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Change in microstructural characteristics of laser powder bed fused Al–Fe binary alloy at elevated temperature

Journal of Materials Science & Technology 2022年第2期97卷 38-53页

作者： Xing Qi Naoki Takata Asuka Suzuki Makoto Kobashi masaki kato Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Aichi Center for Industry and Science Technology 1267-1 AkiaiYakusa-choToyota 470-0356Japan

The present study addressed the change in the microstructure of Al-2.5 wt%Fe binary alloy produced using laser powder bed fusion(L-PBF)technique by thermal exposure at 300℃,and the associated mechanical and thermal properties were systematically examined as ***-semi-cylindrical patterns corresponding to melt pools in the microstructure were macroscopically observed for the asmanufactured *** change in the melt-pool morphology was observed after thermal exposure for1000 *** the melt pools,a large number of the nanoscale metastable Al6 Fe phase particles were uniformly distributed inside columnar grains of theα-Al matrix containing concentrated solute Fe in *** sequential formation and coarsening of stableθ-Al13 Fe4 phases were observed upon exposure to a 300℃ environment,but a considerable amount of nano-sized metastable Al6 Fe phases remained even after 1000 ***,the thermal exposure continuously reduced the concentration of solute Fe atoms in theα-Al *** significant grain growth was found inα-Al matrix after 1000 h owing to the pinning effect of the dispersed fine particles on grain boundary *** results demonstrate a sluggish change in microstructural morphologies of the Al-2.5 wt%Fe *** quantified microstructural parameters addressed dominant strengthening contributions by the solid solution of Fe element and Orowan strengthening mechanism by fine Al-Fe intermetallics in the L-PBF-produced *** high strength level was sustained even after being exposed to 300℃ for long *** superior balance of mechanical properties and thermal conductivity can be achieved in the experimental alloys by taking advantage of the various microstructural parameters related to the Al-Fe intermetallic phases andα-Al matrix.

关键词： Al-Fe alloy Laser powder bed fusion Phase transformation Microstructure Tensile properties

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Microstructural origins of high strength of Al-Si alloy manufactured by laser powder bed fusion:In-situ synchrotron radiation X-ray diffraction approach

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Journal of Materials Science & Technology 2024年第11期178卷 80-89页

作者： Naoki Takata Mulin Liu Masahiro Hirata Asuka Suzuki Makoto Kobashi masaki kato Hiroki Adachi Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603 Japan Graduate School of Engineering University of HyogoHimeji 671-2280Japan Aichi Center for Industry and Science Technology 1267-1 AkiaiYakusa-choToyota 470-0356 Japan

The microstructural factors contributing to the high strength of additive-manufactured Al-Si alloys us-ing laser-beam powder bed fusion(PBF-LB)were identified by in-situ synchrotron X-ray diffraction in tensile deformation and transmission electron ***-LB and heat treatment were employed to manufacture Al-12%Si binary alloy specimens with different *** an early stage of de-formation prior to macroscopic yielding,stress was dominantly partitioned into the α-Al matrix,rather than the Si phase in all *** concentrated Si solute(~3%)in the α-Al matrix promoted the dynamic precipitation of nanoscale Si phase during loading,thereby increasing the yield *** macroscopic yielding,the partitioned stress in the Si phase monotonically increased in the strain-hardening regime with an increase in the dislocation density in the α-Al *** a later stage of strain hardening,the flow curves of the partitioned stress in the Si phase yielded stress relaxation owing to plastic ***,Si-phase particles localized along the cell walls in the cellular-solidified microstructure play a significant role in dislocation obstacles for strain *** with the results of the heat-treated specimens with different microstructural factors,the dominant strengthening factors of PBF-LB manufactured Al-Si alloys were discussed.

关键词： Laser powder bed fusion Aluminum alloys Microstructures X-ray diffraction(XRD) Strain hardening

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Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

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World Journal of Gastroenterology 2014年第10期20卷 2653-2663页

作者： Kosuke Tanaka Yuko masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta masaki kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan Department of Clinical Pharmacology Faculty of Pharmaceutical Science Fukuoka University Fukuoka 814-0180 Japan Department of Gastroenterology Kyushu Medical Center National Hospital Organization Fukuoka 810-8563 Japan Innovation Center for Medical Redox Navigation Kyushu University Fukuoka 812-8582 Japan

AIM: To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease (NAFLD).

关键词： Adipose tissue Energy expenditure Exenatide Glucagon-like peptide-1 Hepatic steatosis Lipolysis Nonalcoholic fatty liver disease

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Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第29期23卷 5379-5385页

作者： Masayuki Miyazaki Masayoshi Yada Kosuke Tanaka Takeshi Senjyu Takeshi Goya Kenta Motomura Motoyuki Kohjima masaki kato Akihide Masumoto Kazuhiro Kotoh Department of Hepatology Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical Science Kyushu University Department of Hepatology Harasanshin Hospital

To investigate the factors influenced the efficacy of tolvaptan (TLV) in liver cirrhosis. METHODSWe retrospectively enrolled 61 consecutive patients with refractory hepatic ascites. All of them had been treated with furosemide and spironolactone before admission, and treated with TLV for 7 d in our hospital. The effect of TLV was defined by the rate of body weight loss, and the factors that influenced TLV efficacy were analyzed using multiple regression. RESULTSCoexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV. In stratified analysis, high doses of furosemide decreased the efficacy of TLV in patients with HCC, and increased efficacy in those without HCC. In the latter, a high Child-Pugh-Turcotte score had a positive influence and a high concentration of lactate dehydrogenase had a negative influence on the effectiveness of TLV. CONCLUSIONDevelopment of ascites may differ between patients with liver failure and those with HCC progression. A sufficient preceding dose of furosemide decreases diuretic effect of TLV.

