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The Emotional Expression Response of a Patient Based on their Facial Expression—Focus on Music Stimuli

Health 2022年第11期14卷 1143-1160页

作者： masako higo Chiharu Akazawa Department of Nursing Science Sonoda Women’s University Hyogo Japan Doctoral Program Graduate School of Nursing Osaka Medical and Pharmaceutical University Osaka Japan

Objective: To determine whether patients with unresponsive wakefulness syndrome respond to auditory stimuli based on changes in facial expressions. Participants: Six patients diagnosed with disorders of consciousness due to brain injury with permission for participation from their doctor. Design: In this hypothesis-driven observational study, the facial expressions of patients with unresponsive wakefulness syndrome were video-recorded for 5 min before and during auditory stimulation in three consecutive weekly sessions. Main Measures: Facial muscle movement was quantified using FaceReader® software (Noldus, Wageningen, Netherlands). Valence/action unit values were plotted to detail facial expression changes. Heart rate values were also plotted. These parameters were compared before and after stimulation. Results: No significant differences in valence integral values or average heart rate were observed between the pre- and intra-stimulus conditions. However, valence signals increased in approximately half of the sessions, indicating that some patients with unresponsive wakefulness syndrome may exhibit emotional responses to auditory stimuli. Analysis of action unit integral values indicated that movement of the eyebrows and eyelids on the upper part of the face occurred during auditory stimulation. Furthermore, the types of auditory stimuli differed depending on the session for the 12 sessions of voice stimuli, whereas the changes in average heart rate differed in each of nine sessions of music stimuli. Because the changes in average heart rate were similar, it is possible that musical stimuli are more suitable than voice stimuli. Conclusion: Some patients with unresponsive wakefulness syndrome may have an emotional response to auditory stimuli. Our findings indicate that it may be possible to distinguish the emotional expression response of a patient based on their facial expression.

关键词： Facial Expression Unresponsive Wakefulness Syndrome Music Stimuli

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Sleeping Conditions of Older Adults with Delirium Receiving Home Care

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Health 2023年第8期15卷 895-907页

作者： masako higo Kiyomi Morimoto Department of Evidence-Based Clinical Nursing Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Department of Nursing Science Seisen University Shiga Japan

We aimed to clarify the sleep status before delirium onset among older adults receiving home care. The sleep status of 21 participants aged ≥65 years was monitored while they slept with a sensor placed under their bedding, after ruling out insomnia and dementia. The incidence of delirium was 28.6%;delirium onset occurred within an average of 2.7 (SD = 12) days after the start of home care among those whose care environment was changed due to hospital discharge or moving. Increased interrupted sleep and activity during sleep indicated that sleep fragmentation occurred before delirium onset. In conclusion, individuals aged ≥65 years and those whose care environment has changed should be screened for delirium because the time to delirium onset is short. Further, interventions to monitor the sleep status and prevent delirium onset should be implemented from the day home care begins.

关键词： Patients in Home Care Elderly Delirium Sleep

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Disease modeling of desmosome-related cardiomyopathy using induced pluripotent stem cell-derived cardiomyocytes

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World Journal of Stem Cells 2023年第3期15卷 71-82页

作者： Shuichiro higo Department of Medical Therapeutics for Heart Failure Osaka University Graduate School of MedicineSuita 565-0871Japan

Cardiomyopathy is a pathological condition characterized by cardiac pump failure due to myocardial dysfunction and the major cause of advanced heart failure requiring heart *** optimized medical therapies have been developed for heart failure during the last few decades,some patients with cardiomyopathy exhibit advanced heart failure and are refractory to medical ***,which is a dynamic cell-to-cell junctional component,maintains the structural integrity of heart *** mutations in desmo-somal genes cause arrhythmogenic cardiomyopathy(AC),a rare inheritable disease,and predispose patients to sudden cardiac death and heart *** advances in sequencing technologies have elucidated the genetic basis of cardiomyopathies and revealed that desmosome-related cardiomyopathy is concealed in broad *** desmosomal genes,mutations in PKP2(which encodes PKP2)are most frequently identified in patients with ***2 deficiency causes various pathological cardiac *** cardiomyocytes differentiated from patient-derived induced pluripotent stem cells(iPSCs)in combination with genome editing,which allows the precise arrangement of the targeted genome,are powerful experimental tools for studying *** review summarizes the current issues associated with practical medicine for advanced heart failure and the recent advances in disease modeling using iPSC-derived cardiomyocytes targeting desmosome-related cardiomyopathy caused by PKP2 deficiency.

