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Relating brain structure images to personality characteristics using 3D convolution neural network

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CAAI Transactions on Intelligence Technology 2021年第3期6卷 338-346页

作者： Lixian Cao Yanchun Liang Wei Lv Kaechang Park Yasuhiro miura Yuki Shinomiya Shinichi Yoshida Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Jilin UniversityZhuhaiChina Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and TechnologyJilin UniversityChangchunChina School of Information&Research Institute Kochi University of TechnologyKochiJapan

The Keras deep learning framework is employed to study MRI brain data in a preliminary analysis of brain structure using a convolutional neural *** results obtained are matched with the content of personality *** Big Five personality traits provide easy differentiation for dividing personalities into different *** now,the highest accuracy obtained from the results of personality prediction from the analysis of brain structure is about 70%.Although there is still no effective evidence to prove a clear relationship between brain structure and personality,the obtained results could prove helpful in understanding the basic relationship between brain structure and personality characteristics.

关键词： convolution structure dividing

Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 941-945页

作者： Kentaro Iwasaki Yoshihiro Takamura Yusuke Orii Shogo Arimura masaru Inatani Department of Ophthalmology Faculty of Medical SciencesUniversity of FukuiFukui 910-1193Japan Department of Ophthalmology Obama HospitalFukui 917-8567Japan

AIM:To compare surgical outcomes of phacoemulsification combined with glaucoma surgical techniques performed with either Kahook Dual Blade(KDB)or iStent for Japanese patients with either primary open angle glaucoma or exfoliation ***:We retrospectively evaluated the surgical outcomes of 129 eyes of 84 Japanese patients with glaucoma who underwent KDB or 44 eyes of 34 patients who underwent phacoemulsification with iStent procedures combined with cataract *** primary outcome was surgical success or failure[with surgical failure being indicated by18 mm Hg as criterion A;IOP>14 mm Hg as criterion B on two consecutive study visits;or reoperation requirement].In addition,we assessed the number of postoperative glaucoma medications and the resulting ***:The probability of success was significantly higher in the KDB group than in the iStent group for criterion A(60.2%vs 46.4%,P=0.019).In the KDB group,the mean preoperative IOP of 19.8±7.3 mm Hg decreased significantly to 13.0±3.1 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.5±1.4 decreased significantly to 1.6±1.6(P<0.01)12 mo *** the iStent group,the mean preoperative IOP of 17.8±2.9 mm Hg significantly decreased to 14.3±2.3 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.2±1.1 decreased significantly to 0.9±1.4(P<0.01)12 mo *** overall IOP reduction percentage was higher in the KDB group(26.2%)than in the iStent group(19.0%)12 mo postoperatively(P=0.03).Hyphema occurred significantly more frequently in the KDB group(16.3%)than in the iStent group(2.3%,P=0.017).CONCLUSION:KDB and iStent procedures combined with cataract surgery both result in significant IOP and glaucoma medication reductions after the 12-month *** patients in the KDB group have a higher success rate for the target IOP of less than 18 mm Hg and a higher complication rate than those

关键词： glaucoma surgery surgical outcome Kahook Dual Blade iStent

SELECTIVE FORMATION OF OXYGENATED COMPOUNDS BY SILICA-SUPPORTED Ru-Co BIMETALLIC CLUSTER-DERIVED CATALYSTS IN CO HYDROGENATION

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Chinese Science Bulletin 1992年第4期37卷 347-348页

作者：肖丰收郭燮贤 ICHIKAWA masaru Department of Chemistry Jilin University Changchun 130023 PRC Dalian Institute of Chemical Physics Academia Sinica Dalian 116023 PRC Catalysis Research Center Hokkaido University Sapporo 060 Japan

It is well known that catalysts prepared from organometallic compounds exhibit high activity and selectivity for oxygenates in CO-based reactions such as CO hydrogenation and olefin hydroformylation, in contrast to the conventional metal catalysts from the usual way of the metal salts. It is also reported that bimetallic catalysts provide quite different

关键词： hydrogenation selectivity salts olefin usual alcohols silica carbonyl aldehyde molar

