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Three novel NEIL1 promoter polymorphisms in gastric cancer patients

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 117-120页

作者： masanori Goto Kazuya Shinmura Shoichiro Tsugane Haruhiko Sugimura First Department of Pathology Hamamatsu University School of Medicine1-20-1 HandayamaHigashi WardHamamatsuShizuoka 431-3192Japan Epidemiology and Prevention Division Research Center for Cancer Prevention and ScreeningNational Cancer CenterTokyo 104-0045Japan

AIM:To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer ***:The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing ***:Three novel genetic polymorphisms,i.e.c.-3769C>T,c.-3170T>G,and c.-2681TA[8],were identified in the NEIL1 promoter region at an allele frequency of 0.6%,9.4%,and 4.4%,respectively,in Japanese gastric cancer ***:Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

关键词： Gastric cancer NEIL1 Base excision repair Genetic polymorphism

Influence of thin-film device with curvature on natural frequency of rectangle membrane under uniaxial tension

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Astrodynamics 2019年第3期3卷 257-272页

作者： masanori Matsushita Nobukatsu Okuizumi Yasutaka Satou Osamu Mori Takashi Iwasa Saburo Matunaga Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara252-5210Japan Department of Mechanical and Aerospace Engineering Tottori UniversityTottori680-8552Japan Department of Mechanical Engineering School of EngineeringTokyo Institute of TechnologyTokyo152-8552Japan

A solar power sail demonstrator“IKAROS”demonstrated solar sailing technology in *** membrane of the spinning solar sail IKAROS is estimated to be deformed toward the *** deformation was kept even under low *** studies suggest that curvature of thin-film solar cells on the membrane increases the out-of-plane stiffness by finite element ***,out-of-plane stiffness,and natural frequency of membranes have to be predicted for solar sails with thin-film devices,such as thin-film solar cells,dust counters,and reflectivity control devices in order to reduce the margins of sail size and propellant mass against disturbance solar pressure torque acting on the *** this paper,the effect of a curved thin-film device on the natural frequency of a rectangle membrane under uniaxial tension was *** types of membranes were evaluated:a membrane with a curved thin-film device,a membrane with a flat thin-film device,and a plane *** nonlinear finite element analysis and eigenvalue analysis were conducted to investigate the natural frequencies under varying *** simulations were verified by vibration *** was found that under low tension,the natural frequency of the membrane with the curved thin-film device is significantly higher than that of the others and that under high tension,the natural frequency of the membrane with the thin-film device is slightly lower than that of the plane *** addition,parametric analysis on the curvature of the thin-film device shows that natural frequency at low tension is sensitive to the *** eigenvalue analysis of a whole solar sail with the curved thin-film devices also suggests that the curvature remarkably affects the vibration *** conclusion,curved thin-film devices have a significant impact on the out-of-plane stiffness of a membrane under low tension.

关键词： membrane structures thin-film device vibration eigenvalue analysis experiment

Nanotubes in a Gradient Electric Field as Revealed by STM TEM Technique

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Nano Research 2008年第2期1卷 166-175页

作者： Dmitri Golberg Pedro M.F.J.Costa masanori Mitome Yoshio Bando Nanoscale Materials Center Namiki 1-1TsukubaIbaraki 305-0044Japan International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan Center for Research in Ceramics and Composite Materials University of Aveiro3810-193 AveiroPortugal

We have investigated the behavior of two nanotube systems,carbon and boron nitride,under controlled applied voltages in a high-resolution transmission electron microscope(TEM)equipped with a scanning tunneling microscope(STM)*** nanotubes(or thin bundles)were positioned between a piezo-movable gold electrode and a biased(up to±140 V)STM tip inside the pole-piece of the *** structures studied include double-and multi-walled carbon nanotubes(the latter having diverse morphologies due to the various synthetic procedures utilized),few-layered boron nitride nanotube bundles and multi-walled boron nitride nanotubes(with or without functionalized surfaces).The electrical breakdown,physical failure,and electrostatic interactions are documented for each system.

