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单剂量二氯化镭－223(BAY 88－8223)在去势抵抗性前列腺癌骨转移日本患者中的药代动力学研究

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中华核医学与分子影像杂志 2017年第5期37卷 318-318页

作者： Keisuke Yoshida Tomohiro Kaneta Shoko Takano Madoka Sugiura Tsuyoshi Kawano Ayako Hino Tou Yamamoto Kazuya Shizukuishi masato kaneko Christian Zurth Tomio Inoue 华中科技大学同济医学院附属协和医院核医学科 Department of Radiology Yokohama City University

目的该非盲、非随机的一期临床研究旨在评估单剂量223Ra在去势抵抗性前列腺癌骨转移日本患者中的药代动力学和辐射剂量学表现。方法研究纳入6例经组织学或细胞学证实为前列腺Ⅳ期腺癌日本患者(平均年龄72.5岁, 范围65～79岁)。2～5 min... 详细信息

目的该非盲、非随机的一期临床研究旨在评估单剂量223Ra在去势抵抗性前列腺癌骨转移日本患者中的药代动力学和辐射剂量学表现。方法研究纳入6例经组织学或细胞学证实为前列腺Ⅳ期腺癌日本患者(平均年龄72.5岁, 范围65～79岁)。2～5 min内静脉缓慢推注单一剂量的223Ra, 组1剂量为50 kBq/kg, 组2剂量为100 kBq/kg。结果经静脉注射后, 223Ra以多相式从血液中快速清除。注射后24 h, 全身残留的223Ra为注射活度的85%。生物分布结果显示, 骨骼初始摄取为52%(范围41%～57%)。223Ra在骨骼中摄取的峰值时间为给药后2 h。给药24 h内, 在小肠中可以检测到有放射性, 其他器官未检测到放射性。223Ra的主要辐射剂量在成骨细胞中。通过计算发现, 成骨细胞和红骨髓中的吸收剂量分别为0.76 Gy/MBq和0.09 Gy/MBq。结论在去势抵抗性前列腺癌骨转移的日本患者中, 223Ra(静脉注射)可在骨组织中快速达到摄取峰值, 并在24 h内通过小肠, 而其他器官无明显放射性分布。本研究显示, 日本患者器官和组织中该药物的药代动力学和吸收辐射剂量与非日本患者的数据相似。临床试验注册号:NCT01565746。

关键词： 223Ra 去势抵抗性前列腺癌转移药代动力学

Improving the performance of conventional base isolation systems by an external variable negative stiffness device under near-fault and long-period ground motions

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Earthquake Engineering and Engineering Vibration 2020年第4期19卷 985-1003页

作者： Sandhya Nepal masato Saitoh Graduate School of Science and Engineering Saitama University255 Shimo-OkuboSakura-kuSaitamaJapan

Recent studies have shown that base-isolated objects with long fundamental natural periods are highly influenced by long-period earthquakes. These long-period waves result in large displacements for isolators, possibly leading to exceedance of the allowable displacement limits. Conventional isolation systems, in general, fail to resist such large displacements. This has prompted the need to modify conventional base isolation systems. The current work focuses on the development of an external device, comprising a unit of negative and positive springs, for improving the performance of conventional base isolation systems. This unit accelerates the change in the stiffness of the isolation system where the stiffness of the positive spring varies linearly in terms of the displacement response of the isolated objects. The target objects of the present study are small structures such as computer servers, sensitive instruments and machinery. Numerical studies show that the increase in the damping of the system and the slope of the linear function is effective in reducing the displacement response. An optimal range of damping values and slope, satisfying the stability condition and the allowable limits of both displacement and acceleration responses when the system is subjected to near-fault and long-period ground motions simultaneously, is proposed.

