检索结果-南通市图书馆

Synthesis and Enhanced Guest-Binding Affinities of Dendrimer-Based Cyclophane Tetramer and Octamer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Chemical Engineering and Science 2013年第3期3卷 33-37页

作者： Osamu Hayashida Tomomi Nakashima Yu kaku Department of Chemistry Faculty of Science Fukuoka University Fukuoka Japan

Dendritic cyclophane tetramer and octamer were prepared by aminolysis of succinimidyl ester derivative of tetraaza [6.***.6.1] paracyclophane with the corresponding poly(amidoamine) dendrimers as a scaffold, followed by removal of the protecting groups. The present cyclophane tetramer and octamer showed enhanced guest-binding affinities toward fluorescent guests such as 6-p-toluidinonaphthalene-2-sulfonate and 6-anilinonaphthalene-2-sulfonate, in comparison with those of monocyclic cyclophane, reflecting multivalency effects in macrocycles.

关键词： Cyclophane Oligomer Host-Guest Chemistry Multivalency Effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本的大学汉语教育问题

世界汉语教学 2005年第4期19卷 91-97页

作者：郭春贵日本广岛市西区己斐东2—21—19 733-0081

日本汉语教育是国际汉语教学重要的一部分。每年日本大学学汉语的学生近30万人,可是考HSK的仅有3千多人,而且真正掌握好汉语的也寥寥无几。问题出在日本大学汉语教育的环境不很理想。大学方面过分重研究轻教学,重学问轻语言。教学目标... 详细信息

日本汉语教育是国际汉语教学重要的一部分。每年日本大学学汉语的学生近30万人,可是考HSK的仅有3千多人,而且真正掌握好汉语的也寥寥无几。问题出在日本大学汉语教育的环境不很理想。大学方面过分重研究轻教学,重学问轻语言。教学目标不明确,缺乏专业师资。本文建议在环境无法即时改善的情况下,为适应时代要求,应制定一定的教学目标,以形成重视教学的风气,同时尽量提高师资水平与教学意识。

关键词：日本大学汉语教育师资教学目标

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第34期14卷 5311-5315页

作者： Hisato Igarashi Tetsuhide Ito Ken Kawabe Terumasa Hisano Yoshiyuki Arita Toyoma kaku Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University

AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, ***: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases.

关键词：胰腺癌化学疗法肿瘤标志物药物剂量管理

Generalized Additive Mixed Modelling of River Discharge in the Black Volta River

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Statistics 2017年第4期7卷 621-632页

作者： Wahab A. Iddrisu kaku S. Nokoe Albert Luguterah Eric O. Antwi Department of Mathematics and Statistics University of Energy and Natural Resources Sunyani Ghana Department of Statistics University for Development Studies Navrongo Ghana Department of Energy and Environmental Engineering University of Energy and Natural Resources Sunyani Ghana

River discharge data offer a rich source of information for reservoir management and flood control, if modelling can separate out the effects of rainfall, land use, soil type, relief, and weather conditions. In this paper, we model river discharge data from the Black Volta River, using Generalised Additive Mixed Models (GAMMs) with a space-time interaction represented via a tensor product of continuous time and discrete space. River discharge data from January 2000 to December 2009 for the four gauge stations along the Black Volta River namely, Lawra, Chache, Bui and Bamboi were obtained from the hydrological services department of Ghana and used for model fitting. Four GAMMs were explored, two with space-time interactions and two without space-time interactions. The comparison of the performance of the models with space-time interactions and those without space-time interactions based on Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) suggests that in this application, the former is better overall and in particular for modelling local variations. Further, a model with space and time main effects performed better compared with one without space and time main effects. After model selection, checking and validation, there is evidence for increasing river discharge from the most upstream gauge station to the most downstream gauge station for the study period.

关键词： River Discharge GAMM Tensor Product Smooth Space-Time Interaction Black Volta River

超空间科学家的冒险之旅平行宇宙、时间弯曲、第十维度

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Xyloglucan for Generating Tensile Stress to Bend Tree Stem

丛书名：科学可以这样看丛书

2018年

作者：（美）加来道雄（Michio kaku）

《超空间》重在为普通读者打开科学的心扉，将最前沿的科学思想告知大众，打开对未来科学的探索之门。内容包括：进入第五维空间；统一在十维中；虫洞：通往另一个宇宙的关口？；超空间的主人。

ISBN: (数字)9787229130176

ISBN: (纸本)9787229130176

关键词：科学知识普及读物

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Molecular Plant 2009年第5期2卷 893-903页

作者： Kei'ichi Baba Yong Woo Park Tomomi kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi Kyoto University RISH Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural-Sciences Nagoya University Nagoya 464-8601 Japan Forest Tree Breeding Center Hitachi Ibaraki 319-1301 Japan CBD Technologies Rehovot 76100 Israel Division of Forest and Biomaterials Science Kyoto University Kyoto 606-8502 Japan Graduate School of Frontier Biosciences Osaka University Suita Osaka 565-0871 Japan Institute of Sustainability Science Kyoto University Gokasho Uji Kyoto 611-0011 Japan

