检索结果-南通市图书馆

Neural Regeneration Research 2021年第12期16卷 2359-2366页

作者： masako nakano Mineko Fujimiya Department of Anatomy Sapporo Medical University School of MedicineSapporoHokkaidoJapan

Mesenchymal stem cells are multipotent cells that possess anti-inflammatory,antiapoptotic and immunomodulatory properties.The effects of existing drugs for neurodegenerative disorders such as Alzheimer’s disease are limited,thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction.Since mesenchymal stem cells are known to scarcely differentiate into neuronal cells in damaged brain after transplantation,paracrine factors secreted from mesenchymal stem cells have been suggested to exert therapeutic effects.Extracellular vesicles and exosomes are small vesicles released from mesenchymal stem cells that contain various molecules,including proteins,mRNAs and microRNAs.In recent years,administration of exosomes/extracellular vesicles in models of neurological disorders has been shown to improve neuronal dysfunctions,via exosomal transfer into damaged cells.In addition,various microRNAs derived from mesenchymal stem cells that regulate various genes and reduce neuropathological changes in various neurological disorders have been identified.This review summarizes the effects of exosomes/extracellular vesicles and exosomal microRNAs derived from mesenchymal stem cells on models of stroke,subarachnoid and intracerebral hemorrhage,traumatic brain injury,and cognitive impairments,including Alzheimer’s disease.

关键词： exosomes extracellular vesicles mesenchymal stem cells microRNA neurological disorders

Esophageal intramural pseudodiverticulosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第2期30卷 137-145页

作者： masako Shintaku Department of Gastroenterology Japan Community Healthcare Organization Hoshigaoka Medical CenterHirakata 573-8511OsakaJapan

Esophageal intramural pseudodiverticulosis(EIPD)is a disease of unknown pathogenesis characterized by usually systemic,cystic dilatation of the excretory ducts of esophageal submucosal glands.In this article,I review the epidemiology,clinical manifestations,endoscopic findings,esophagographic findings,and histopathology of EIPD.I also discuss the etiology and possible pathogenesis of EIPD based on my experiences with this disease and a review of the literature.EIPD usually presents with dysphagia in middle-aged individuals.It is often complicated with secondary infections,most commonly candidiasis.On esophagography,EIPD is delineated as small,multiple,flask-shaped outward projections within the esophageal wall.In recent years,EIPD has been mainly diagnosed by endoscopic findings of multiple,localized,small mucosal depressions.The orifices of the“pseudodiverticula”periodically open and close,and excrete mucus onto the mucosal surface.On histopathological examination,the luminal surface of dilated ducts in EIPD is covered by multilayered,hyperplastic epithelial cells,but myoepithelial cells in the glandular acini are well preserved.Treatment of EIPD is usually symptomatic therapy,and prevention of the infectious complications is important.The etiology and pathogenesis of EIPD are largely unknown,but functional abnormalities of autonomic nerve fibers innervating the esophageal glands likely play an important role,since the structures of the glands are basically preserved in this disease.

关键词： Esophageal endoscopy Esophageal intramural pseudodiverticulosis Esophagography Dysphagia

Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji nakano Eishi Baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on autopsy.Malignant tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are rare.CASE SUMMARY The case of a 60-year-old man who complained of dysphagia is presented.Upper gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing stenosis.Contrast-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural effusion.Pathological examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal sarcoma.The disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered difficult.Given his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the disease.The autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological features.Cancer stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac metastasis.CONCLUSION To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal SCC.This case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智能网联汽车多目标预测优化换道决策方法

同济大学学报(自然科学版) 2024年第7期 1109-1117页

作者：程硕夏新 nakano Kimihiko 东京大学生产技术研究所加州大学洛杉矶分校土木与环境工程系

换道决策是智能网联汽车的核心难题之一，其面临着高动态、复杂交通场景下需要综合考虑行驶安全及效率等目标的巨大挑战。提出一种多目标预测优化的换道决策方法，主要包括动力学矩阵建模及多目标预测优化问题解算。基于智能网联汽车的... 详细信息

换道决策是智能网联汽车的核心难题之一，其面临着高动态、复杂交通场景下需要综合考虑行驶安全及效率等目标的巨大挑战。提出一种多目标预测优化的换道决策方法，主要包括动力学矩阵建模及多目标预测优化问题解算。基于智能网联汽车的通讯大数据信息构建交通流矩阵模型，然后分别设计表征车辆换道安全、行驶效率的动力学模型，通过多目标综合预测优化方法，求解条件约束下预测优化问题从而优化出最优换道决策指令。结果表明，所提出的预测优化换道方法较其他方法提高了智能汽车的行驶安全性和效率。

关键词：智能网联汽车换道决策多目标优化预测优化

Fundamental Study on Response Properties of Structures Constructed on Lunar Regolith

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Earthquake Research 2024年第1期13卷 27-40页

作者： Yuji Miyamoto Takaharu nakano Toshio Kobayashi Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan SANSEI Inc. Tokyo Japan

The Artemis Program, for constructing the lunar base, is in progress. How to design and construct architectural and civil engineering structures in the lunar environment has become an important issue. The lunar surface is covered with soft sand, called regolith, and it is required to protect lunar bases and structures, as well as internal precision equipment, against vibrational disturbances such as moonquakes and meteorite collisions. Therefore, in this study, the static and cyclic triaxial compression tests of the regolith simulant were conducted. The reference strain and equivalent damping factor of the regolith simulant were smaller compared to sandy soil on Earth. In addition, a shaking table test using model specimens was conducted on the response properties of regolith ground alone and structures set on regolith ground. The buried foundation and pile foundation notably suppressed the horizontal response attributed to the rocking component compared to a direct foundation.