关键词： base isolation near-fault earthquakes long-period earthquakes negative stiffness variable stiffness

Special variation of infiltration-growth processed bulk YBCO fabricated using new liquid source: Ba_(3)Cu_(5)O_(8) (1:1.3) and YbBa_(2)Cu_(3)O_(y)

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1048-1056页

作者： Sushma Miryala masato Murakami Superconducting Material Laboratory Department of Material Science and EngineeringShibaura Institute of Technology3-7-5 ToyosuKoto-kuTokyo 135-8546Japan School of Engineering and Applied Science Princeton UniversityPrincetonNJ 08544United States

Utilization of novel materials,particularly high-T_(c)(critical temperature)superconductors,is essential to pursue the United Nations’Sustainable Goals,as well as to meet the increasing worldwide demand for clean and carbon-free electric power *** magnets are beneficial in several real-life applications including transportation,energy production,magnetic resonance imaging(MRI),and drug delivery *** achieve high performance,one must develop uniform,large-grain,infiltration-growth(IG)processed bulk YBa_(2)Cu_(3)O_(y)(Y-123)*** this study,we report the magnetic and microstructural properties of a large-grain,top-seeded,IG-processed Y-123 pellet,which is 20 mm in diameter and 6 mm in height;the pellet is produced utilizing liquid Yb-123+Ba_(3)Cu_(5)O_(8) as the liquid *** the samples cut from the top of the bulk exhibit a sharp superconducting transition(approximately 1 K wide)with the onset T_(c) of approximately 90 ***,in the samples cut from the bottom surface,the onset T_(c) values slightly decreased to between 88 and 90 K,although still exhibiting a sharp superconducting *** top and bottom samples exhibited the highest remnant value of J_(c)(critical current density)at 77 K H//c-axis of 50 and 55 kA/cm^(2),*** remnant J_(c) and irreversibility field values significantly fluctuated,being fairly low in some bottom *** electron microscopy identified nanometer size Y-211(Y2BaCuO5)secondary-phase particles dispersed in the Y-123 ***-dispersive spectroscopy clarified that the decreased both T_(c) and J_(c) for the bottom samples were attributed to liquid phase dispersion within the Y-123 phase.

关键词： infiltration growth special variation critical current density scanning electron microscopy

Application of the SCC method to the multi-O(4) model:The collective Hamiltonian

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Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1518-1529页

作者： KOBAYASI masato Department of Physics Graduate School of ScienceKyoto University Advancesoft Center for Collaborative ResearchUniversity of Tokyo

The collective Hamiltonian up to the fourth order for a multi-O(4) model is derived for the first time based on the self-consistent collective-coordinate(SCC) method,which is formulated in the framework of the time-dependent Hartree-Bogoliubov(TDHB) *** collective Hamiltonian is valid for the spherical case where the HB equilibrium point of the multi-O(4) model is spherical as well as for the deformed case where the HB equilibrium points are *** validity is tested numerically in both the spherical and deformed *** simulations indicate that the low-lying states of the collective Hamiltonian and the transition amplitudes among them mimic fairly well those obtained by exactly diagonalizing the Hamiltonian of the multi-O(4) *** numerical results for the deformed case imply that the "optimized RPA boundary condition" is also valid for the well-known η*,η expansion around the unstable HB point of the multi-O(4) *** these illuminate the power of the SCC method.

关键词： self-consistent collective-coordinate method multi-O(4) model time-dependent Hartree-Bogoliubov theory collective Hamiltonian

Model tests and numerical analyses on horizontal impedance functions of inclined single piles embedded in cohesionless soil

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Earthquake Engineering and Engineering Vibration 2013年第1期12卷 143-154页

作者： Chandra Shekhar Goit masato Saitoh Department of Civil and Environmental Engineering Saitama University

Horizontal impedance functions of inclined single piles are measured experimentally for model soil-pile systems with both the effects of local soil nonlinearity and resonant *** practical pile inclinations of 5掳 and 10掳 in addition to a vertical pile embedded in cohesionless soil and subjected to lateral harmonic pile head loadings for a wide range of frequencies are *** obtained with low-to-high amplitude of lateral loadings on model soil-pile systems encased in a laminar shear box show that the local nonlinearities have a profound impact on the horizontal impedance functions of *** impedance functions of inclined piles are found to be smaller than the vertical pile and the values decrease as the angle of pile inclination *** values of horizontal impedance functions are obtained for the ＇positive＇ and ＇negative＇ cycles of harmonic loadings,leading to asymmetric force-displacement relationships for the inclined *** of these experimental results is carried out through three-dimensional nonlinear finite element analyses,and the results from the numerical models are in good agreement with the experimental *** analyses conducted on the numerical models suggest that the consideration of local nonlinearity at the vicinity of the soil-pile interface influence the response of the soil-pile systems.

