct analyses and superposition using pile-to-pile interaction *** numerical results are validated using scaled model tests under 1 g *** results highlight the overestimation of pile-to-pile interactions in the pile group when assuming elastic soil *** cases either by direct analyses or superposition approach involving soil and soil-pile interface nonlinearities agree well with the experimental pile group responses under close-to-elastic and nonlinear conditions.

关键词： impedance functions numerical simulations model-scale experiment superposition approach soil-pile interface nonlinearity

Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： masato Nakai Kenichi morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1239-1245页

作者： Takashi Kobayashi Michihiro Iwaki Asako Nogami masato Yoneda Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohamaJapan

Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation *** recent years,immune checkpoint inhibitors have become widely *** has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the *** the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more *** is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but *** addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be *** number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is *** Roussel Uclaf Causality Assessment Method is widely used to assess causality in *** injury is a type of immune-related adverse *** pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been *** cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of *** mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids.

关键词： Drug-induced liver injury Immune-related adverse events Immune checkpoint inhibitor Updated RUCAM

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中国与国际玉米价格的波动关系分析

中国商论 2024年第1期 1-6页

作者：刘凯穆月英山崎雅人小池淳司商务部国际贸易经济合作研究院北京100710 中国农业大学经济管理学院北京100083 名古屋大学减灾合作研究中心日本名古屋4648601 神户大学工学部日本神户6578501

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机... 详细信息

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机波动可以影响中国价格的波动。在生产者补贴期间,中国价格的预期波动和随机波动均可影响国际价格的波动。再次,中国价格的影响力在中国市场和进口市场占据主导地位,与国产玉米供给本国市场的数量地位相符。最后,中国玉米进口的不断增加将降低对本国市场价格的主导能力,需重视通过“期货+保险”规避价格风险,并分散玉米进口源,以提高市场主导力。

关键词：玉米价格波动价格风险波动溢出 VAR-BEKK-GARCH模型

Dorsal approach for isolated volar fracture-dislocation of the base of the second metacarpal:A case report

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世界临床病例杂志 2023年第28期11卷 6871-6876页

作者： Taketo Kurozumi masato Saito Kazuhiko Odachi Fumiaki Masui Trauma Center Toranomon HospitalTokyo 105-8470Japan Department of Orthopedic Surgery Chiba-Nishi General HospitalChiba 270-2251Japan

BACKGROUND We report a case with the displacement of an articular fracture fragment of the base of the second metacarpal from the ulnar to the volar side,treated via the dorsal *** dorsal approach can be a good option not only because it allows direct observation of ligament damage and fixation of bone fragments but also because the thin subcutaneous tissue makes the approach *** SUMMARY A 45-year-old man with a right hand injury visited the hospital.A small bone fragment was identified using plain *** radiography revealed the fragment as lying over the volar aspect of the carpometacarpal(CMC)*** tomography revealed that approximately one-third of the CMC joint surface of the second metacarpal was *** provisionally diagnosed an intra-articular fracture with significant CMC joint instability and performed open reduction and internal *** made a dorsal longitudinal incision over the CMC joint between the second and third *** dorsal ligament of the third CMC joint was *** thought it had been dislocated to the volar side and spontaneously reduced to that *** are only few reports of volar dislocation of CMC joint fractures,particularly of the second and third metacarpals;our report is unique as our patient had an intact interosseous ligament between the second and third *** Although past reports have used a palmar approach,the dorsal approach is a good option for these cases.

关键词： Metacarpal bone Fracture-dislocation Mechanism Dorsal approach Carpometacarpal joint Case report