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Earthquake Science 2011年第6期24卷 609-637页

作者： masashi Hayakawa Advanced Wireless Communications Research Center and Research Station on Seismo Electromagnetics The University of Electro-Communications1-5-1 ChofugaokaChofu Tokyo 182-8585Japan Earthquake Analysis Laboratory Information Systems Inc.Kita-Aoyama 2-12-42-R305Minato-kuTokyo 107-0061Japan

There have been reports for many years that the ionosphere is very sensitive to seismic effects, and the detection of ionospheric perturbations associated with earthquakes （EQs） attracts a lot of attention as a very promising candidate for short-term EQ prediction. In this review we present a possible use of VLF/LF （very low frequency （3-30 kHz）/low frequency （30-300 kHz）） radio sounding of seismo-ionospheric perturbations. In order to avoid the overlapping with my own previous reviews, we first show some pioneering results for the Kobe EQ and we try to present the latest results including the statistical evidence on the correlation between the VLF/LF propagation anomalies （ionospheric perturbations） and EQs （especially with large magnitude and with shallow depth）, medium-distance （6-8 Mm） propagation anomalies, the fluctuation spectra of subionospheric VLF/LF data （the effect of atmospheric gravity waves, the effect of Earth＇s tides, etc.）, and the mechanism of lithosphere-atmosphere-ionosphere coupling. Finally, we indicate the present situation of this kind of VLF/LF activities going on in different parts of the globe and we suggest the importance of international collaboration in this seismo-electromagnetic study.

关键词： Earth-ionosphere waveguide subionospheric VLF/LF propagation seismo-ionosphericperturbation earthquake lithosphere-atmosphere-ionosphere coupling

Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay

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Journal of Pharmaceutical Analysis 2018年第2期8卷 119-123页

作者： Yuta Yamamoto Tetsuya Saita Yutaro Yamamoto masashi Shin Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University

A selective and sensitive competitive enzyme-linked immunosorbent assay(ELISA) method was developed and validated for the quantification of erlotinib in 50 mL of samples of human serum. Anti-erlotinib serum was obtained by immunizing mice with an antigen conjugated with bovine serum albumin and 3,4-bis(2-methoxyethoxy)benzoic acid using the N-succinimidyl ester method. Enzyme labeling of erlotinib with horseradish peroxidase was similarly performed using 3,4-bis(2-methoxyethoxy)benzoic acid. A simple competitive ELISA for erlotinib was developed using the principle of direct competition between erlotinib and the enzyme marker for anti-erlotinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Serum erlotinib concentrations lower than 40 ng/mL were reproducibly measurable using the ELISA. This ELISA was specific to erlotinib and showed very slight cross-reactivity(6.7%) with a major metabolite, O-desmethyl erlotinib. Using this assay, drug levels were easily measured in the blood of mice after oral administration of erlotinib at a single dose of 30 mg/kg. ELISA should be used as a valuable tool for therapeutic drug monitoring and in pharmacokinetic studies of erlotinib.

关键词： Erlotinib Enzyme-linked immunosorbent assay O-desmethyl erlotinib Tyrosine-kinase inhibitor

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： Hiroaki Samata Katsutoshi Kobayashi masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

Yellow luminescence of co-doped gadolinium oxyhydroxide

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Journal of Rare Earths 2015年第7期33卷 712-716页

作者： Hiroaki Samata Shungo Imanaka masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Fukaeminami International Center for Materials Nanoarchitectonics National Institute for Materials Science

Crystals of co-doped gadolinium oxyhydroxide （GdOOH）, Gd0.98Eu0.02-xTbxOOH and Gd1-y-zDyyBizOOH, were synthesized by a flux method. The color coordinates in the Commission Internationale de I＇Eelairage （CIE） chromaticity diagram of Gd0.98Eu0.02-xTbxOOH, obtained under 254 nm irradiation, shifted along a straight line with the changing values ofx to include the yellow region. The CIE coordinates of Dy^3＋ doped in GdOOH were located in the yellow region, while the emission intensity of Dy^3＋ under 286 nm irradiation increased by more than 40 times when co-doped with Bi^3＋.

关键词： gadolinium oxyhydroxide phosphor co-doping yellow luminescence rare earths

Recent Progress of Optical Fibers

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光学学报 2003年第S1期23卷 61-62页

作者： masashi Onishi Eisuke Sasaoka Sumitomo Electric Ind. Ltd. Taya-cho Sakae-ku Yokohama 244-8588 JapanSumitomo Electric Ind. Ltd. Taya-cho Sakae-ku Yokohama 244-8588 Japan

This paper reviews recent progress of advanced optical fibers that are expected to be as candidates for the future trunk-line systems, metropolitan networks and access lines for subscribers.

关键词： of been Recent Progress of Optical Fibers for have in that

Large-Scale Electromagnetic Modeling for Multiple Inhomogeneous Domains

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Communications in Computational Physics 2009年第7期6卷 269-289页

作者： masashi Endo Martin Cuma Michael S.Zhdanov Department of Geology and Geophysics University of Utah135S 1460ERm 719Salt Lake CityUT 84112USA

We develop a new formulation of the integral equation(IE)method for three-dimensional(3D)electromagnetic(EM)field computation in large-scale models with multiple inhomogeneous *** problem arises in many practical applications including modeling the EM fields within the complex geoelectrical structures in geophysical *** geophysical applications,it is difficult to describe an earth structure using the horizontally layered background conductivity model,which is required for the efficient implementation of the conventional IE *** a result,a large domain of interest with anomalous conductivity distribution needs to be discretized,which complicates the *** new method allows us to consider multiple inhomogeneous domains,where the conductivity distribution is different from that of the background,and to use independent discretizations for different *** reduces dramatically the computational resources required for largescale *** addition,using this method,we can analyze the response of each domain separately without an inappropriate use of the superposition principle for the EM field *** method was carefully tested for the modeling the marine controlled-source electromagnetic(MCSEM)fields for complex geoelectric structures with multiple inhomogeneous domains,such as a seafloor with the rough bathymetry,salt domes,and *** have also used this technique to investigate the return induction effects from regional geoelectrical structures,e.g.,seafloor bathymetry and salt domes,which can distort the EM response from the geophysical exploration target.

关键词： Large-scale EM modeling multiple inhomogeneous domains marine CSEM

An extended Fibonacci sequence associated with the discrete hungry Lotka-Volterra system

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International Journal of Biomathematics 2017年第3期10卷 245-260页

作者： Masato Shinjo Kanae Akaiwa masashi Iwasaki Yoshimasa Nakamura Graduate School of Informatics Kyoto University Yoshida-Hommachi Sakyo-ku Kyoto 606-8501 Japan Faculty of Life and Environmental Sciences Kyoto Prefectural University Nakaragi-cho Shimogamo Sakyo-ku Kyoto 606-8522 Japan

The integrable hungry Lotka-Volterra （hLV） system stands for a prey-predator model in mathematical biology. The discrete-time hLV （dhLV） system is derived from a time discretization of the hLV system. The solution to the dhLV system is known to be represented by using the Casorati determinant. In this paper, we show that if the entries of the Casorati determinant become an extended Fibonacci sequence at the initial discrete time, then those are also an extended Fibonacci sequence at any discrete time. In other words, the extended Fibonacci sequence always appears in the entries of the Casorati determinant under the time evolution of the dhLV system with suitable initial setting. We also show that one of the dhLV variables converges to the ratio of two successive extended Fibonacci numbers as the discrete time goes to infinity.

关键词： Fibonacci sequence Casorati determinant discrete hungry Lotka Volterra system.

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

New adaptive vector control methods for induction motors with simpler structure and better performance

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Control Theory and Technology 2015年第2期13卷 173-183页

作者： Kang-Zhi LIU masashi YOKOO Keiichiro KONDO Tadanao ZANMA Department of Electrical and Electronics Engineering Chiba University

This paper deals with the vector control, including both the direct vector control(DVC) and the indirect vector control(Id VC),of induction motors. It is well known that the estimation of rotor flux plays a fundamental role in the DVC and the estimation of rotor resistance is vital in the slip compensation of the Id VC. In these estimations, the precision is significantly affected by the motor resistances. Therefore, online estimation of motor resistances is indispensable in *** a fast estimation of motor resistances, it is necessary to slow down the convergence rate of the current estimate. On the other hand, for a fast estimation of the rotor flux, it is necessary to speed up its convergence rate. It is very difficult to realize such a trade-off in convergence rates in a full order *** this paper, we propose to decouple the current observer from the flux observer so as to realize independent convergence rates. Then, the resistance estimation algorithm is applied to both DVC and Id VC. In particular, in the application to Id VC the flux observer needs not be used, which leads to a simpler structure. Meanwhile, independent convergence rates of current observer and flux observer yield an improved performance. A superior performance in the torque and flux responses in both cases is verified by numerous simulations.

关键词： Induction motor current observer flux observer parameter adaptation indirect vector control direct vector control

DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus

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World Journal of Gastroenterology 2014年第14期20卷 3916-3926页

作者： Keisuke Matsusaka Sayaka Funata masashi Fukayama Atsushi Kaneda Department of Molecular Oncology Graduate School of MedicineChiba University Department of Pathology Graduate School of MedicineThe University of Tokyo CREST Japan Science and Technology Agency

Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric *** particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric *** etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(***)and Epstein-Barr virus(EBV),are known to participate in gastric *** inflammation of the gastric epithelium due to *** infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric *** addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target ***,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with *** and EBV.

关键词： Gastric cancer Epigenetics DNA methylation Epstein-Barr virus Helicobacter pylori