关键词： inclined single piles harmonic loads horizontal impedance functions local nonlinearity finite element model

Motion Analysis of Trunk Using Simplified Human Model in Sagittal Plane

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 20-27页

作者： masato Kawaguchi Shoichiro Takehara Division of Mechanical Engineering Graduate School of Science and TechnologySophia University Department of Engineering and Applied Sciences Sophia University

The mass of very small vehicles is often comparable to that of their drivers,and thus there is a greater degree of coupling between the vehicle and the driver,compared with a case for traditional *** developing small vehicles,it is necessary to give ample consideration to the dynamics of the person who ride ***,a model of a human body riding a small personal vehicle was constructed to investigate the dynamics of the person inside such a ***,an experiment on posture maintenance by acceleration of direction of travel was conducted and the parameters for posture control were identified using agenetic *** shows that body behavior could be successfully simulated using the proposed model,and the control parameters were effective in determining the posture maintenance characteristics of the vehicle occupant.

关键词： human dynamics trunk simulation human body vehicles

Modeling and measurement of curing properties of photocurable polymer containing magnetic particles and microcapsules

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Microsystems & Nanoengineering 2017年第1期3卷 175-183页

作者： masato Yasui Koji Ikuta Laboratory for Cell Signaling Dynamics RIKEN Quantitative Biology Center6-2-3 FuruedaiSuitaOsaka 565-0874Japan Graduate School of Information Science and Technology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8685Japan

In microstereolithography,three-dimensional microstructures are created by scanning an ultraviolet laser on a photocurable resin and stacking several such layers to form the desired *** mixing different types of particles in the resin,the formed microstructures exhibit various physical *** example,the magnetism and density of the microstructure can be controlled by adding magnetic particles and microcapsules to the *** method has been used to fabricate magnetic *** such functional resins are useful,the incorporated magnetic particles and microcapsules can affect the fabrication resolution,making it difficult to fabricate microstructures with high ***,it is necessary to understand the effects of such microparticles and microcapsules on the fabrication *** this study,we propose a simple model of curing resins containing magnetic particles and microcapsules to explain the effects of the magnetic particles and *** proposed model can explain the observed curing characteristics of a resin that contains particles for all concentrations as well as for different types of magnetic particles and ***,using the proposed model,we discuss how to improve the characteristics of resins containing microparticles to realize the high-resolution fabrication of three-dimensional microstructures with desirable material properties.

关键词： Magnetic particles Microcapsules Microstereolithography Photocurable model Photocurable polymer Resin

Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

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Nano Research 2016年第5期9卷 1267-1275页

作者： masato Ohnishi Ken Suzuki Hideo Miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage

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Neural Regeneration Research 2019年第2期14卷 262-264页

作者： masato Shiba Hidenori Suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Subarachnoid hemorrhage by a ruptured cerebral aneurysmremains the most devastating cerebrovascular disorderswith high morbidity and mortality (Suzuki et al.,2017), which are mainly caused by early brain injury anddelayed cerebral ischemia. Despite many experimentaland clinical research efforts, the mechanisms of earlybrain injury as well as delayed cerebral ischemia remainunclarified. However, recent works have suggested thattenascin-C, which is a special type of secreted extracellularmatrix proteins, is promising as a novel therapeutictarget against post-subarachnoid hemorrhage early braininjury and delayed cerebral ischemia.

关键词： cerebral clinical ischemia hemorrhage