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Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity

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World Journal of Gastroenterology 2006年第7期12卷 1071-1077页

作者： Osamu Kanauchi masanobu fukuda Yoshiaki Matsumoto Shino Ishii Toyokazu Ozawa Makiko Shimizu Keiichi Mitsuyama Akira Andoh Kirin Brewery Co.Ltd. 10-1-2 Shinkawa Chuo-kuTokyo104-8288Japan College of Pharmacy Nihon University 7-7-1 Narashinodai FunabashiChiba 274-8555Japan Department of Clinical Pharmacology and Toxicology Showa Pharmaceutical University3-3165Higashi-TamagawagakuenMachidaTokyo194-8543Japan Kurume University School of Medicine 67 Asahi-machiKurumeFukuoka 830-0011Japan Shiga University of Medical Science TsukinowaSetaOtsuShiga520-2100Japan

瞄准：为了检验真细菌类高级轿车的效果，加(E。高级轿车和) 在结肠的上皮的房间线在试管内上，并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法：E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory... 详细信息

瞄准：为了检验真细菌类高级轿车的效果，加(E。高级轿车和) 在结肠的上皮的房间线在试管内上，并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法：E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory 效果。T84 房间上的高级轿车和代谢物被 IL-6 生产被 SUDH 活动，和反煽动性的效果评估。在象受体 4 一样的使用费(TLR4 ) 的 mRNA 的变化被实时 PCR 评估。大肠炎被用 2.0% 葡聚糖硫酸钠喂 BALB/C 老鼠导致。这些老鼠收到了任何一个 5% lyophilized E。高级轿车和(n = 7 ) 或控制节食(n = 7 ) 。在大肠炎正式就职，临床、组织学的分数，冒号长度，和盲肠的有机酸层次以后的七天是坚定的。结果：E。高级轿车和在 0.25， 1.0， 0.025 和 0.07 mmol/L 生产了丁酸盐，醋酸盐，丙酸盐，和 lactate，分别地在里面中等。在这集中，每酸没有生长在 T84 细胞上刺激活动；然而，当这些酸在上述层次一起被混合时，它比控制显示出显著地高的活动。除了 lactate，这些酸显著地在就 0.1 mmol/L 稀释了 IL-6 生产。在 TNF-alpha 刺激下面，另外，丁酸盐稀释了 TLR4 mRNA 的生产。有 E 的处理。高级轿车和显著地随盲肠的丁酸盐层次的增加稀释了大肠炎的临床、组织学的分数，与控制组相比。结论：E。高级轿车和能改善试验性的结肠的发炎。部分地， E 的代谢物。高级轿车和，丁酸盐，增加粘膜正直和表演经由 TLR4 的粘膜防卫系统的反煽动性的行动调整。

关键词：真菌实验研究肠炎微生物结肠炎

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Law Education in Japan and China:Comparative Analysis Focusing on Law-Related Materials

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ECNU Review of Education 2023年第2期6卷 261-279页

作者： masanobu Umeno Yoshihiko fukuda Naho Inoue Gakushuin University Hyogo University of Teacher Education Naruto University of Education

Purpose:This study examines law-related education in Japan and China to reveal the current state of research and identify the roles,possibilities,and challenges facing such teaching at the elementary,junior high,and senior high school *** study conducts a comparative review of research on perspectives toward law education in both countries,as well as the characteristics of and issues facing law education in ***/Approach/Methods:This study examines trends in research and educational reform related to law education in *** doing so,it evaluates how the characteristics of and issues facing law education in Japan are related to law education in ***:Results show no evidence of a systematic study of law in *** subjects to engage in collaborative learning is a more realistic strategy than attempting to design wholly new ***,exploring what kind of learning activities are linked to law-abiding education in China offers insights and references for *** these strategies to the Japanese context and law material can help create a more systematic form of ***/Value:Through joint research by researchers and educators from East Asian countries,we intend to conduct further research on the development of curricula,textbooks,and class models suited to specific *** the joint research learning approach discussed in this study in Japan and China may result in further learning possibilities.

关键词： Curriculum East Asia law-related education normative awareness social studies

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Late-onset non-islet cell tumor hypoglycemia: A case report

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World Journal of Clinical Cases 2021年第1期9卷 163-169页

作者： Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi Takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko Horiguchi Emi Ishida Masashi Yoshikawa Jun Nagaoka Sho Sekiguchi Mai Sue Shuichi Okada Izumi fukuda Ken Shirabe masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Division of General Thoracic Surgery Integrative Center of General SurgeryGunma University HospitalMaebashi 371-8511GunmaJapan Department of Endocrinology Diabetes and MetabolismGraduate School of Medicine Nippon Medical SchoolTokyo 1138602Japan

BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well *** report a case of NICTH that was observed 30 years before the onset of *** SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared *** years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete *** tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely *** NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period.

关键词： Hypoglycemia Non-islet cell tumor hypoglycemia Blood glucose Solitary tumor Late onset Case report Insulin-like growth factor II

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