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Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 980-994页

作者： Motomichi Fujita Hideo suzuki Fumio Fukai Department of Molecular Patho-Physiology Tokyo University of ScienceNoda 278-8510ChibaJapan Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan

Tenascin-C(TNC)is an adhesion modulatory protein present in the extracellular matrix that is highly expressed in several malignancies,including colon *** TNC is considered a negative prognostic factor for cancer patients,the substantial role of the TNC molecule in colorectal carcinogenesis and its malignant progression is poorly *** previously found that TNC has a cryptic functional site and that a TNC peptide containing this site,termed TNIIIA2,can potently and persistently activate *** contrast,the peptide FNIII14,which contains a cryptic bioactive site within the fibronectin molecule,can inactivate *** review presents the role of TNC in the development of colitis-associated colorectal cancer and in the malignant progression of colon cancer,particularly the major involvement of its cryptic functional site *** propose new possible prophylactic and therapeutic strategies based on inhibition of the TNIIIA2-induced beta1-integrin activation by peptide FNIII14.

关键词： Tenascin-C TNIIIA2 Beta1-integrin Integrin activation Colitis-associated colorectal cancer Colon cancer

Structure and function of ALG-2,a penta-EF-hand calcium-dependent adaptor protein

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Science China(Life Sciences) 2011年第8期54卷 770-779页

作者： Masatoshi MAKI Hironori suzuki Hideki SHIBATA Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya University Structural Biology Research Center Photon FactoryInstitute of Materials Structure ScienceHigh Energy Accelerator Research Organization

ALG-2(a gene product of PDCD6) is a 22-kD protein containing five serially repetitive EF-hand structures and belongs to the penta-EF-hand(PEF) family,including the subunits of typical ***-2 is the most conserved protein among the PEF family members and its homologs are widely found in eukaryotes.X-ray crystal structures of various PEF proteins including ALG-2 have common features:presence of eightα-helices and dimer formation via paired EF5s that are positioned in anti-parallel ***-2 forms a homodimer and a heterodimer with its closest paralog *** calmodulin,a well-known four-EF-hand protein,ALG-2 interacts with various proteins in a Ca2+-dependent fashion,but the binding motifs are completely *** some exceptions,ALG-2-interacting proteins commonly contain Pro-rich regions,and ALG-2 recognizes at least two distinct Pro-containing motifs:PPYP(X) nYP(X,variable;n=4 in ALIX and PLSCR3) and PXPGF(represented by Sec31A) .A shorter alternatively spliced isoform,lacking two residues and designated ALG-2 GF122,does not bind ALIX but maintains binding capacity to Sec31A.X-ray crystal structural analyses have revealed that binding of calcium ions induces the configuration of the side chain of R125 so that it opens Pocket 1,which accepts PPYP,but Pocket 1 remains closed in the case of ALG-2 ***-2 dimer has two ligand-binding sites,each in a monomer molecule,and appears to function as a Ca2+-dependent adaptor protein to either stabilize a preformed complex or to bridge two proteins on scaffolds in systems of the endosomal sorting complex required for transport(ESCRT) and ER-to-Golgi transport.

关键词： ALG-2 calcium penta-EF-hand X-ray crystal structure protein-protein interaction membrane trafficking

Local convergence zones or discontinuous lines in the Taklimakan Desert, Northwest China

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Journal of Arid Land 2010年第2期2卷 77-86页

作者： Masatoshi YOSHINO Takashi ISHIYAMA Jun suzuki Professor Emeritus University of Tsukuba Center for Environmental Remote Sensing Chiba University IDEA Consultants

In order to study convergence zones or discontinuous lines formed locally in the Taklimakan Desert,we analyzed available MODIS images onboad TERRA or AQUA satellite for ten cases:29 March 2002,14 April 2002;2 January 2003;21 April 2003;26 March 2004;28 April 2004;30 January 2005;25 June 2005;3 December 2005;and 26 July *** used weather maps published by the Japan Mete-orological Agency for the Asia and Pacific region at 500 hPa,700 hPa and 850 hPa,at 00Z and 12Z to analyze the meteorological conditions occurring in each *** estimated the positions of air streams,convergence zones or discontinuous lines between them,and thermal conditions on the maps and con-firmed the presence of cumulus and cumulonimbus clouds through satellite images in *** a review of previous studies,this paper introduced the results of the present *** warm areas in the Taklimakan Desert and on the Tibetan Plateau and local convergence zones or discontinuous lines in the Taklimakan Desert were discussed together with their diurnal changes,using composite maps of the ten *** the long axis of the desert the convergence zones or discontinuous lines normally extend 70-80 km in a west-east direction,but are suspected to exceed 100 km in extreme *** the other hand,the convergence zones or discontinuous lines extending in a north-south direction on the southern fringe of the desert have a length of 40-60 *** closed warm areas show clear diurnal changes,but they were not detected at the 500 hPa *** example of a clear convergence zone running in a north-south direction on 26 July 2006 was presented in detail with corresponding satellite images.