Case of pseudo-Meigs' syndrome caused by gastric cancer-related metastatic ovarian tumor with prolonged survival

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World Journal of Gastrointestinal Oncology 2016年第11期8卷 801-804页

作者： masaru Okamoto Kazunori Maeda Atsushi Yanagitani Kiwamu Tanaka Department of General Internal Medicine Tottori Prefectural Central Hospital Department of Gastroenterology Tottori Prefectural Central Hospital

A 48-year-old woman presented with bilateral enlarged ovaries, ascites, bilateral pleural effusion, and advanced gastric cancer. Pleural fluid cytology did not reveal malignant cells. Oophorectomy, performed as a palliative procedure, was followed by rapid resolution of the pleural effusion and ascites. The patient was diagnosed with pseudo-Meigs’ syndrome, and underwent chemotherapy followed by partial gastrectomy. At the last follow-up, 84 mo following oophorectomy, she was alive, and free of disease recurrence, despite not receiving any further treatment. Pseudo-Meigs’ syndrome should be considered in patients with bilateral ovarian tumors, ascites and pleural effusion, and treatment such as oophorectomy may result in symptomatic improvement and better prognosis in similar patients.

关键词： Pseudo-Meigs&rsquo syndrome Ovarian tumor Gastric cancer Pleural effusion Ascites

TTF-1 is useful for primary site determination in duodenal metastasis

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 360-363页

作者： Tomofumi miura Yuichi Shimaoka Junichiro Nakamura Satoshi Yamada Tsutomu miura Masahiko Yanagi Kazuhiro Sato Hiroyuki Usuda Iwao Emura Toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Respiratory Medicine Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

We report here on a case of duodenal metastasis from primary lung adenocarcinoma. A 69-year old man was diagnosed with primary lung adenocarcinoma. Four courses of combined chemotherapy with carboplatin and paclitaxel associated with irradiation of 60 Gy shrunk the lung tumor. However, soon after,the para-aortic lymph node became swollen. Esophagogastroduodenoscopy revealed three duodenal tumors. Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a complete remission in this duodenal metastasisand para-aortic lymph node swelling with only scarring remaining in computed tomography. He is now on the continuous generalized chemotherapy. In conclusion, duodenal metastasis from primary lung adenocarcinoma is rare and hard to diagnose. In such an instance, TTF-1 immunostaining is crucial to obtain the correct diagnosis.

关键词： Lung adenocarcinoma Duodenal metastasis Thyroid transcription factor-1

Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review

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Cancer Drug Resistance 2021年第4期4卷 946-964页

作者： Shogo Ozawa Toshitaka miura Jun Terashima Wataru Habano Division of Pharmacodynamics and Molecular Genetics School of PharmacyIwate Medical UniversityYahabaIwate 0283694Japan

Treatment with pharmacological drugs for colorectal cancer(CRC)remains unsatisfactory.A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs,creating an urgent *** this review,we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for *** review presents the following five major causes of irinotecan resistance in human CRC:(1)cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter,ABCG2;(2)cellular irinotecan resistance is also induced in association with a nuclear receptor,pregnane/steroid X receptor(PXR/SXR),which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38;(3)irinotecan-resistant cells possess either reduced DNA topoisomerase I(Top1)expression at both the mRNA and protein levels or Top1 missense mutations;(4)alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs;and(5)CRC stem cells are the most difficult targets to successfully treat *** the clinical setting,CRC gradually develops resistance to initially effective irinotecan-based *** solve this problem,several clinical trials,such as irinotecan plus cetuximab *** monotherapy,have been *** clinical trial on irinotecan plus guadecitabine,a DNA-methyltransferase inhibitor,has also been conducted.

