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Comparative study on pharmacokinetics and toxicity of intravitreal and sub-Tenon injection of triamcinolone acetonide in ocular tissues

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1864-1871页

作者： Yuko Arie Hiroko Miyai Ayako Suzuki Takeshi Okabe Mitsuyo Takashima Mayumi Takata Takashi Kurasawa Masaki Ito Reijiro Arakawa Yuichiro Ogura Akira naito Sagami Research Laboratories Wakamoto Pharmaceutical Corporation Ltd.Kanagawa 2580018Japan Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoya 4678601Japan

AIM:To compare the differences in kinetics,distribution,and toxicity of triamcinolone acetonide(TA)between the injection methods,sub-Tenon and intravitreal injections in rabbit ocular ***:TA was injected into the vitreous or the sub-Tenon in *** pharmacokinetic study,rabbits were sacrificed periodically and then TA in blood and ocular tissues(retina/choroids,vitreous,and aqueous humor)were measured over 91 *** toxicological study,clinical signs,slit-lamp microscopic examination,ophthalmological test were *** eyeballs and surrounding tissues were collected and fixed with glutaraldehyde-formalin solution,and then paraffin embedded for histological ***:Higher levels of TA were distributed in the intraocular tissues when injected into the vitreous compared to the ***,TA level was remarkably lower in the rabbits which received intravitreal TA injections than those treated with sub-Tenon injection throughout the study period in *** discharge probably caused by systemic circulation of TA was observed by receiving sub-Tenon TA ***,technicassociated toxicological ocular symptoms and findings were more frequently observed in intravitreal injection than in sub-Tenon ***:There are significant differences in kinetics and distribution of TA in vitreous body,aqueous humor and plasma,between the two injection *** further study is needed to explain the species difference between human and rabbit,it is assumed that the difference in the frequency of intraocular pressure elevation and cataract formation by TA between the two injection methods are directly related to the TA concentrations in aqueous humor and vitreous body in each injection *** toxicity and technic-associated toxicity are also closely related to kinetics of TA in plasma and each injection method itself,respectively.

关键词： corticosteroid(s) pharmacokinetics injection ophthalmic drug delivery toxicity

A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney

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Asian Journal of Urology 2023年第3期10卷 376-378页

作者： Keisuke Funajima Sei naito Takanobu Kabasawa Hayato Nishida Tomoyuki Kato Mitsuru Futakuchi Norihiko Tsuchiya Department of Urology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan Department of Pathology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan

Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting *** is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carcinomas[1].We described a patient with CDC and psoriasis,who showed complete response(CR)after being treated with combination therapy of nivolumab and ipilimumab(NI).The study was conducted in accordance with and approved by the Ethics Committee of Yamagata University Faculty of Medicine(approval no.2019-35).The need for patient consent was waived by the same institutional review board;all the patients provided written informed consents.

关键词： markedly nivolumab approval

Combining Motor Imagery and Action Observation with Vibratory Stimulation Increases Corticomotor Excitability in Healthy Young Adults

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Journal of Behavioral and Brain Science 2022年第5期12卷 177-195页

作者： Nodoka Kimura Tomoya Furuta Gen Miura Eiichi naito Center for Information and Neural Networks (CiNet) Advanced ICT Research Institute National Institute of Information and Communications Technology (NICT) Osaka Japan Graduate School of Frontier Biosciences Osaka University Osaka Japan

Vibratory stimulation but also motor imagery and action observation can induce corticomotor modulation, as a bottom-up stimulus and top-down stimuli, respectively. However, it remains unknown whether the combination of motor imagery, action observation, and vibratory stimulation can effectively increase corticomotor excitability. This study aimed to investigate the effect of motor imagery and/or action observation, in the presence or absence of vibratory stimulation, on the corticomotor excitability of healthy young adults. Vibratory stimulation was provided to the palm of the right hand. Action observation consisted in viewing a movie of someone else’s finger flexion and extension movements. The imagery condition required the participants to imagine they were moving their fingers while viewing the movie and attempting to move their fingers in accordance with the movie. Eleven right-handed healthy young adults were asked to perform six conditions randomly: 1) vibratory stimulation, imagery, and action observation, 2) vibratory stimulation and action observation, 3) vibratory stimulation and viewing of a blank screen, 4) imagery and action observation, 5) action observation, and 6) viewing of a blank screen. Single-pulse transcranial magnetic stimulation was conducted to assess corticomotor excitability and the peak-to-peak amplitude of the motor evoked potentials. The results showed that vibratory stimulation increases corticospinal excitability. The findings further revealed that performing motor imagery while viewing finger movement is more effective at inducing an augmentation of corticomotor excitability compared to action observation alone. Thus, the combination of motor imagery, action observation, and vibratory stimulation can effectively augment corticomotor excitability.

