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Journal of Cancer Therapy 2017年第4期8卷 341-348页

作者： masanori naito Takeo Sato Takatoshi Nakamura Takahiro Yamanashi Hirohisa Miura Atsuko Tsutsui Masahiko Watanabe Department of Surgery School of Medicine Kitasato University Sagamihara Japan

Introduction: Systematic lymphadenectomy and ligation of the feeding artery is extremely important when performing radical resection in colorectal cancer. However, vascular surgery via laparoscopy requires advanced skills and techniques;thus, this procedure needs to be simplified while maintaining quality of the surgery to make it a preferred technique for the surgeons. Methods: There were 49 patients who underwent laparoscopic sigmoidectomy or anterior resection till T2 level for sigmoid colon cancer and recto-sigmoid colon cancer. We analyzed short-term and long-term outcomes between stapling ligation and clipping ligation techniques used in these surgeries. Results: The mean volume of blood loss in the stapling ligation group was 12.8 ± 12.3 ml, which was significantly lower than 41.9 ± 71.2 ml of mean volume of blood loss in the clipping ligation group. There was no significant difference in the mean duration of surgery, the mean number of harvested lymph nodes, morbidity, recurrence, and 5-year relapse free survival rates between the 2 groups. Conclusions: This study demonstrates a surgical technique using staplers for vascular treatment of tumor-feeding arteries as a new technical improvement in laparoscopic colectomy for the treatment of early-stage colon cancer. We found that the described procedure was technically safe, simple, convenient, and oncologically valid.

关键词： Laparoscopic Surgery Colorectal Cancer Vascular Ligation Linear Stapler

Analysis of the Relationship between Eating and Swallowing Function and Lifestyle of the Elderly Living in the Community-A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第2期8卷 56-69页

作者： naito Tomoyoshi Yamada Masami Nakamura Mi Eiko Ojima Toshiyuki Hamamatsu Medical University Shizuoka 431-3125HamamatsuJapan Department of Nursing Faculty of Medical SciencesTeikyo University of Science and TechnologyTokyo 120-0045Japan Hamamatsu Medical University Department of Health and Social MedicineShizuoka 431-3125HamamatsuJapan

Objectives:The relationship between eating and swallowing function,and lifestyle among community-dwelling elderly people has not been extensively *** study aimed to analyze the characteristics of eating and swallowing function and their association with the lifestyle among the ***:A self-administered questionnaire survey was conducted on 419 elderly people who participated in the oral function improvement project operated by the Community Comprehensive Support Center.A total of 288 valid responses(58 males,230 females,average age 73.6 years)were *** survey items included basic demographics,health status,lifestyle,and eating and swallowing *** chi-square(χ2)test was used to compare for a difference in the risk of ***:72 patients(25.0%)were judged to be at risk for dysphagia,and 216(75.0%)were judged to be not at risk for dysphagia using the revised dysphagia risk assessment *** mean score for oral preparatory dysphagia was the highest,while the mean score for pharyngeal dysphagia was the *** group at risk of dysphagia had significant difficulty in chewing and had bad sleep quality as compared to the group that was not at ***:Concerning the risk of dysphagia,there is a need to maintain and improve masticatory *** addition,improving the swallowing function of the elderly may prevent insomnia and improve sleep quality.

关键词： Elderly living in the community Eating and swallowing function Lifestyle

Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi Yamagishi Masanobu naito Yohei Yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

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Journal of Pharmaceutical Analysis 2022年第6期12卷 852-859页

作者： Takashi Mochizuki Kaito Shibata Takafumi naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi Kawakami Department of Hospital Pharmacy Hamamatsu University School of MedicineHamamatsu431-3192Japan Department of Pharmacy Shinshu University HospitalMatsumotoNagano390-8621Japan Third Division Department of Internal MedicineHamamatsu University School of MedicineHamamatsu431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu431-3192Japan

