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Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 257-262页

作者： Yoshinori Fujiwara Shuichi Fukuda masanori Tsujie Hajime ishikawa Kotaro Kitani Keisuke Inoue Masao Yukawa Masatoshi Inoue Department of Digestive Surgery Nara HospitalKindai University School of Medicine Department of Digestive Surgery Kawasaki Medical School

To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting (IPTW) method using propensity score. METHODSWe enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old (Group A), and 333 patients were aged < 79 years old (Group B). We compared the surgical outcomes and survival of the two groups after IPTW. RESULTSPostoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B (P < 0.05). Overall survival (OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage I disease, OS was significantly lower in Group A (P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection were independent prognostic values for OS. CONCLUSIONWhen the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients.

关键词： Gastric cancer Mortality Morbidity Elderly Lymphadenectomy Propensity score matching Prognosis Survival

Retrocaval liver lifting maneuver and modifications of total hepatic vascular exclusion for liver tumor resection

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World Journal of Hepatology 2016年第8期8卷 411-420页

作者： Saiho Ko Yuuki Kirihatayfa Yayoi Matsumoto Tadataka Takagi masanori Matsusaka Tomohide Mukogawa Hirofumi ishikawa Akihiko Watanabe Department of Surgery Nara Prefecture General Medical Center

AIM: To evaluate the efficacy of technical modifications of total hepatic vascular exclusion(THVE) for hepatectomy involving inferior vena cava(IVC).METHODS: Of 301 patients who underwent hepatectomy during the immediate previous 5-year period, 8(2.7%) required THVE or modified methods of IVC cross-clamping for resection of liver tumors with massive involvement of the IVC. Seven of the patients had diagnosis of colorectal liver metastases and 1 had diagnosis of hepatocellular carcinoma. All tumors involved the IVC, and THVE was unavoidable for combined resection of the IVC in all 8 of the patients. Technical modifications of THVE were applied to minimize the extent and duration of vascular occlusion, thereby reducing the risk of ***: Broad dissection of the space behind the IVC coupled with lifting up of the liver from the retrocaval space was effective for controlling bleeding around the IVC before and during THVE. The procedures facilitate modification of the positioning of the cranial IVC cross-clamp. Switching the cranial IVC cross-clamp from supra- to retrohepatic IVC or to the confluence of hepatic vein decreased duration of the THVE while restoring hepatic blood flow or systemic circulation via the IVC. Oblique cranial IVC cross-clamping avoided ischemia of the remnant hemi-liver. With these technicalmodifications, the mean duration of THVE was 13.4 ± 8.4 min, which was extremely shorter than that previously reported in the literature. Recovery of liver function was smooth and uneventful for all 8 patients. There was no case of mortality, re-operation, or severe complication(i.e., Clavien-Dindo grade of Ⅲ or more).CONCLUSION: The retrocaval liver lifting maneuver and modifications of cranial cross-clamping were useful for minimizing duration of THVE.

关键词： Total hepatic vascular exclusion Retrocaval liver lifting maneuver Oblique clamping Switching the clamp Hepatectomy

Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

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World Journal of Hepatology 2017年第1期9卷 57-63页

作者： Yuichi Torisu masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa ishikawa Masayuki Saruta Mikio Zeniya Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Internal Medicine Fuji City General Hospital Department of Internal Medicine Sanno Medical Center

AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA *** In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in pat

关键词： Autoimmune hepatitis Japanese patients Adverse events Corticosteroids Ursodeoxycholic acid

A prolonged granitoid formation in Saglek Block,Labrador:Zonal growth and crustal reworking of continental crust in the Eoarchean

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Geoscience Frontiers 2017年第2期8卷 355-385页

