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Giant primary angiosarcoma of the small intestine showing severe sepsis

World Journal of Gastroenterology 2014年第43期20卷 16359-16363页

作者： Mizuna Takahashi masanori ohara Noriko Kimura Hiromitsu Domen Takumi Yamabuki Kazuteru Komuro Takahiro Tsuchikawa Satoshi Hirano Nozomu Iwashiro Department of Surgery National Hospital Organization Hakodate HospitalHakodate 041-8512Japan Pathology National Hospital Organization Hakodate HospitalHakodate 041-8512Japan Department of Gastroenterological Surgery II Hokkaido University HospitalHokkaido 060-8648Japan

Primary malignant tumors of the small intestine are rare, comprising less than 2% of all gastrointestinal tumors. An 85-year-old woman was admitted with fever of 40 °C and marked abdominal distension. Her medical history was unremarkable, but blood examination showed elevated inflammatory markers. Abdominal computed tomography showed a giant tumor with central necrosis, extending from the epigastrium to the pelvic cavity. Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected. Because no improvement occurred in response to antibiotics, surgery was performed. Laparotomy revealed giant hemorrhagic tumor adherent to the small intestine and occupying the peritoneal cavity. The giant tumor was a solid tumor weighing 3490 g, measuring 24 cm × 17.5 cm × 18 cm and showing marked necrosis. Histologically, the tumor comprised spindle-shaped cells with anaplastic large nuclei. Immunohistochemical studies showed tumor cells positive for vimentin, CD31, and factor VIII-related antigen, but negative for c-kit and CD34. Angiosarcoma was diagnosed. Although no postoperative complications occurred, the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively. The prognosis of small intestinal angiosarcoma is very poor, even after volume-reducing palliative surgery.

关键词： Angiosarcoma Small intestine Prognosis Sepsis Immunohistological marker

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Cervical Castleman's disease mimicking lymph node metastasis of esophageal carcinoma

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 397-401页

作者： Takumi Yamabuki masanori ohara Mototsugu Kato Noriko Kimura Tomohide Shirosaki Kunishige Okamura Aki Fujiwara Ryo Takahashi Kazuteru Komuro Nozomu Iwashiro Satoshi Hirano Department of Surgery National Hospital Organization Hakodate Hospital Department of Gastroenterology National Hospital Organization Hakodate Hospital Department of Pathology National Hospital Organization Hakodate Hospital Department of Gastroenterological Surgery Ⅱ Hokkaido University Hospital

Castleman's disease(CD) is an uncommon benign lymphoproliferative disorder of unknown etiology. A rare case of cervical CD diagnosed at lymph node dissection for esophageal carcinoma is reported. An esophageal tumor was identified in a 67-year-old man during a follow-up examination after surgery for oral carcinoma. Esophagoscopy revealed a type 1 tumor in the cervical esophagus. Histology of esophagoscopic biopsies indicated squamous cell carcinoma. Contrastenhanced computed tomography revealed swollen lymph nodes of the right cervical region. No distant metastasis was detected. Esophageal carcinoma, T2N2M0, Stage ⅢA was diagnosed. Neoadjuvant chemotherapy was recommended, but the patient rejected the chemotherapy. The patient underwent laparoscopic-assisted transhiatal esophagectomy. The histopathological diagnosis was moderately differentiated squamous cell carcinoma with pT1bN0M0, Stage ⅠA. On histology, the swollen lymph nodes of the right cervical region revealed CD. The patient's postoperative course was relatively good.

关键词： Castleman’s disease Lymph node metastasis Esophageal carcinoma

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Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction

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World Journal of Gastroenterology 2012年第21期18卷 2735-2738页

作者： Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai masanori ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi Division of Gastroenterology National Hospital Organization Tokyo Medical CenterTokyo 1528902 Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of MedicineTokyo 1608582 Japan Division of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555 Japan Division of Gastroenterology National Kyushu Medical CenterFukuoka 8108563 Japan Division of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 7208520 Japan Division of Gastroenterology National Hospital Organization Kure Medical CenterKure 7370023 Japan Division of Gastroenterology National Hospital Organization Hakodate Medical CenterHakodate 0418512 Japan Division of Gastroenterology National Hospital Organization Maizuru Medical CenterMaizuru 6258502 Japan Division of Gastroenterology National Hospital Organization Higashihiroshima Medical CenterHigashihiroshima 7390041 Japan Division of Gastroenterology National Hospital Organization Sendai Medical CenterSendai 9838520 Japan Division of Gastroenterology National Hospital Organization Osaka Medical CenterOsaka 5400006 Japan Division of Gastroenterology National Hospital Organization Ureshino Medical CenterUreshino 8430393 Japan Division of Gastroenterology National Hospital Organization Osaka Minami Medical CenterKawachinagano 5868521 Japan Division of Gastroenterology National Hospital Organization Fukuoka Higashi Medical CenterKoga 8113195 Japan Division of Gastroenterology National Hospital Organization Yonago Medical CenterYonago 6838518 Japan Division of Gastroenterology National Hospital Organization Disaster Medical CenterTachikawa 1900014 Japan Pharmaceutical Department National Center for Global Health and MedicineTokyo 1658655 Japan

We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.

关键词： Helicobacter pylori Amoxicillin Dual therapy Eradication Urea breath test

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A Null-Steering Adaptive Antenna Array for Mobile Stations——Performance Evaluation for Burst Pilot Transmission System

A Null-Steering Adaptive Antenna Array for Mobile Stations—...

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IEEE第14届国际个人无线移动通信大会

作者： masanori Kato Kugo Morita Kazumi Saburi Shigeru Kimura Tohru Sunaga Yokohama R＆D Center Kyocera Corporation 2-1-1 Kagahara Tsuzuki-ku Yokohama-shi Kanagawa 224-8502 Japan Yokohama R＆D Center Kyocera Corporation 2-1-1 Kagahara Tsuzuki-ku Yokohama-shi Kanagawa 224-8502 Japan Yokohama R＆D Center Kyocera Corporation 2-1-1 Kagahara Tsuzuki-ku Yokohama-shi Kanagawa 224-8502 Japan Yokohama R＆D Center Kyocera Corporation 2-1-1 Kagahara Tsuzuki-ku Yokohama-shi Kanagawa 224-8502 Japan KDDI R＆D Laboratories Inc. 2-1-15 ohara Kamifukuoka-shi Saitama 356-8502 Japan

A local virtual signal tuned (VST) null-steering adaptive antenna array applied to mobile stations is proposed in this paper. The VST adaptive array detects the spatial signature of the incident si

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