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A Note on Approximation of Likelihood Ratio Statistic in Exploratory Factor Analysis

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Open Journal of Statistics 2015年第6期5卷 600-603页

作者： masanori Ichikawa Graduate School of Global Studies Tokyo University of Foreign Studies Tokyo Japan

In normal theory exploratory factor analysis, likelihood ratio (LR) statistic plays an important role in evaluating the goodness-of-fit of the model. In this paper, we derive an approximation of the LR statistic. The approximation is then used to show explicitly that the expectation of the LR statistic agrees with the degrees of freedom of the asymptotic chi-square distribution.

关键词： Factor Analysis Likelihood Ratio Statistic Maximum Likelihood Estimation

Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第18期24卷 1989-1994页

作者： Kazuki Takakura Tsunekazu Oikawa Yoichi Tomita Yusuke Mizuno masanori Nakano Chisato Saeki Yuichi Torisu Masayuki Saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

As the incidence of hepatocellular carcinoma(HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis(NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Research into the pathological progression of NASH to HCC has advanced by use of several beneficial rodent models. In this review, we summarize the established mouse models for preclinical research of NASH-associated HCC and discuss the underlying hepatic mechanisms of NASH-related tumorigenesis identified to date that could lead to new targets for treatment and prevention.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease

Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 257-262页

作者： Yoshinori Fujiwara Shuichi Fukuda masanori Tsujie Hajime Ishikawa Kotaro Kitani Keisuke Inoue Masao Yukawa Masatoshi Inoue Department of Digestive Surgery Nara HospitalKindai University School of Medicine Department of Digestive Surgery Kawasaki Medical School

To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score. METHODSWe enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW. RESULTSPostoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

关键词： Gastric cancer Mortality Morbidity Elderly Lymphadenectomy Propensity score matching Prognosis Survival

Sensitivity Numerical Analysis of Human Body Exergy Balance under an Unsteady-State Thermal Environment —Behavioral Adaptation Induced by Undesirable Cold Storage by Building Envelope in Winter

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Health 2016年第8期8卷 737-748页

作者： Koichi Isawa masanori Shukuya Department of Architecture Faculty of Engineering Fukuyama University Fukuyama Japan Department of Restoration Ecology and Built Environment Tokyo City University Yokohama Japan

We analyzed the relationships between the human body exergy balance and behavioral adaptations induced by undesirable cold storage by a building envelope under an unsteady-state thermal environment in winter. The complex interaction of the warm exergy production by shivering, lifting of the shell ratio, and reduction of the blood flow rate was considered to constitute the physiological adaptation necessary for maintaining the constant core temperature, which was an important aspect in living organisms. In the case of intermittent use room, it was suggested that better thermal comfort and desirable behavioral adaptations, which decreased the consumption of fossil fuels, could be achieved if interior wooden cladding was used in constructions with building envelopes that had a comparatively large heat capacity, or in cases of wooden constructions in which the building envelope heat capacity was comparatively small.

关键词： Passive System Exergy Human Body Adaptive Comfort Unsteady State

Acquired hemophilia A in solid cancer: Two case reports and review of the literature

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World Journal of Clinical Cases 2018年第14期6卷 781-785页

作者： Makoto Saito Reiki Ogasawara Koh Izumiyama Akio Mori Takeshi Kondo masanori Tanaka Masanobu Morioka Masahiro Ieko Department of Internal Medicine and Hematology Aiiku Hospital Department of Internal Medicine Health Sciences University of Hokkaido

Acquired hemophilia A （AHA） is a rare, hemorrhagic autoimmune disease, whose pathogenesis involves reduced coagulation factor Ⅷ （FⅧ） activity related to the appearance of inhibitors against FⅧ. Common etiological factors include autoimmune diseases, ma-lignancy, and pregnancy. We report two cases of AHA in solid cancer. The first case is a 63-year-old man who developed peritoneal and intestinal bleeding after gastrectomy for gastric cancer. He was diagnosed with AHA, and was treated with prednisone, followed by cyclophosphamide. In the second case, a 68-year-old man developed a subcutaneous hemorrhage. He was diagnosed with AHA in hepatocellular carcinoma on CT imaging, and treated with rituximab alone. Hemostasis was achieved for both patients without bypassing agents as the amount of inhibitors was reduced and eradicated. However, both patients died within 1 yeardue to cancer progression. Successful treatment for AHA in solid cancer can be diffcult because treatment of the underlying malignancy is also required.

