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In vitro discrimination between sedative and non-sedative histamine H1 receptor antagonists by an intact cell binding assay.

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In vitro discrimination between sedative and non-sedative hi...

Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis

第十五届国际药理学大会

作者： Hishinuma Shigeru saito masaki Department of Pharmacodynamics Meiji Pharmaceutical University Department of Pharmacodynamics Meiji Pharmaceutical University

＜正＞ We investigated the changes in the binding properties of sedative and non - sedative antihistamines by histamine（HA） - induced intemalization of histamine H1 receptors （H1Rs） in intact human U373 MG astrocytoma cells. Intemalization of H1Rs was induced without their degradation by treatment with 0.1 mM HA for 30 min at 37℃. The binding properties of [3H]mepyramine. a cell - penetrating radioligandfor H1Rs. were not changed by the HA pretreatment. The displacement curves for sedative antihistamines （6 drugs tested） against [3H]mepyramine binding were not changed by the HA pretreatment. In contrast, the displacement analyses for non - sedative antihistamines （5 drugs tested） showed that their affinities for H1Rs were reduced by the HA pretreatment. which was prevented under hy- pertonic conditions where the clathrin - mediated receptor intemalization was inhibited. These results suggest that non - sedative antihistamines have the lower affinities for the intracellular H1Rs than for the cell surface H1Rs. possibly due to their less accessibility through the biomembrane. This intact cell binding assay might provide us a novel method for screening sedative and non - sedative antihistamines in vitro.

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World Journal of Hepatology 2012年第1期4卷 11-17页

作者： Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi masaki saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi Division of Hepatobiliary and Pancreatic Disease Department of Internal Medicine Hyogo College of Medicine Department of Gasteroenterology Nissay Hospital

AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver ***: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P 3.0) was as follows: its sensitivity

关键词： Glycated albumin Glycated hemoglobin Liver fibrosis Liver biopsy Hepatitis C virus

Automated crystal structure analysis based on blackbox optimisation

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npj Computational Materials 2020年第1期6卷 1022-1028页

作者： Yoshihiko Ozaki Yuta Suzuki Takafumi Hawai Kotaro saito masaki Onishi Kanta Ono Artificial Intelligence Research Center(AIRC) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan GREE Inc.TokyoJapan Institute of Materials Structure Science(IMSS) High Energy Accelerator Research Organization(KEK)IbarakiJapan SOKENDAI(The Graduate University for Advanced Studies) IbarakiJapan Paul Scherrer Institute VilligenSwitzerland Medley IncTokyoJapan

In the present study,we show that time-consuming manual tuning of parameters in the Rietveld method,one of the most frequently used crystal structure analysis methods in materials science,can be automated by considering the entire trial-and-error process as a blackbox optimisation *** automation is successfully achieved using Bayesian optimisation,which outperforms both a human expert and an expert-system type automation despite the absence of *** approach stabilises the analysis quality by eliminating human-origin variance and bias,and can be applied to various analysis methods in other areas which also suffer from similar tiresome and unsystematic manual tuning of extrinsic parameters and human-origin variance and bias.

关键词： analysis black structure

Current status of function-preserving surgery for gastric cancer

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World Journal of Gastroenterology 2014年第46期20卷 17297-17304页

作者： Takuro saito Yukinori Kurokawa Shuji Takiguchi masaki Mori Yuichiro Doki Department of Gastroenterological Surgery Osaka University Graduate School of MedicineOsaka 565-0871Japan

Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early *** to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be ***-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric *** gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is ***,these disadvantages may be overcome by the reconstruction method *** other important problem after PG is remnant GC,which was reported to occur in approximately 5%of ***,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric *** safety seems to be assured in both procedures,if the preoperative diagnosis is *** selection should be carefully *** many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been *** prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery.

