检索结果-南通市图书馆

The FISITA 2012 World Automotive Congress--Volume 1：Advanced Internal Combustion Engines

作者： Keita Ishizaki Shinichi tanaka Atsushi Kishimoto masamichi tanaka Naoki Ohya Nobuhiro Hidaka Automobile R&D Center.Honda R&D Co. LtdTochigiJapan New Technology Research Laboratory.Sumitomo Osaka Cement Co. LtdChibaJapan

The pore structure of DPF is known to have a significant effect on filtration efficiency,pressure drop,and soot *** is reported that the formation of a nanoparticle porous layer on the surface of the DPF inlet wall promotes soot oxidation[1-3].However,the correlation between pore size in the nanoparticle layer and soot oxidation performance,the effect of the layer in actual use environments,and the oxidation mechanism involved have not yet been *** research discussed in this paper therefore formed SiC nanoparticle porous layers of various pore sizes on the inlet wall surfaces of SiC-DPF(creating what will be termed"NPLDPF"here)using the dip-coating method|4|.The NPL thickness was set at 20μm to help enable uniform coating samples to be *** regard to filter pressure drop without soot loading,results for a bare DPF and a Pt/γ-AlO-eoated DPF(catalyzed DPF:Pt=1 g/L)were virtually *** the NPL-DPF,pressure drop increased as pore size was *** contrast,in the case of pressure drop following soot loading(3 g/L).despite the fact that results for pressure drop for the NPL-DPF were higher than those for the bare DPF,they were lower than those for the catalyzed *** is possible to stop deep-bed filtration by forming a nanoparticle porous layer on the surface of the DPF inlet wall[1.5].With regard to soot oxidation performance,the T80 of an NPL-DPF(NPL pore size=350 nm)was found to be40%lower than that of a bare DPF and identical to that of a catalyzed *** addition,reducing the NPL pore size enhanced soot oxidation performance.X-ray photoelectron spectra(XPS),transmission electron microscopy(TEM),andhydrogen temperature-programmed desorption(H2-TPD)results indicated that the vSiC nanoparticle surface was covered by a 5 am SiO oxide *** was found that these oxidized SiC nanoparticles desorbed oxygen at around 450℃.This desorbed oxygen promoted the oxidation of diesel *** addition,the filtration efficiency of the NPL-DPF wi

关键词： Diesel vehicle Partieulate-emissions Paniculate filters Sootoxidation Desorhed oxygen

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer

引用

World Journal of Gastroenterology 2017年第14期23卷 2519-2526页

作者： Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri tanaka Chie tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine Division of Biostatistics Clinical Research Center Aichi Medical University Hospital

AIMTo identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative ***-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal gastrectomy or total gastrectomy) were included in the analysis. Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications (grade II or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease ***-six patients (21.1%) experienced grade II or higher postoperative complications. The platelet-lymphocyte ratio (PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value (0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71 (sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94 (95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications (OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative *** preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer.

关键词： Gastric cancer Gastrectomy Platelet-lymphocyte ratio Postoperative complication Prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Decoding value-related signal represented in multiple areas of the prefrontal cortex using ECoG electrodes

Decoding value-related signal represented in multiple areas ...

引用

第四届全国神经动力学学术会议

作者： masamichi Sakagami Shingo tanaka Brain Science Institute Tamagawa University Department of Physiology Niigata University School of Medicine

Decision making is one of the important mental processes. For making a decision between multiple options, the values of the options are used. A lot of studies have shown that areas in the prefrontal cortex(PFC) play different but essential roles for value calculation and comparison [1-3]. However, few studies directly examined the functional difference among subareas in the PFC and their interaction. To examine dynamic signal processing related to value-based decision-making in the PFC, we recorded local field potentials(LFPs) from electrocorticographic(ECoG) electrodes implanted in the left lateral prefrontal cortex(LPFC),the left orbitofrontal cortex(OFC) and both side of the medial prefrontal cortex(MPFC),while two monkeys performed a free-choice task with 6 different juices. In this task, two reward cues which indicated the kinds of juices were presented sequentially with a short blank. Then, two cues were presented simultaneously and the monkeys touched one of them to obtain juice reward. From the choice behavior between two alternatives, the values of the rewards could be estimated. Then we decoded the values of juices from the ECo G signals during 1 st reward cue presentation. We used the wavelet power and phase in five frequency domains(delta, theta, alpha, beta, gamma) as features and decoded the values of the rewards with Sparse Linear Regression(SLiR) algorithm. Decoded values from 3 areas were significantly correlated with the behaviorally estimated values. Also, to examine the causal role of prefrontal value related signals, we applied the decoded neurofeedback(DecNef)technique to modulate the value of juice. We could successfully increase the decoded value of less preferred juice and decrease that of more preferred juice. Accordingly values of juices estimated from behavior were changed in consistent directions.

