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CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie masataka ikeda Mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

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Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 311-322页

作者： Kei Kimura Naohito Beppu Hiroshi Doi Kozo Kataoka Tomoki Yamano Motoi Uchino masataka ikeda Hiroki Ikeuchi Naohiro Tomita Division of Lower Gastrointestinal Surgery Department of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiology Hyogo College of MedicineNishinomiyaHyogo 663-8501Japan Department of Radiation Oncology Kindai University Faculty of MedicineSayamaOsaka 589-8511Japan Department of Inflammatory Bowel Disease Division of SurgeryHyogo College of MedicineNishinomiyaHyogo 663-8501Japan

BACKGROUND Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical *** To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimeracil/oteracil(S-1)plus irinotecan(CPT-11).METHODS This was a single-center retrospective study of 82 patients who underwent radical surgery for rectal cancer after chemoradiotherapy with S-1(80 mg/m2/d),CPT-11(60 mg/m2/d),and radiation(total 45 Gy)between 2009 and *** median follow-up was 51 mo(range:17–116 mo).RESULTS Twenty-nine patients(35.4%)had T3 or T4 rectal cancer with mesorectal fascia invasion,36(43.9%)had extramural vascular invasion,24(29.8%)had N2 rectal cancer and eight(9.8%)had lateral lymph node *** relative dose intensity was 90.1%for S-1 and 92.9%for ***-nine patients(96.3%)underwent R0 *** regard to pathological response,13 patients(15.9%)had a pathological complete response and 52(63.4%)a good response(tumor regression grade 2/3).The 5-year local recurrence-free survival,relapsefree survival and overall survival rates were 90.1%,72.5%and 91.3%,*** analyzed the risk factors for local recurrence-free survival by Cox regression analysis and none were *** described risk factors such as T4 stage,mesorectal fascia invasion or lateral lymph node swelling were not detected as negative factors for local recurrence-free *** We demonstrated good compliance and favorable tumor regression in patients with locally advanced rectal cancer treated with preoperative S-1 and CPT-11.

关键词： Preoperative chemoradiotherapy Rectal cancer Irinotecan Tegafur/gimeracil/oteracil Neoadjuvant chemoradiotherapy Radiation therapy

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Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

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Science China Mathematics 2024年

作者： masataka Iwai Chen Jiang Haidong Liu Department of Mathematics Graduate School of Science Osaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X）·c2（X）≠0,then c1（X）·c2（X）≥1/252;if further X is not rationally connected,then c1（X）·c2（X）≥4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dimX-2·c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

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Feasibility and Efficacy Study of Biweekly Irinotecan Combined with Oral Tegafur/Uracil in Advanced Colorectal Cancer

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Journal of Cancer Therapy 2013年第6期4卷 8-14页

作者： masataka ikeda Mitsugu Sekimoto Ichiro Takemasa Tsunekazu Mizushima Hirofumi Yamamoto Hideshi Ishii Yuichiro Doki Masaki Mori Department of Surgery Gastroenterological Surgery Osaka University Graduate School of Medicine Osaka Japan Department of Surgery Natinal Hospital Organization Osaka National Hospital Osaka Japan

Background: We evaluated the feasibility and efficacy of irinotecan (CPT-11) plus tegafur/uracil (UFT) combination chemotherapy in patients with advanced colorectal cancer. Patients and Methods: PK parameters were concurrently measured to confirm the presence of drug interactions in this treatment schedule. CPT-11 was administered intravenously at the dose of 150 mg/m2 on days 1, 15. UFT was administered at the dose of 375 mg/m2/day (B.I.D.) on days 3 - 7, 10 - 14, 17 - 21, 24 - 28 repeated every 5 weeks. Results: 31 patients were enrolled. PK parameters for CPT-11, FT, 5-FU and uracil are available from 5 patients. The overall response rate was 16.1%. The median time to treatment discontinuation was 3.9 months. There was no significant difference in PK parameters of CPT-11 between day 1 and day 15 and of UFT between day 3 and day 10. Conclusion: CPT-11 plus UFT combination chemotherapy exhibited a tolerable toxicity profile with acceptable efficacy. Pharmacokinetic analysis showed that there were no drug interactions in this treatment schedule.

