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Open Journal of Nursing 2017年第6期7卷 671-682页

作者： masako kageyama Keiko Yokoyama Yukako Nakamura Iwao Oshima Area of Integrated Health and Nursing Science Osaka University Graduate School of Medicine Suita Japan Department of Nursing Faculty of Health Sciences Saitama Prefectural University Koshigaya Japan Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan Japan College of Social Work Kiyose Japan

Families need sufficient learning opportunities about mental illness. Therefore, family peer education program has been developed in Japan following the U.S. and Hong Kong. We aimed to identify program components that families recognize which would provide suggestions in modifying the program. We used qualitative and inductive study design. Data were collected through group interviews for six family research participants. We coded the data to focus on relationships between program components, program processes, and impacts. Data Analysis resulted in seven assumptions based on causal relationships and three types of program components: program form, learning style and facilitation skills. The program form is family-led peer group, closed-membership, 5 times per course, and small group. The learning style is combination of textbook and experiential knowledge, family peer learning, and sharing experiences. The facilitation skills are group work focusing on strengths of family members, the acceptance of emotional disclosure, omotenashi, and teamwork skills.

关键词： Mental Disorders Schizophrenia Family Support Family Education Program Evaluation Program Component

Use of Analogy by Public Health Nurses in Problem Solving for Individual Consultations in Japan: A Multiple Case Study

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Open Journal of Nursing 2017年第3期7卷 345-360页

作者： masako kageyama Taeko Shimazu Atsuko Taguchi Satoko Nagata Kathy Magilvy Area of Integrated Health and Nursing Science Osaka University Graduate School of Medicine Suita Japan National College of Nursing Kiyose Japan Department of Public Health Nursing Division of Health Sciences Tohoku University Graduate School of Medicine Sendai Japan Department of Community Health Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan University of Colorado College of Nursing Denver USA

Aim: Nurses must develop good problem-solving skills (PSS) to work in the complex health care environment. This study explored PHNs’ use of analogy in PSS development. The purposes of the study were to clarify how PSS developed in one area (i.e., mental health) could be applied to another area (i.e., maternal health) and whether new PSS could develop in response to PSS gained in another area. Methods: A multiple case study was conducted using interviews. We interviewed 27 consultations from eight Japanese PHNs who consulted in mental health departments before transferring to maternal health departments. The data on how PHNs applied PSS in the selection, mapping, evaluation, and learning stages of the analogy process were extracted from transcribed interviewed data and compared. Results: PHNs provided 59 PSS used in 27 consultations. All PHNs applied past mental health PSS to solve new problems in maternal health. They tended to select past PSS based on structural similarity and to apply PSS via low-level abstraction in serious situations or preventively to avoid causing the current situation to worsen. Notably, PHNs developed maternal health PSS by using past mental health PSS;these new PSS were derived through analogy from various failures and successes. Conclusions: PSS developed in one area can be applied in another area, and new PSS can develop through applying these previous PSS. Identification of structural similarities and preventive analogies must be included in nursing education, especially for nurses working in public health fields.

关键词： Analogy Consultation Nursing Education Problem Solving Public Health Nurse

IMMERSIVE VR VISUALIZATIONS BY VFIVE PART 1: DEVELOPMENT

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S01期4卷 40-53页

作者： AKIRA kageyama NOBUAKI OHNO Graduate School of System Informatics Kobe University Kobe657-8501Japan Graduate School of Simulation Studies University of Hyogo Kobe650-0047Japan

We have been developing a visualization application for CAVE-type virtual reality(VR)systems for more than a *** application,VFIVE,is currently used in several CAVE systems in Japan for routine *** is also used as a b... 详细信息

关键词： Virtual reality CAVE immersive display system.

Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats

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World Journal of Gastroenterology 2008年第30期14卷 4784-4790页

作者： Koyuki Tajima Kiyoto kageyama Takashi Kyoi Department of Pharmacology Discovery Research LaboratoriesNippon Shinyaku Co. Ltd.

AIM： To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin in rats. METHODS： Gastric mucosal injury was induced in male Hos：Donryu rats by oral administration of indomethacin at a dose of 48 mg/kg. One hour before indomethacin treatment, animals were orally pretreated with irsogladine maleate at doses of 1 mg/kg, 3 mg/kg or 10 mg/kg. Four hours after indomethacin administration, the animals were sacrificed and their stomachs were rapidly removed and processed for the evaluation of gastric mucosal damage and the determination of the concentrations of tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β）, IL-8 and myeloperoxidase （MPO） in mucosal tissues. RESULTS： Linear hemorrhagic mucosal lesions were observed primarily in the glandular stomach 4 h alter oral administration of indomethacin. Pretreatment with irsogladine maleate markedly reduced the number and severity of these lesions in a dose-dependent manner. The mucosal concentrations of proinflammatory cytokines （TNF-α, IL-1β, and IL-8） and MPO, which indicates the degree of mucosal infiltration by neutrophils, increased concomitantly with the occurrence of gastric injury in the indomethacintreated rats. Pretreatment with irsogladine maleate significantly decreased the levels of these inflammatory factors in gastric tissue elicited by ***： The mucosal protective effects afforded by irsogladine maleate on gastric injury induced by indomethacin are mediated by inhibition of mucosal proinflammatory cytokine production and neutrophil infiltration, leading to suppression of mucosal inflammation and subsequent tissue destruction.

关键词： Irsogladine Gastric injury Indomethacin Cytokine Myeloperoxidase

Flexible visualization framework for head-mounted display with gesture interaction interface

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 22-41页

作者： Pierre J.Jarsaillon Naohisa Sakamoto Akira kageyama Computer Science Department INSA Lyon 20 avenue Albert EinsteinVilleurbanne Cedex 69621France Graduate School of System Informatic Kobe University 1-1 Rokko-daiNada-ku Kobe 657-8501Japan Department of Computational Science Kobe University 1-1 Rokko-dai Nada-kuKobe 657-8501Japan

As the development of new visualization systems,within the field of simulation,offers their users more insights from their simulations,immersive systems are becoming a part of the visualization *** the recent advancements of the Head-Mounted Displays(HMDs)and popularity of motion sensors,human beings and computer become more *** study aims to evaluate the potential of such systems as a visualization tool through the development of a new flexible framework for visualization within virtual reality(VR)environment,using an Oculus Rift and a Leap *** approaches are then compared:high-3D object rendering within the virtual scene approach and a user experience-oriented system with an intuitive *** assess the quality of the interface and its relevance for the user,different types of gestures are implemented and *** an experiment on users to evaluate the developed system as a proper visualization tool,the HMDs,paired with a motion sensor to make a gesture-controlled interface seem to be promising mediums despite various constraints on development regarding the technology limitations.

关键词： Virtual reality motion sensor interactive tool user experience immersive visualization.

Upconversion time-stretch infrared spectroscopy

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Light(Science & Applications) 2023年第3期12卷 465-474页

作者： Kazuki Hashimoto Takuma Nakamura Takahiro kageyama Venkata Ramaiah Badarla Hiroyuki Shimada Ryoich Horisaki Takuro Ideguchi Institute for Photon Science and Technology The University of TokyoTokyo113-0033Japan Department of Physics The University of TokyoTokyo113-0033Japan Graduate School of Information Science and Technology The University of TokyoTokyo113-8656Japan

High-speed measurement confronts the extreme speed limit when the signal becomes comparable to the noise *** the context of broadband mid-infrared spectroscopy,state-of-the-art ultrafast Fourier-transform infrared spectrometers,in particular dual-comb spectrometers,have improved the measurement rate up to a few MSpectra s^(-1),which is limited by the signal-to-noise ***-stretch infrared spectroscopy,an emerging ultrafast frequency-swept mid-infrared spectroscopy technique,has shown a record-high rate of 80 MSpectra s^(-1) with an intrinsically higher signal-to-noise ratio than Fourier-transform spectroscopy by more than the square-root of the number of spectral ***,it can measure no more than~30 spectral elements with a low resolution of several ***,we significantly increase the measurable number of spectral elements to more than 1000 by incorporating a nonlinear upconversion *** one-to-one mapping of a broadband spectrum from the mid-infrared to the near-infrared telecommunication region enables low-loss time-stretching with a single-mode optical fiber and low-noise signal detection with a high-bandwidth *** demonstrate high-resolution mid-infrared spectroscopy of gas-phase methane molecules with a high resolution of 0.017 cm^(-1).This unprecedentedly high-speed vibrational spectroscopy technique would satisfy various unmet needs in experimental molecular science,e.g.,measuring ultrafast dynamics of rreversible phenomena,statistically analyzing a large amount of heterogeneous spectral data,or taking broadband hyperspectral images at a high frame rate.

