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Changes in Alanine Aminotransferase/Aspartate Aminotransferase Ratio Are Associated with Changes in Insulin Resistance in Japanese Community-Dwelling Middle-Aged and Elderly Women

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Open Journal of Endocrine and Metabolic Diseases 2016年第6期6卷 159-166页

作者： Ryuichi Kawamoto Daisuke Ninomiya Yoshihisa Kasai Tomo Kusunoki Nobuyuki Ohtsuka Teru Kumagi masanori abe Department of Community Medicine Ehime University Graduate School of Medicine Ehime Japan Department of Internal Medicine Seiyo Municipal Nomura Hospital Ehime Japan

Liver marker {e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST)} levels independently predict insulin resistance. The aim of the present study is to examine how changes in liver markers are associated with changes in insulin resistance after exercise in Japanese community-dwelling adults. The participants were 76 women aged 67 ± 6 years from a rural village. Nordic walk (NW) exercise of 120 min per week was performed for 12 weeks. Before and at the end of the 12-week intervention, various confounding factors and insulin resistance {e.g., Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)} were measured. The baseline, follow-up, and changes in ALT/AST ratio (β = 0.390, P β = 0.393, P β = 0.321, P = 0.004, respectively) were each significantly and independently associated with HOMA-IR. When the data were further stratified by baseline and change in ASL/AST ratio, changes in HOMA-IR decreased more significantly in participants with baseline ASL/AST ratio ≥ 0.762 and change in ALT/AST ratio of < 0 than those with change in ALT/AST ratio of ≥ 0 (baseline ASL/AST ratio P = 0.002 and ASL/AST ratio ≥ 0.762, P = 0.047). This study is of interest because liver transaminase markers, which are inexpensive and routinely collected in clinical settings, may provide a simple and accurate enhancement to models currently used to identify subjects with changes in insulin resistance. These results suggest that a higher baseline and decreased change in ALT/AST ratio may be a predictor for decreased insulin resistance after a 12-week walking exercise in community-dwelling middle-aged and elderly women.

关键词： ALT/AST Ratio Insulin Resistance HOMA-IR Change Walking Exercise Women

Myeloid-derived suppressor cells induce T cell exhaustion resulting in suppression of antigen-specific immune responses in mice consuming high fat diet

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Myeloid-derived suppressor cells induce T cell exhaustion re...

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

中华医学会第十二次全国内分泌学学术会议

作者： Shiyi Chen Sheikh Mohammad Fazle Akbar masanori abe Yoichi Hiasa Morikazu Onji Department of Endocrinology The Second Affiliated Hospital of Shantou University Medical College Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Department of Medical Sciences Toshiba General Hospital

Background/Aims Obesity and its complications have reached worldwide epidemic *** is a chronic inflammatory condition and associated with increased production of cytokines and exacerbated immune ***,obese

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN masanori KAWANO TATSUYA IWASAKI ICHRO ITONAGA YUTA KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Triplet−Triplet Annihilation-Based Photon Upconversion with a Macrocyclic Parallel Dimer

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Precision Chemistry 2024年第10期2卷 539-544页

作者： Catherine H.Mulyadi masanori Uji Bhavesh Parmar Kana Orihashi Nobuhiro Yanai Department of Applied Chemistry Graduate School of EngineeringKyushu UniversityNishi-kuFukuoka 819-0395Japan Department of Chemistry Graduate School of ScienceThe University of TokyoBunkyo-kuTokyo 113-0033Japan CREST JSTKawaguchiSaitama 332-0012Japan

The integration of multiple chromophore units into a single molecule is expected to improve the performance of photon upconversion based on triplet−triplet annihilation(TTA-UC)that can convert low energy photons to higher energy photons at low excitation *** this study,a macrocyclic parallel dimer of 9,10-diphenylanthracene(DPA)with a precisely parallel orientation,named MPD-2,is synthesized,and its TTAUC properties are ***-2 shows a green-to-blue TTA-UC emission in the presence of a triplet sensitizer,platinum octaethylporphyrin(PtOEP).Compared to monomeric DPA,MPD-2 results in an enhancement of the spin statistical factor of TTA and a decrease in the excitation light intensity due to the intramolecular TTA *** obtained structure−property relationship provides important information for the further improvement of TTA-UC properties.

关键词： photon upconversion triplet−triplet annihilation macrocyclic parallel dimer spin statistical factor anthracene

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN masanori KAWANO TATSUYA IWASAKI ICHIRO ITONAGA YUTA KUBOTA HIROSHI TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Hand Cooling Enhances the Proprioceptive Drift during Rubber Hand Illusion

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Journal of Behavioral and Brain Science 2024年第7期14卷 210-226页

作者： masanori Sakamoto Yuta Akaike Kazuya Tatsumi Hirotoshi Ifuku Division of Health and Physical Education Graduate School of Education Kumamoto University Kumamoto City Japan Lifelong Sports and Welfare Course Faculty of Education Kumamoto University Kumamoto City Japan