关键词： Acquired hemophilia A Coagulation factor Ⅷ Solid cancer Gastric cancer Hepatocellular carcinoma Case report

Mechanical properties of Fe-rich Si alloy from Hamiltonian

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npj Computational Materials 2017年第1期3卷 391-404页

作者： Tetsuo Mohri Ying Chen masanori Kohyama Shigenobu Ogata Arkapol Saengdeejing Somesh Kumar Bhattacharya Masato Wakeda Shuhei Shinzato Hajime Kimizuka Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Fracture and Reliability Research Institute School of EngineeringTohoku UniversitySendai 980-8579Japan Research Institute of Electrochemical Energy Department of Energy and EnvironmentNational Institute of Advanced Industrial Science and TechnologyIkedaOsaka 563-8577Japan Department of Mechanical Science and Bioengineering Osaka UniversityOsaka 560-8531Japan Center for Elements Strategy Initiative for Structural Materials Kyoto UniversityKyoto 606-8501Japan Computational Structural Materials Design Group Research Center for Structural MaterialsNational Institute for Materials ScienceTsukuba 305-0047Japan

The physical origins of the mechanical properties of Fe-rich Si alloys are investigated by combining electronic structure calculations with statistical mechanics means such as the cluster variation method,molecular dynamics simulation,etc,applied to homogeneous and heterogeneous ***,we examined the elastic properties based on electronic structure calculations in a homogeneous system and attributed the physical origin of the loss of ductility with increasing Si content to the combined effects of magneto-volume and D03 *** a typical example of a heterogeneity forming a microstructure,we focus on grain boundaries,and segregation behavior of Si atoms is studied through high-precision electronic structure *** kinds of segregation sites are identified:looser and tighter *** on the site,different segregation mechanisms are ***,the dislocation behavior in the Fe-Si alloy is investigated mainly by molecular dynamics simulations combined with electronic structure *** solid-solution hardening and softening are interpreted in terms of two kinds of energy barriers for kink nucleation and migration on a screw dislocation ***,the clue to the peculiar work hardening behavior is discussed based on kinetic Monte Carlo simulations by focusing on the preferential selection of slip planes triggered by kink nucleation.

关键词： alloy softening microstructure

Relevance of ADAMTS13 to liver transplantation and surgery

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World Journal of Hepatology 2015年第13期7卷 1772-1781页

作者： Saiho Ko Hisanao Chisuwa masanori Matsumoto Yoshihiro Fujimura Eiji Okano Yoshiyuki Nakajima Department of Surgery Nara Prefecture General Medical Center Departement of Surgery Nara Medical University Department of Surgery Kofu City Hospital Departement of Blood Transfusion Medicine Nara Medical University

A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13(ADAMTS13) specifically cleaves unusually-large von Willebrand factor(VWF) multimers under high shear stress,and down-regulates VWF function to form platelet *** of plasma ADAMTS13 activity induces a life-threatening systemic disease,termed thrombotic microangiopathy(TMA) including thrombotic thrombocytopenic purpura(TTP).Children with advanced biliary cirrhosis due to congenital biliary atresia sometimes showed pathological features of TMA,with a concomitant decrease of plasma ADAMTS13 *** of their clinical findings of TTP after successful liver transplantation suggested that the liver is a major organ producing plasma *** situ hybridization analysis showed that ADAMTS13 was produced by hepatic stellate ***,it was found that ADADTS13 was not merely responsible to development of TMA and TTP,but also related to some kinds of liver dysfunction after liver ***-reperfusion injury and acute rejection in liver transplant recipients were often associated with marked decrease of ADAMTS13 and concomitant formation of unusually large VWF multimers without findings of TMA/*** similar phenomenon was observed also in patients who underwent hepatectomy for liver *** between ADAMTS13 and VWF in the hepatic sinusoid might cause liver damage due to microcirculatory *** can be called as "local TTP like mechanism" which plays a crucial role in liver dysfunction after liver transplantation and surgery.

