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An extended Fibonacci sequence associated with the discrete hungry Lotka-Volterra system

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International Journal of Biomathematics 2017年第3期10卷 245-260页

作者： masato Shinjo Kanae Akaiwa Masashi Iwasaki Yoshimasa Nakamura Graduate School of Informatics Kyoto University Yoshida-Hommachi Sakyo-ku Kyoto 606-8501 Japan Faculty of Life and Environmental Sciences Kyoto Prefectural University Nakaragi-cho Shimogamo Sakyo-ku Kyoto 606-8522 Japan

The integrable hungry Lotka-Volterra （hLV） system stands for a prey-predator model in mathematical biology. The discrete-time hLV （dhLV） system is derived from a time discretization of the hLV system. The solution to the dhLV system is known to be represented by using the Casorati determinant. In this paper, we show that if the entries of the Casorati determinant become an extended Fibonacci sequence at the initial discrete time, then those are also an extended Fibonacci sequence at any discrete time. In other words, the extended Fibonacci sequence always appears in the entries of the Casorati determinant under the time evolution of the dhLV system with suitable initial setting. We also show that one of the dhLV variables converges to the ratio of two successive extended Fibonacci numbers as the discrete time goes to infinity.

关键词： Fibonacci sequence Casorati determinant discrete hungry Lotka Volterra system.

Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1239-1245页

作者： Takashi Kobayashi Michihiro Iwaki Asako Nogami masato Yoneda Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohamaJapan

Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation *** recent years,immune checkpoint inhibitors have become widely *** has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the *** the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more *** is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but *** addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be *** number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is *** Roussel Uclaf Causality Assessment Method is widely used to assess causality in *** injury is a type of immune-related adverse *** pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been *** cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of *** mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids.

关键词： Drug-induced liver injury Immune-related adverse events Immune checkpoint inhibitor Updated RUCAM

Neo-adjuvant therapy for hepatocellular carcinoma before liver transplantation:Where do we stand?

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World Journal of Gastroenterology 2014年第18期20卷 5308-5319页

作者： masato Fujiki Federico Aucejo Minsig Choi Richard Kim Transplant Center Cleveland ClinicClevelandOH 44195United States Department of Gastrointestinal Oncology Wayne State University/Karmonos Cancer Center DetroitMI 48202United States Department of Gastrointestinal Oncology H Lee Moffitt Cancer CenterTampaFL 33612United States

Liver transplantation (LT) for hepatocellular carcinoma (HCC) within Milan criteria is a widely accepted optimal therapy. Neo-adjuvant therapy before transplantation has been used as a bridging therapy to prevent dropout during the waiting period and as a down-staging method for the patient with intermediate HCC to qualify for liver transplantation. Transarterial chemoembolization and radiofrequency ablation are the most commonly used method for locoregional therapy. The data associated with newer modalities including drug-eluting beads, radioembolization with Y90, stereotactic radiation therapy and sorafenib will be discussed as a tool for converting advanced HCC to LT candidates. The concept “ablate and wait” has gained the popularity where mandated observation period after neo-adjuvant therapy allows for tumor biology to become apparent, thus has been recommended after down-staging. The role of neo-adjuvant therapy with conjunction of “ablate and wait” in living donor liver transplantation for intermediate stage HCC is also discussed in the paper.

关键词： Bridging therapy Neo-adjuvant therapy Locoregional therapy Intermediate stage Living donor liver transplantation Ablation Transarterial chemotherapy Transarterial radioembolization External beam radiotherapy

Erythropoietin ameliorates early ischemia-reperfusion injury following the Pringle maneuver

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World Journal of Gastroenterology 2010年第38期16卷 4838-4845页

作者： masato Kato Tokihiko Sawada Junji Kita Mitsugi Shimoda Keiichi Kubota Second Department of Surgery Dokkyo Medical UniversityKitakobayash 880

AIM:To investigate the protective effect of erythropoietin (Epo) against ischemia-reperfusion injury (IR/I) following the Pringle maneuver (PM),in comparison with conventional steroid administration in a prospective randomized trial. METHODS:Patients were randomized by age, sex, diagnosis, and surgical method, and assigned to three groups:(1) A steroid group (STRD, n= 9) who received 100 mg of hydrocortisone before PM, and on postoperative days 1, 2 and 3, followed by tapering until postoperative day 7; (2) An EPO1 group (n=10) who received 30 000 U of Epo before the PM and at the end of surgery; and (3) An EPO2 group (n=8) who received 60 000 U of Epo before the PM. Hemoglobin (Hb), hematocrit (Ht), aspartate aminotransferase (AST), alanine transaminase (ALT),lactate dehydrogenase (LDH), lactate, interleukin-6 (IL-6),and tumor necrosis factor(TNF)-α were measured before and just after (Day 0) surgery, and on postoperative days 1, 3, 7 and 14. RESULTS: There were no increases in Hb and Ht in the EPO1 and EPO2 groups. AST was signif icantly lower in EPO1 than in STRD on Day 0 (P=0.041), and lower in EPO1 than in STRD and EPO2 on Day 1 (P=0.018). ALT was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.020) and Day 1 (P=0.004). There were no signif icant inter-group differences in the levels of LDH and lactate. IL-6 was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0036) and Day 1 (P=0.0451). TNF-α was signif icantly lower in EPO1 than in STRD and EPO2 on Day 0 (P=0.0006) and Day 1 (P<0.0001). Furthermore, hospitalization was signif icantly shorter in EPO1 and EPO2 than in ***:Epo has greater potential than steroids to ameliorate IR/I after the PM. Epo at a dose of 30000 U, administered before PM and just after surgery, yields better results.

