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The Effect of Material Surface Microstructure on the Enhancement of Bone-Bonding Ability of a Hydroxyapatite-Implant by Low-Intensity Pulsed Ultrasound (LIPUS)

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Materials Sciences and Applications 2021年第1期12卷 42-51页

作者： masanori Kobayashi Department of Physical Therapy College of Life and Health Sciences Chubu University Kasugai Japan

Excellent firm bonding between the biomaterials and bone tissue (osseointegration and osteo-conductivity) has been desired for the stability in vivo of dental implants and artificial joints. Much has been learned about this concept, which has led to significant improvements in the design and surface modification of implants in the field of implant dentistry, orthopedic surgery. We have already reported that low-intensity pulsed ultrasound (LIPUS) irradiation can accelerate the bone bonding ability of the bio-conductive materials such as bioactive titanium and hydroxyapatite implant. However, it is still unclear whether the LIPUS could have same effect to different types of the bioactive-materials. Therefore, in this study, the differences of bone-like hydroxyapatite formation on some kind of hydroxyapatite surface in simulated body fluid (SBF) under the LIPUS irradiation were investigated. Two kinds of hydroxyapatite samples immersed in SBF was exposed to ultrasound waves, the bone-like apatite on the surface was analyzed by Scanning electron microscopy and X-ray diffraction. As a result, the enhancement of hydroxyapatite formation on the surface by LIPUS was confirmed, the initial epitaxial nucleation and crystal growth of apatite depended on crystal structure of the surface of matrix materials.

关键词： Low-Intensity Pulsed Ultrasound (LIPUS) Simulated Body Fluid (SBF) Hydroxyapatite (HA) Osseointegration Osteo-Conductivity

Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy

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World Journal of Gastroenterology 2012年第1期18卷 90-95页

作者： Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Hospital Department of Pathology Osaka University Hospital

An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed.

关键词： Inflammatory pseudotumor Percutaneous liver biopsy Percutaneous spleen biopsy Steroid pulse therapy

Pathological response measured using virtual microscopic slides for gastric cancer patients who underwent neoadjuvant chemotherapy

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World Journal of Gastroenterology 2019年第35期25卷 5334-5343页

作者： Sadayuki Kawai Tadakazu Shimoda Takashi Nakajima masanori Terashima Katsuhiro Omae Nozomu Machida Hirofumi Yasui Division of Gastrointestinal Oncology Shizuoka Cancer Center Sunto-gun 411-8777 Shizuoka Japan Division of Pathology Shizuoka Cancer Center Suntogun 411-8777 Shizuoka Japan Division of Gastric Surgery Shizuoka Cancer Center Nagaizumi 411- 0932 Shizuoka Japan Clinical Research Center Shizuoka Cancer Center Sunto-gun 411-8777 Shizuoka Japan Department of Gastrointestinal Oncology Shizuoka Cancer Center Suntogun 411-8777 Shizuoka Japan

BACKGROUND Although pathological response is a common endpoint used to assess the efficacy of neoadjuvant chemotherapy (NAC) for gastric cancer, the problem of a low rate of concordance from evaluations among pathologists remains unresolved. Moreover, there is no globally accepted consensus regarding the optimal evaluation. A previous study based on a clinical trial suggested that pathological response measured using digitally captured virtual microscopic slides predicted patients’ survival well. However, the pathological concordance rate of this approach and its usefulness in clinical practice were unknown. AIM To investigate the prognostic utility of pathological response measured using digital microscopic slides in clinical practice. METHODS We retrospectively evaluated pathological specimens of gastric cancer patients who underwent NAC followed by surgery and achieved R0 resection between March 2009 and May 2015. Residual tumor area and primary tumor beds were measured in one captured image slide, which contained the largest diameter of the resected specimens. We classified patients with < 10% residual tumor relative to the primary tumorous area as responders, and the rest as non-responders;we then compared overall survival (OS) and relapse-free survival (RFS) between these two groups. Next, we compared the prognostic utility of this method using conventional Japanese criteria. RESULTS Fifty-four patients were evaluated. The concordance rate between two evaluators was 96.2%. Median RFS of 25 responders and 29 non-responders was not reached (NR) vs 18.2 mo [hazard ratio (HR)= 0.35, P = 0.023], and median OS was NR vs 40.7 mo (HR = 0.3, P = 0.016), respectively. This prognostic value was statistically significant even after adjustment for age, eastern cooperative oncology group performance status, macroscopic type, reason for NAC, and T- and Nclassification (HR = 0.23, P = 0.018). This result was also observed even in subgroup analyses for different macroscopic ty