关键词： A disintegrin-like and metalloproteinase withthrombospondin type-1 motifs 13 Thrombocytopenia Microcirculation Liver dysfunction von Willebrandfactor Liver transplantation Acute rejection Ischemiareperfusioninjury Hepatectomy Liver surgery Localthrombotic thrombocytopenic purpura like mechanism

Triplet−Triplet Annihilation-Based Photon Upconversion with a Macrocyclic Parallel Dimer

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Precision Chemistry 2024年第10期2卷 539-544页

作者： Catherine H.Mulyadi masanori Uji Bhavesh Parmar Kana Orihashi Nobuhiro Yanai Department of Applied Chemistry Graduate School of EngineeringKyushu UniversityNishi-kuFukuoka 819-0395Japan Department of Chemistry Graduate School of ScienceThe University of TokyoBunkyo-kuTokyo 113-0033Japan CREST JSTKawaguchiSaitama 332-0012Japan

The integration of multiple chromophore units into a single molecule is expected to improve the performance of photon upconversion based on triplet−triplet annihilation(TTA-UC)that can convert low energy photons to higher energy photons at low excitation *** this study,a macrocyclic parallel dimer of 9,10-diphenylanthracene(DPA)with a precisely parallel orientation,named MPD-2,is synthesized,and its TTAUC properties are ***-2 shows a green-to-blue TTA-UC emission in the presence of a triplet sensitizer,platinum octaethylporphyrin(PtOEP).Compared to monomeric DPA,MPD-2 results in an enhancement of the spin statistical factor of TTA and a decrease in the excitation light intensity due to the intramolecular TTA *** obtained structure−property relationship provides important information for the further improvement of TTA-UC properties.

关键词： photon upconversion triplet−triplet annihilation macrocyclic parallel dimer spin statistical factor anthracene

Understanding of the activity difference between nanogold and bulk gold by relativistic effects

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Journal of Energy Chemistry 2015年第4期24卷 485-489页

作者： Keju Sun masanori Kohyama Shingo Tanaka Seiji Takeda The Institute of Scientific and Industrial Research Osaka University Research Institute for Ubiquitous Energy Devices National Institute of Advanced Industrial Science and Technology (AIST)

It is a challenge to thoroughly understand the astonishing difference in catalytic activity between nanogold and bulk gold for some oxidation reactions. In this work,the Au–O interactions in various surroundings were investigated by DFT calculations and compared with the Ag–O interactions. We have found the three ***,only Au–O bond can be significantly strengthened by the linear O–Au–O structure. Second,the Au–O bond is always stronger than the Ag–O bond when the bonds are embedded in common surroundings. Third,the Au–O bond becomes weaker than the Ag–O bond when the number of neighboring Au atoms becomes large,because the Au–O interactions are suppressed by the presence of neighboring gold atoms. The origin of these three points can be attributed to wider spatial extension of d orbitals of gold,induced by strong relativistic effects. The strong relativistic effects make nanogold with smaller coordinate numbers highly active due to the ease in forming strong Au–O bonds,especially for the O–Au–O bond,whereas gold atoms in bulk with larger coordination numbers chemically inert due to the strong suppression by neighboring gold atoms destabilizing the O–Au–O bond.

关键词： Nanogold Au–O interactions Relativistic effects DFT calculations