关键词： Cardiomyopathy Advanced heart failure Induced pluripotent stem cell-derived cardiomyocytes Desmosome Genome editing Gene therapy

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Pressure and Temperature Dependences of Elastic Properties of Grossular Garnet up to 17 GPa and 1 650 K

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Journal of Earth Science 2010年第5期21卷 782-791页

作者： Yoshio Kono Steeve Gréaux Yuji higo Hiroaki Ohfuji Tetsuo Irifune Geodynamics Research Center Ehime University JASRI 1-1-1 Mikazuki-cho Sayo-gun Hyogo 679-5198 Japan

Simultaneous ultrasonic elastic wave velocity and in situ synchrotron X-ray measurements on grossular garnet were carried out up to 17 GPa and 1 650 K. P- and S-wave vdoeities and bulk and shear modulus showed linear pressure and temperature dependence. These data yielded a pressure derivative of the bulk modulus of 4.42（7） and a shear modulus of 1.27（3）, which are in good agreement with those of garnets with variable chemical compositions. Temperature dependence of the bulk modulus of grossular （-1.36×10^-2 GPafK） is also similar to that of other garnets, while the temperature dependence of the shear modulus of grossular （-1.11×10^-2 GPa/K） is higher than those of magnesium end-member garnets and pyrolitic garnet.

关键词： elastic property grossular garnet high pressure high temperature.

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Influence of Sowing Season and Host Crop Identity on the Community Structure of Arbuscular Mycorrhizal Fungi Colonizing Roots of Two Different Gramineous and Leguminous Crop Species

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Advances in Microbiology 2015年第2期5卷 107-116页

作者： Masao higo Katsunori Isobe Yukiya Matsuda Mio Ichida Yoichi Torigoe College of Bioresource Sciences Nihon University Fujisawa Japan

Introduction of cover crops may improve the diversity of arbuscular mycorrhizal fungi (AMF) in roots and soil under crop rotational systems;therefore, it is necessary to determine the potential for AMF communities to improve sustainable food production. We investigated the impact of cover crops, including wheat (Triticum aestivum L.), barley (Hordeum vulgare L.), pea (Pisum sativum L.), and hairy vetch (Vicia villosa Roth.), on the AMF communities in their roots in autumn and spring sowing seasons with PCR-DGGE analysis. Although all four cover crops impacted the AMF community structure in roots, the diversity of AMF communities was unchanged among crop type or sowing season. Redundancy analysis (RDA) demonstrated that AMF communities within crop type were significantly different. However, the AMF community structures were not influenced by growing season, suggesting that growth stage in crops may be more responsive to shaping AMF community structure in crop roots than host crop identity.

关键词： Arbuscular Mycorrhizal Fungi Community Structure Crop Identity Host Selectivity Sowing Season

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住友化学公司拟除虫菊酯杀虫气雾剂的生物学研究

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农药译丛 1989年第6期11卷 34-39,5页

作者： A.higo 晓岚日本住友化学公司家庭和公共卫生化学品部

本世纪三十年代,日本除虫菊干花产量创13,000吨的记录,约占当时世界总产量的70％。其中本国消费为1/3,其余2/3供出口,对象主要是美国。然而二次大战后,产量急剧下降,大量种植除虫菊的土地改种农作物。在日本,除虫菊素主要用于制造蚊香,... 详细信息

本世纪三十年代,日本除虫菊干花产量创13,000吨的记录,约占当时世界总产量的70％。其中本国消费为1/3,其余2/3供出口,对象主要是美国。然而二次大战后,产量急剧下降,大量种植除虫菊的土地改种农作物。在日本,除虫菊素主要用于制造蚊香,后从日本传播到其他大部分热带国家。由于蚊香使用广泛,因此住友公司当时就开始研究和开发化学合成除虫菊酯。

关键词：拟除虫菊酯气雾剂生物学杀虫剂

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如何打造价值导向的供应链？

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商学院 2012年第12期 I0055-I0056页

作者： Dario Gaspar Carlos higo 科尔尼

供应链管理往往比较粗放——商业和营销部门致力于满足所有必要的顾客需求，但供应链领域的目的是服务客户同时优化成本。更精确地从细分市场和协作的角度看待供应链对于公司及其顾客来说更有价值。通过决定如何给每个细分顾客市场提供... 详细信息

供应链管理往往比较粗放——商业和营销部门致力于满足所有必要的顾客需求，但供应链领域的目的是服务客户同时优化成本。更精确地从细分市场和协作的角度看待供应链对于公司及其顾客来说更有价值。通过决定如何给每个细分顾客市场提供价值，公司不仅能更好地给顾客提供需要的服务，而且同时可以保持利润增长。

关键词：供应链管理价值顾客需求导向服务客户细分市场营销部门市场提供

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Effects of Sowing Time on the Seed Yield of Quinoa (Chenopodium quinoa Willd) in South Kanto, Japan

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Agricultural Sciences 2016年第3期7卷 146-153页

