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Communications in Computational Physics 2011年第5期9卷 1397-1413页

作者： Toshiro Murayama masato Yoshino Tetsuo hirata Department of Mathematics and System Development Engineering Interdisciplinary Graduate School of Science and TechnologyShinshu University4-17-1 WakasatoNagano-shiNagano 380-8553Japan Satellite Venture Business Laboratory(SVBL) Shinshu University3-15-1 TokidaUeda-shiNagano 386-8567Japan Department of Mechanical Systems Engineering Faculty of EngineeringShinshu University4-17-1 WakasatoNagano-shiNagano 380-8553Japan CREST Japan Science and Technology Agency4-1-8 HonchoKawaguchi-shiSaitama 332-0012Japan

The lattice Boltzmann method(LBM)with an elastic model is applied to the simulation of two-phase flows containing a deformable body with a viscoelastic *** numerical method is based on the LBM for incompressible two-phase fluid flows with the same *** body has an internal fluid covered by a viscoelastic membrane of a finite *** elastic model is introduced to the LBM in order to determine the elastic forces acting on the viscoelastic membrane of the *** the present method,we take account of changes in surface area of the membrane and in total volume of the body as well as shear deformation of the *** using this method,we calculate two problems,the behavior of an initially spherical body under shear flow and the motion of a body with initially spherical or biconcave discoidal shape in square pipe *** deformations of the body(the Taylor shape parameter)for various shear rates are in good agreement with other numerical ***,tank-treading motion,which is a characteristic motion of viscoelastic bodies in shear flows,is simulated by the present method.

关键词： Lattice Boltzmann method(LBM) two-phase flow viscoelastic membrane shear flow tank-treading motion

Lattice Boltzmann Simulation of Nucleate Pool Boiling in Saturated Liquid

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Communications in Computational Physics 2011年第5期9卷 1347-1361页

作者： Yoshito Tanaka masato Yoshino Tetsuo hirata Department of Mathematics and System Development Engineering Interdisciplinary Graduate School of Science and TechnologyShinshu University4-17-1WakasatoNagano-shiNagano 380-8553Japan Department of Mechanical Systems Engineering Faculty of EngineeringShinshu UniversityNagano-shiNagano 380-8553Japan CREST Japan Science and Technology Agency4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan

A thermal lattice Boltzmann method(LBM)for two-phase fluid flows in nucleate pool boiling process is *** the present method,a new function for heat transfer is introduced to the isothermal LBM for two-phase immiscible fluids with large density *** calculated temperature is substituted into the pressure tensor,which is used for the calculation of an order parameter representing two phases so that bubbles can be formed by nucleate *** using this method,twodimensional simulations of nucleate pool boiling by a heat source on a solid wall are carried out with the boundary condition for a constant heat *** flow characteristics and temperature distribution in the nucleate pool boiling process are *** is seen that a bubble nucleation is formed at first and then the bubble grows and leaves the wall,finally going up with deformation by the buoyant *** addition,the effects of the gravity and the surface wettability on the bubble diameter at departure are numerically *** calculated results are in qualitative agreement with other theoretical predictions with available experimental data.

关键词： Lattice Boltzmann method(LBM) two-phase fluid flows heat transfer nucleate pool boiling wettability

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

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World Journal of Gastroenterology 2020年第9期26卷 918-932页

作者： Chieko Tashita masato Hoshi Akihiro hirata Kentaro Nakamoto Tatsuya Ando Takayuki Hattori Yasuko Yamamoto Hiroyuki Tezuka Hiroyuki Tomita Akira Hara Kuniaki Saito Department of Disease Control and Prevention Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Department of Biochemical and Analytical Science Fujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Division of Animal Experiment Life Science Research CenterGifu UniversityGifu 501-1193Japan Department of Cellular Function Analysis Research Promotion and Support HeadquartersFujita Health University Graduate School of Health SciencesToyoake 470-1192Japan Faculty of Medical Technology Gifu University of Medical ScienceGifu 501-3892Japan Department of Tumor Pathology Gifu University Graduate School of MedicineGifu 501-1193Japan

BACKGROUND Inflammatory bowel disease,such as Crohn’s disease and ulcerative colitis,is characterized by chronic intestinal inflammation leading to intestinal mucosal *** bowel disease causes dysregulation of mucosal T cell responses,especially the responses of CD4+T ***,we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate(TNBS)-induced *** indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan(Trp)and immunomodulatory Trp metabolites,the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain *** To investigate role of kynurenine 3-monooxygenase(KMO)in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal *** Colitis was induced in eight-week-old male KMO+/+or KMO−/−mice of C57BL/6N background using *** days later,the colon was used for hematoxylin-eosin staining for histological grading,immunohistochemical or immunofluorescence staining for KMO,cytokines,and immune *** and anti-inflammatory cytokines were measured using quantitative RT-PCR,and kynurenine(Kyn)pathway metabolites were measured by high-performance liquid *** cell proportions of colonic lamina propria and mesenteric lymph nodes were analyzed by flow *** KMO expression levels in the colonic mononuclear phagocytes,including dendritic cells and macrophages increased upon TNBS ***,KMO deficiency reduced TNBS-induced colitis,resulting in an increased frequency of Foxp3+regulatory T cells and increased mRNA and protein levels of antiinflammatory cytokines,including transforming growth factor-βand *** Absence of KMO reduced TNBS-induced colitis via generation of Foxp3+regulatory T cells by producing ***,Kyn may play a therapeutic role in colon protection

关键词： Kynurenine 3-monooxygenase Kynurenine Regulatory T cell Inflammatory bowie diseases

Endoscopic papillary large balloon dilation for removal of bile duct stones

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World Journal of Gastroenterology 2014年第45期20卷 17148-17154页

作者： Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura Dai Sakamoto masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Department of Gastroenterology Tokai University Hospital Department of Gastroenterology Kameda Medical Center Division of Gastroenterology Department of Medicine Showa University School of Medicine Department of Internal Medicine Kikkoman General Hospital Department of Gastroenterology Kimitsu Central Hospital Department of Gastroenterology Isesaki Municipal Hospital Department of Gastroenterology Iwate Medical University Hospital Department of Gastroenterology Tokyo Women’s Medical University Yachiyo Medical Center

AIM: To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation (EPLBD) for bile duct stones in a multicenter prospective study.

关键词： Endoscopic retrograde cholangiopancreatography Endoscopic sphincterotomy Endoscopic papillary large balloon dilation Large bile duct stones Multiple bile duct stones