Background: The neural representation of the body is easily altered by integrating multiple sensory signals in the brain. The “Rubber Hand Illusion” (RHI) is one of the most popular experimental paradigms to investigate this phenomenon. During this illusion, ownership of a rubber hand is temporarily induced. It was shown that external and continuous cooling of the palm enhanced the RHI, suggesting an association between altered the autonomic nervous system regulation and altered the sense of ownership of a specific limb. Purpose: To investigate whether artificially cooling the entire hand for a short period affects the magnitude of the illusion. Methods: Participants immersed their entire hand in cool, cold, or warm water for 1 min before the RHI procedure. Results: We found that cooling the entire hand enhanced the proprioceptive drift during the RHI but not the subjective feeling of ownership. In contrast, warming and intense cooling of the entire hand did not affect the RHI strength. Conclusion: Our results suggest that transient and moderate cooling of the entire hand was sufficient in enhancing the illusory disembodiment of one’s own hand.

关键词： Hand Temperature Cooling Rubber Hand Illusion Ownership Proprioceptive Drift

Penetration analysis of elements and bioleaching treatment of spent refractory for recycling

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Journal of Environmental Sciences 2007年第9期19卷 1146-1152页

作者： TATEDA Masafumi FUJITA masanori College of Technology Toyama Prefecture University5180 KurokawaImizuToyama 939-0398 Japan Kochi National College of Technology 200-1 Monobe-OtsuNamgokuKochi 783-8508 Japan

Acidithiobacillusferrooxidans ATCC23270 and Acidithiobacillus thiooxidans TM-32 were used for bioleaching of spent refractories of aluminium and copper melting furnaces for their recycling. Firstly, penetration of elements into ahiminium melting furnace refractory was investigated and it was found that up to 7 cm from surface was contaminated. Comparison on leaching efficiency by the strains ATCC23270 and TM-32 found that the strain ATCC23270 could treat larger amount of the refractories than the strain TM-32 could do. In the experiment of bioleaching of spent refractory alumiulum melting furnace by the strain ATCC23270, high leaching efficiency were obtained on A1, Si, and Ca, and extremely low leaching performance was, however, shown on the rest of elements i.e., Na, Mn, and Zn. Under the strain TM-32 use, relatively high leaching performance was recognized on A1, Si, Ca, Na, Mn, and Zn. In the experiment of bioleaching for spent refractory copper melting furnace, almost the same leaching trends were shown on Cu, Zn, A1, and Si under the strains ACTT23270 and TM-32 uses.

关键词： spent refractory penetration of elements bioleaching recycling

Nano-structural Modification of Amorphous Carbon Thin Films by Low-energy Electron Beam Irradiation

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材料热处理学报 2004年第5B期25卷 1247-1252页

作者： Eiji Iwamura masanori Yamaguchi PRESTO Japan Science and Technology Agency Tokyo JapanLamp Company Ushio INC. Himeji Japan

A new approach using a low-energy electron beam radiation system was investigated to synthesize carbon hybrid structures in amorphous carbon thin films. Two types of amorphous carbon films, which were 15at% iron containing film and with column/inter-column structures, were deposited onto Si substrates by a sputtering technique and subsequently exposed to an electron shower of which the energy and dose rate were much smaller compared to an intense electron beam used in a transmission electron microscopy. As a result of the low-energy and low-dose electron irradiation process, graphitic structures formed in amorphous matrix at a relatively low temperature up to 450 K. Hybrid carbon thin films containing onion-like structures in an amorphous carbon matrix were synthesized by dynamic structural modification of iron containing amorphous carbon thin films. It was found that the graphitization progressed more in the electron irradiation than in annealing at 773 K, and it was attributed to thermal and catalytic effects which are strongly related to grain growth of metal clusters. On the other hand, a reversal of TEM image contrast was observed in a-C films with column/inter-column structures. It is presumed that preferable graphitization occurred in the inter-column regions induced by electron irradiation.

关键词：无定形碳溅射石墨化低能电子注辐射毫微结构

基于图像处理技术的轨道车辆底部视觉检测系统

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智慧轨道交通 2024年第2期61卷 98-100页

作者： Akihide Uno Takehito Fujii Hiroyuki Nakajima [日]masanori Endo 林凯(译) 王慧(译) 宋微(译) 吕俊超(译) 不详

利用图像处理技术,本文开发了一种用于机车车辆故障检测的系统。该系统能够自动检测诸如底部设备紧固螺栓松动或设备箱盖手柄转动等故障,如有必要,检验人员可以根据该系统显示的图像对机车车辆进行具体检查。目前系统已经具备了车辆底... 详细信息

利用图像处理技术,本文开发了一种用于机车车辆故障检测的系统。该系统能够自动检测诸如底部设备紧固螺栓松动或设备箱盖手柄转动等故障,如有必要,检验人员可以根据该系统显示的图像对机车车辆进行具体检查。目前系统已经具备了车辆底部设备侧面检测功能,我们正致力于将该系统应用于车辆底部设备中间区域及车顶设备的检测。本文对该系统及其用户界面进行了概述。

关键词：机车车辆底部设备检查图像处理线路摄像头