关键词： Drug resistance colorectal cancer anti-cancer drugs irinotecan ABCG2 DNA topoisomerase I cancer stem cells epigenetics

Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 97-100页

作者： Tsukasa Takayashiki Hideyuki Yoshitomi Katsunori Furukawa Satoshi Kuboki masaru Miyazaki Masayuki Ohtsuka Department of General Surgery Graduate School of MedicineChiba University Department of Gastroenterological Surgery Mita HospitalInternational University of Health and Welfare

To the Editor:Pancreaticobiliary maljunction(PBM)is a congenital anomaly in which the pancreatic and bile ducts join anatomically outside of the duodenal wall away from the Oddi’s *** condition causes the reflux of pancreatic juice into the bile duct under high pressure,resulting in various pathologic *** features of PBM patients are common bile duct dilatation,long common channel,and high amylase levels in bile *** them,one of the most significant problems is the development of biliary cancer,including extrahepatic bile duct and gallbladder cancers[1].A nationwide survey in Japan reported biliary cancer in 21.6%of adult patients with PBM concomitant with congenital biliary dilatation,32.1%and 62.3%extrahepatic bile duct and gallbladder cancers,respectively[2].

关键词： biliary cancer congenital

Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?

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World Journal of Gastroenterology 2009年第26期15卷 3283-3287页

作者： Yuji Sakai Toshio Tsuyuguchi Takeshi Ishihara Seigo Yukisawa Tadashi Ohara masaru Tsuboi Yoshihiko Ooka Kazuki Kato Kiyotake Katsuura Michio Kimura Makoto Takahashi Kazuhisa Nemoto masaru Miyazaki Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of MedicineChiba University Department of Internal Medicine Funabashi Central Hospital Department of Surgery Funabashi Central Hospital Department of Radiology Funabashi Central Hospital Department of General Surgery Graduate School of MedicineChiba University

AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile ***:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary *** symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on *** these patients were subjected to ERCP within 3 d of MRCP to check for the presence of ***:No stones were detected by ERCP in any patient,confi rming the results of ***:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary.

关键词： Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiopancreatography Spontaneous passage of bile duct stones Bile duct stones Pancreatitis

An examination of active sites on Au-Ag bimetallic catalysts based on CO oxidation over Au/Ag_2O and a comparison to Ag-contaminated Au powder

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Chinese Journal of Catalysis 2016年第10期37卷 1712-1720页

作者： Yasuo Iizuka Yasuhiro Hiragi Hikaru Yakushiji Takumi miura 日本京都技术研究所研究生院化学与材料技术系日本京都606-8585 日本国立产业技术综合研究所(aist)大众能源研究部日本大阪563-8577

There are two theories regarding the origin of the remarkable synergistic effect observed in Au‐Ag bimetallic catalysts when applied to various oxidative reactions. One is based on the importance of the contact interfaces between AgOx regions and the surface of the bulk Au as active working sites, while the other holds that charge transfer from Ag to Au in a surface Au‐Ag alloy causes the catalytic activity. One key point in examining these theories and determining the origin of the synergy in‐volves determining whether or not Ag exists as an oxide or as a metallic alloy on the Au surface. To confirm that enhanced activity results from contact between Ag2O and Au nanoparticles （NPs）, a comparative study of catalytic CO oxidation over Au/Ag2O and Ag2O was performed in the present work, using a closed recirculation reaction system. A reaction mixture consisting of a stoichiometric composition of CO and O2 （CO/O2=2/1） was supplied to both catalysts and the resulting pressure decrease rates were tracked, from which the amounts of gas consumed as well as the quantity of CO2 produced were determined. The steady state reactions of both Au/Ag2O and Ag2O did not lead to any meaningful difference in the rate of pressure decrease during the oxidation. The pressure decrease over both catalysts was attributed to the reduction of surface lattice O on Ag2O by CO. The results obtained for Au/Ag2O are in good agreement with previous data resulting from the use of Ag‐contaminated Au powder （Ag/Au‐b） having an oxidized surfaces. This finding suggests that the perimeters between AgOx zones and the bulk Au surface may not function as active sites during CO oxidation. A review of previous results obtained with Ag/Au‐b specimens having so‐called steady state surfaces indicates that AgOx species in such materials are reduced to the 0 state to form a Ag‐Au alloy that provides the active sites.

关键词： Gold-silver bimetallic catalyst Synergy effect Carbon monoxide oxidation Active site Gold-silver alloy