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The Emotional Expression Response of a Patient Based on their Facial Expression—Focus on Music Stimuli

Health 2022年第11期14卷 1143-1160页

作者： masako Higo Chiharu Akazawa Department of Nursing Science Sonoda Women’s University Hyogo Japan Doctoral Program Graduate School of Nursing Osaka Medical and Pharmaceutical University Osaka Japan

Objective: To determine whether patients with unresponsive wakefulness syndrome respond to auditory stimuli based on changes in facial expressions. Participants: Six patients diagnosed with disorders of consciousness due to brain injury with permission for participation from their doctor. Design: In this hypothesis-driven observational study, the facial expressions of patients with unresponsive wakefulness syndrome were video-recorded for 5 min before and during auditory stimulation in three consecutive weekly sessions. Main Measures: Facial muscle movement was quantified using FaceReader® software (Noldus, Wageningen, Netherlands). Valence/action unit values were plotted to detail facial expression changes. Heart rate values were also plotted. These parameters were compared before and after stimulation. Results: No significant differences in valence integral values or average heart rate were observed between the pre- and intra-stimulus conditions. However, valence signals increased in approximately half of the sessions, indicating that some patients with unresponsive wakefulness syndrome may exhibit emotional responses to auditory stimuli. Analysis of action unit integral values indicated that movement of the eyebrows and eyelids on the upper part of the face occurred during auditory stimulation. Furthermore, the types of auditory stimuli differed depending on the session for the 12 sessions of voice stimuli, whereas the changes in average heart rate differed in each of nine sessions of music stimuli. Because the changes in average heart rate were similar, it is possible that musical stimuli are more suitable than voice stimuli. Conclusion: Some patients with unresponsive wakefulness syndrome may have an emotional response to auditory stimuli. Our findings indicate that it may be possible to distinguish the emotional expression response of a patient based on their facial expression.

关键词： Facial Expression Unresponsive Wakefulness Syndrome Music Stimuli

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Sleeping Conditions of Older Adults with Delirium Receiving Home Care

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Health 2023年第8期15卷 895-907页

作者： masako Higo Kiyomi Morimoto Department of Evidence-Based Clinical Nursing Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Department of Nursing Science Seisen University Shiga Japan

We aimed to clarify the sleep status before delirium onset among older adults receiving home care. The sleep status of 21 participants aged ≥65 years was monitored while they slept with a sensor placed under their bedding, after ruling out insomnia and dementia. The incidence of delirium was 28.6%;delirium onset occurred within an average of 2.7 (SD = 12) days after the start of home care among those whose care environment was changed due to hospital discharge or moving. Increased interrupted sleep and activity during sleep indicated that sleep fragmentation occurred before delirium onset. In conclusion, individuals aged ≥65 years and those whose care environment has changed should be screened for delirium because the time to delirium onset is short. Further, interventions to monitor the sleep status and prevent delirium onset should be implemented from the day home care begins.

关键词： Patients in Home Care Elderly Delirium Sleep

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Plexiform angiomyxoid myofi broblastic tumor of the stomach

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World Journal of Gastroenterology 2010年第23期16卷 2835-2840页

作者： Yoshihisa Takahashi masako Suzuki Toshio Fukusato Department of Pathology Teikyo University School of Medicine Department of Pathology Sekishinkai Sayama Hospital

Plexiform angiomyxoid myofibroblastic tumor of the stomach is a unique mesenchymal tumor that we first described in *** tumor is very rare,and to date,only 18 cases confirmed by immunohistochemistry have been reported in the *** patients' ages ranged from 7 to 75 years(mean,43 years),and the male-to-female ratio was approximately 1:*** clinical symptoms are ulceration,associated upper gastrointestinal bleeding(hematemesis),and *** tumors are located at the antrum in all cases,and grossly,the tumor is whitish to brownish or reddish,and forms a lobulated submucosal or transmural ***,the tumor is characterized by a plexiform growth pattern,the proliferation of cytologically bland spindle cells,and a myxoid stroma that is rich in small vessels and positive for Alcian blue ***,the tumor cells are positive for α-smooth muscle actin and negative for KIT and *** diagnoses include gastrointestinal stromal tumor and other mesenchymal tumors of the gastrointestinal *** authors proposed that this tumor should be designated as "plexiform fibromyxoma",but this designation might cause *** tumor is probably benign and thus far,neither recurrence nor metastasis has been reported.