关键词： atmospheric circulation convergence zone discontinuous line satellite image Taklimakan Desert

Study of pruritus in chronic hepatitis C patients

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World Journal of Gastroenterology 2014年第47期20卷 17877-17882页

作者： Kazuyoshi suzuki Masaya Tamano Yasumi Katayama Toru Kuniyoshi Kagemasa Kagawa Hiroshi Takada Kazutomo suzuki Department of Gastroenterology Dokkyo Medical University Koshigaya HospitalSaitama 343-8555Japan

AIM: To investigate the occurrence and severity of pruritus in chronic hepatitis C patients treated with or without interferon (IFN) therapy.

关键词： Hepatitis C Pruritus Peginterferon Ribavirin Thymus and activation-regulated chemokine

STUDY ON THE DUCTILE DEFORMATION DOMAIN OF THE SIMPLE SHEAR IN ROCKS——TAKING BRITTLE FAULTS OF THE COVERING STRATA IN THE SOUTHERN JIANGSU AREA AS AN EXAMPLE

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Science China Chemistry 1992年第12期35卷 1512-1520页

作者：孙岩沈修志 T.suzuki Department of Earth Sciences Nanjing UniversityNanjing 210008PRC Department of Geology Kochi University Kochi 780 Japan

A study on the ductile deformation domain of the brittle fault in the shallow level ofthe crust is a new probe field for the modern structural geology. Taking the southern Jiang-su Province area as an example the orientation measurement of quartz crystals, the com-positional texture observation of three pressure sensitive minerals and the rheological param-eter determination of dislocation densities, etc. have been demonstrated and analysed basedon typical samples in the present paper. In addition, their generation mechanisms arealso discussed from the cataclastic rheology, the dynamic differentiation and the simpleshearing, specially, from the Ode strength theory. Finally, a generative relationship betweenthe ductile deformation domain of the brittle fault system, in the regional layer--slip andthe formation of the stratabound ore deposit is shown as well.

关键词： simple shear ductile deformation btittle fault crystal orientation dislocation structure southern Jiangsu area

Automated estimation of materials parameter from X-ray absorption and electron energy-loss spectra with similarity measures

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npj Computational Materials 2019年第1期5卷 815-821页

作者： Yuta suzuki Hideitsu Hino Masato Kotsugi Kanta Ono Department of Materials Science and Technology Tokyo University of ScienceTokyoJapan High Energy Accelerator Research Organization Institute of Materials Structure ScienceTsukubaJapan The Institute of Statistical Mathematics TokyoJapan Center for Materials Research by Information Integration(CMI2) Research and Services Division of Materials Data and Integrated System(MaDIS)National Institute for Materials Science(NIMS)Tsukuba 305-0047Japan

Materials informatics has significantly accelerated the discovery and analysis of materials in the past *** of the key contributors to accelerated materials discovery is the use of on-the-fly data analysis with high-throughput experiments,which has given rise to the need for accelerated and accurate automated estimation of the properties of *** this regard,spectroscopic data are widely used for materials discovery because these data include essential information about *** important requirement for the realisation of the automated estimation of materials parameters is the selection of a similarity measure,or kernel *** required measure should be robust in terms of peak shifting,peak broadening,and ***,the determination of appropriate similarity measures for spectra and the automated estimation of materials parameters from these spectra currently remain *** examined major similarity measures to evaluate the similarity of both X-ray absorption and electron energy-loss *** similarity measures show good correspondence with the materials parameter,that is,the crystal-field parameter,in all *** Pearson's correlation coefficient was the highest for the robustness against noise and peak *** obtained the regression model for the crystal-field parameter 10 Dq from the similarity of the *** regression model enabled the materials parameter,that is,10 Dq,to be automatically estimated from the *** regard to research progress in similarity measures,this methodology would make it possible to extract the materials parameter from a large-scale dataset of experimental data.