作者： Tsuyoshi Komiya Shinji Yamamoto Shogo Aoki Keiko Koshida masanori Shimojo Yusuke Sawaki Kazumasa Aoki Shuhei Sakata Takaomi D.Yokoyama Kenshi Maki Akira ishikawa Takafumi Hirata Kenneth D.Collerson Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoTokyo 153-8902Japan Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguroTokyo 152-8551Japan Laboratory for Planetary Sciences Kyoto UniversityKitashirakawa OiwakechoKyoto 606-8502Japan School of Earth Sciences The University of QueenslandBrisbaneQueenslandAustralia KDC Consulting 33 Cramond StWitstonQld 4051Australia

The Archean continental crusts account for ca.20% of the present volume,but the thermal history of the Earths＇ mantle suggests much more continental crusts were formed in the early *** the Archean continental crust underwent severe metamorphism,it is important to avoid influence by the later thermal *** carried out a comprehensive geochronological work of Cathodoluminescence（CL） observation and U-Pb dating of zircons from orthogneisses and supracrustal rocks over the Saglek Block to obtain their protolith *** zircons were classified into three domains of core,mantle and rims,and the cores were further classified into three groups of inherited,altered and zoned cores based on the zonation on the CL *** estimated the protolith ages from Pb-Pb ages of the zoned-cores of zircons with low U *** made a detailed sketch of a small outcrop in ***＇s Harbour South（SJHS） area,and classified the orthogneisses and mafic enclaves into seven generations based on the geologic *** first and second generations comprise mafic rocks and lack magmatic *** conducted CL imaging and U-Pb dating of zircons from the third,sixth and seventh generation of the orthogneisses to estimate the protolith ages at 3902 L 25,3892 ± 33 and 3897 ± 33 Ma for each,supporting the presence of the over 3.9 Ca Iqaluk *** geological occurrence that the mafic rocks occur as enclaves within the 3.9 Ga Iqaluk Gneiss indicates that they are the oldest supracrustal rocks in the *** geochronological and geological studies show the Uivak Gneiss is quite varied in lithology and age from 3.6 to 〉3.9 Ga,and tentatively classified into six groups based on their *** oldest Uivak Gneiss components including the Iqaluk Gneiss are present around the SJHS area,and the orthogneisses become young as it is *** lines of evidence of overprinting of younger granitoid on older granitoid in small outcrops and geological-map scale as well as presence of in

关键词： Eoarchean Geochronology Uivak Gneiss Iqaluk Gneiss Continental recycling The oldest rocks

Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature

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World Journal of Gastroenterology 2020年第42期26卷 6689-6697页

作者： Masahiro Hirakawa Kohichi Takada masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa Akihiro Sakurai Junji Kato Department of Medical Oncology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Gastroenterology National Hospital Organization Hokkaido Cancer CenterSapporo 003-0804HokkaidoJapan Department of Surgery Surgical Oncology and ScienceSapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Surgical Pathology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Medical Genetics Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan Department of Hematology Sapporo Medical University School of MedicineSapporo 060-8556HokkaidoJapan

BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 ***,the frequency of CDH1 mutations is low in patients with HDGC in East Asian ***,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese *** SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric *** genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric *** analysis revealed a CDH1 c.1679C>G variant in all three *** It is important for individuals suspected of having HDGC to be actively offered genetics *** report will contribute to an increased awareness of HDGC.

关键词： Hereditary diffuse gastric cancer Signet ring cell carcinoma CDH1 Ecadherin Endoscopic findings Case report

Determination of Telomere Length by the Quantitative Fluorescence <i>in Situ</i>Hybridization (Q-FISH) Method

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American Journal of Analytical Chemistry 2014年第12期5卷 775-783页

作者： Junko Aida Naotaka Izumiyama-Shimomura Ken-ichi Nakamura Naoshi ishikawa masanori Terai Yoko Matsuda Shinsuke Aida Tomio Arai Kaiyo Takubo Department of Pathology International University of Health and Welfare Mita Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Team for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan

Telomeres are nucleoprotein complexes located at the ends of eukaryotic chromosomes and are shorten with aging or various causes. Shortened telomere plays an important role for chromosomal instability in carcinogenesis, or a number of diseases in relation to aging. FISH using peptide-nucleic acid (PNA) probe is suitable for analyzing telomeres, because telomere is a part of DNA molecule and localized in chromosomal end in loop shape structure (T-loop). We introduce our telomere analysis for tissue sections and cultured cells in this paper. On the tissue sections, we analyze telomere length with telomere intensity to centromere intensity ratio (TCR), centromere as an inner control. In the cultured cells, we analyze telomere lengths on each chromosome with karyotyping. Those Q-FISH methods by PNA probe are an accurate and reliable tool for research on telomere lengths in various conditions in biology.