关键词： Carbon nanotubes boron nitride nanotubes transmission electron microscope scanning tunneling microscope

Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment

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World Journal of Gastroenterology 2020年第14期26卷 1628-1637页

作者： masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori Hasegawa Kentaro Kawasaki Takatoshi Nakashima Department of Gastroenterology Takatsuki General HospitalTakatsuki 5691192Japan Department of Pathology Takatsuki General HospitalTakatsuki 5691192Japan Department of Surgery Takatsuki General HospitalTakatsuki 5691192Japan

BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal *** surgical removal of the damaged portion is effective,some patients can recover with conservative *** To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical *** Thirty-four cases of HPVG(patients aged 34-99 years)were *** for surgery had been determined mainly by CT findings(***-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical *** Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)*** each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was ***-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general ***,however,three(25%)of the twelve inoperable patients *** remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)*** analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal *** mortality was 90%if two or all of these three clinical findings were *** HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical *** non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated

关键词： Hepatic portal venous gas Surgical treatment Conservative treatment Computed tomography Intestinal necrosis Prognostic factor

HYDRO:Optimizing interactive hybrid images for digital signage content

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Virtual Reality & Intelligent Hardware 2023年第6期5卷 565-577页

作者： masanori NAKAYAMA Karin UCHINO Ken NAGAO Issei FUJISHIRO Department of Information&Computer Science Keio UniversityTokyoJapan Center for Information&Computer Science Keio UniversityTokyoJapan

Background In modern society,the digital signage installed in many large-scale facilities supports daily ***,owing to their limited screen size,it is difficult to simultaneously provide different types of information to many viewers at varying distances from the ***,in this study,we extend the existing research on the use of hybrid images for tiled *** To facilitate smoother information selection,a new interactive display method is proposed that incorporates touch-activated widgets as high-frequency parts of hybrid *** widgets are novel because they are more visible to viewers near the *** developed an authoring tool called the hybrid image display resolution optimizer(HYDRO),which features two types of control functions to optimize the visibility of touch-activated widgets in terms of placement and *** The effectiveness of the proposed method is demonstrated empirically through a quantitative user study and an eyetracking-based qualitative evaluation.

关键词： Digital signage Hybrid image Authoring tool Information design

The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

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Oncology Research 2023年第5期31卷 631-643页

作者： masanori KAWANO KAZUHIRO TANAKA ICHIRO ITONAGA TATSUYA IWASAKI YUTA KUBOTA HIROSHI TSUMURA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5593Japan

Heat shock protein(HSP)90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins,assisting them in folding into proper ***90 is critical in maintaining the normal functions of various proteins within cells,as essential factors for cellular ***,HSP90 simultaneously supports the maturation of cancer-related proteins,including mesenchymal epithelial transition factor(MET)within tumor *** osteosarcoma cell lines had elevated MET expression in the cDNA array in our ***,a tyrosine kinase receptor,promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by *** this study,we treated osteosarcoma cells with an HSP90 inhibitor,17-demethoxygeldanamycin hydrochloride(17-DMAG),and assessed the changes in the MET signaling pathway and also the antitumor effect of the *** cell cycle in osteosarcoma cells administered 17-DMAG was found to be halted at the G2/M ***,treatment with 17-DMAG inhibited cell proliferation and induced *** of tumor cell proliferation was also observed in an in vivo model system,mice that were treated with *** on the results of this study,we were able to confirm that 17-DMAG promotes inhibition of osteosarcoma cell proliferation and induction of apoptosis by inhibition of MET,a protein highly expressed in osteosarcoma *** approach may be useful for the establishment of a new treatment strategy for patients resistant to the standard treatment for osteosarcoma.

