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Clinical significance of white gastric crypt openings observed via magnifying endoscopy

World Journal of Gastroenterology 2013年第48期19卷 9392-9398页

作者： masashi kawamura Hitoshi Sekine Shu Abe Daisuke Shibuya Katsuaki Kato Takayuki Masuda Department of Gastroenterology Sendai City Hospital Miyagi 984-8501 Japan Department of Gastroenterology JR Sendai HospitalMiyagi 980-0022 Japan Cancer Detection Center Miyagi Cancer Society Miyagi 980-0011 Japan Division of Pathology Tohoku University School of Health Sciences Miyagi 980-8575 Japan

AIM:To evaluate the relationship between Helicobacter pylori(***)-induced gastritis and white gastric mucosal crypt openings(COs)in the gastric ***:A total of 175 consecutive patients(including 69 patients with gastric cancer)were enrolled in this *** used magnifying endoscopy(ME)to observe the mucosa microsurface of the lesser and greater curvature of the gastric corpus(350 areas in all).We focused on areas with a round pit microstructure(primarily observed in non-atrophied areas)and evaluated the white openings of these gastric *** classified the whiteness of the COs as the"white-edged dark spot"type(consisting of a dark spot bordered by white);the"white"type(pure white with no dark spot);and the"dense white pit(DWP)"type(dense white,resembling a snowball).Gastritis was also histologically evaluated according to the updated Sydney ***:We detected round COs using ME in 246 of the 350 areas *** histological examination showed significantly more mononuclear cells and neutrophil infiltration in the"white"and"DWP"types than the"white-edged dark spot"type(P<0.001).Furthermore,significantly high-grade inflammation and evidence of active ***-induced gastritis was observed in the"DWP"type(P<0.001).Significant differences were observed in the whiteness of COs between ***-positive(n=139)and negative(n=36)patients(P<0.001).The sensitivity and specificity of the"white"and"DWP"types for predicting *** infection were78.5%and 81.7%,*** the patients with gastric cancer,22.5%(18/80)had"white-edged dark spots",51.3%(41/80)had"white"COs,and 26.3%(21/80)had"DWP"-type COs."DWPs"were frequently observed among patients with undifferentiated gastric cancer[45.7%(16/35)].CONCLUSION:CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation and *** activity.

关键词： Magnifying endoscopy Helicobacter pylori Gastritis Gastric cancer Inflammation

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AN EXPERIMENTAL STUDY ON ADVANCEMENT OF DAMPING PERFORMANCE OF FOUNDATIONS IN SOFT GROUND PART2 EXPERIMENT FOCUSING ON DAMPING AND ANTIVIBRATION PERFORMANCE OF SIDE SURFACE OF FOUNDATION BLOCKS

AN EXPERIMENTAL STUDY ON ADVANCEMENT OF DAMPING PERFORMANCE ...

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第十八届国际反应堆结构力学大会

作者： Shinji Ishimaru Yukio Shimomura masashi kawamura Yoshio Ikeda Ippei Hata Shinya Miwa College of Science and Technology Nihon University Junior College of Nihon University College of Industrial Technology Nihon University Taisei Corporation Research Institute of Science and Technology Nihon University Tokyu Construction

＜正＞ 1 INTRODUCTION To aim at progress of damping performance of foundations that will be built at soft ground, we have proposed an improved foundation work of backfilling a damping material into trenches dug along a foundation supported by improved soil medium. This damping material is a mixture of asphalt with crushed stones and rubber chips （MACSRC） and has itself high attenuation and mitigation performance. We carried out forced vibration tests for two test blocks, which were constructed by a normal construction work and the above improved foundation work.

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Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience

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World Journal of Pediatrics 2019年第3期15卷 270-275页

作者： Kenji Kishimoto masashi Kasai Noriko kawamura Yusuke Ito Makiko Yoshida Daiichiro Hasegawa Keiichiro Kawasaki Yoshiyuki Kosaka Department of Hematology and Oncology Children’s Cancer CenterKobe Children’s HospitalMinatojima—Minamimachi 1—6-7Chuo—kuKobe 650—0047 Japan Department of Infectious Disease Kobe Children’s Hospital KobeJapan Department of Clinical Laboratory Kobe Children’s HospitalKobeJapan Department of Diagnostic Pathology Kobe Children’s HospitalKobeJapan Department of Pediatrics Kita—Harima Medical Center KobeJapan

Background There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in *** aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care *** Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively *** and probable IFD were defined according to the European Organization for Research and Treatment of Cancer/Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group *** with possible IFD were *** The incidence of proven or probable IFD was 26 of 20,079 hospitalized patients (0.13%).The predominant underlying disease was malignancy (54%) and congenital anomaly (27%).The most common diagnosis was candidemia among the patients with proven IFD (8 of 13,62%).All the isolated pathogens in the candidemia patients were non-albicans Candida *** most common site of infection was the lungs in patients with probable IFD (11 of 13 patients,85%).In probable IFD episodes,positive β-D-glucan and galactomannan were found in 12 of 13 (92%) and 5 of 13 (38%) patients,*** but one patient (96%) received empirical antifungal *** patients underwent surgical resection of residual *** overall mortality was 23% and the attributable mortality of IFD was 12%.Conclusion Our results suggest the emergence of non-albicans Candida species as important pathogens in childhood IFD.

关键词： Children Invasive fungal disease Incidence Mortality

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Integrated Arrays of Palladium ＆ Platinum Nanotubules on Aluminum for Electrolysis

Integrated Arrays of Palladium ＆ Platinum Nanotubules on Al...

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2006年上海电子电镀学术报告会

作者： Hirotaka kawamura masashi MORI MaterialsScienceLab. CentralResearchInstituteofElectricPowerIndustry(CRIEPI)Nagasaka2-6-1.YokosukaKanagawa240-0196Japan MaterialsSeiceceLab. CentralResearchInstituteofElectricPowerIndustry(CRIEPI)Nagasaka2-6-1.YokosukaKanagawa240-0196Japan

＜正＞Introduction This study is aimed at fabricating integrated arrays of Pd and Pt nanotubules with large surface areas on Al by combining anodization and electroless deposition, towards high-performance catalytic e...

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In Vitro Activation(IVA) of Ovarian Follicles

In Vitro Activation(IVA) of Ovarian Follicles

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第七次全国妇科内分泌学术会议

作者： Yuan Cheng Jing Li Yorino Sato masashi Deguchi Seido Takae Kazuhiro kawamura Aaron J Hsueh Department of Ob/Gyn Stanford University

Most ovarian follicles in mammals remain dormant for *** reproductive life,a small number of primordial follicles are activated for further *** studies demonstrated that oocyte-specific deletion of the PTEN gene led to the activation of dormant primordial *** in vitro activation(IVA) of primordial follicles by incubating ovaries from neonatal mice with PTEN inhibitors and a PI3K(phosphotidylinositol-

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Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel

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World Journal of Clinical Urology 2014年第2期3卷 139-143页

作者： Takumi Endo Naoto Kamiya Hiroyoshi Suzuki Ryo Oka Fang-Ching Lee Takanobu Utsumi masashi Yano Shuichi Kamijima Koji kawamura Takashi Imamoto Tomohiko Ichikawa Department of Urology Toho University Sakura Medical CenterSakura-shiChiba 285-8741Japan Department of Urology Graduate School of MedicineChiba UniversityChiba-shiChiba 260-8670Japan

AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with ***: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with ***: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.

关键词： Prostate cancer Docetaxel chemotherapy Carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen Alkaline phosphatase Prognostic factor

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