关键词： Motor Evoked Potential Transcranial Magnetic Stimulation Vibratory Stimulation Motor Imagery Action Observation

Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7

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Journal of Sport and Health Science 2021年第4期10卷 470-477页

作者： Ferenc Torma Zoltan Gombos Marcell Fridvalszki Gergely Langmar Zsofia Tarcza Bela Merkely Hisashi naito Noriko Ichinoseki-Sekine Masaki Takeda Zsolt Murlasits Peter Osvath Zsolt Radak Research Center for Molecular Exercise Science University of Physical EducationBudapest 1123Hungary Department of Kinesiology University of Physical EducationBudapest 1123Hungary Heart and Vascular Center Semmelweis UniversityBudapest 1122Hungary Faculty of Health and Sports Science Juntendo UniversityChiba 270-1695Japan Faculty of Health and Sports Science Doshisha UniversityKyotanabe 610-0394Japan Laboratory of Animal Research Center Qatar UniversityDoha 2713Qatar Department of Health Sciences and Sport Medicine University of Physical EducationBudapest 1123Hungary

Backgroud:Blood flow re striction(BFR) with low-intensity re sistance training has been shown to result in hypertrophy of skeletal *** this study,we tested the hypothesis that BFR during the rest periods between acute,high-intensity resistance exercise sessions(70% of 1 repetition maximum,7 sets with 10 repetitions) enhances the effects of the resistance ***:A total of 7 healthy young men performed squats,and between sets BFR was carried out on one leg while the other leg served as a *** BFR was applied during rest periods,even severe occlusion pressure(approximately 230 mmHg),which almost completely blocked blood flow,was well-tolerated by the *** muscle-specific microRNAs were measured from the biopsy samples,which were taken 2 h after the acute ***:Doppler data showed that the pattern of blood flow recovery changed significantly between the first and last ***-206 levels significantly decreased in the BFR leg compared to the *** mRNA levels of RAC-β serine/threonine-protein kinase v22,nuclear re spiratory factor 1,vascular endothelial growth factor,lupus Ku autoantigen protein p70 genes(p <0.05),and paired box 7(p <0.01) increased in the BFR *** protein levels of paired box 7,nuclear respiratory factor 1,and peroxisome proliferator-activated receptor y coactivator 1α did not differ between the BFR leg and the control ***:BFR,during the rest periods of high-load resistance training,could lead to mRNA elevation of those proteins that regulate angiogenesis,mitochondrial biogenesis,and muscle hypertrophy and ***,BFR also can cause DNA damage,judging from the increase in mRNA levels of lupus Ku autoantigen protein p70.

关键词： Blood flow restriction High-intensity resistance training microRNA Satellite cells

Criteria for versatile GaN MOVPE tool:high growth rate GaN by atmospheric pressure growth

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Journal of Semiconductors 2011年第1期32卷 21-23页

作者： Koh Matsumoto Kazutada Ikenaga Jun Yamamoto Kazuki naito Yoshiki Yano Akinori Ubukata Hiroki Tokunaga Tadanobu Arimura Katsuaki Cho Toshiya Tabuchi Akira Yamaguchi Yasuhiro Harada Yuzaburo Ban Kousuke Uchiyama TN-EMC Ltd 2008-2 Wada TamaTokyo 206-0001Japan Business Strategy Planning div.Electronics Group TAIYO NIPPON SANSO Corporation 10 OkuboTsukuba 300-2611Japan Compound-semiconductor Division TAIYO NIPPON SANSO Corp. 6-2 KojimachoKawasaki-shi210-0861Japan

Growth rate has a direct impact on the productivity of nitride LED production. Atmospheric pressure growth of GaN with a growth rate as high as 10/zm/h and also *** growth of 1μm/h by using 4 inch by 11 production scale MOVPE are described. XRD of （002） and （102） direction was 200 arcsec and 250 arcsec, respectively. Impact of the growth rate on productivity is discussed.