关键词： Colorectal Neoplasms Pharmacokinetics Drug Therapy Fluorouracil Tegafur/Uracil UFT

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Phase Ⅱ study of protracted irinotecan infusion and a low-dose cisplatin for metastatic gastric cancer

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World Journal of Gastroenterology 2006年第40期12卷 6522-6526页

作者： Hiroshi Imamura masataka ikeda Hiroshi Furukawa Toshimasa Tsujinaka Kazumasa Fujitani Kenji Kobayashi Hiroyuki Narahara Michio Kato Haruhiko Imamoto Arimichi Takabayashi Hideaki Tsukuma Department of Surgery Sakai Municipal Hospital Osaka Japan Department of Surgery Osaka National Hospital Osaka Japan Department of Surgery Kinki Central Hospital Hyogo Japan Department of Internal Medicine Osaka Medical Center for Cancer and Cardiovascular Diseases Osaka Japan Department of Surgery Kinki University School of Medicine Osaka Japan Department of Surgery Kansai Rosai Hospital Hyogo Japan Department of Surgery Kitano Hospital & Research Institute Osaka Japan

AIM: To test protracted irinotecan infusion plus a low-dose cisplatin in this Phase Ⅱ trial to decrease its toxic-ity. METHODS: The eligibility criteria were: (1) histologi-cally proven measurable gastric cancer; (2) performance status of 0 or 1; (3) no prior chemotherapy or comple-tion of prior therapy at least 4 wk before enrollment; (4) adequate function of major organs; (5) no other active malignancy; and (6) written informed consent. The regi-men consisted of irinotecan (60 mg/m2) on d 1 and 15 by 24-h infusion and cisplatin (10 mg/m2) on d 1, 2, 3, 15, 16, and 17. Treatment was repeated every 4 wk. RESULTS: Thirty-one patients were registered between April 2000 and January 2001. The response rate for all 31 patients, 20 patients without prior chemotherapy, and 11 patients with prior chemotherapy was 52% (16/31), 60% (12/20), and 36% (4/11), respectively. The median survival time was 378 d. The median number of courses given to all patients was 2. Grade 4 neutropenia oc-curred in 11 (35%) patients, while grade 3 to 4 diarrhea or nausea occurred in 1 (3%) and 3 (10%) patients, respectively. Fatigue was minimal as grade 1 fatigue was found only in 3 (10%) patients. Other adverse events were mild and no treatment-related deaths ***: This regimen showed a high level of ac-tivity and acceptable toxicity in patients with metastatic gastric cancer.

关键词：病理治疗临床胃癌

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Effect of multifunction cavitation using phosphoric acid on fatigue and surface properties of AZ31 magnesium alloy

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镁合金学报(英文) 2023年第6期11卷 1996-2005页

作者： Shunta Matsuoka Fumihiro Kato Toshihiko Yoshimura masataka Ijiri Shoichi Kikuchi Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Department of Mechanical Engineering Sanyo-Onoda City University1-1-1 Daigaku-DoriSanyo-OnodaYamaguchi 756-0884Japan Tokyo Metropolitan University 1-1 Minami-OsawaHachiojiTokyo 192-0397Japan Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1 JohokuNaka-kuHamamatsu-shiShizuoka 432-8561Japan

Magnesium alloy is attractive for lightweight construction but often suffers from poor corrosion resistance and low *** processing with chemicals,i.e.,multifunction cavitation(MFC),was introduced to form a high-corrosion film and improve the fatigue properties of an AZ31 magnesium *** analysis and plane bending fatigue tests were conducted for the MFC-treated magnesium alloy at a stress ratio,R,*** mechanical action of cavitation bubbles improved the fatigue life of magnesium alloys due to increasing the surface hardness and generating compressive residual ***,the combined mechanical and electrochemical action during MFC formed pits on the *** pits were large enough to easily nucleate an initial fatigue *** addition,the magnesium alloys without pit formation,for which a coating process using phosphoric acid was conducted after MFC using water,showed superior fatigue properties.

关键词： Magnesium alloy Multifunction cavitation Surface modification Fatigue Residual stress

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Molecular typing guiding treatment and prognosis of endometrial cancer

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 7-17页

作者： Junya Tabata masataka Takenaka Aikou Okamoto Department of Obstetrics and Gynecology The Jikei University School of MedicineJapan

Genetic abnormalities,such as PTEN,PIK3CA,CTNNB1,ARID1A,and ERBB2,which frequently occur in endometrial cancer(EC),are potential therapeutic *** 2013,integrated genomic analysis conducted by The Cancer Genome Atlas identified four molecular subtypes,including POLE ultra-mutated,microsatellite instability hypermutated,copy-number low,and copy-number high,which strongly correlate with *** markers-based molecular classification methods have been developed to make these molecular classifications accessible and affordable,achieving classification into POLEmut,mismatch repair deficient(MMRd),p53abn,and no specific molecular profile(NSMP)with normal p53 *** POLEmut EC has aggressive pathologic features,there are few cases of advanced and/or ***,the possibility of de-escalating adjuvant therapy can be ***,immune checkpoint inhibitors(ICI)may be a candidate for treating advanced and recurrent POLEmut EC because of their high *** EC shows an intermediate prognosis between those of POLEmut and p53abn *** EC is generally characterized by high immunogenicity similar to POLEmut EC,suggesting that ICI can also be a potential therapeutic *** the four molecular subtypes,p53abn EC has the worst ***,some p53abn tumors have the molecular hallmark of homologous recombination deficiency and could be treated with poly(ADP-ribose)polymerase *** addition,some p53abn tumors overexpress the human epidermal growth factor receptor 2,which can also be a potential therapeutic *** EC are a heterogeneous population because they lack characteristic molecular biological *** half of the NSMP EC show high expression of estrogen receptor/progesterone receptor,suggesting the possibility of hormonal *** addition,the PI3K/AKT/mTOR pathway frequently altered in EC may be a therapeutic *** review summarizes the molecular biological character

