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Clinicopathological features of small T1 colorectal cancers

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World Journal of Clinical Cases 2021年第33期9卷 10088-10097页

作者： Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori masashi misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi Digestive Disease Center Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Gastroenterology Nikko Kinen HospitalMuroran 051-8501Japan Clinical Effectiveness Research Group Institute of Health and SocietyUniversity of OsloOslo 0001Norway Department of Pathology Showa University Nothern Yokohama HospitalYokohama 224-8503Japan

BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the *** To clarify the clinicopathological features of small T1 colorectal *** Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two *** The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic *** Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size.

关键词： Colorectal neoplasms Lymphatic metastasis Biological phenomena Polyps Colorectal cancers

Time series analysis of L-band PALSAR-2 images in Istanbul and Kocaeli,Turkey

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Big Earth Data 2024年第3期8卷 467-493页

作者： Sadra Karimzadeh Abdullah Can Zulfikar masashi Matsuoka Department of Remote Sensing and GIS University of TabrizTabrizIran Department of Architecture and Building Engineering Tokyo Institute of TechnologyYokohamaJapan Disaster Management Institute Istanbul Technical UniversityMaslakIstanbulTurkey

ABSTRACT Conducting long measurements of infrastructure deformation is a critical engineering *** methods are both timeconsuming and expensive,limiting their use for large-scale *** synergy of synthetic aperture radar(SAR)and geographic information systems(GIS)offers a complementary *** study focuses on the feasibility of using time series analysis of L-band PALSAR-2 images to discover land displacements in Istanbul and Kocaeli,significant industrial and residential areas in ***-2 phase and intensity information were *** phase analysis,14 L-band images from 2014 to 2021 were taken into *** baseline subset(SBAS)analysis was performed using 44 pairs,and results of the velocity,coherence and back-scattering values are *** of all pairs and their correlations were *** Component Analysis(PCA)reduced the dimension of coherence pairs,enhancing feature extraction and the final geocoded velocity map revealed a fastest subsidence rate of−58 mm/yr and a mean subsidence of−20 mm/*** findings were confirmed through mean vertical velocity from Sentinel-1 datasets and field *** results showed that immature land subsidence in the mentioned areas are growing slowly,which can be taken as a serious risk in future.

关键词： InSAR time series PALSAR-2 SAR intensity infrastructure deformation

A new electric field mill array with each of the mill’s rotor controlled precisely by a GPS module:Equipment and initial results

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Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki Iwasaki Kazuo Yamamoto Koichiro Michimoto masashi Hayakawa Department of Production Systems Engineering and Sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPS *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

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World Journal of Gastroenterology 2015年第7期21卷 2108-2115页

作者： Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada masashi misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani Digestive Disease Center Showa University Northern Yokohama Hospital Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Hospital Endoscopy Center Showa Hospital Department of Pathology Showa University Northern Yokohama Hospital

AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral *** included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December *** was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or *** was indicative of inactive disease,while Visible and Dilated were indicative of acute *** study received Institutional Review Board *** primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological *** conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active ***:Fifty-two patients were *** was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,*** with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

关键词： Endosytoscopy Narrow-band imaging Magnified endosc

Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

Radical radiotherapy without surgical tumor resection for rectal cancer

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World Journal of Clinical Oncology 2024年第11期15卷 1390-1393页

作者： Takashi Ono masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

In this editorial,I would like to comment on the article,recently published in the World Journal of Clinical *** article focuses on non-surgical treatments for locally recurrent rectal cancer,including the watch-and-wait(WW)strategy after total neoadjuvant therapy(TNT)and particle beam *** treatment options for rectal cancer continue to evolve,the high complete response rate achieved with TNT has led to the development of a new non-surgical approach:*** followed by consolidation chemotherapy,in particular,has a low rate of tumor growth and is a treatment aimed at achieving a cure without ***,the risk of recurrence within two years is significant,necessitating careful *** standardized follow-up methods that can be implemented by many physicians is *** ion radiotherapy has demonstrated high local control with a low incidence of severe late toxicities,even after previous pelvic *** these new non-surgical curative treatments for rectal cancer require further investigation,future advancements in this field are anticipated.

