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Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 323-329页

作者： Masataka Amisaki Hiroaki saito Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Yoshiyuki Fujiwara Division of Surgical Oncology Department of SurgerySchool of MedicineTottori University Faculty of Medicine

Background: Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma(HCC).Methods: We included 145 HCC patients who underwent initial and curative resection between January2004 and December 2013. Postoperative complications of grade III or higher based on Clavien–Dindo classification were defined as clinically relevant postoperative complications. Recurrence within two years after hepatectomy was defined as early-phase ***: Thirty-eight patients(26%) developed postoperative complications. The only predictive factor for postoperative complication was longer operative duration(P = 0.037). The disease-specific survival rate of patients with complication was lower than that of patients without complications(P = 0.015). Earlyphase recurrence was observed in 20/38(53%) patients who suffered postoperative complications and36/107(34%) patients with no complications, which was statistically significant(P = 0.039). Multivariate analysis identified four factors contributing to early-phase recurrence: high serum AFP level(P = 0.042),multiple tumors(P < 0.001), poor differentiation(P = 0.036) and presence of postoperative complication(P = 0.039).Conclusions: Postoperative complication is an independent prognostic factor for early-phase recurrence after curative resection of HCC. Close observation of patients with postoperative complications may be a necessary treatment strategy for HCC.

关键词： Neoplasm metastasis Complications Risk factors Hepatocellular carcinoma

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Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma

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World Journal of Gastroenterology 2013年第31期19卷 5187-5194页

作者： Kazuhiro Takahashi Shigeki Tsukamoto Ken saito Nobuhiro Ohkohchi Katsu Hirayama Division of Gastro-enterological and Hepatobiliary Surgery and Organ Transplantation Department of Surgery University of Tsukuba Tsukuba 3058575 Japan Department of Surgery Hiraka General Hospital Yokote 0138610 Japan

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated *** with lymph node dissection followed by chemotherapy is the treatment of *** used for gastric adenocarcinoma are usually ***,median survival remains less than six *** this case report,we describe a case of primary gastric choriocarcinoma with a clinical complete response to multidisciplinary treatment including surgery,chemotherapy,and radiofrequency ablation(RFA).The patient was originally referred for general *** demonstrated a large tumor occupying the fornix,and total gastrectomy with lymph node dissection was *** days later,multiple liver metastatic recurrences with high serum levels of beta-human chorionic gonadotropin(β-hCG) were *** with a gonadal choriocarcinoma regimen consisting of etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA/CO),was *** three cycles,serum β-hCG decreased markedly and the tumors *** months later,multiple lung metastatic recurrences were *** one cycle of EMA/CO,only one nodule *** tomography-guided RFA was performed for this oligometastatic *** patient has been alive with no evidence of disease for 10 years after the initial *** the best of our knowledge,this patient with recurrent primary gastric choriocarcinoma has achieved the longest *** present case is the first report of choriocarcinoma metastatic to the lung successfully treated with *** our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma,we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma.

关键词： Primary gastric choriocarcinoma Betahuman chorionic gonadotropin Etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine Oligometastatic Radiofrequency ablation

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Dorsal approach for isolated volar fracture-dislocation of the base of the second metacarpal:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6871-6876页

作者： Taketo Kurozumi Masato saito Kazuhiko Odachi Fumiaki Masui Trauma Center Toranomon HospitalTokyo 105-8470Japan Department of Orthopedic Surgery Chiba-Nishi General HospitalChiba 270-2251Japan

BACKGROUND We report a case with the displacement of an articular fracture fragment of the base of the second metacarpal from the ulnar to the volar side,treated via the dorsal *** dorsal approach can be a good option not only because it allows direct observation of ligament damage and fixation of bone fragments but also because the thin subcutaneous tissue makes the approach *** SUMMARY A 45-year-old man with a right hand injury visited the hospital.A small bone fragment was identified using plain *** radiography revealed the fragment as lying over the volar aspect of the carpometacarpal(CMC)*** tomography revealed that approximately one-third of the CMC joint surface of the second metacarpal was *** provisionally diagnosed an intra-articular fracture with significant CMC joint instability and performed open reduction and internal *** made a dorsal longitudinal incision over the CMC joint between the second and third *** dorsal ligament of the third CMC joint was *** thought it had been dislocated to the volar side and spontaneously reduced to that *** are only few reports of volar dislocation of CMC joint fractures,particularly of the second and third metacarpals;our report is unique as our patient had an intact interosseous ligament between the second and third *** Although past reports have used a palmar approach,the dorsal approach is a good option for these cases.