关键词： Endometrial cancer Molecular classification Molecular typing Surrogate markers Targeted therapy Precision medicine

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The Possibility of Active Attitude Control for Fuel Spray

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Engineering 2019年第3期5卷 519-534页

作者： masataka Arai Tokyo Denki University Tokyo 120-8551 Japan

The internal combustion engine (ICE) is an attractive power source for automobiles, with its superior storability, transportability, and suppliability of liquid fuel with high energy density. Compact ICEs with high performance and a low environmental load are greatly needed. In the future, smart active control of combustion by means of fuel spray injection must be considered as a breakthrough technology to address serious issues related to conventional ICEs, such as emissions. A designed fuel injection rate and spray pattern during the injection period have been technically developed, and combustion can be partially controlled in the conventional ICE. However, spatial fuel distribution is not progressing as desired in the field of combustion;thus, new and effective active control technologies for fuel spray are very necessary for the smart control of combustion. Cavitation, flash boiling, spray-to-spray interaction, spray-to-wall interaction, and air flow have potential as a basis for active attitude control of fuel spray. This article uses evidence from the literature to discuss the possibility of active spray attitude control for future fuel spray combustion technology in a smart compact ICE.

关键词： Internal combustion engine Fuel spray Spray control behavior injector

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Identification of shared and unique gene families associated with oral clefts

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International Journal of Oral Science 2017年第2期9卷 104-109页

作者： Noriko Funato masataka Nakamura Department of Signal Gene Regulation Research Center for Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyoJapan

Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip(CL),CL and/or palate(CL/P) and cleft palate(CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained. Here, using a gene ontology analysis approach, we grouped these candidate genes on the basis of different functional categories to gain insight into the genetic etiology of oral clefts. We identified different genetic profiles and found correlations between the functions of gene products and oral cleft phenotypes. Our results indicate inherent differences in the genetic etiologies that underlie oral cleft phenotypes and support epidemiological evidence that genes associated with CL/P are both developmentally and genetically different from CP only, incomplete CP, and submucous CP. The epidemiological differences among cleft phenotypes may reflect differences in the underlying genetic causes. Understanding the different causative etiologies of oral clefts is important as it may lead to improvements in diagnosis, counseling, and prevention.

关键词： cleft palate epidemiology gene ontology mutations soft palate syndrome

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Characteristics of Nb/Al superconducting tunnel junctions fabricated using ozone gas

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Chinese Physics B 2015年第9期24卷 182-186页

作者： Masahiro Ukibe Go Fujii masataka Ohkubo Nanoelectronics Research Institute (nano) National Institute of Advanced Industrial Science and Technology (AIST)

To improve the energy resolution（？E） of Nb/Al superconducting tunnel junctions（STJs）, an ozone（O3） oxidation process has been developed to fabricate a thin defect-free tunnel barrier that simultaneously shows high critical current JC〉 1000 A/cm^2 and high normalized dynamic resistance RDA 〉 100 MΩ·μm^2, where A is the size of the STJ. The 50-μm^2 STJs produced by O3 exposure of 0.26 Pa·min with an indirect spray of O3 gas, which is a much lower level of exposure than the O2 exposure used in a conventional O2 oxidation process, exhibit a maximum JC= 800 A/cm^2 and a high RDA = 372 MΩ ·μm^2. The 100-pixel array of the 100-μm^2STJs produced using the same O3 oxidation conditions exhibits a constant leak current I leak= 14.9 ± 3.2 n A at a bias point around △ /e（where e is half the energy gap of an STJ）,and a high fabrication yield of 87%. Although the I leak values are slightly larger than those of STJs produced using the conventional O2 oxidation process, the STJ produced using O3 oxidation shows a ？E = 10 eV for the C-Kα line, which is the best value of our Nb/Al STJ x-ray detectors.

关键词： Nb/Al superconducting tunnel junctions high critical current density high energy resolution ozone

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