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Prevention and treatment of cerebral palsy with cord blood stem cells and cord-derived mesenchymal stem cells

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Neural Regeneration Research 2021年第4期16卷 672-673页

作者： Haruo shintaku Donated Course“Disability medicine and Regenerative medicine” Osaka City University Graduate School of MedicineOsakaJapan

Prevention and treatment of cerebral palsy(CP)by regenerative medicine:Perinatal asphyxia is a well-known medical condition that can lead to *** etiologies are involved in this process,but the primary cause is hypoxic-ischemic encephalopathy(HIE)that is characterized by reduced blood flow and oxygen supply to the baby’s *** is one of the possible consequences of this neurologic *** developed,CP is difficult to treat,and the role of rehabilitation in functional recovery is still *** Neonatal Resuscitation Program is one of the various approaches that have been tried to *** program has been providing training courses since 2006 for midwives and nurses in addition to physicians,and we saw a marked reduction in mortality associated with birth asphyxia just after a year of the ***,further efforts are required to achieve 0%mortality.

关键词： nurse cerebral treatment

Karyotypes of field mice of the genus Apodemus (Mammalia： Rodentia) from China

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Zoological Research 2018年第5期39卷 348-355页

作者： Masaharu Motokawa Yi Wu Masashi Harada Yuta shintaku Xue-Long Jiang Yu-Chun Li Kyoto University Museum Kyoto University Kyoto 606-8501 Japan Key Laboratory of Conservation and Application in Biodiversity of South China School of Life Sciences Guangzhou University Guangzhou Guangdong 510006 China Laboratory Animal Center Graduate School of Medicine Osaka City University Osaka 545-8585 Japan Wildlife Research Center Kyoto University Sakyo Kyoto 606-8203 Japan Japan Monkey Centre Inuyama Aichi 484-0081 Japan Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Marine College Shandong University(Weihai) Weihai Shandong 264209 China

Karyotypes of four Chinese species of field mice of the genus Apodemus were examined,including Apodemus chevrieri （diploid chromosome number,2n=48,fundamental number of autosomal arms,FNa=56）,*** （2n=48,FNa=48）,*** （2n=48,FNa=48）,and *** （2n=48,FNa=48）.Karyotypes of ***,***,and *** are reported here for the first time,providing useful information for their species *** the karyotypes of all species of Apodemus in Asia,both in this and previous studies,provides a solid overview of the chromosome evolution and species differentiation of the genus in East *** addition to allopatric speciation,chromosome rearrangements likely played an important role in the formation of the four Apodemus species groups as well as speciation within each group in East *** example,increased centromeric heterochromatin in *** may have contributed to the post-mating reproductive isolation from the *** clade.

关键词： Karyotype Chromosome evolution Speciation Taxonomy Field mice

A novel large deletion(exons 12,13)and a missense mutation(p.G46R)in the PAH in a Japanese patient with phenylketonuria

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World Journal of Pediatrics 2015年第2期11卷 181-184页

作者： Yoshihiro Maruo Masafumi Suzaki Katsuyuki Matsui Yu Mimura Asami Mori Haruo shintaku Yoshihiro Takeuchi Department of Pediatrics Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Central Research Laboratory Shiga University of Medical ScienceTsukinowaSetaOtsuShiga 520-2192Japan Department of Pediatrics Osaka City University Graduate School of MedicineOsakaJapan

Background:Phenylketonuria(PKU)is caused by a defect in phenylalanine hydroxylase(PAH).More than 500 mutations have been reported for the gene encoding ***,approximately l%-5%of these include large deletions and large duplications that cannot be detected by conventional ***:In this report we tried to fully characterize a PAH-deficient *** patient was a 2-year-old Japanese boy who was diagnosed with classical PKU at the time of neonatal screening,which was confirmed by the tetrahydrobiopterin-loading ***-related direct sequencing and multiplex ligation-dependent probe amplification(MLPA)were used to analyze of the PAH of the ***:Using PCR-related direct sequencing method,we could detect only a heterozygous novel missense mutation:p.136G>C(p.G46R).A second mutation was detected by *** patient was heterozygous for a novel large deletion of exons 12 and 13:c.1200-?_1359+?del(EX12_13del).For genetic counseling,an accurate genetic diagnosis is often ***:Through a combination of MLPA and conventional methods,the success rate of PAH mutation identification can be close to 100%.

关键词： large deletion multiplex ligation-dependent probe amplification phenylalanine hydroxylase phenylketonuria

Viscosity Transient Phenomenon in Drop Impact Testing of Soft Material

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World Journal of Mechanics 2016年第5期6卷 181-191页

作者： Chen Liu Yukio Fujimoto Yoshikazu Tanaka Eiji shintaku Toshiki Nakanishi Department of Transportation and Environmental Engineering Graduate School of Engineering Hiroshima University Higashi-Hiroshima Japan

The authors carried out drop impact tests for several soft materials under a flat frontal impact condition in which a drop hammer with a flat bottom surface strikes a plate-like soft material in the normal direction. The experimental results indicated that the impact force waveforms of soft materials consisted of a thorn-shaped waveform and a subsequent mountain-shaped waveform. The thorn-shaped waveform was strongly affected by the strain rate. In the present study, the occurrence mechanism of this distinctive waveform was discussed from the viewpoint of the viscosity transient phenomenon. A standard linear solid (SLS) model in which the viscosity transient phenomenon was considered was applied to the simulation. Some features of the impact force waveform of soft materials could be explained by the SLS model. Furthermore, the thorn-shape waveform could also be observed in the impact force waveforms of human skin and free-falling hollow balls.

