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Recurrent colorectal cancer after endoscopic resectionwhen additional surgery was recommended

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World Journal of Gastroenterology 2016年第7期22卷 2336-2341页

作者： Yukiko Takatsu Yosuke Fukunaga Shunsuke Hamasaki Atsushi Ogura Jun Nagata Toshiya Nagasaki,Takashi Akiyoshi Tsuyoshi Konishi Yoshiya Fujimoto Satoshi Nagayama masashi ueno Department of Gastroenterological Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

AIM: To evaluate the type of recurrence after endoscopic resection in colorectal cancer patients and whether rescue was possible by salvage ***: Among 4972 patients who underwent surgical resection at our institution for primary or recurrent colorectal cancers from January 2005 to February 2015, we experienced eight recurrent colorectal cancers after endoscopic resection when additional surgical resection was ***: The recurrence patterns were: intramural local recurrence(five cases), regional lymph node recurrence(three cases), and associated with simultaneous distant metastasis(three cases). Among five cases with lymphatic invasion observed histologically in endoscopic resected specimens, four cases recurred with lymph node metastasis or distant metastasis. All cases were treated laparoscopically and curative surgery was achieved in six cases. Among four cases located in the rectum, three cases achieved preservation of the anus. Postoperative complications occurred in two cases(enteritis).CONCLUSION: For high-risk submucosal invasive colorectal cancers after endoscopic resection, additional surgical resection with lymphadenectomy is recommended, particularly in cases with lymphovascular invasion.

关键词： Colorectal neoplasms Colorectal surgery Laparoscopy Endoscopy Recurrence

Colonic J-pouch Anal Anastomosis with Autonomic Nerve Preservation for Low-lying Rectal Cancer

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Colonic J-pouch Anal Anastomosis with Autonomic Nerve Preser...

Genetic diagnosis of lymph-node metastasis in colorectal cancer

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Takashi Takahashi Hirotosi Ohta Kaoru Azekura masashi ueno Surgical Department Caneer Institute Hospital Tokyo Surgical Department Caneer Institute Hospital Tokyo Surgical Department Caneer Institute Hospital Tokyo Surgical Department Caneer Institute Hospital Tokyo

＜正＞In order to carry out a complete lymph node dissection for an advanced rectal cancer on the lower rectum, we have to realized three spaces around the rectum which are clearly limited by anatomical elements in the pelvis. The inner space is located within the autonomic nerve system which is correspond with TME （total mesorectal excision） space after Mr. Heald. The intermediate space are between the nerve elements and internal iliac vessels and the outer one is identified the space outside the iliac vessels. Since the lymphatic spread of lower rectal cancer proceeds through these spaces, the clearance of lymph nodes in three spaces is inevitable for curing cancer.

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Genetic diagnosis of lymph-node metastasis in colorectal can...

Preoperative chemoradiation and extended pelvic lymphadenectomy for rectal cancer:Two distinct principles

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Sachiko Sugai Yoshio Miki Hirotoshi Ohta masashi ueno Makoto Seki Takashi Takahashi Dept. of Clinical Laboratory The Cancer Institutehospital Surgery The Cancer Institutehospital Dept. of Clinical Laboratory The Cancer Institutehospital

The presence of metatatic tumor in regional lymph nodes at the time of colorectal surgery is of major significance for tumor recurrence and prognosis in patients with colorectal cancer. However, conventional staining may not be sensitive enough. Mutant allele-specific amplification(MASA) is a method to be able to detect micrometastasis to lymph nodes that are histologically diagnosed as negative.

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World Journal of Gastrointestinal Surgery 2010年第4期2卷 95-100页

作者： Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya masashi ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto Department of Gastroenterological Surgery Cancer Institute HospitalTokyo135-8550Japan Department of Surgical Oncology University of TokyoTokyo113-8655Japan Department of Surgery Teikyo University School of MedicineTokyo173-8605Japan

Extended pelvic lymphadenectomy(EPL) with total mesorectal excision(TME) has been reported to provide oncological benefit in lower rectal cancer in *** Western countries EPL is not widely accepted because of frequent morbidity but instead preoperative chemoradiation(CRT) followed by TME has been established as a standard treatment for decreasing local ***,several studies have focused on the comparison between these two distinct therapeutic approaches in Western countries and Japan.A study comparing Dutch trial data and Japanese data revealed that EPL and RT are almost equivalent in decreasing local recurrence in lower rectal cancer as compared with TME *** that almost 45 survival can be achieved by EPL even in the presence of metastatic lateral lymph nodes(LLNs),EPL performed by experienced surgeons definitely contributes to decrease local *** the other hand,a randomized controlled trial in Japan that compared EPL with conventional TME following preoperative RT revealed that EPL is associated with a higher frequency of sexual and urinary dysfunction without oncological benefits in the presence of preoperative *** this point,preoperative CRT followed by conventional TME without EPL would be a better therapeutic approach in patients without evident metastatic *** future treatment,it would be desirable to have a narrower indication for EPL using full advantage of recent improvement in image *** objective comparison of these two principles between Japan and the West is difficult due to differences in patient groups,further studies would lead to the next great step towards future improvement in treating lower rectal cancer.

关键词： Rectal cancer Extended lymphadenectomy Chemoradiation Pelvic lymph node Lateral lymph node

Treatment of colorectal carcinoids:A new paradigm

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World Journal of Gastrointestinal Surgery 2010年第5期2卷 153-156页

作者： Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya masashi ueno Hiroya Kuroyanagi Yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto Department of Gastroenterological Surgery Cancer Institute Hospital Department of Surgical Oncology University of Tokyo Department of Surgery Teikyo University School of Medicine

It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids.

关键词： Lymphovascular invasion Neuroendocrine tumor Carcinoid Colorectal cancer

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： Takashi Ono masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity

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World Journal of Gastroenterology 2010年第26期16卷 3339-3342页

作者： Soichi Sano Hiroki ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki masashi Takemura Takeshi Inoue Masayuki Hosoi Department of Internal Medicine Osaka City General Hospital Osaka 534-0021 Japan Department of Metabolism and Endocrinology Osaka City General Hospital Osaka 534-0021 Japan Department of Gastrointestinal Surgery Osaka City General Hospital Osaka 534-0021 Japan Department of Pathology Osaka City General Hospital Osaka 534-0021 Japan

We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.

关键词： Terbinafi ne Drug hypersensitivity Human herpesvirus 6 Cytomegalovirus Intestinal perforation Ileum

Studies on multiferroic materials in high magnetic fields

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Frontiers of physics 2012年第4期7卷 386-398页

作者： masashi Tokunaga The International MegaGauss Science Laboratory The Institute for Solid State Physics (IMGSL-ISSP) The University of Tokyo Kashiwa 277-8581 Japan

In this article, studies on the magnetoelectric effects of multiferroic materials in high magnetic fields, particularly pulsed magnetic fields, are discussed and results for some representative ma- terials are presented. In the discussions on representative materials, the relationship between the crystallographic symmetry and the linear magnetoelectric effect in Cr203 is introduced. Then dras- tic changes in polarization caused by magnetic transitions are discussed through a case study of manganites with a perovskite4ype structure. In addition, high field studies on the magnetoelectric effects in BiFeO3, which is an exceptional multiferroic material, are presented and discussed in the framework of the Landau-Ginzburg theory.

关键词： high magnetic field multiferroic materials magnetoelectric effect