In response to environmental variation, angiosperm trees bend their stems by forming tension wood, which consists of a cellulose-rich G （gelatinous）-Iayer in the walls of fiber cells and generates abnormal tensile stress in the secondary xylem. We produced transgenic poplar plants overexpressing several endoglycanases to reduce each specific polysaccharide in the cell wall, as the secondary xylem consists of primary and secondary wall layers. When placed horizontally, the basal regions of stems of transgenic poplars overexpressing xyloglucanase alone could not bend upward due to low strain in the tension side of the xylem. In the wild-type plants, xyloglucan was found in the inner surface of G-layers during multiple layering. In situ xyloglucan endotransglucosylase （XET） activity showed that the incorporation of whole xyloglucan, potentially for wall tightening, began at the inner surface layers S1 and S2 and was retained throughout G-layer development, while the incorporation of xyloglucan heptasaccharide （XXXG） for wall loosening occurred in the primary wall of the expanding zone. We propose that the xyloglucan network is reinforced by XET to form a further connection between wall-bound and secreted xyloglucans in order to withstand the tensile stress created within the cellulose G-layer micro fibrils.

关键词： G-layer tensile stress xyloglucan xyloglucan endotransglucosylase

Fractalkine and TGF-β1 levels reflect the severity of chronic pancreatitis in humans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第42期14卷 6488-6495页

作者： Mikihiko Yasuda Tetsuhide Ito Takamasa Oono Ken Kawabe Toyoma kaku Hisato Igarashi Taichi Nakamura Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

AIM: To clarify whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of chronic pancreatitis (CP). This study aimed at clarifying whether serum chemokine and cytokine levels can become useful biological and functional markers to assess the severity of CP. METHODS: Serum monocyte chemoattractant protein-1 (MCP-1), transforming growth factor beta-1 (TGF-β1), and soluble type fractalkine (s-fractalkine) concentrations were examined in patients with CP (n = 109) and healthy controls (n = 116). Severity of disease was classified in patients with CP by a staging system. Relationships between stage-specifi c various clinical factors and serum MCP-1, TGF-β1, and s-fractalkine levels were investigated. Furthermore, 57 patients with non-alcoholic CP were similarly evaluated in order to exclude in? uence of alcohol intake. RESULTS: Patients with CP showed signifi cant higher levels of serum TGF-β1 and s-fractalkine, but not MCP-1, compared to the controls. Serum TGF-β1 in the severe stage and s-fractalkine in the mild and thesevere stage of CP significantly increased compared to those of controls. However, it was observed that both TGF-β1 and s-fractalkine levels were affected by alcohol intake. In patients with non-alcoholic CP, serum TGF-β1 showed significant increase in the moderate stage of CP, and serum s-fractalkine revealed signifi cant increase in the early stage of CP. CONCLUSION: It is suggested that the measurement of serum F-fractalkine is useful to diagnose early-stage CP. Moreover, the combined determination of both, s-fractalkine and TGF-β1, in human sera may be helpful in evaluating the severity status of CP.

关键词：慢性胰腺炎生长因子转换单核细胞化学诱导物

Simultaneous Application of Controlled Availability Fertilizers to Seeding Furrows with Seeding Increases Grain Yield and Quality of No-Till Cultivated Common Wheat in Japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences 2015年第3期6卷 279-290页

作者： Toshio Tani Motoki Hayashi kaku Hiraiwa Ikumi Ochia Shiro Mitsuya Roel R. Suralta Akira Yamauchi Aichi College of Agriculture Okazaki Japan Aichi Agricultural Production Division Nagoya Japan Aichi Agricultural Research Center Nagakute Japan Graduate School of Bioagricultural Sciences Nagoya University Nagoya Japan Philippine Rice Research Institute Munoz Philippines

In Japan, common wheat is cultivated in upland fields converted from paddy fields, where poor drainage and high precipitation cause delay of sowing, lodging at the jointing stage, difficulty in topdressing at the ripening stage, and low yield. No-till cultivation has been promoted to overcome these problems but the yield is still low due to the lack of proper fertilizer application protocols. In this study, we determined whether an additional application of two kinds of Sigmoid coated urea as controlled availability fertilizers (CAFs) to the standard fertilization protocol for tillage cultivation can increase the yield and lodging resistance in no-till cultivated common wheat. Also, additional fertilization was applied to the seeding furrow simultaneously with seeding using a V-furrow no-till direct sowing (VFDS) machine. No-till cultivated plants had more tillers than tillage cultivated ones and consequently higher number of panicles and yield, caused by increased fertilizer application. The point-injected CAFs to the seeding furrow, which eluted at the jointing and ripening stages greatly increased the grain yield and protein content, respectively, compared to broadcast topdressing of ammonium sulfate at each stage. The simultaneous sowing and fertilization of additional CAFs using VFDS method in multi-year tests in farmers’ fields significantly increased the yield of no-till cultivated common wheat, and can be adopted by Japanese local farmers.

关键词： Controlled Availability Fertilizer No-Till Cultivation Triticum aestivum V-Furrow No-Till Direct Sowing Method