关键词： Gastric cancer Function preserving surgery Quality of life Pylorus preserving surgery Proximal gastrectomy

Post-operative albumin-bilirubin grade predicts long-term outcomes among Child–Pugh grade A patients with hepatocellular carcinoma after curative resection

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 502-509页

作者： Masataka Amisaki Ei Uchinaka masaki Morimoto Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Hiroaki saito Yoshiyuki Fujiwara Division of Surgical Oncology Department of Surgery School of Medicine Tottori University Faculty of Medicine

Background: Although Child–Pugh grade A patients with hepatocellular carcinoma(HCC) are candidates for curative resection, some may have a poor prognosis. The albumin-bilirubin(ALBI) grade, a measure of liver function based on albumin and bilirubin, has the potential to detect Child–Pugh grade A HCC patients with poor prognosis. Because components of the ALBI grade can be measured easily even after surgery, we explored the predictive values of ALBI in patient prognosis after HCC resection. Methods: In this retrospective case-control study, we included 136 HCC patients who underwent curative resection between January 2004 and December 2013 at our hospital. ALBI grade was calculated from laboratory data recorded the day before surgery and at post-operative day 5. Results: Pre-and post-operative ALBI grade predicted patients’ long-term outcomes( P = 0.020 and P < 0.001, respectively, for overall survival, and P = 0.012 and P = 0.015, respectively, for recurrence-free survival). Post-operative ALBI grade was associated with patients’ surgical factors of repeated hepatic resection( P = 0.012), intra-operative bleeding( P = 0.006), and surgery duration( P = 0.033). Furthermore, post-operative ALBI grade, rather than pre-operative ALBI grade, was an independent predictive factor of long-term outcome of Child–Pugh grade A patients with HCC. Conclusions: Post-operative ALBI grade is useful to predict the prognosis in patients after HCC resection.

关键词： Prognosis Hepatic resection Albumin Bilirubin

Measurement of Ion Cyclotron Emissions by Using High-Frequency Magnetic Probes in the LHD

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Plasma Science and Technology 2013年第3期15卷 209-212页

作者： Kenji saito Ryuhei KUMAZAWA Tetsuo SEKI Hiroshi KASAHARA Goro NOMURA Fujio SHIMPO Hiroe IGAMI Mitsutaka ISOBE Kunihiro OGAWA Kazuo TOI masaki OSAKABE masaki NISHIURA Tsuguhiro WATANABE Satoshi YAMAMOTO Makoto ICHIMURA Takashi MUTOH National Institute for Fusion Science Graduate School of Engineering Nagoya University Institute of Advanced Energy Kyoto University Tsukuba University Plasma Research Center

Two pairs of high-frequency magnetic probes were installed in the Large Helical Device （LHD）. During the injection of a perpendicular neutral beam, ion cyclotron emissions （ICEs） with the fundamental frequency corresponding to the ion cyclotron frequency at the plasma edge were detected, which are the same type of ICE as measured with the former spare ion cyclotron range of frequencies （ICRF） heating antennas. This type of ICE was further investigated with regard to the phase and intensity of signals. Another type of ICE was found in the LHD, and these ICEs were synchronized with bursts of toroidicity induced Alfv^n eigenmodes （TAE） and the rise of intensity of lost ion flux. Therefore the source of these ICEs was thought to be the particles transferred from the core to the outer region of plasma by the TAE bursts. The frequency of ICEs induced by the TAE bursts increases linearly with the magnetic field strength, since the ion cyclotron frequency increases with the magnetic field strength.

关键词： LHD ICE TAE lost particle high-frequency magnetic probe

East Asia Winter Monsoon changes inferred from environmentally sensitive grain-size component records during the last 2300 years in mud area southwest off Cheju Island,ECS

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Science China Earth Sciences 2006年第6期49卷 604-614页

作者： Yoshiki saito Geological Survey of Japan Tsukuba Ibaraki 305-8567 Japan

Environmentally sensitive grain-size component (ESGSC) extracted from grain-size data of a sediment core B2, which were retrieved from mud area southwest off Cheju Island (MACI), East China Sea (ECS), can be used to indicate the variations of East Asia Winter Monsoon (EAWM), with high (low) content/mean-size of ESGCS denote to strong (weak) EAWM. Combined with AMS14C datings core B2 provides a continuous high-resolution record of EAWM changes over the past 2300 years, with an average resolution of 13 years. The results show that the variations of EAWM are con-sistent with temperature changes inferred from historical documents in eastern China over the past 2300 years, from which four climate stages may be identified. In stages before 1900 aBP (50 AD) and 1450―780 aBP (50―1170 AD) the EAWM were comparatively weak, corresponding to warm climate periods in eastern China, respectively. And in stages of 1900―1450 aBP (50―500 AD) and 780―219 aBP (1170―1731 AD) the EAWM were strongly developed, which correspond well to climate changes of two cold periods in eastern China. It is also shown from this study that the stage at 780―219 aBP (1170―1731 AD) was the coldest climate period during the last 2300 years and could be, therefore, related to the Little Ice Age (LIA). Climatic fluctuations appeared obviously in all the four stages, and two climate events of abrupt changes from warm to cold occurred at around 1900 aBP (50 AD) and 780 aBP (1170 AD), of which the latter is probably related to globe-scale changes of atmospheric circulation at that time.