关键词： Strain Rate Dependence Soft Material Impact Force Thorn-Shape Waveform Viscosity Transient Standard Linear Solid (SLS) Model Flat Frontal Impact

Thorn-Shape Waveform and Double-Strike Phenomenon Seen in the Impact Force of Soft Materials

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World Journal of Mechanics 2015年第4期5卷 59-69页

作者： Yukio Fujimoto Chen Liu Yoshikazu Tanaka Eiji shintaku Toshiki Nakanishi Department of Transportation and Environmental Engineering Graduate School of Engineering Hiroshima University Hiroshima Japan

In the impact tests of soft materials, we sometimes observe a thorn shape in the rising segment of the impact force waveform. However, the reason for the occurrence of the thorn shape has not been made clear. In this study, thorn-shape waveforms of several soft materials are measured using compact drop test equipment under the condition of a flat frontal impact. A flat frontal impact is the condition where a drop hammer with a flat bottom surface strikes a plate-like soft material in the normal direction. Synchronized impact forces are measured using two sensors installed on both the drop hammer side and the floor side. The examined soft materials are a sponge sheet, sponge rubber sheet, gel sheet, rubber sheet, flat oil clay, low-rebound urethane foam, cork sheet, sliced ham, pork ham steak, and pork. Based on the test results, the features of the thorn-shape waveforms are discussed from a bird’s-eye view. Furthermore, the occurrence mechanism of the thorn-shape waveforms is discussed from the viewpoint of viscosity discontinuity and the double-strike phenomenon.

关键词： Impact Force Thorn-Shape Waveform Soft Material Drop Hammer Viscosity Discontinuity Strain Rate Dependence Double-Strike Phenomenon

琥珀酰辅酶A:3酮酸辅酶A转移酶T435N突变的纯合子患者未显现出永久性酮病

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 46-47页

作者： Fukao T. shintaku H. Kusubae R. 虎小毅 Department of Pediatrics Graduate School of Medicine Gifu University 1-1 Yanagido Gifu Gifu 501-1194 Japan Dr.

Succinyl-CoA:3-ketoacid CoA transferase (SCOT; locus symbol OXCT; E.C.2.***.3.5) is themain determinant of the ketolytic capacity of *** SCOT deficiency causes episodic *** ketosis has been regarded as a pathognomonic feature of SCOT *** are three SCOT-deficient patients from a small region in Japan and they have not manifested permanent ketosis, even though their ketoacidotic crises were as severe as those of other SCOT-deficient *** three were homozygous for the T435N *** expression analysis of wild-type and mutant cDNA showed that the T435N mutant retained significant residual SCOT activities (20%for that of the wild-type at 39.5℃, 25%at 37℃, and 50%at 30℃).The difference of residual SCOT activities at these temperatures in expression analyses was due to differences in the level of the mutant *** activity of the T435N protein was more vulnerable than the wild-type to heat treatment at 42℃and 55℃.These temperature-sensitive characteristics of the mutant protein may explain, in part, why the patients developed ketoacidotic crises during febrile *** SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent.

关键词：琥珀酰 T435N 酮酸纯合子酮病酮症酸中毒周期发作野生型热性疾病突变体

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四氢生物蝶呤反应性苯丙氨酸羟化酶缺乏症

中国当代儿科杂志 2005年第4期7卷 301-304页

作者： Haruo shintaku Shigeo KURE Toshihiro OHURA Yoshiyuki OKANO Misao OHWADA Naruji SUGIYAMA Nobuo SAKURA Ichiro YOSHIDA Makoto YOSHINO Yohichi MATSUBARA Ken SUZUKI Kikumaro AOKI Teruo KITAGAWA 大阪市立大学医学院儿科大阪日本545-8585

目的四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PK... 详细信息

目的四氢生物蝶呤(BH4)可以使BH4缺乏症病人的血液苯丙氨酸水平正常化,但是对苯丙酮酸尿症(PKU)病人无效。最近在新生儿PKU筛查中发现了对BH4有反应的轻度PKU患者。本研究将探讨BH4和苯丙氨酸羟化酶(PAH)基因突变在对BH4有反应的轻度PKU和轻度高苯丙酸血症(HPA)患者中的作用。方法对经新生儿PKU筛查中发现的生物蝶呤代谢正常的轻度HPA患者,进行单次(10mg/kg)、4次、1周[20 mg/(kg·d)]的BH4口服负荷试验及长期BH4治疗,评估其对BH4口服负荷试验的反应性。结果在单剂量BH4口服负荷试验中,典型PKU患者的血苯丙氨酸水平没有降低。在单剂量BH4口服负荷试验中血苯丙氨酸水平下降超过20%的患者,在4次BH4口服负荷试验中下降亦超过20%。1周BH4负荷试验确认在单剂量和4次BH4负荷试验中表现出弱反应性的病人对BH4有反应。许多患轻度PKU和轻度HPA且有R241C基因位点的病人,都对BH4治疗有反应。在无BH4反应性的典型PKU病人中未发现R241C、P407S和A373T基因突变。结论1周BH4负荷试验用于诊断BH4反应性PAH缺乏症最为有效。等位基因R241C、P407S和A373T与轻度HPA和轻度PKU病人具有H4反应性有关。BH4治疗是针对轻度HPA和轻度PKU的一种新颖、有效的药物治疗,有望代替限制苯丙氨酸饮食的方法。

关键词：苯丙氨酸尿症四氢生物蝶呤突变基因儿童