关键词： Stomach neoplasm Neoadjuvant therapy Drug therapy Pathology Prognostic factor

HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer

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World Journal of Clinical Cases 2019年第15期7卷 1964-1977页

作者： Akio Kaito Takeshi Kuwata masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita Department of Gastric Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Gastrointestinal Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research&Clinical Trial Center(EPOC) National Cancer Center Hospital EastKashiwa 277-8577Japan Juntendo University Graduate School of Medicine Tokyo 163-8001Japan Department of Radiation Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan

BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based *** To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based *** Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were *** patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were *** A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based ***,HER2 heterogeneity should be considered during the assessment of HER2 expression.

关键词： Human epidermal growth factor receptor 2 Heterogeneity Trastuzumab Gastric cancer Chemotherapy

Heparin bridge therapy and post-polypectomy bleeding

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World Journal of Gastroenterology 2016年第45期22卷 10009-10014页

作者： Toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura masanori Nojima Hiroshi Nakase Department of Gastroenterology and Hepatology Sapporo Medical University Department of Gastroenterology Otaru City General Hospital Center for Translational Research the Institute of Medical Science the University of Tokyo

AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants.

关键词： Post-polypectomy bleeding Heparin bridge therapy Colonic polypectomy Anticoagulants Antiplatelets Endoscopic surgery

Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib

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World Journal of Gastroenterology 2018年第28期24卷 3155-3162页

作者： masanori Ochi Toshiro Kamoshida Atsushi Ohkawara Haruka Ohkawara Nobushige Kakinoki Shinji Hirai Akinori Yanaka Department of Gastroenterology Hitachi General Hospital Hitachi Medical Education and Research Center University of Tsukuba

AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of *** We conducted a retrospective study involving 40 patients treated with sorafenib. Intervention by pharmacists began at the time of treatment introduction and continued until the appearance of symptomatic exacerbation or non-permissible adverse reactions. We examined the relationship between MKI-associated HFSR and overall survival(OS) after the initiation of *** The median OS was 10.9 mo in the MKI-associated HFSR group and 3.4 mo in the no HFSR group, showing a significant difference in multivariate analysis. A multivariate analysis of the time to treatment failure indicated that the intervention by pharmacists and MKI-associated HFSR were significant factors. The median cumulative dose and the mean medication possession ratio were significantly higher in the intervention group than in the non-intervention group. A borderline significant difference was observed in terms of OS in this *** Intervention by pharmacists increased drug adherence. Under increased adherence, MKI-associated HFSR was an advantageous surrogate marker. Intervention by healthcare providers needs to be performed for adequate sorafenib treatment.

关键词： Hepatocellular carcinoma Surrogate marker Multikinase inhibitor-associated hand-foot skin reaction Sorafenib Intervention by pharmacists

Patellar dislocation following distal femoral replacement after extraarticular knee resection for bone sarcoma:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3561-3572页

作者： Yuta Kubota Kazuhiro Tanaka Masashi Hirakawa Tatsuya Iwasaki masanori Kawano Ichiro Itonaga Hiroshi Tsumura Orthopaedic Surgery Oita UniversityYufu City 879-5593OitaJapan

BACKGROUND For the treatment of bone sarcoma in the distal femur,wide-margin resection and knee reconstruction with tumor endoprosthesis are standard *** knee resection is required in cases of tumor invasion of the knee joint;however,the incidence of complications,such as aseptic loosening,prosthesis infection,and implant failure,is higher than that following intra-articular knee *** the best of our knowledge,there are three reports of patellar dislocations after replacement of a tumor *** SUMMARY A 36-year-old man with no significant past medical history was admitted to our institution with continuous pain in his left knee for 4 *** open biopsy was performed,and the patient was diagnosed with a left distal femoral malignant bone ***-articular knee resection and knee reconstruction with a tumor endoprosthesis were *** the alignment of the tumor prosthesis was acceptable,knee instability was noticed *** axial radiographic view of the patellar and computed tomography showed lateral patellar dislocation at 4 wk *** patient had to undergo a lateral release and proximal *** could perform his daily activities at 9 mo *** revealed no patellar *** Proximal realignment may be considered during primary surgery if there is an imbalance in the forces controlling the patellar tracking.