关键词： Osteosarcoma MET HSP90 17-DMAG

Cell-Based Microfluidic Device Utilizing Cell Sheet Technology

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Cyborg and Bionic Systems 2022年第1期2022卷 35-42页

作者： Katsuhisa Sakaguchi Kei Akimoto masanori Takaira Ryu-ichiro Tanaka Tatsuya Shimizu Shinjiro Umezu Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advaneed Science and Enginring TWInsWaseda University2-2 Wakamatsu-ChoShinju-KuTokyo 162-8480Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University 1-104 Totsuka-ChoShinju-KuTokyo 169-8555Japan Insttute of Advanced BiomedicalEngineering and Seience TWIns Tokyo Women's Medical University8-1 Kawada-ChoShinju-KuTokyo 162-8666Japan

The developmentof microelectromechanical systems hasresulted in the rapid development of polydimethylpolysiloxane(PDMS)microfluidic devices for drug screening *** cell functions,such as the response of endothelial cells to fluids,have beenelucdated using microuidic ***,organon-achip systems that includeorgans that are importantfor biologicalcirculation,such as the heart,liver,pancreas,kidneys,and brain,have been *** organs realize the biologicalcirculation system in a manner that cannot be reproduced by artificial organs;however,the flow channels between the organsare often artifically created by *** this study,we developeda microfluidic device consisting only of cels,by combiningcell sheet technology with microtitanium *** were placed between stacked fibroblast cellsheets,and the celisheets adhered to each other,afer which the microwires were removed leaving a luminal structure with a size approximatelyequal to the arteriolar *** lumen structure was constructed using wires with diameters of 50,100,150,and 200μm,which were approximations of the arteriole *** using a perfusion device,we successfully perfused theluminal structure created inside the *** results revealed that a aulture solution can be supplied toa cellsheet witha very high cell *** biofabrication technology proposed in this study can contribute to the development of organ-on-a-chip systems.

关键词： organs fluid diameters

Memory consolidation during sleep and adult hippocampal neurogenesis

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Neural Regeneration Research 2019年第1期14卷 20-23页

作者： Iyo Koyanagi Katherine G.Akers Pablo Vergara Sakthivel Srinivasan Takeshi Sakurai masanori Sakaguchi International Institute for Integrative Sleep Medicine University of Tsukuba Shiffman Medical Library Wayne State University

In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.

关键词： rapid eye movement sleep sleep deprivation optogenetics real-time sleep analysis hippocampus fear memory synaptic plasticity memory processing

The Effect of Material Surface Microstructure on the Enhancement of Bone-Bonding Ability of a Hydroxyapatite-Implant by Low-Intensity Pulsed Ultrasound (LIPUS)

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Materials Sciences and Applications 2021年第1期12卷 42-51页

作者： masanori Kobayashi Department of Physical Therapy College of Life and Health Sciences Chubu University Kasugai Japan

Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned about this concept, which has led to significant improvements in the design and surface modification of implants in the field of implant dentistry, orthopedic surgery. We have already reported that low-intensity pulsed ultrasound (LIPUS) irradiation can accelerate the bone bonding ability of the bio-conductive materials such as bioactive titanium and hydroxyapatite implant. However, it is still unclear whether the LIPUS could have same effect to different types of the bioactive-materials. Therefore, in this study, the differences of bone-like hydroxyapatite formation on some kind of hydroxyapatite surface in simulated body fluid (SBF) under the LIPUS irradiation were investigated. Two kinds of hydroxyapatite samples immersed in SBF was exposed to ultrasound waves, the bone-like apatite on the surface was analyzed by Scanning electron microscopy and X-ray diffraction. As a result, the enhancement of hydroxyapatite formation on the surface by LIPUS was confirmed, the initial epitaxial nucleation and crystal growth of apatite depended on crystal structure of the surface of matrix materials.

关键词： Low-Intensity Pulsed Ultrasound (LIPUS) Simulated Body Fluid (SBF) Hydroxyapatite (HA) Osseointegration Osteo-Conductivity