关键词： Telomere Telomere Length Q-FISH Tissue Section Chromosome

Breast Conserving Surgery and Sentinel Lymph Node Biopsy under Local Anesthesia for Breast Cancer

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Journal of Cancer Therapy 2012年第5期3卷 810-813页

作者： Shinichiro Kashiwagi Naoyoshi Onoda Tsutomu Takashima Yuka Asano Naoki Aomatsu masanori Nakamura Hidemi Kawajiri Tetsuro ishikawa Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine Osaka Japan

Background: Breast conserving surgery and sentinel lymph node biopsy has become the standard operation for early breast cancer. This operation has been performed under local anesthesia for patients that would like short-term admission or for those not indicated for general anesthesia due to complications. This report presents the outcomes of breast conserving surgery and sentinel lymph node biopsy under local anesthesia. Patients and Methods: The study included 61 patients with breast cancer that were all definitely diagnosed before surgery. The indications were preoperatively diagnosed localized DCIS, invasive carcinoma measuring less than 3 cm in tumor diameter on ultrasound, and tumors with negative axillary lymph nodes. The surgical procedures included breast conserving surgery associated with sentinel lymph node navigation biopsy. Results: The surgery could be performed under local anesthesia in all 61 patients, and no patient was converted to general anesthesia. Four patients had sentinel lymph node metastasis. Surgical stumps were positive in 18 patients (29.5%). Ten Gy of boost irradiation of the tumor bed was added to the conventional breast irradiation for these patients. There were no serious complications associated with surgery. Conclusion: Breast conserving surgery and sentinel lymph node biopsy for early breast cancer can be performed safely under local anesthesia. This procedure contributes to shortening the length of hospitalization and thereby saving medical resources without deceasing the quality of treatment.

关键词： Breast Cancer Local Anesthesia Breast Conserving Surgery

The Quantitative Density Measurement of Unsteady Flow around the Projectile

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Journal of Flow Control, Measurement & Visualization 2019年第2期7卷 111-119页

作者： Yusuke Hirose Kazuki ishikawa Yoshiyuki Ishimoto Takumi Nagashima masanori Ota Shinsuke Udagawa Tatsuro Inage Kazuki Fujita Hideki Kiritani Koji Fujita Kiyonobu Ohtani Hiroki Nagai Graduate School of Engineering Chiba University Chiba Japan Aerospace Engineering Course Tokyo Metropolitan College of Industrial Technology Tokyo Japan Department of Mechanical Engineering Shonan Institute of Technology Fujisawa Kanagawa Japan Institute of Fluid Science Tohoku University Sendai Miyagi Japan

Three-dimensional density measurement of unsteady flow field around a sphere is carried out in the ballistic range at Institute of Fluid Science, Tohoku University. Simultaneous multi-angle measurement system using twelve digital cameras is installed in the test chamber of the ballistic range to achieve the three-dimensional density measurement. The Colored-Grid Background Oriented Schlieren (CGBOS) technique using colored-grid background is utilized for the reconstruction of density. The Mach number of the sphere is set to 1.5. The short pulse LEDs to illuminate the backgrounds are also installed in the chamber to capture the unsteady flow field around a flying sphere. Three-dimensional density distribution around a sphere is successfully reconstructed.

关键词： Background Oriented Schlieren Flow Visualization High Speed Flows Unsteady Flow Simultaneous Measurement

Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

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Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri Noritomo Shimada Hiroshi Shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro Nouso Akemi Tsutsui Takuya Nagano Norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro Nakamura Kojiro Michitaka Yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib