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Differences in the Histopathology and Cytokine Expression Pattern between Chronological Aging and Photoaging of Hairless Mice Skin

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Modern Research in Inflammation 2014年第3期3卷 82-89页

作者： Masaaki Sakura Yoichi Chiba Emi Kamiya Ayako Furukawa Noriko Kawamura Masanao niwa Minoru Takeuchi Yasushi Enokido Masanori Hosokawa Department of Pathology Institute for Developmental Research Aichi Human Service Center Kasugai Japan Faculty of Life Science Kyoto Sangyo University Kyoto Japan Faculty of Pharmaceutical Sciences Suzuka University of Medical Science Suzuka Japan Fundamental Research Laboratory General Research & Development Institute Hoyu Co. Ltd. Nagakute Japan

Skin photoaging is a complex, multifactorial process resulting in functional and structural changes of the skin, and different phenotypes from chronological skin aging are well-recognized. Ultraviolet (UV)-irradiated hairless mice have been used as a skin photoaging animal model. However, differences in morphology and gene expression patterns between UV-induced and chronological skin changes in this mouse model have not been fully elucidated. Here we investigated differences in histopathology and cytokine expression between UV-irradiated and non-irradiated aged hairless mice to clarify the factor(s) that differentiate photoaging from chronological skin aging phenotypes. Eight-week-old HR-1 hairless mice were divided into UV-irradiated (UV-irradiated mice) and non-irradiated (control mice) groups. Irradiation was performed three times per week for 10 weeks. In addition, 30-week-old HR-1 hairless mice were reared until 70 weeks of age without UV irradiation (aged mice). Histopathologies revealed that the flattening of dermal-epidermal junctions and epidermal thickening were observed only in UV-irradiated mice. Decreases in fine elastic fibers just beneath the epidermis, the thickening of elastic fibers in the reticular dermis, and the accumulation of glycosaminoglycans were more prominent in UV-irradiated mice as compared to non-irradiated aged mice. Quantitative PCR analyses revealed that UV-irradiated mice showed an increase in the expression of IFN-γ. In contrast, aged mice exhibited proportional up-regulation of both pro-inflammatory and anti-inflammatory cytokines. The IFN-γ/IL-4 ratio, an indicator for the balance of pro-inflammatory and anti-inflammatory cytokines, was significantly higher in UV-irradiated mice as compared to control and non-irradiated aged mice. An elevated IFN-γ/IL-4 ratio was also observed in aged senescence-accelerated mouse-prone 1 (SAMP1) mice, a spontaneous skin photoaging model we recently reported. Thus, an imbalance between pro-inflam

关键词： Photoaged Skin Chronologically-Aged Skin Pro-Inflammatory Cytokines Anti-Inflammatory Cytokines Hairless Mice

A Case of Serous Tubal Intraepithelial Carcinoma Diagnosed by Cytology during the Operation

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Open Journal of Pathology 2018年第3期8卷 69-77页

作者： Kenji niwa Tsuneo Ishihara Yoko Ueda Motoki Takenaka Tomomi Shiga Sakae Mori Keigo Kuwabara Yoshio Yamaguchi Takuji Tanaka Department of Obstetrics & Gynecology Gujo City Hospital Gujo City Japan Department of Obstetrics & Gynecology Gifu University School of Medicine Gifu City Japan Section of Laboratory Medicine Gujo City Hospital Gujo City Japan Department of Diagnostic Pathology & Research Center of Diagnostic Pathology Gifu Municipal Hospital Gifu City Japan

We experienced a case of serous tubal intraepithelial carcinoma (STIC), which is the earliest morphologically recognizable precursor of pelvic high grade serous carcinoma, diagnosed by cytology during the operation. A 48-year-old Japanese woman visited to our department because of abnormal cytological result and the left adnexal mass on female cancer screening. Pre-operatively, she was diagnosed as cervical intraepithelial neoplasia (CIN) 3, adenomyosis, and the left adnexal cystic lesion with papillary growth. At laparotomy, the left adnexal tumor turned out to be cystic fallopian tube with small papillary growth on the inner surface, but abnormal findings were not present on bilateral ovaries. The cytology of the imprint smears from the papillary projection and ascitic fluid showed positive, suggesting serous adenocarcinoma. Histopathological examination of the lesion revealed the left fallopian tube lesion was STIC with immunohistochemically positive reactivity against p53. No metastases including disseminated lesions were noted. The patient received four courses of systemic chemotherapy, and had no recurrent signs 10 months after the operation.

关键词： Serous Tubal Intraepithelial Carcinoma Cytology Immonohistochemistry p53 Ki-67

系统性红斑狼疮和其他自身免疫病时的免疫缺陷状态和免疫不平衡

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国外医学(免疫学分册) 1980年第3期03卷 147-148页

作者： Yukie niwa 史久华

在自身免疫病中,高丙种球蛋白血症十分常见,但是自身免疫病特别是系统性红斑狼疮(SLE)患者往往发生反复感染。现已了解自身免疫病患者的细胞免疫功能(如结核菌素反应和DNCB致敏试验)减弱。本文报导对SLE和其他自身免疫病患者的各种免疫... 详细信息

在自身免疫病中,高丙种球蛋白血症十分常见,但是自身免疫病特别是系统性红斑狼疮(SLE)患者往往发生反复感染。现已了解自身免疫病患者的细胞免疫功能(如结核菌素反应和DNCB致敏试验)减弱。本文报导对SLE和其他自身免疫病患者的各种免疫应答进行评价,并研究了免疫功能抑制与类固醇治疗以及疾病活动性之间的相互关系。

关键词：系统性红斑狼疮免疫缺陷状态患者自身免疫病自身免疫性疾病 SLE

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现有钢筋混凝土建筑物的加固方法

世界地震工程 1981年第5期 26-31+39页

作者： Toshio Hayashi Hideakira niwa Masashi Fakuhara 王龙

绪言有几座按过去的条件和规范设计的钢筋混凝土建筑物,在日本最近发生的强地震中遭到严重破坏。为了减轻建筑物这种严重的破坏,有必要对那些在强震下不能确保安全的钢筋混凝土建筑物,从强度和刚度方面进行加固。这样,我们研究了现有建... 详细信息

绪言有几座按过去的条件和规范设计的钢筋混凝土建筑物,在日本最近发生的强地震中遭到严重破坏。为了减轻建筑物这种严重的破坏,有必要对那些在强震下不能确保安全的钢筋混凝土建筑物,从强度和刚度方面进行加固。这样,我们研究了现有建筑物从强度和刚度方面进行加固的方法。

关键词：加固方法砂浆试件钢筋混凝土增强材料焊接钢丝网建筑物加固柱填充墙

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拱坝的非线性地震反应

世界地震工程 1983年第4期 38-44页

作者： Akira niwa Ray W.Clough 刘达

引言世界上地震活动频繁的地区,水坝的抗震安全问题越来越受到人们的关注,因为一个大型水库的潜在危险可能造成的危害,是与大坝下游人口的增长成正比例的,因此不论现有的水坝结构和提出的各种设计方案

关键词：拱坝接缝气蚀机理临界断面坝段地震动地震原型结构动力反应动力响应模型材料非线性地震反应下游面

Antibody markers in the diagnosis of inflammatory boweldisease

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World Journal of Gastroenterology 2016年第3期22卷 1304-1310页

作者： Keiichi Mitsuyama Mikio niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke Yamauchi Shuhei Fukunaga Takuji Torimura Inflammatory Bowel Disease Center Kurume University School of MedicineKurume 830-0011Japan Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Institute for Advanced Sciences Toagosei Co.Ltd.2 OhkuboTsukubaIbaraki 300-2611Japan

Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD.

关键词： Biomarker Crohn's disease Serologicalantibody Ulcerative colitis

Efficacy of Postoperative Adjuvant Chemotherapy According to Prognostic Factor in Patients with Stage III Colon Cancer

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Journal of Cancer Therapy 2014年第8期5卷 806-816页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto Yutaka Kojima Hiromitsu Komiyama Makoto Takahashi Shun Ishiyama Koichiro niwa Haruna Okubo Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan

Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.

关键词： Colorectal Cancer Postoperative Adjuvant Chemotherapy Prognostic Factor Stage III Colon Cancer TNM Classification 7th Edition

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考虑箍筋效应的PP-ECC梁抗剪试验研究

中国公路学报 2017年第12期30卷 234-241,249页

作者：张锐孟庆利何畏二羽淳一郎西南交通大学土木工程学院四川成都610031 西南科技大学土木工程与建筑学院四川绵阳621010 东京工业大学东京152-8552

为了研究钢筋加强工程水泥基复合材料(ECC)梁中的箍筋抗剪加强效应,针对发生剪切破坏的普通钢筋混凝土(RC)构件,考虑箍筋率的影响,分别进行RC与ECC梁的四点加载试验研究。首先开展ECC材料试验,采用直接拉伸的加载方式,对聚丙烯纤维工程... 详细信息