关键词： decision making reward value prefrontal cortex

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors

引用

Cancer Communications 2023年第4期43卷 415-434页

作者： Hiroyuki Suzuki Hideki Iwamoto Takahiro Seki Toru Nakamura Atsutaka Masuda Takahiko Sakaue Toshimitsu tanaka Yasuko Imamura Takashi Niizeki Masahito Nakano Shigeo Shimose Tomotake Shirono Yu Noda Naoki Kamachi Miwa Sakai Kazutoyo Morita masamichi Nakayama Tomoharu Yoshizumi Ryoko Kuromatsu Hirohisa Yano Yihai Cao Hironori Koga Takuji Torimura Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume CityFukuokaJapan Liver Cancer Research Division Research Center for Innovative Cancer TherapyKurume UniversityKurume CityFukuokaJapan Iwamoto Internal Medicine Clinic Kitakyushu CityFukuokaJapan Department of Microbiology Tumor and Cell biologyKarolinska InstitutetStockholmSweden Department of Surgery and Science Graduate School of Medical ScienceKyushu UniversityFukuoka CityFukuokaJapan Department of Pathology Kurume University School of MedicineKurume CityFukuokaJapan

Background:Antiangiogenic tyrosine kinase inhibitors(TKIs)provide one of the few therapeutic options for effective treatment of hepatocellular carcinoma(HCC).However,patients with HCC often develop resistance toward antiangiogenic TKIs,and the underlying mechanisms are not *** aim of this study was to determine the mechanisms underlying antiangiogenic TKI resistance in ***:We used an unbiased proteomic approach to define proteins that were responsible for the resistance to antiangiogenic TKIs in HCC *** evaluated the prognosis,therapeutic response,and serum insulin-like growth factor-binding protein-1(IGFBP-1)levels of 31 lenvatinib-treated HCC *** on the array of results,a retrospective clinical study and preclinical experiments using mouse and human hepatoma cells were ***,in vivo genetic and pharmacological gain-and loss-of-function experiments were ***:In the patient cohort,IGFBP-1 was identified as the signaling molecule with the highest expression that was inversely associated with overall ***,antiangiogenic TKI treatment markedly elevated tumor IGFBP-1 levels via the hypoxia-hypoxia inducible factor ***-1 stimulated angiogenesis through activation of the integrinα5β1-focal adhesion kinase ***,loss of IGFBP-1 and integrinα5β1 by genetic and pharmacological approaches re-sensitized HCC to lenvatinib ***:Together,our data shed light onmechanisms underlying acquired resistance of HCC to antiangiogenic *** TKIs induced an increase of tumor IGFBP-1,which promoted angiogenesis through activating the IGFBP-1-integrinα5β1 *** data bolster the application of a new therapeutic concept by combining antiangiogenic TKIs with IGFBP-1 inhibitors.

关键词： hepatocellular carcinoma hypoxia IGFBP-1 lenvatinib molecular targeting resistance tyrosine kinase inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan

引用

World Journal of Gastroenterology 2019年第1期25卷 107-117页

作者： Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa Department of Medicine Division of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Department of Surgery Kindai University Faculty of Medicine Department of Surgery National Hospital Organization Sendai Medical Center Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of Emergency Medicine University of Occupational and Environmental Health Department of Hepatobiliary-Pancreatic and Transplant Surgery Mie University School of Medicine Department of Gastroenterology Tokai University School of Medicine Department of Nutritional Sciences Nagoya University of Arts and Sciences Department of Gastroenterology Ogaki Municipal Hospital Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Gastroenterology Fujita Health University Bantane Hospital Department of Gastroenterology Graduate School of Medicine University of Tokyo Department of Healthcare Center Kumamoto Regional Medical Center General Internal Medicine Japanese Red Cross Nagoya Daini Hospital The Third Department of Internal Medicine Division of Gastroenterology and Hepatology Kansai Medical University Third Department of Internal Medicine Nara Medical University Department of Gastroenterology Kitakyushu General Hospital Department of Internal Medicine Matsumoto Dental University Department of Surgery and Oncology Graduate School of Medical SciencesKyushu University Division of Gastroenterology Department of Internal Medicine Shiga University of Medical Science Department of Gastroenterological General Breast and Thyroid SurgeryYamagata University Faculty of Medicine Department of Gastroenterology and Hepatology Kochi Medical School Faculty of Medicine Department of Medical Oncology Kyorin University Department of Biostatistics Hokkaido University

BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute *** To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in *** Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare *** A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT *** We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis.

关键词： Acute pancreatitis Trypsinogen activation peptide Urinary trypsinogen-2 dipstick test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：