关键词： materials similarity parameter

Recycle for Sludge Scrap of Nd-Fe-B Sintered Magnet as Isotropic Bonded Magnet

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Journal of Rare Earths 2004年第1期22卷 168-171页

作者： Masahiro Itoh Masahiro Masuda Shunji suzuki Ken-ichi Machida Collaborative Research Center for Advanced Science and Technology Collaborative Research Center for Advanced Science and TechnologyCollaborative Research Center for Advanced Science and TechnologyCollaborative Research Center for Advanced Science and Technology Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871 Osaka University 2-1 Yamadaoka Suita Osaka 565-0871

The reduction diffusion method was performed for the sludge scrap of Nd-Fe-B sintered magnets with adding Ca metal to recover the oxidized Nd-Fe-B phase. After washing the resultant powders to remove Ca metal component, the powders obtained were recycled as an isotropic magnetic powder by the melt spinning method. The magnetic properties of powders as recycled were inferior, especially for the coercivity value, due to the deletion of rare earth metals during the washing process. The adjustment of metal composition, i.e., the addition of Nd metal, at the melt spinning process improved the magnetic properties to be B r=～0.75 T, H cj=～0.93 mA·m -1, and (BH) max=～91 kJ·m -3. The magnetic properties of the bonded magnets prepared from the composition-adjusted powders were B r=～0.66 T, H cj=～0.92 mA·m -1, and (BH) max=～70 kJ·m -3, which are approximately comparable to the commercially available MQPB boned one (B r=～0.73 T, H cj=～0.79 mA·m -1, and (BH) max=～86 kJ·m -3).

关键词： Nd-Fe-B sintered magnet recycling isotropic Nd-Fe-B bonded magnet melt-spinning method sludge scrap rare earths

Boundary-representable partition of unity for image magnification

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Science China(Information Sciences) 2013年第11期56卷 216-227页

作者： NAGAI Yukie OHTAKE Yutaka YOKOTA Hideo suzuki Hiromasa School of Engineering The University of Tokyo153-8904 Japan Bio-Research Infrastructure Construction Team ASI RIKEN 351-0198 Japan RCAST The University of Tokyo153-8904 Japan

This paper proposes a simple yet efective algorithm to magnify 2D/3D images with preserving discontinuities of *** algorithm is based on the partition of unity(PU)approximation,which ofers many advantages such as smooth representation,noise-robustness,and precise ***,PU encounters difculties when scaling images and maintaining boundaries within images owing to the nature of its *** overcome this problem,we propose an approximation that preserves *** is realized by dividing the local spherical support of PU into two parts along a locally detected discontinuity and by individually approximating intensities on each side of the *** algorithm is suitable for magnifying a variety of images,including scanned documents,pictures,and CT-scanned *** demonstrate the efectiveness of the proposed method,we show some experimental results for 2D/3D images.

关键词： image approximation partition of unity piecewise smooth function volume data magnification

Effects of Vertical Angle of Conical Punch on Stretch Flangeability of High Strength Steel

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1503-1509页

作者： Yasuhiro Ito Yoshiaki Nakazawa Yukihisa Kuriyama Katsuyuki Suzuk Noriyuki suzuki Nippon Steel and Sumitomo Metal Corporation The University of Tokyo

To clarify the effects of the vertical angle of a conical punch on stretch flangeability, hole expansion forming tests were conducted. Test results showed that the hole expansion ratio becomes larger as the vertical angle *** also showed that the fracture strain at the fracture location on the hole edge was constant and independent of the vertical angle. This is because the hole expansion ratio was controlled not only by the fracture strain, which is independent of the vertical angle, but also by deformation uniformity along the hole edge. From the result of numerical analyses, it was determined that deformation uniformity depends on the gradient of circumferential stress along the radius direction. When the vertical angle is sharp, the circumferential stress showed a steep decline and the deformation localization was suppressed. Consequently, the hole edge deformed more uniformly and the hole expansion ratio became larger. It is concluded that in order to improve stretch flangeability of high strength steel, it is important to uniformly deform the hole edge by applying a conical punch with a sharp vertical angle.

关键词： Formability Ductile fracture Finite element analysis Hole expansion test