关键词： East China Sea, mud area, environmentally sensitive grain-size component, East Asia Winter Monsoon, Little Ice Age, Late Holocene.

Multilayer polarization elements and their applications to polarimetric studies in vacuum ultraviolet and soft X-ray regions

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Nuclear Science and Techniques 2008年第4期19卷 193-203页

作者： WATANABE Makoto HATANO Tadashi saito Katsuhiko HU Weibing EJIMA Takeo TSURU Toshihide TAKAHASHI Masahiko KIMURA Hiroaki HIRONO Toko WANG Zhangshan CUI Mingqi YAMAMOTO masaki YANAGIHARA Mihiro Shanghai Dianji University Shanghai 200240 China Institute of Composite Materials Shanghai Jiaotong University China and Venture Business Laboratory Saga University Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University Sendai 980-8577 Japan Changchun Institute of Optics Fine Mechanics and Physics Changchun 130033 China Japan Synchrotron Radiation Research Institute SPring-8 Hyogo 679-5198 Japan Institute of Precision Optical Engineering Tongji University Shanghai 200092 China BSRF Institute of High Energy Physics Beijing 100049 China

Multilayer polarization elements and their applications to polarimetric studies in 20～400 eV region are mainly reviewed. General principle of selecting material combinations to get high linear polarizance multilayers of reflection type is given with practical examples,with periodic or non-periodic layer structures depending on the usage. Transmission type is introduced as linear polarizer and phase shifter. Their applications include polarization diagnosis of laboratory optical systems and synchrotron radiation beamlines of linear and circular polarization,magnetic rotation experiments such as Faraday rotation and magnetic Kerr rotation on magnetic films and multilayers,and ellipsometry to measure optical constants of thin films precisely. Polarization analysis of soft X-ray fluorescence using multilayer-coated grating is also mentioned. Finally this review is summarized with outlook of further developments.

关键词： X射线偏振色散核技术

A Bubble Column Dehumidifier using Ionic Liquid Desiccant for Low-Humidity Industries: Insights into Transfer Processes Integrating Experiment and CFD Modelling

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Journal of Thermal Science 2024年第6期33卷 2348-2371页

作者： CAO Bowen YIN Yonggao saito Kiyoshi School of Energy and Environment Southeast UniversityNanjing 210096China School of Fundamental Science and Engineering Waseda UniversityTokyo 169-8555Japan Department of Applied Mechanics and Aerospace Engineering Waseda UniversityTokyo 169-8555Japan

Liquid desiccant deep dehumidification(LDDD)is an excellent energy-saving technology for low-humidity *** liquids(ILs)are favored as optimal working fluids for LDDD,owing to their low vapor pressure,non-crystallization,and *** combined application of IL desiccant with the bubble column has been proven to effectively improve deep *** present work focuses specifically on the insights into air-liquid transfer processes in bubble column dehumidifier using ionic liquid *** effect of operating parameters on volumetric transfer coefficient is examined based on the experimental ***,the bubble swarms meso-scale flow structure is predicted using computational fluid dynamics coupled with a population balance model(CFD-PBM).Besides,the structure-activity relationship between meso-scale flow structure and transfer performance is *** results indicated a notable phenomenon of bubble aggregation/breakage in the moist air-IL desiccant bubbly deep dehumidification(MA-ILD BDD)system,with a specific interfacial area is basically less than 40 m^(-1).Meanwhile,a decrease in solution temperature,correlated with a significant increase in viscosity,leads to larger turbulent eddies and a slower breakage ***,a high transfer potential difference enhances heat and mass transfer coefficients at lower solution temperatures,with the mass transfer coefficient at 4℃ being approximately three times that at 10℃.As the superficial velocity changes,the specific interfacial area and heat and mass transfer coefficients have a positive synergistic effect on volumetric transfer ***,this synergistic effect is reversed with variations in solution *** study aims to clarify the air-liquid transfer mechanism in bubble column dehumidifierusingILdesiccant.

关键词： liquid desiccant ionic liquid bubble column deep dehumidification heat and mass trans low-humidityindustries