The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry(LC-MS/MS)method has not been widely applied in clinical settings because of its time-consuming and costly sample *** present study aimed to develop a validated LC-MS/MS method for detecting serum tocilizumab by utilizing immobilized trypsin without an immunoglobulin G purification step and evaluate its applicability in the treatment of rheumatoid arthritis(RA)patients administered intravenously or subcutaneously with *** tocilizumab-derived signature peptide was deciphered using a nano-LC system coupled to a hybrid quadrupole-orbitrap mass *** serum tocilizumab was rapidly digested by immobilized trypsin for 30 *** chromatographic peak of the signature peptide and that of the internal standard were separated from the serum digests for a total run time of 15 *** calibration curve of serum tocilizumab concentration was linear with a range of 2-200 μg/*** intra-and inter-day accuracy and relative standard deviation(RSD)were 90.7%-109.4%and<10%,*** serum tocilizumab concentrations in the RA patients receiving intravenous and subcutaneous injections were 5.8-28.9 and 2.4-63.5 μg/mL,*** serum tocilizumab concentrations using the current method positively correlated with those using the enzyme-linked immunosorbent assay,although a systematic error was observed between these *** conclusion,a validated LC-MS/MS method with minimal sample pretreatments for monitoring serum tocilizumab concentrations in RA patients was developed.

关键词： Tocilizumab LC-MS/MS Immobilized trypsin IgG purification Proteomics Rheumatoid arthritis

Specific acupuncture stimulation of Shenshu(BL23)affects sympathetic nervous activity-associated plasma renin concentration changes

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Journal of Traditional Chinese Medicine 2022年第2期42卷 250-255页

作者： Kanae Umemoto Tomoya Hayashi Kaori Fukushige Shuichi Hirai Hayato Terayama Kou Sakabe Munekazu naito Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Department of Anatomy Division of Basic Medical Sc+ienceTokai University School of MedicineIseharaKanagawa 259-1193Japan Department of Anatomy Aichi Medical University School of MedicineNagakuteAichi 480-1195Japan Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto629-0392Japan Department of Physiology Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Division of Anatomical Science Department of Functional MorphologyNihon University School of MedicineItabashi-kuTokyo 173-0032Japan Department of Anatomy Division of Basic Medical ScienceTokai University School of MedicineIseharaKanagawa 259-1193Japan

OBJECTIVE:To examine whether specific stimulation of Shenshu(BL23)affects sympathetic nervous activity(SNA)-associated plasma renin concentration(PRC).METHODS:Eight healthy volunteers participated in three pattern conditions in random order:control(Cont),stimulation of Shenshu(BL23),and stimulation of sham point(Sham).All participants were initially in the supine position for>60 min,and then remained in the standing position during the experimental procedure to increase *** electrocardiogram was used to calculate low frequency/high frequency(LF/HF)ratio;blood was collected to analyze ***:The LF/HF ratio was significantly increased in the standing position when compared with the supine position(P<0.01).There was no difference in LF/HF ratio during or after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,the LF/HF ratio was significantly increased in Cont and Sham conditions(P<0.01).There was no difference in PRC after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,there was a significant increase in PRC in the Cont and Sham conditions(Cont P<0.05,Sham P<0.01).CONCLUSION:Our results demonstrated that specific acupuncture stimulation of Shenshu(BL23)in the standing position decreased SNA-associated PRC,which was not observed during acupuncture stimulation of the sham point.

关键词： Acupuncture Point BL23(Shenshu) Sympathetic nervous activity Plasma renin concentration

Fabrication and modelling of Si_(3)N_(4)ceramics with radial grain alignment generated through centripetal sinter-forging

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Journal of Materials Science & Technology 2022年第31期126卷 1-14页

作者： Da-Wang Tan Zhen-Yong Lao Wei-Ming Guo Akira Kondo Takahiro Kozawa Makio naito Kevin Plucknett Hua-Tay Lin Department of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China Joining and Welding Research Institute Osaka University11-1 MihogaokaIbarakiOsaka 567-0047Japan Department of Mechanical Engineering Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada

Silicon nitride(Si_(3)N_(4))based ceramics are one of the most attractive advanced engineering materials,which have been widely used under high-speed rotational operation or for mechanical contacts across a curved *** the present study,rotationally symmetric texturing of Si_(3)N_(4),with radial grain align-ment,was obtained by centripetal sinter-forging(CSF)of a partially sintered *** average values of the included angles between the c-axis of the local Si_(3)N_(4)grain and radial direction were approxi-mately 16.4°and 11.0°,on the section plane perpendicular to the pressing direction,and parallel to both the pressing and radial directions,*** compressive strain in the pressing direction forced the ceramic body to flow towards the central axis,resulting in compressive strain in the tangential di-rection and tensile strain in the radial direction.A fundamental physical model was created to simulate the grain rotation during the 3-dimentional strain reorientation,which revealed the rod-like grain would preferentially rotate toward the center of the sample under the CSF *** addition,due to the fric-tion between the sample surface and the pressing punch,the increased shear strain could enhance the Si_(3)N_(4)grain ***,ceramics with rod-like grains perpendicular to the curved side sur-face could be anticipated by applying the centripetal forming concept in a controlled manner.

关键词： Si_(3)N_(4)ceramic Texture Radial grain alignment Modeling CSF

基于机械干态颗粒涂层技术制备cBN@TiN粉体

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机械工程材料 2024年第3期48卷 37-42页

作者：罗展鹏刘润平郭伟明谭大旺罗嗣春林华泰内藤牧男广东工业大学机电工程学院广州510006 岭南师范学院机电工程学院湛江524048 萍乡学院机械电子工程学院萍乡337055 大阪大学接合科学研究所大阪565-0871

采用机械干态颗粒涂层技术分别制备了cBN@TiO_(2)(TiO_(2)包覆立方氮化硼)粉体和cBN@(TiO_(2)+C)(TiO_(2)+碳包覆立方氮化硼)粉体,然后在1600℃、N_(2)气氛下进行高温热处理制备cBN@TiN(TiN包覆立方氮化硼)粉体,研究了高温热处理前后粉... 详细信息

采用机械干态颗粒涂层技术分别制备了cBN@TiO_(2)(TiO_(2)包覆立方氮化硼)粉体和cBN@(TiO_(2)+C)(TiO_(2)+碳包覆立方氮化硼)粉体,然后在1600℃、N_(2)气氛下进行高温热处理制备cBN@TiN(TiN包覆立方氮化硼)粉体,研究了高温热处理前后粉体的物相组成与微观形貌以及高温反应机理。结果表明:机械干态颗粒涂层技术可以使纳米TiO_(2)和纳米TiO_(2)+C颗粒均匀包裹在cBN颗粒表面。在高温热处理过程中,TiO_(2)与cBN反应生成液相B_(2)O_(3),促进了cBN相变成六方氮化硼(hBN),cBN的高温稳定性差,以cBN@TiO_(2)为原料制备的cBN@TiN粉体颗粒表面形成由TiN相和hBN相组成的片状结构层;当存在碳时,TiO_(2)会优先与碳发生还原反应生成TiN,抑制B_(2)O_(3)的生成,从而降低cBN相变量,此时cBN的高温稳定性好,以cBN@(TiO_(2)+C)为原料制备的cBN@TiN粉体颗粒表面形成主要为TiN相的颗粒结构层。

关键词： TiN包覆cBN粉体高温热处理机械干态颗粒涂层技术热稳定性

Functionalization of silica nanoparticles for nucleic acid delivery

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Nano Research 2018年第10期11卷 5219-5239页

作者： Rimpei Kamegawa Mitsuru naito Kanjiro Miyata Department of Materials Engineering Graduate School of Engineering The University of Tokyo Tokyo 113-8656 Japan Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo Tokyo 113-0033 Japan