关键词： MOVPE GaN: AlGaN atmospheric pressure growth high growth rate

在相模海槽使用一种新型三分量海底磁力仪的地磁观测

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世界地震译丛 1989年第2期20卷 76-83页

作者： naito,Y. 戴钟雄

在日本北海道Tokachi district，马铃薯晚疫病菌占主导地位的基因型的变化及不同基因型在水平抗病品种‘Matilda’上产生不同病斑的研究

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河北农业大学学报 2001年第2期24卷 10-15页

作者： MasayasuKato S.naito 北海道国家农业试验站，日本062－8555 北海道农业大学农学系，日本062－0809

在Memuro城镇,位于日本北海道Tokachi地区中部,主要种植田间抗病品种Matilda.1998年马铃薯晚疫病在此品种上发生较前几年早.为了了解Matilda品种抗性降低的原因,对1996-1999年Tokachi地区的晚疫病菌基因型的时间变化进行了研究及不同基... 详细信息

在Memuro城镇,位于日本北海道Tokachi地区中部,主要种植田间抗病品种Matilda.1998年马铃薯晚疫病在此品种上发生较前几年早.为了了解Matilda品种抗性降低的原因,对1996-1999年Tokachi地区的晚疫病菌基因型的时间变化进行了研究及不同基因型间病菌产生病斑能力进行了比较.在1997年以前基因型JP-1在Tokachi地区占主导地位.在1997年基因型A首次在Tokachi地区被发现并且局限在Tokachi北部.在1998和1999年基因型A遍及整个Tokachi地区,1999年其比例上升至72%.用孢子囊悬浮液接种法检测不同基因型病菌对Matilda品种的致病力结果发现,基因型A比基因型JP-1和基因型B产生更大的病斑.然而通过液滴接种法所有3个基因型都可产生扩展的病斑.结果表明,Matilda减少的田间抗性是由于基因型A 传播到Memuro城镇的Matilda品种上所致.

关键词：马铃薯晚疫病菌田间抗性基因型

Asymptotic Expansion for the Distribution of a Median Unbiased Estimator of ARCH（0,1） Coefficient

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Northeastern Mathematical Journal 2007年第2期23卷 176-188页

作者：王德辉 Kanta naito School of Mathematics Jilin University Changchun 130012 Department of Mathematics Shimane University Matsue Japan 690-8504

This paper is concerned with the distributional properties of a median unbiased estimator of ARCH（0,1） coefficient. The exact distribution of the estimator can be easily derived, however its practical calculations are too heavy to implement, even though the middle range of sample sizes. Since the estimator is shown to have asymptotic normality, asymptotic expansions for the distribution and the percentiles of the estimator are derived as the refinements. Accuracies of expansion formulas are evaluated numerically, and the results of which show that we can effectively use the expansion as a fine approximation of the distribution with rapid calculations. Derived expansion are applied to testing hypothesis of stationarity, and an implementation for a real data set is illustrated.

关键词： ARCH(0,1) process asymptotic distribution Cornish-Fisher expansion Edgeworth expansion median unbiased

Two-and Three-Layered Dissolving Microneedles for Transcutaneous Delivery of Model Vaccine Antigen in Rats

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Journal of Biomaterials and Nanobiotechnology 2012年第3期3卷 325-334页

作者： Asuka Ikejiri Yukako Ito Seishiro naito Kanji Takada Department of Pharmacokinetics Kyoto Pharmaceutical University Kyoto Japan Department of Safety Research on Blood and Biological Products National Institute of Infectious Diseases Tokyo Japan.

Purpose: Comparison of transcutaneous immunization of ovalbumin (OA) between two-and three-layered dissolving microneedles (MN) in rats. Methods: We prepared 500 μm long two-layered and three-layered dissolving microneedle (2-MN and 3-MN, respectively) arrays from chondroitin sulfate as the base, and OA as the model antigen. The 2-MN containing OA at the acral portion and 3-MN with OA at the second portion were administered to rat skin transcutaneously. As a positive control, OA solution was injected subcutaneously (sc). The OA delivery and diffusion in the rat skin were studied using confocal microscopy with fluorescein-conjugated OA (FL-OA). Results: The formulated positions of OA were 0-155 ± 5 μm for 2-MN and 175 ± 4 – 225 ± 5 μm for 3-MN. The administered doses of OA were 2.2 ± 0.1 μg, 12.0 ± 0.2 μg and 22.0 ± 0.2 μg for 2-MN, 1.8 ± 0.2 μg, 12.6 ± 0.7 μg, and 20.4 ± 0.3 μg for 3-MN, 10 μg, 100 μg and 1000 μg for sc injection. At 4 weeks after the first administration, 3-MN showed about 2.5-7.0 fold and 5.4 fold higher total Ig (G + A + M) antibody than 2-MN and sc injection of the OA solution. Conclusions: The 3-MN, which delivered OA to the epidermis, is a useful drug delivery system for transcutaneous antigen delivery.

关键词： Dissolving Microneedles (Mns) Two-Layered Mns Three-Layered Mns Transcutaneous Vaccine Ovalbumin Fl-Ovalbumin (Fl-Oa)