关键词： Rectal cancer Locally recurrent rectal cancer Total neoadjuvant therapy Watch-and-wait Carbon ion radiotherapy Proton beam therapy

Variations of Atmospheric ELF/VLF Radio Noise Due to Seismogenic Modifications in Tropospheric Conductivity

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Open Journal of Earthquake Research 2024年第2期13卷 113-132页

作者： masashi Hayakawa Alexander P. Nickolaenko Hayakawa Institute of Seismo Electromagnetics Co. Ltd. (Hi-SEM) UEC Alliance Center #521 Tokyo Japan The University of Electro-Communications (UEC) Advanced Wireless & Communications Research Center (AWCC) Chofu-shi Tokyo O.Ya. Usikov Institute for Radiophysics and Electronics National Academy of Sciences of the Ukraine Kharkov Ukraine

We suggest a possible explanation of the influence of pre-seismic activity on the registration rate of natural ELF(extremely low frequency)/VLF(very low frequency) pulses and the changes of their characteristics. The main idea is as follows. The distribution of the electric field around a thundercloud depends on the conductivity profile of the atmosphere. Quasi-static electric fields of a thundercloud decrease in those tropospheric regions where an increase of air conductivity is generated by pre-seismic activities due to emanation of radioactive gas and water into the lower atmosphere. The electric field becomes reduced in the lower troposphere, and the probability decreases of the cloud-to-ground (CG) strokes in such “contaminated” areas. Simultaneously, the electric field grows inside and above the thunderclouds, and hence, we anticipate a growth in the number of horizontal and tilted inter-cloud (or intra-cloud) (both termed as IC discharges) strokes. Spatial orientation of lightning strokes reduces vertical projection of their individual amplitudes, while the rate (median number strokes per a unit time) of discharges grows. We demonstrate that channel tilt of strokes modifies the spectral content of ELF/VLF radio noise and changes the rate of detected pulses during the earthquake preparation phase.

关键词： ELF/VLF Radio Noise Earthquake Precursor Pre-Seismic Modification Conductivity Anomaly in the Lower Atmosphere Radioactive Radon Gases CG Lightning Discharges IC Discharges Cloud-to-Ionosphere Discharge

Association of Omega-3 Polyunsaturated Fatty Acids with Sarcopenia in Liver Cirrhosis Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 613-624页

作者： Akitoshi Sano Jun Inoue Eiji Kakazu masashi Ninomiya Mio Tsuruoka Kosuke Sato Masazumi Onuki Satoko Sawahashi Keishi Ouchi Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Liver Disease The Research Center for Hepatitis and ImmunologyNational Center for Global Health and MedicineIchikawaChibaJapan

Background and Aims:Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma(HCC).Given their diverse physiological activities,we hypothesized that plasma fatty acids might influence the progression of *** study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with ***:In this singlecenter retrospective study,we registered 516 cases and analyzed 414 cases of liver cirrhosis and *** skeletal muscle mass index was measured using a transverse computed tomography scan image at the third lumbar *** cutoff value for sarcopenia followed the criteria set by the Japan Society of *** acid concentrations were measured by gas ***:Fatty acid levels,particularly omega-3(n-3)polyunsaturated fatty acid(PUFA),were lower in patients with poor liver function(Child-Pugh grade B/C)and were negatively correlated with the albumin-bilirubin score(p<0.0001).The prognosis of HCC patients with low PUFA levels was significantly *** the different fatty acid fractions,only n-3 PUFAs significantly correlated with skeletal muscle mass index(p=0.0026).In the multivariate analysis,the n-3 PUFA level was an independent variable associated with sarcopenia(p=0.0006).Conclusions:A low level of n-3 PUFAs was associated with sarcopenia in patients with liver cirrhosis and HCC.

关键词： Liver cirrhosis Hepatocellular carcinoma Sarcopenia Skeletal Muscle Fatty Acids Omega-3 polyunsaturated fatty acids

Enhancing clinical proficiency through laparoscopic training using Japanese origami

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 102-106页

作者： Shunsuke Furukawa Masatsugu Hiraki Naoya Kimura Ryota Sakurai Ryo Kohata Naohiko Kohya masashi Sakai Akashi Ikubo Ryuichiro Samejima Department of Surgery Japanese Red Cross Society Karatsu Red Cross HospitalSaga847-8588Japan Department of Surgery Saga University Faculty of MedicineSaga849-8501Japan

Objective This study aimed to investigate the clinical efficacy of laparoscopic training using origami,a traditional Japanese papercraft,using laparoscopic forceps to create origami *** In this retrospective study,4 surgeons were randomly divided into 2 groups:The training group,consisting of surgeons 1 and 2,and the non-training group,consisting of surgeons 3 and *** the course of a one-year study period,the training group regularly underwent laparoscopic surgery training with a dry box,wherein they folded a total of 1000 origami cranes using laparoscopic *** non-training group periodically underwent common laparoscopic surgery training of techniques such as suturing and *** surgeon regularly performed the transabdominal preperitoneal approach for inguinal *** training was conducted concurrently with the *** procedure time(peritoneum detachment,mesh placement,and closure of the peritoneum),total operation time(time from peritoneum detachment to closure of the peritoneum),and surgical outcomes were *** The training group showed greater improvement in the total operation time and more stable performance than the non-training ***,the time taken for peritoneum detachment was significantly shorter in the training *** Laparoscopic training using origami has the potential to enhance laparoscopic surgical skills and improve surgical outcomes.

关键词： Laparoscopic surgery Training Dry box Origami