作者： Katsunori Isobe Hikaru Sugiyama Daisuke Okuda Yudai Murase Hiroki Harada Misa Miyamoto Syunsuke Koide Masao higo Yoichi Torigoe College of Bioresource Sciences Nihon University Kanagawa Japan

The objective of the present study was to determine the optimum sowing time of three quinoa ecotypes (Altipllano, sea level, and valley) for high seed yields in south Kanto, Japan. Pot experiments were conducted in the experimental field at Nihon University during 2011, 2012, 2013, and 2014. In this experiment, the following quinoa varieties were used NL-6, Baer Cajon and Cauquenes (sea-level type), Amarilla de Marangani, Blanca de Junin, CICA-127, ECU-420, ECU-525, Ingapirica, and Narino (valley type), 94R and Isluga (Altiplano type). The quinoa seeds were sown on March 29, June 17 and September 22, 2011;March 27, June 17 and August 28, 2012;March 26, June 15 and 5 September 5, 2013;and March 27, June 17 and August 28, 2014. When the sea-level type and Altiplano type seeds were sowed from March to September, the seeds could be gained in all sowing plots. However, the seed weights of all varieties were the highest in the sowing plots of March. And the seed weights in the sowing plot of March were significantly higher than that in the other sowing plots. The sea-level type and Altiplano type quinoa had almost the same seed growth reaction for day length and day temperature. Thus, to gain a high seed yield of the sea-level and Altiplano type quinoa, March was the optimum sowing time in south Kanto, Japan. When the valley-type seeds were sowed from March to June, the seeds could not be gained, except in 2012. In 2012, the seed weights and seed numbers in sowing plots of March and June were significantly lower than those in the sowing plot of September. Thus, to obtain a high seed yield of the valley type quinoa, the optimum sowing time in south Kanto, Japan was from August to September.

关键词： Day Length Day Temperature Ecotype Sowing Time Quinoa

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Arbuscular Mycorrhizal Fungal Community Structure in Soybean Roots: Comparison between Kanagawa and Hokkaido, Japan

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Advances in Microbiology 2011年第1期1卷 13-22页

作者： Katsunori Isobe Kohei Maruyama Singo Nagai Masao higo Tomiya Maekawa Gaku Mizonobe Rhae A. Drijber Ryuichi Ishii 不详

The objectives of this study were to determine arbuscular mycorrhizal fungi (AMF) community structure in colonized roots of soybean cultivated from Kanagawa and Hokkaido in Japan and to relate the community structure to environmental conditions, which included soil type, preceding crops, and soil chemical properties. The average number of AMF OTU (operational taxonomic unit) colonizing soybean roots collected from Kanagawa and Hokkaido was 11.2 and 5.8, respectively, a significant difference. Moreover, AMF from the family Gigasporasera was not identified in soybean roots collected from Hokkaido, suggesting that AMF in the family Gigasporasea is absent or rare in the soybean fields of sampled in Hokkaido. We postulate that the soil type, preceding crops or soil chemical properties are not the underlying factor differentiating AMF community structure colonizing in soybean roots between Kanagawa and Hokkaido. Instead we conclude that temperature and phosphate absorption coefficient are the determining factors of AMF OTU in this study.

关键词： AM Fungi Colonization Community Structure Soybean

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Implementation of Quick HIV Tests in a Basic Health Unit in the Town of Santa Cruz-RN:Experiment Experienced by the PRO/PET-Saude Students

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Health 2015年第13期7卷 1782-1787页

作者： Ana Rafaela Dantas dos Santos Ana Mayara Gomes de Sousa Fernanda Diniz de Sá Adriana Gomes Magalhaes Fábia Barbosa de Andrade higo Luiz Amorim Belo Maia Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

This article is about a report of the experiment of PRO/PET-Saúde students in the anti-HIV tests implementation in the town of Santa Cruz-RN. The goal is to report the importance and discuss the aspects of the moment experienced above inside the basic health unit in the town of Santa Cruz-RN. The experience occurred in the months from February to March 2014 and they were conducted within 8 hours per week. This way, it is observed that the period lived made possible great reflection about the making of the examination in the pre-natal appointment routines, cataloguing challenges which come up during their adequacy within the services. Lastly, the action developed aimed for the aggregation of an active learning process in the search for a critical sense in the experienced practice, allowing and prioritizing the basic health unit as a scope of reference and counter-reference in the public health service, increasing concrete answers and the needs of the population, guaranteeing an adequate service delivery and strengthening the SUS more and more. The insertion of students through the PRO/PET-Saúde-Rede Cegonha enables a reorientation of professional formation, from the integration between service and teaching.

关键词： Pregnant Student Teaching-Service HIV Tests Vertical Transmissions

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