关键词： Plexiform angiomyxoid myofibroblastic tumor Stomach Gastrointestinal stromal tumor Plexiform fibromyxoma Myofi broblast Fibroblast

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Patient blinding with blunt tip placebo acupuncture needles:comparison between 1 mm and 2 mm skin press

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Journal of Integrative Medicine 2018年第3期16卷 164-171页

作者： Nobuari Takakura Miho Takayama Morihiro Nasu masako Nishiwaki Akiko Kawase Hiroyoshi Yajima Department of Acupuncture and Moxibustion Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Physiology Showa University School of Medicine Japan School of Acupuncture Moxibustion and Physiotherapy

Objective： To investigate the influence of the depth of skin press in blunt tip placebo acupuncture needles on patient blinding and its relationship to needle ***： Forty healthy volunteers were enrolled as subjects for patient blinding. Four acupuncturists applied the following needles randomly at three points in each forearm： 0.18 mm and 0.25 mm diameter penetrating needles inserted to a depth of 5 mm, and 0.18 mm and 0.25 mm diameter skin-touch needles depressing the skin at the acupoint to a depth of 1 mm and 2 mm from the skin surface. The subjects reported their guesses at the nature of needles they received, and rated needle pain and de qi. A blinding index was calculated to define the success of blinding for ***： The blinding status of subjects for 1 mm press needles of 0.18 mm diameter was ＂random guess＂,but ＂unblinded＂ for 1 mm press needles of 0.25 mm diameter. For 2 mm press needles of both diameters,the blinding status was ＂opposite guess＂ and the blinding status for penetrating needles of both diameters was ＂unblinded.＂ The percentages of ＂felt pain＂ with 2 mm press needles of both diameters were similar to that with penetrating needles, but those were not similar for 1 mm press needles. The frequency of de qi occurrence with 2 mm press needles of 0.18 mm diameter was similar to that of penetrating needles of both ***： Placebo needles of 2 mm press made more subjects guess that the needles penetrated the skin than 1 mm press needles. The use of small diameter needles increased patient blinding.

关键词： Double-blind method Acupuncture Placebo Sham De qi

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Human pluripotent stem cells:Towards therapeutic development for the treatment of lifestyle diseases

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World Journal of Stem Cells 2016年第2期8卷 56-61页

作者： Miwako Nishio masako Nakahara Akira Yuo Kumiko Saeki Research Institute National Center for Global Health and Medicine PRESTO Japan Science and Technology Agency

There are two types of human pluripotent stem cells: Embryonic stem cells(ESCs) and induced pluripotent stem cells(iPSCs),both of which launched themselves on clinical trials after having taken measures to overcome problems: Blocking rejections by immunosuppressants regarding ESCs and minimizing the risk of tumorigenicity by depleting exogenous gene components regarding iP *** is generally assumed that clinical applications of human pluripotent stem cells should be limited to those cases where there are no alternative measures for treatments because of the risk in transplanting those cells to living *** lifestyle diseases,we have already several therapeutic options,and thus,development of human pluripotent stem cell-based therapeutics tends to be ***,human pluripotent stem cells can contribute to the development of new therapeutics in this *** we will show,there is a case where only a short-term presence of human pluripotent stem-derived cells can exert long-term therapeutic effects even after they are *** those cases,immunologically rejections of ESC-or allogenic iP SC-derived cells may produce beneficial outcomes by nullifying the risk of tumorigenesis without deterioration of therapeutic *** utility of human pluripotent stem cells is the provision of an innovative tool for drug discovery that are otherwise *** example,clinical specimens of human classical brown adipocytes(BAs),which has been attracting a great deal of attention as a new target of drug discovery for the treatment of metabolic disorders,are unobtainable from living individuals due to scarcity,fragility and ethical ***,BA can easily be produced from human pluripotent stem *** this review,we will contemplate potential contribution of human pluripotent stem cells to therapeutic development for lifestyle diseases.

关键词： Arteriostenosis Human embryonic stem cells Glucose intolerance Human induced pluripotent stem cells

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Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral

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Fundamental Research 2022年第2期2卷 321-328页

作者： Mengge Feng Yulan Wang Yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan University Department of Oral and Mxillfacial Surgery The Nippon Dental University School of Life Dentistry at TokyoTokyoJapan Department of Periodontology University of BernBernSwitzerland Clinical Assistant Professor State University of New York Story Brook Department of PeriodontologyPrivate Practice New YorkNew YorkUSA Medical Research Institute School of MedicineWuhan UniversityWuhan 430071China

Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these *** address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological *** bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+*** time for solidification and the degradation properties were subsequently *** electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each *** bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to *** and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time *** bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used *** clinical studies are warranted to further support the clinical application of PRF bone blocks in bo

关键词： Blood Platelet-rich fibrin Bone formation Dental implant Regeneration

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A case of auditory neuropathy revealed by OTOF gene mutation analysis in a junior high school girl

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Journal of Otology 2017年第4期12卷 202-206页