关键词： Bone tumor Distal femoral replacement Lateral release Patellar dislocation Proximal realignment Case report

Effects of denosumab treatment in chronic liver disease patients with osteoporosis

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World Journal of Gastroenterology 2020年第33期26卷 4960-4971页

作者： Chisato Saeki Mitsuru Saito Tsunekazu Oikawa masanori Nakano Yuichi Torisu Masayuki Saruta Akihito Tsubota Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineTokyo 1058461Japan Department of Orthopaedic Surgery The Jikei University School of MedicineTokyo 1058461Japan Core Research Facilities Research Center for Medical ScienceThe Jikei University School of MedicineTokyo 1058461Japan

BACKGROUND Effective treatment of osteoporosis is essential for improving morbidity and health-related quality of life in chronic liver disease(CLD)*** has been shown to increase bone mineral density(BMD)and decrease the risk of osteoporotic fracture in the general ***,there are few reports evaluating the efficacy of denosumab in CLD *** To investigated the effects and safety of denosumab in CLD patients with *** Sixty CLD patients with osteoporosis were subcutaneously administered denosumab once every 6 *** study period for evaluating efficacy and safety was 12 *** from baseline in BMD at the lumbar spine,femoral neck,and total hip were evaluated at 12 mo of denosumab *** turnover and quality were assessed by measuring serum tartrate-resistant acid phosphatase-5b(bone resorption marker),serum total procollagen type I N-terminal propeptide(bone formation maker),and plasma pentosidine(bone quality marker).RESULTS Among the 405 CLD patients,138(34.1%)patients were diagnosed with osteoporosis;among these,78 patients met the exclusion criteria and thus 60 patients were finally included in the present *** median percentage changes from baseline to 12 mo of denosumab treatment in BMD at the lumbar spine,femoral neck,and total hip were+4.44%,+3.71%,and+4.03%,*** significantly improved BMD,regardless of sex,patient age,and presence of liver *** tartrate-resistant acid phosphatase-5b and procollagen type I N-terminal propeptide levels constantly and significantly declined after denosumab treatment(P<0.001).Plasma pentosidine levels were also significantly lower at 12 mo of treatment(P=0.010).No patients experienced fractures and moderate-to-severe adverse events,except for transient *** Denosumab treatment was safe and increased BMD,suppressed bone turnover,and improved bone quality marker levels in CLD patients with osteoporosis,irrespective

关键词： Chronic liver disease Denosumab Osteoporosis Bone mineral density Bone turnover Bone quality

Thermal physiological response to local heating and cooling during sleep

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Frontiers of Architectural Research 2012年第1期1卷 51-57页

作者： Yu Hibino Shuichi Hokoi Katsuaki Yoshida Satoru Takada masanori Nakajima Miho Yamate KVOtO University Japan Kobe University Japan The Kansai Electric Power Co. Inc. Japan

For a healthy and productive life, good steep is essential, which has prompted studies on how comfortable sleep can be achieved. Understanding the relationship between thermal environment and physiological responses such as skin and core temperatures, and psychological responses such as thermal and sleep sensations is necessary to identify the most suitable thermal environment for steep. As an energy-saving and practical method of creating the most appropriate thermal environment for sleep, local heating or cooling is sometimes used, which takes into consideration the differences in local thermal responses. We performed this study to identify the most effective thermal environment for inducing comfortable sleep by identifying the physiological responses during sleep on the basis of sleep experiments conducted under local body heating or cooling conditions. We also used a human thermal model, which can be applied for predicting physiological responses. In the experiments, the feet of the subject were the primary area to be heated or cooled, which was achieved by installing a flexible duct with an outlet placed close to the subject＇s feet and inlet connected to an air conditioner. Differences in the fluctuation of body temperature and sleep stage depended on the airflow direction from the duct to the feet. When air was blown downward towards the feet, body temperature decreased and the subject was able to sleep well. Measured skin and core temperatures were calculated using an improved 27-node human thermal model that was originally developed for use in subjects who are not in steep. Although skin

关键词： Sleep Thermal environ-ment Local air conditioning Physiologicalresponse Human thermal mode[