关键词： Lunar Development Regolith Soil-Structure Interaction Triaxial Compression Test Shaking Table Test

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

基于异质边增强时空图注意力网络的自动驾驶换道轨迹规划

在线全文

学校读者我要写书评

暂无评论

中国公路学报 2024年第3期37卷 147-156页

作者：董晴中野公彦杨波季学武刘亚辉清华大学车辆与运载学院北京100084 东京大学生产技术研究所东京153-8505

轨迹规划仍然是自动驾驶技术大规模应用所面临的关键难题之一。例如,自动驾驶中的换道轨迹规划算法通常被构建为一个针对代价函数的优化过程。然而,为适应多样化的交通场景而手动调整代价函数中的特征权重,是一项极具挑战性的任务。针... 详细信息

轨迹规划仍然是自动驾驶技术大规模应用所面临的关键难题之一。例如,自动驾驶中的换道轨迹规划算法通常被构建为一个针对代价函数的优化过程。然而,为适应多样化的交通场景而手动调整代价函数中的特征权重,是一项极具挑战性的任务。针对这一问题,提出了一种基于异质边增强时空图注意力网络(Heterogeneous Edge-enhanced Spatial-Temporal Graph ATtention network, HEST-GAT)的新型换道轨迹规划方法。首先,采用逆强化学习技术,从大量专家级换道示范中提取代价函数的特征权重向量,构建了一个专家级换道示范数据集。然后,将交通场景构建为一个异质有向图,其中,交通参与者的位置定义为节点属性,交通参与者间的相对位置作为边属性,交通参与者之间的关联类型则定义为边类型。边的属性和类型组合,形成了边的特征表示。为捕获交通场景中的空间和时间信息,采用HEST-GAT网络进行特征提取,并计算了各场景下代价函数的特征权重。接着构建了一个结合轨迹特征和特征权重的代价函数,并通过优化过程生成最终的换道轨迹规划。为验证所提出方法的实用性,在真实驾驶数据集上进行了多轮换道轨迹规划测试和评估。研究结果显示:与基于时空图卷积网络方法相比,基于HEST-GAT的换道轨迹规划在模拟专家示范轨迹方面的误差显著减少。纵向舒适性、纵向效率、横向舒适性和安全性4项关键指标的误差分别降低了5.5%、5.4%、1.4%和6.0%。结果表明提出的方法能够生成与人类驾驶行为高度一致的换道轨迹,具有卓越的场景适应能力。

关键词：汽车工程换道轨迹规划逆强化学习图注意力网络代价函数权重自动驾驶

Effect of fiber-reinforcement on the mechanical behavior of sand approaching the critical state

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1241-1252页

作者： Jakhongirbek Ganiev Shotaro Yamada Masaki nakano Takayuki Sakai Department of Civil Engineering Nagoya UniversityNagoya464-8603Japan Department of Civil Engineering Tohoku UniversitySendai980-8579Japan

Several types of ground improvement methods that employ fiber-reinforcement have been developed in recent years.A series of consolidated drained triaxial compression tests has been conducted here to examine the effect of short fibers on the mechanical properties of Toyoura sand.Sand with 0%,0.2%,0.4%,and 1%fiber contents,prepared to yield random distribution,was sheared under several confining pressures and controlled via their initial relative densities.The test results showed that the maximum and residual deviatoric stresses increased,whereas the volumetric expansion decreased with an increase in fiber content.Although the stress ratio h(=q/p′)and specific volume changed depending on the fiber content and confining pressure with shear progression,they each reached the same values for a definite fiber content at the end of shearing,independent of initial relative density.In other words,the unique critical state line can be found for a definite fiber content.Moreover,the greater the fiber content,the larger the slope of the critical state line at the end of shearing.Additionally,as the length of fibers shortened with the same percentage of fiber inclusions in sand,the deviatoric stress and the stress ratio decreased,approaching the shear-strain-volumetric response of unreinforced sand.

关键词： Fiber-reinforced sand Triaxial compression Stress ratio Critical state Relative density

A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 107-108页

作者： Takayuki Nakagomi Hideaki Nishie Toshinori Sawano Akiko nakano-Doi Institute for Advanced Medical Sciences Hyogo College of MedicineHyogoJapan Department of Therapeutic Progress in Brain Diseases Hyogo College of MedicineHyogoJapan Department of Biomedical Sciences Ritsumeikan UniversityShigaJapan

Ischemic stroke is a leading disease of the central nervous system,frequently coupled to severe damage and dysfunction in patients.Animal models mimicking human stroke provide useful tools for studying the pathomechanisms(e.g.,inflammation,neuroprotection,and neural regeneration),the treatment efficiency of various materials(e.g.,bioactive molecules or drugs),and transplantation usefulness by various cell types[e.g.,neural stem/progenitor cells(NSPCs),and mesenchymal or hematopoietic stem cells]under ischemic stroke.

关键词： inflammation damage neural

Mutual synchronization of eyeblinks between dogs/cats and humans

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2022年第2期68卷 229-232页

作者： Hikari KOYASU Risa GOTO Saho TAKAGI Miho NAGASAWA Tamami nakano Takefumi KIKUSUI Laboratory of Human-Animal Interaction and Reciprocity Azabu University1-17-71 FuchinobeChuo-kuSagamihara-shiKanagawa252-5201Japan Japan Society for the Promotion of Science 5-3-1 KojimachiChiyoda-kuTokyo102-0083Japan Graduate School of Frontiers and Biosciences Osaka University1-3 YamadaokaSuitaOsaka565-0871Japan

In humans Homo sapiens,eyeblinks play an important role in communication.Blinks are synchronized between 2 individuals during conversation,with shared breaks between contexts,suggesting that blink synchronization can ... 详细信息

关键词： blink cat communication dog synchronization