关键词： spectroscopy noise resolution

IMMERSIVE VR VISUALIZATIONS BY VFIVE: PART 2: APPLICATIONS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S01期4卷 54-69页

作者： AKIRA kageyama NOBUAKI OHNO SHINTARO KAWAHARA KAZUO KASHIYAMA HIROAKI OHTANI Graduate School of System Informatics Kobe University Kobe 657-8501Japan Graduate School of Simulation Studies University of Hyogo Kobe 650-0047Japan Earth Simulator Center Japan Agency for Marine-Earth Science and Technology Yokohama 236-0001 Japan Department of Civil and Environmental Engineering Chuo University Bunkyo-ku 112-8551Japan National Institute for Fusion Science Toki 509-5292 Japan The Graduate University for Advanced Studies(SOKENDAI)Toki 509-5292Japan

VFIVE is a scientific visualization application for CAVE-type immersive virtual reality(VR)*** source codes are freely *** is used as a research tool in various VR *** also lays the groundwork for developments of new visualization software for *** this paper,we pick up five CAVE systems in four different institutions in *** of VFIVE in each CAVE system are *** emphases will be placed on scientific and technical achievements made possible by VFIVE.

关键词： Virtual reality CAVE system immersive display system.

Discrete-Time Hybrid Decision Processes: The Discounted Case

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Applied Mathematics 2013年第11期4卷 1490-1494页

作者： Buheeerdun Yang Pingjun Hou Masayuki kageyama Graduate School of Science Chiba University Chiba Japan Nagoya City University Nagoya Japan

This paper is a sequel to kageyama et al. [1], in which a Markov-type hybrid process has been constructed and the corresponding discounted total reward has been characterized by the recursive equation. The objective of this paper is to formulate a hybrid decision process and to give the existence and characterization of optimal policies.

关键词： Hybrid Decision Process Discounted Reward Criteria Optimal Equation Chance Space Fixed Point Theorem

The Notch-Hes pathway in mammalian neural development

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Cell Research 1999年第3期9卷 179-188页

作者： kageyama RYOICHIRO TOSHIYUKI OHTSUKA(Institute for Virus Research, Kyoto University, Sakyo-ku,Kyoto 606-8507 Japan) 1Institute for Virus Research Kyoto University Sakyo-ku Kyoto 606-8507 Japan 1Institute for Virus Research Kyoto University Sakyo-ku Kyoto 606-8507 Japan

A wide variety of neurons and gIial cells differentiatefrom common precursor cells in the developing nervoussystem. During this process, Notch-mediated cell-cell in-teraction is essential for maintenance of dividing cells andsubsequellt generation of cell type diversity. Activation ofNotch inhibits cellular differentiation, and abnormality ofthe Notch pathway leads to premature neuronal differenti-ation, the lack of some cell types, and severe defects of tis-sue morphogenesis. Recent data demonstrate that Notchfails to inhibit cellular differentiation in the absence of thebHLH genes Hes1 and He5, which functionally afitago-nize the neuronal bHLH genes such as theh1- These re-sults indicate that the two Hes genes are essential effecorsfor the Notch pathway and that neuronal differentiation iscontrolled by the pathway "Notch-+He1/Hs5,Mish1".

关键词： bHLH Hes lateral inhibition neuron Notch

Complete response with sorafenib and transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第42期22卷 9445-9450页

作者： Michitoshi Takano Takashi Kokudo Yoshihiro Miyazaki Yumiko kageyama Amane Takahashi Katsumi Amikura Hirohiko Sakamoto Division of gastroenterological surgery Saitama Cancer Center

Patients with advanced hepatocellular carcinoma(HCC) showing portal vein tumor thrombosis(PVTT) have an extremely poor prognosis. According to treatment guidelines, the only option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. We herein report the first case of a patient with an initially unresectable advanced HCC with PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization(TACE) showing complete histological response. Two months after induction with sorafenib, a significant decrease in serum alpha-fetoprotein level was observed and computed tomography imaging showed a significant decrease in tumor size. Because of remaining PVTT, TACE and curative resection were performed. The combination of sorafenib and TACE may be an effective treatment for HCC patients with PVTT.

关键词： Hepatocellular carcinoma Sorafenib Complete response Portal vein tumor thrombosis Transcatheter arterial chemoembolization