关键词： Metacarpal bone Fracture-dislocation Mechanism Dorsal approach Carpometacarpal joint Case report

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A model to estimate available timber and forest biomass and reforestation expenses in a mountainous region in Japan

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Journal of Forestry Research 2013年第2期24卷 345-356页

作者： Kazuhiro Aruga Ayami Murakami Chikara Nakahata Reiko Yamaguchi Masashi saito Kanae Kanetsuki Department of Forest Science Faculty of Agriculture Utsunomiya University Frontier Agriscience and Technology Center Faculty of Agriculture Shinshu University Nasunogahara Land Improvement Districts

We developed a model to estimate supply potentials and available amounts of timber and forest biomass resources from profitable sub-compartments of thinning and final felling operations. Economic balances were estimated while considering not only harvesting expenses but also reforestation expenses after final felling, which should be considered for sustainable forest management. Harvesting expenses were estimated based on two types of timber harvesting systems and three types of forest biomass harvesting systems in each sub-compartment. Then, the model was applied to Nasushiobara city of Tochigi prefecture, Japan. Reforestation expenses had large negative impacts on the financial balances of final felling operations. Few sub-compartments were profitable after considering reforestation expenses. Most profitable sub-compartments were those with mechanized operation systems and landing sales. These accounted for 17.19% of all sub-compartments, while only 5.75% of the sub-compartments were profitable based on their current operation systems and landing sales. Although the overall supply potentials of timber and forest biomass resources were 380,000 m3 and 210,000 Mg, respectively, and 15 times the planned harvest of coniferous tree volume of 25,000 m3year-1 and 50 times the annual demand for the woody gasification power generation of 4,000 Mg year-1 in Nasushiobara, available amounts of timber and forest biomass resources were only49,429 m3 and 33,333 Mg, which were 13.0% and 15.7% of supply potentials for landing sales with mechanized operation systems.

关键词： forest biomass resources supply potentials available amounts economic balance GIS

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Flexible,solid-state,fiber-network-reinforced composite solid electrolyte for long lifespan solid lithium-sulfurized polyacrylonitrile battery

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Nano Research 2022年第4期15卷 3290-3298页

作者： Shiqiang Luo Enyou Zhao Yixuan Gu Nagahiro saito Zhengxi Zhang Li Yang Shin-ichi Hirano School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China Department of Chemical Systems Engineering Nagoya UniversityNagoya 4648603Japan Shanghai Electrochemical Energy Devices Research Center Shanghai 200240China Hirano Institute for Materials Innovation Shanghai Jiao Tong UniversityShanghai 200240China

Solid lithium-sulfur batteries(SLSBs)show potential for practical application due to their possibility for high energy ***,SLSBs still face tough challenges such as the large interface impedance and lithium dendrite ***,a highperformance SLSB is demonstrated by using a fiber network reinforced Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(LLZTO)based composite solid electrolyte(CSE)in combination with sulfurized polyacrylonitrile(SPAN)*** CSE consisting of an electrospun polyimide(PI)film,LLZTO ionically conducting filler and polyacrylonitrile(PAN)matrix,which is named as PI-PAN/LLZTO CSE,possesses high room-temperature ionic conductivity(2.75×10^(-4)S/cm),high Li^(+)migration number(tLi+)of 0.67 and good interfacial *** is utilized due to its unique electrochemical properties:reasonable electronic conductivity and no polysulfides shuttle *** CSE enables a highly stable Li plating/stripping cycle for over 600 h and good rate ***,the assembled SLSB exhibits good cycle performance of accomplishing 120 cycles at 0.2 C with the capacity retention of 474 mAh/g,good rate properties and excellent long-term cycling stability with a high capacity retention of 86.49%from 15^(th)to 1,000^(th)cycles at 1.0 *** work rationalizes our design concept and may guide the future development of SLSBs.

关键词： solid lithium-sulfur battery composite solid electrolyte sulfurized polyacrylonitrile cathode interfacial wettability dendritefree

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Increased utilization and mass activity of PtRu on reduced graphene oxide by heat treatment of its aerogel followed by composite with nanomaterials

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Carbon Resources Conversion 2023年第3期6卷 205-214页

作者： Kenta Dejima Hirokazu Ishitobi He Gao Mai saito Nobuyoshi Nakagawa Graduate School of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Division of Environmental Engineering Science Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Faculty of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan

The method to increase PtRu utilization and its catalytic activity of PtRu nanoparticles supported on reduced graphene oxide(RGO)by avoiding its restacking was proposed with the aim of developing an active catalyst for a direct methanol fuel *** heat treatment at 200◦C of the GO aerogel(GOA)prepared by freeze drying of GO ice was introduced to weaken the attractive force of the hydrogen bonding between the GO sheets followed by the composite with the nanoparticles,i.e.,ketjenblack(KB),TiO_(2)and Ti_(4)O_(7),at different weight *** catalyst supported on the heat-treated GOA(RGOA),PtRu/RGOA,improved the PtRu utilization to some extent and also increased the ECSA and mass activity compared to that of PtRu/*** had fewer oxygen functional groups,especially the epoxy *** to the treatment and composite,the PtRu utilization was increased from 66.5%for PtRu/RGO to 128.6%for PtRu/RGOA+Ti_(4)O_(7)(4:1)and the mass activity was improved from 50.7 A/g-PtRu for PtRu/RGO to 130.5 A/g-PtRu for PtRu/RGOA+Ti_(4)O_(7)(1:1).The Ti_(4)O_(7)nanoparticles showed the best catalytic performance for the composite suggesting that the strong interaction between Ti_(4)O_(7)and the Pt nanoparticles was effective due to its high electronic conductivity.

关键词： Reduced graphene oxide Restacking Catalyst utilization Mass activity Composite catalyst Methanol oxidation Ti4O7

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Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy

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World Journal of Gastroenterology 2013年第11期19卷 1673-1682页

作者： Junichi Iwamoto Yoshifumi saito Akira Honda Yasushi Matsuzaki Department of Gastroenterology Tokyo Medical UniversityIbaraki Medical CenterIbaraki 300-0395Japan

Low-dose aspirin(LDA) is clinically used for the prevention of cardiovascular and cerebrovascular events with the advent of an aging *** the other hand,a very low dose of aspirin(10 mg daily) decreases the gastric mucosal prostaglandin levels and causes significant gastric mucosal *** incidence of LDAinduced gastrointestinal mucosal injury and bleeding has *** has been noticed that the incidence of LDA-induced gastrointestinal hemorrhage has increased more than that of non-aspirin non-steroidal anti-inflammatory drug(NSAID)-induced *** pathogenesis related to inhibition of cyclooxygenase(COX)-1 includes reduced mucosal flow,reduced mucus and bicarbonate secretion,and impaired platelet *** pathogenesis related to inhibition of COX-2 involves reduced angiogenesis and increased leukocyte *** pathogenic mechanisms related to direct epithelial damage are acid back diffusion and impaired platelet *** factors associated with an increased risk of upper gastrointestinal(GI) complications in subjects taking LDA are aspirin dose,history of ulcer or upper GI bleeding,age > 70 years,concomitant use of non-aspirin NSAIDs including COX-2-selective NSAIDs,and Helicobacter pylori(***) ***,no significant differences have been found between ulcer and non-ulcer groups in the frequency and severity of symptoms such as nausea,acid regurgitation,heartburn,and *** has been shown that the ratios of ulcers located in the body,fundus and cardia are significantly higher in bleeding patients than the ratio of gastroduodenal ulcers in patients taking *** pump inhibitors reduce the risk of developing gastric and duodenal *** contrast to NSAIDinduced gastrointestinal ulcers,a well-tolerated histamine H2-receptor antagonist is reportedly effective in prevention of LDA-induced gastrointestinal *** eradication of *** is equivalent to treatment with omeprazole in preventing recurrent b

关键词： Gastroduodenal ulcer Upper gastrointestinal bleeding Low-dose aspirin Non-steroidal antiinflammatory drugs

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Drug-induced entero-colitis due to interleukin-17 inhibitor use;capsule endoscopic findings and pathological characteristics:A case report

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World Journal of Gastroenterology 2023年第32期29卷 4912-4919页

作者： Keita saito Kiichiro Yoza Shinichiro Takeda Yoshihiro Shimoyama Ken Takeuchi Department of Gastroenterology Tsujinaka Hospital Kashiwano-HaKashiwa 277-0871Japan

BACKGROUND Interleukin-17(IL-17)inhibitors are known to cause exacerbation or new onset of inflammatory bowel disease upon ***,few reports have described characteristic endoscopic and histopathologic findings,and no small intestinal lesions have been reported so *** SUMMARY A woman in her 60s with psoriasis was administered ixekizumab(IXE),an anti-IL-17A antibody,for the treatment of *** months after commencing treatment,the patient visited our hospital because of persistent *** tests performed at the time of the visit revealed severe inflammation,and colonoscopy revealed multiple round ulcers throughout the colon.A tissue biopsy of the ulcer revealed infiltration of inflammatory cells and granuloma-like findings in the submucosal *** endoscopy revealed multiple jejunal *** the withdrawal of IXE,the symptoms gradually improved,and ulcer reduction and scarring of the colon were endoscopically *** To the best of our knowledge,17 reports have documented IL-17 inhibitorinduced entero-colitis with endoscopic images,endoscopic findings,and pathological characteristics,including the present *** of these cases showed diffuse loss of vascular pattern,coarse mucosa/ulcer formation in the left colon,and endoscopic findings similar to those of ulcerative *** the remaining eight cases,discontinuous erosions and ulcerations from the terminal ileum to the rectum were seen,with endoscopic findings similar to those of Crohn’s *** this case,the findings were confirmed by capsule endoscopy,which has not been previously reported.