Silica nanoparticles （SiNPs） have been widely engineered for biomedical applications, such as bioimaging and drug delivery, because of their high tunability, which allows them to perform specific functions. In this review, we discuss the functionalization and performance of SiNPs for nucleic acid delivery. Nucleic acids, including plasmid DNA （pDNA） and small interfering RNA （siRNA）, constitute the next generation molecular drugs for the treatment of intractable diseases. However, their low bioavailability requires delivery systems that can circumvent nuclease attack and kidney filtration to ensure efficient access to the target cell cytoplasm or nucleus. First, we discussed the biological significance of nucleic acids and the parameters required for their successful delivery. Next, we reviewed SiNP designing for nucleic acid delivery with respect to nucleic acid loading and release, cellular uptake, endosomal escape, and biocompatibility. In addition, we discussed the co-delivery potential of SiNPs. Finally, we analyzed the current challenges and future directions of SiNPs for advanced nucleic acid delivery.

关键词： silica nanoparticle mesoporous silica silica coating nucleic acid drug delivery

Body composition changes following chemotherapy for testicular germ cell tumor:obesity is the long-term problem

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Asian Journal of Andrology 2022年第5期24卷 458-462页

作者： Yuki Takai Sei naito Hidenori Kanno Atsushi Yamagishi Mayu Yagi Toshihiko Sakurai Hayato Nishida Takuya Yamanobe Tomoyuki Kato Norihiko Tsuchiya Department of Urology Yamagata University Faculty of MedicineYamagata 990-9585Japan

Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor(TGCT).It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic *** this study,changes in the body composition of patients over time were quantitatively analyzed up to 24 months after *** study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December *** and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months,6 months,12 months,and 24 months after *** subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height *** total fat area had already significantly increased 3 months after the initiation of chemotherapy(P=0.004).However,it did not return to prechemotherapeutic levels even at 24 months after *** skeletal muscle area was significantly decreased at the end of chemotherapy(P<0.001);however,the value returned to baseline within 12 *** multivariable analysis,the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy(P=0.001 and P=0.027,respectively).In patients with TGCT,skeletal muscle mass decreased during chemotherapy and recovered within 12 months,whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy.

关键词： body composition chemotherapy obesity sarcopenia secondary hypogonadism testicular cancer

Safety of pancreatic surgery with special reference to antithrombotic therapy:A systematic review of the literature

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World Journal of Clinical Cases 2021年第23期9卷 6747-6758页

作者： Takahisa Fujikawa Shigetoshi naito Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555Japan

BACKGROUND Postpancreatectomy hemorrhage(PPH)is the most severe type of complication after pancreatic surgery,although the effect of antithrombotic therapy(ATT)on PPH is largely *** safety and efficacy of chemical thromboprophylaxis for venous thromboembolism(VTE)remains *** To elucidate the effect of ATT on *** Published articles between 2013 and 2020 were searched from PubMed and Google Scholar,and after careful reviewing of all studies,studies concerning ATT and pancreatic surgery were *** such as study design,type of surgical procedures,type of antithrombotic drugs,and surgical outcome were extracted from the *** Nineteen published articles with a total of 37863 patients who underwent pancreatic surgery were included in the systematic *** were cohort studies,with only three being prospective in *** studies demonstrated that in patients receiving chronic ATT,which were mostly managed by heparin bridging,the risk of PPH was higher compared with those without ATT,and one study showed that patients with direct-acting oral anticoagulants managed by heparin bridging had significantly higher postoperative bleeding rates than *** remaining six studies reported that pancreatic surgery can be safely performed in patients receiving chronic ATT,even under preoperative aspirin *** chemical thromboprophylaxis for VTE,most studies have shown a potentially high risk of PPH in patients undergoing chemical thromboprophylaxis;however,its effectiveness against VTE has not been statistically demonstrated,particularly among Asian *** Pancreatic surgery in chronically ATT-received patients can be safely performed without an increase in the occurrence of PPH,although the safety and efficacy of chemical thromboprophylaxis for VTE during pancreatic surgery is still *** investigation using reliable studies with good design is required to establish definite pr

关键词： Antithrombotic therapy Pancreatic surgery Perioperative management Antiplatelet therapy Anticoagulation therapy Pancreaticoduodenectomy