为了研究钢筋加强工程水泥基复合材料(ECC)梁中的箍筋抗剪加强效应,针对发生剪切破坏的普通钢筋混凝土(RC)构件,考虑箍筋率的影响,分别进行RC与ECC梁的四点加载试验研究。首先开展ECC材料试验,采用直接拉伸的加载方式,对聚丙烯纤维工程水泥基复合材料(PP-ECC)的拉伸力学性能进行试验研究。在材料试验结果的基础上,通过考虑箍筋效应,分别设计5根不同箍筋率的钢筋增强PP-ECC梁和2根普通钢筋混凝土梁试件,对7根梁进行四点加载试验,并在加载过程中对5根PP-ECC梁的斜裂缝进行观测,分析箍筋率对ECC梁斜裂缝开展行为的影响。通过修正桁架模型,分析箍筋率对ECC梁抗剪承载力的影响。试验结果表明:PP-ECC具有拟应变硬化和微裂缝的多缝开裂特征,其屈服拉伸强度和拉伸极限强度分别不小于2,3MPa,极限拉应变大于2.5%;PP-ECC梁有较好的剪切延性,随着箍筋率的增长,PP-ECC梁的抗剪承载力也逐渐加大;在相同箍筋率下PP-ECC梁的抗剪承载力大于RC梁,而无箍筋PP-ECC梁的抗剪承载力2倍于无箍筋RC梁;由于箍筋限制了R/ECC梁斜裂缝的开展,加剧了斜裂缝的剪切滑移,从而削弱了斜裂缝间的纤维桥接作用,导致PP-ECC承担的剪力随着箍筋率的增大而减小;现有规范未考虑斜裂缝的剪切滑移对PP-ECC抗剪承载力的削弱作用,使得计算剪切承载力过大而导致偏危险。

关键词：桥梁工程钢筋PP-ECC梁四点加载剪切滑移箍筋效应

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Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder in Patients with Chronic Pain

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Open Journal of Psychiatry 2017年第4期7卷 261-275页

作者： Satoshi Kasahara Yumiko Okamura Ko Matsudaira Hiroyuki Oka Yoshie Suzuki Yasuko Murakami Toshiharu Tazawa Hayato Shimazaki Shin-ichi niwa Yoshitsugu Yamada Anesthesiology and Pain Relief Center Faculty of Medicine University of Tokyo Tokyo Japan Department of Neuropsychiatry Faculty of Medicine University of Tokyo Tokyo Japan Department of Medical Research and Management for Musculoskeletal Pain 22nd Century Medical and Research Center Faculty of Medicine University of Tokyo Tokyo Japan Department of Anesthesiology and Pain Medicine Faculty of Medicine Juntendo University Tokyo Japan Department of Anesthesiology and Pain Medicine Yokohama City University Medical Center Yokohama Japan Department of Psychiatry Jikei University School of Medicine Tokyo Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Aims: To investigate rates of attention-deficit hyperactivity disorder (ADHD) in patients with chronic pain attending a pain clinic, the effects of a screening measure for ADHD in patients with chronic pain, and the effects of ADHD drugs on both pain and ADHD symptoms. Methods: We retrospectively surveyed 110 patients with chronic pain visiting the Anesthesiology and Pain Relief Center at the University of Tokyo in Japan, who had also consulted a psychiatrist, between April 2012 and July 2015. Results: Of the total of 110 patients with chronic pain, 35 (31.8%) were also diagnosed with ADHD, and the average Wender Utah Rating Scale (WURS) score among the ADHD patients was 39.0 ± 22.1 (n = 25). Only 36.0% of these patients exceeded the cutoff value, suggesting that 64.0% of the patients with ADHD were not identified by screening with the WURS. Twenty-six patients initiated treatment with ADHD medication, with dosage adjustment completed in 21. Of these 21 patients 20 (95.0%) had improved ADHD symptoms. Improved pain symptoms were observed in 14 patients (66.6%), with a reduction in the pain numerical rating scale of 64.7% ± 30.1%. Conclusions: This is the first study investigating the comorbidity of ADHD and chronic pain at pain clinics showing a high level of comorbidity and amelioration of pain and ADHD symptoms with treatment. Careful interpretation is required when the WURS is used to screen patients with chronic pain.

关键词： Atomoxetine Attention Deficit Hyperactivity Disorder Chronic Pain Methylphenidate Wender Utah Rating Scale