关键词： Erythropoietin Hepatic resection Pringle maneuver Steroid Prospective randomized study

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中国与国际玉米价格的波动关系分析

中国商论 2024年第1期 1-6页

作者：刘凯穆月英山崎雅人小池淳司商务部国际贸易经济合作研究院北京100710 中国农业大学经济管理学院北京100083 名古屋大学减灾合作研究中心日本名古屋4648601 神户大学工学部日本神户6578501

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机... 详细信息

本文在政策分析的基础上,建立VAR-BEKK-GARCH模型进行实证分析。首先,国际玉米价格的波动幅度比中国价格波动幅度大,临储政策取消后,中国价格波动幅度变大。其次,临储期间,中国价格的预期波动可以影响国际价格的波动,而国际价格的随机波动可以影响中国价格的波动。在生产者补贴期间,中国价格的预期波动和随机波动均可影响国际价格的波动。再次,中国价格的影响力在中国市场和进口市场占据主导地位,与国产玉米供给本国市场的数量地位相符。最后,中国玉米进口的不断增加将降低对本国市场价格的主导能力,需重视通过“期货+保险”规避价格风险,并分散玉米进口源,以提高市场主导力。

关键词：玉米价格波动价格风险波动溢出 VAR-BEKK-GARCH模型

Intracellular and extracellular TGF-β signaling in cancer： some recent topics

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Frontiers of Medicine 2018年第4期12卷 387-411页

作者： Kohei Miyazono Yoko Katsuno Daizo Koinuma Shogo Ehata masato Morikawa Department of Molecular Pathology Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan

Transforming growth factor （TGF）-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition （EMT） induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-[~ in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells （Tregs）. TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant （GARP, also known as leucine-rich repeat containing 32 or LRRC32）. Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.

关键词： TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP

Influence of oxygen flow rate and compost addition on reduction of organic matter in aerated waste layer containing mainly incineration residue

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Journal of Environmental Sciences 2013年第1期25卷 53-58页

作者： Hiroshi Asakura Kei Nakagawa Kazuto Endo masato Yamada Yusaku Ono Yoshiro Ono Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521Japan National Institute for Environmental Studies Onogawa 16-2TsukubaIbaraki 305-8506Japan Nippon Institute of Technology 4-1 GakuendaiMiyashiro-machiMinamisaitama-gunSaitama 345-8501Japan Kyoto Institute of Technology MatsugasakiSakyo-kuKyoto 606-8585Japan

Landfilling municipal solid waste incineration （MSWI） residue alkalizes the waste layer, causing a subsequent decrease in microbial activity and a delay in the decomposition of organic matter. In this study, efficiencies of neutralization of the leachate and organic matter decomposition in the waste layer in a column filled with MSWI residue using aeration and compost addition were evaluated. Total organic carbon （TOC） reduction in the waste layer is large at high oxygen flow rate （OFR）. To effectively accelerate TOC reduction in the waste layer to which compost was added, a high OFR exceeding that by natural ventilation was required. At day 65, the pH of the leachate when OFR was above 102 mol-O2/（day.m3） was lower than that when OFR was below 101 mol-Oz/（day.m3）. At the same OFR, the pH of waste sample was lower than that of waste sample with compost. Although leachate neutralization could be affected by compost addition, TOC reduction in the waste layer became rather small. It is possible that humic substances in compost prevent the decomposition of TOC in MSWI residue.

关键词： waste landfill aeration neutralization acceleration of stabilization

Designing and generating a mouse model:frequently asked questions

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The Journal of Biomedical Research 2021年第2期35卷 76-90页

作者： Channabasavaiah BGurumurthy Thomas LSaunders masato Ohtsuka Department of Pharmacology and Experimental Neuroscience Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Mouse Genome Engineering Core Facility Department of Pharmacology and Experimental NeuroscienceCollege of MedicineUniversity of Nebraska Medical CenterOmahaNE 68106-5915USA Department of Internal Medicine Division of Genetic MedicineUniversity of Michigan Medical SchoolAnn ArborMI 48109USA Transgenic Animal Model Core University of MichiganAnn ArborMI 48109USA Department of Molecular Life Science Division of Basic Medical Science and Molecular MedicineTokai University School of MedicineIseharaKanagawa 259-1193Japan The Institute of Medical Sciences Tokai UniversityIseharaKanagawa 259-1193Japan

Genetically engineered mouse(GEM)models are commonly used in biomedical *** GEMs involve complex set of experimental procedures requiring sophisticated equipment and highly skilled technical *** of these reasons,most research institutes set up centralized core facilities where custom GEMs are created for research ***,on the other hand,when they begin thinking about generating GEMs for their research,several questions arise in their *** example,what type of model(s)would be best useful for my research,how do I design them,what are the latest technologies and tools available for developing my model(s),and finally how to breed GEMs in my *** there are several considerations and options in mouse designs,and as it is an expensive and time-consuming endeavor,careful planning upfront can ensure the highest chance of *** this article,we provide brief answers to several frequently asked questions that arise when researchers begin thinking about generating mouse model(s)for their work.

关键词： CRISPR transgenic mouse genetic engineering knockout mouse conditional knockout mouse knock-in mouse

Will the magnetic resonance imaging proton density fat fraction replace liver biopsy as the gold standard for detecting steatosis?

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 292-293页

作者： masato Yoneda Kento Imajo Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Yokohama Japan

Accompanied with the ongoing epidemics of obesity and metabolic syndrome arising from the westernization of lifestyles, the incidence of nonalcoholic fatty liver disease (NAFLD) has been getting higher worldwide in th... 详细信息

关键词： liver NAFLD biopsy