关键词： Interleukin-17 inhibitor Ixekizumab Drug-induced entero-colitis Capsule endoscopy Case report

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Corrosion behavior of hypereutectic Al-23%Si alloy (AC9A) processed by severe plastic deformation

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Transactions of Nonferrous Metals Society of China 2010年第2期20卷 195-200页

作者：江静华马爱斌宋丹 N. saito 袁玉春 Y. NISHIDA College of Materials Science and Engineering Hohai University Nanjing 210098 China National Institute of Advanced Industrial Science and Technology 2266-98 Anagahora Shimoshidami Moriyama-ku Nagoya 463-8560 Japan

Ultrafine-grained(UFG) hypereutectic Al-23%Si (mass fraction) alloy was achieved through equal-channel angular pressing(EACP) procedure. And the electrochemical properties after various ECAP passes were investigated in neutral NaCl solution. Potentiostatic polarization curves show that the corrosion potential of the ECAPed sample after 4 passes decreases markedly, while the corrosion current density reaches 1.37 times that of the as-cast alloy. However, the φcorr and Jcorr values after 16 passes are improved and approach those of the as-cast alloy. Immersion tests also show that the mass-loss ratio of ECAPed alloy decreases with increasing the pressing pass, which is lowered to 28.7% with the increase of pass number from 4 to 16. Pitting susceptibility of the ECAPed alloy after initial 4 passes is boosted, due to the presence of biggish voids resulted from the breakage of brittle large primary silicon crystals during ECAP. Increasing ECAP pass makes the voids evanesce and results in the homogeneous ultrafine-grained structure, contributing to a higher pitting resistance. These results indicate that enough ECAP passes are beneficial to increasing corrosion resistance of the hypereutectic Al-23%Si alloy.

关键词： aluminum casting alloys ECAP corrosion behavior ultrafine grained microstructure

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Combined preoperative platelet-to-lymphocyte ratio and serum carbohydrate antigen 19–9 level as a prognostic factor in patients with resected pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 278-284页

作者： Teruhisa Sakamoto Hiroaki saito Masataka Amisaki Naruo Tokuyasu Soichiro Honjo Yoshiyuki Fujiwara Division of Surgical Oncology Department of Surgery School of Medicine Tottori University Faculty of Medicine

Background: Carbohydrate antigen 19–9(CA19-9) is the most frequently used tumor marker and serves as a prognostic indicator in patients with pancreatic cancer(PC). The platelet-to-lymphocyte ratio(PLR) is thought to be an inflammation-related serum marker. An elevated PLR represents increased inflammatory status and is associated with poor prognosis in patients with various cancers including PC. Methods: This study involved 103 patients with a histopathological diagnosis of pancreatic ductal adenocarcinoma who underwent pancreatectomy. The patients were assessed to determine the prognostic significance of the combination of the PLR and CA19-9 level. Results: Based on the receiver operating characteristic analysis results, the patients were divided into PLR H igh(PLR ≥ 129.1) andPLRLow(PLR < 129.1) groups and into CA19-9High(CA19-9 ≥ 74.0 U/mL) and CA19-9Low(CA19-9 < 74.0 U/mL) groups. The cumulative 5-year overall survival(OS) and disease-specific survival(DSS) rates significantly differed by both the PLR(PLR H igh group: 19.5% and 22.9%;PLRLow group: 39.1% and 45.9%) and CA19-9(CA19-9 H igh group: 19.1% and 25.6%;CA19-9Low group: 41.0% and 41.0%). We then divided the patients into Groups A(PLR L ow/CA19-9Low), B(PLR Low/CA19-9High or PLRHigh/CA19-9Low), and C(PLR H igh/CA19-9High). The cumulative 5-year OS rates in Groups A, B, and C were 44.0%, 31.9%, and 11.9%, respectively( P = 0.002). The cumulative 5-year DSS rates in Groups A, B, and C were 47.7%, 36.4%, and 16.8%, respectively( P = 0.002). Multivariate analysis revealed that the combination of the PLR and CA19-9 was an independent prognostic factor in patients with resected PC. Conclusions: The combination of the PLR and CA19-9 is useful for predicting the prognosis of patients with resected PC.

关键词： CA19-9 Pancreatic cancer Platelet-to-lymphocyte ratio Prognosis

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