作者： Ying Cheng masako Nakamura Tatsuo Matsunaga Kimitaka Kaga National Institute of Sensory Organs Tokyo Medical Center Japan The Department of Otolaryngology Head and Neck Surgery in the Second Affiliated Hospital of Xi'an Jiaotong University Shaanxi Province PR China

Objective: Congenital auditory neuropathy(AN) affects hearing and speech development. The degree of hearing difficulty in congenital AN varies as a function of pathology at the inner ear hair cell(IHC) synapses or the auditory nerve. We report a case of a Chinese girl with AN revealed by OTOF(otoferlin) gene mutation analysis who had only a mild hearing ***: A 13-year-old Chinese girl was diagnosed as having congenital AN on the basis of OTOF gene mutation analysis. She manifest a mild sensorineural hearing loss with 50% maximum monosyllable speech discrimination rate, normal DPOAEs(distortion product otoacoustic emissions) beyond ambient noise levels, only SPs(summating potentials) evoked during ECoG(electrocochleography) and absent ABRs(auditory evoked brainstem responses) bilaterally to clicks presented at 100 d Bn HL. She was able to effectively communicate with others by speech reading owing to her mild hearing loss. Moreover, bilateral hearing aids helped her to ***: Our patient was demonstrated to have a mutation on the OTOF gene. Nevertheless, she was able to communicate using auditory visual speech reading in spite of a mild auditory threshold elevation probably due to partial pathology at the IHC synapses or in the auditory nerve.

关键词： Auditory neuropathy Auditory nerve disease Auditory neuropathy spectrum disorders OTOF Speech discrimination

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WE LOVE CHLOE BOOK!

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国际服装技术 2006年第9期 39-48页

作者： masako

时下最让人心动的品牌Chloel从包款到服饰的设计在业界都能引领时尚潮流，时刻受到众人的关注！从品牌的发展大事记，新款包包大检阅到最新时尚情报，全国店铺列表都将在此集结，值得收藏！！

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New fluorimetric assay of horseradish peroxidase using sesamol as substrate and its application to EIA

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Journal of Pharmaceutical Analysis 2012年第2期2卷 156-159页

作者： Hidetoshi Arakawa Shigeo Nakabayashi Ken-ichi Ohno masako Maeda School of Pharmacy Showa University

Horseradish peroxidase (HRP) is generally used as a label enzyme in enzyme immunoassay (EIA).The procedure used for HRP detection in EIA is critical for sensitivity and *** paper describes a novel fluorimetric assay for horseradish peroxidase (HRP) using sesamol as *** principle of the assay is as follow:sesamol (3,4-methylenedioxy phenol) is reacted enzymatically in the presence of hydrogen peroxide to produce dimeric *** dimer is fluorescent and can be detected sensitively at ex.347 nm,em.427 *** measurable range of HRP was 1.0×10-18 to 1.0×10-15 mol/assay,with a detection limit of 1.0×10-18 mol/*** coefficient of variation (CV,n=8) was examined at each point on the standard curve,with a mean CV percentage of 3.8%.This assay system was applied to thyroid stimulating hormone (TSH) EIA using HRP as the label enzyme.

关键词： Sesamol Fluorescence Enzyme immunoassay (EIA) Horseradish peroxidase (HRP) Thyroid stimulating hormone (TSH)

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Investigation of Specifics of Self-Management towards Dealing with Cancer Pain among Adult Outpatients

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Health 2018年第11期10卷 1520-1538页

作者： masako Yamanaka Department of Nursing Science Faculty of Health Care Tenri Health Care University Nara Japan Doctoral Program Graduate School of Nursing Osaka Medical College Osaka Japan

Purpose: This study aimed to identify specifics of self-management towards dealing with cancer pains among adult outpatients. Methods: Semi-structured interviews were conducted with 16 adult outpatients (9 males and 7 females) who suffered from cancer pain and the data obtained were analyzed using the qualitative synthesis method of KJ Ho. Results: An analysis of the results revealed these key findings for the following symbolic wording of the semi-structured interviews: Cooperative relationship with medical professionals;Problems originating from cancer pain;Self-regulation of analgesic medications based on the interactions with medical professionals;Self-regulation of the analgesic medications based on the physical perceptions of the effects;Self-regulation to maintain a balanced and calm mind, Fulfilling life by the pain alleviation and liberation from the restrictions imposed by the cancer;and Efforts to maintain their lives by themselves. Conclusion: Based on the cooperative relationship established with medical professionals, the patient carried out the self-regulation of cancer pain using analgesics, and self-regulation to maintain a balanced and calm mind. Nurses must therefore sufficiently educate patients regarding how to communicate successfully with medical professionals in order to improve cancer patients’ pain management regarding both physical and mental aspects.

关键词： Self-Management Cancer Pain Adult Outpatients

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