关键词： Ascites Tolvaptan Furosemide Cirrhosis Hepatocellular carcinoma

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Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation

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World Journal of Gastroenterology 2015年第2期21卷 533-540页

作者： Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita Nozomi Sato masaki kato Fumio Itoh Department of Gastroenterology and Hepatology St.Marianna UniversitySchool of MedicineKawasaki 216-8511Japan

AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.

关键词： Disseminated intravascular coagulation Acute chola

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Fabrication of ZrC/ZrB₂/C Composites Having High Mechanical Properties at Elevated Temperatures

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Materials Sciences and Applications 2022年第4期13卷 232-248页

作者： Kai Matsumoto masaki kato Ken Hirota Toshiyuki Nishimura Department of Molecular Chemistry & Biochemistry Faculty of Science & Engineering Doshisha University Kyotanabe Japan National Institute for Materials Science Tsukuba Japan

Ultra-high temperature ceramics (UHTCs) are most recently getting much attention for structural parts of hypersonic missiles with their cruising speed of more than Mach 5. Most of the UHTCs are poor sinterability carbides, nitrides, and borides. Therefore, they have been studied and developed for a long time. However, there are still many problems to solve. In this paper, based on the solid-state reaction presented as an equation of (x + y)·ZrC + 2·y·B → x·ZrC + y·ZrB2 + y·C, three-phase ZrC/ZrB2/C composites have been fabricated from ZrC and amorphous B powders using pulsed electric-current pressure sintering at 1373 to 2173 K for 6.0 × 102 s under 50 MPa in a vacuum. ZrC/ZrB2/C = 30/70/C~70/30/C vol% composites with the relative densities Dr of 96.6 to 98.7% were obtained at 2073 K. The 60/40/C vol% composite revealed high bending strength σb (554 MPa), Vickers hardness Hv (19.2 GPa) and moderate fracture toughness KIC (5.25 MPa·m1/2) at room temperature. Furthermore, all composites showed elastic deformation up to 1873 K and revealed σb more than 600 MPa at this temperature, in addition, some composites showed higher σb than 900 MPa at the same temperature. These high mechanical behaviors are discussed with those of the simple binary ZrC/ZrB2 composites which were fabricated under the same conditions except for their starting materials. The best mechanical properties of binary composites were σb (474 MPa), Hv (18.5 GPa), and KIC (4.45 MPa·m1/2) at room temperature, and σb of 400 - 700 MPa at 1873 K. Overall, three-phase composites, nevertheless including soft carbon, have higher mechanical properties than the binary composites.

关键词： ZrC ZrB2 C Composites Pulsed Electric-Current Pressure Sintering Mechanical Properties

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A new treatment strategy for acute liver failure

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World Journal of Hepatology 2010年第11期2卷 395-400页

作者： Kazuhiro Kotoh masaki kato Motoyuki Kohjima Makoto Nakamuta Munechika Enjoji Department of Hepatology and Pancreatology Kyushu University Hospital Department of Gastroenterology and Clinical Research Center Kyushu Medical Center National Hospital Organization Health Care Center Fukuoka University

Acute liver failure (ALF) is a syndrome def ined by coa g ulopathy and encephalopathy and no effective treat ments have been established, except for liver transplantation. However, considering the limited supply of donors, we should endeavor to prevent the progre ssion of this syndrome in its early stage to improve the prognosis of patients with ALF. Recently, several authors have reported that over-activation of intrahepatic macrophages plays an important role in the progression of ALF and we have developed a new treatment method, transcatheter arterial steroid injection therapy (TASIT), to suppress macrophage activation. We have now used TASIT for 5 years and have found that TASIT is effective for patients with over-activation of macrophages in the liver but not for those with les ser activation of macrophages. Therefore, to identify the most appropriate patients for TASIT, we tried to categorize patients with ALF or acute liver injury according to markers for the degree of intrahepatic macrophage activation. This approach was helpful to select the appro-priate treatment including liver transplantation. We believe that it is essential to analyze disease progression in each patient before selecting the most appropriate treatment.

关键词： Acute liver failure Steroids Macrophages Hepatitis Ferritin

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Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia

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World Journal of Gastroenterology 2011年第44期17卷 4928-4931页

作者： Masayuki Miyazaki Masatake Tanaka Akihiro Ueda Tsuyoshi Yoshimoto masaki kato Makoto Nakamuta Kazuhiro Kotoh Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization

Drug-induced hypersensitivity syndrome(DIHS) is a severe reaction usually characterized by fever,rash,and multiorgan failure,occurring 2-6 wk after drug *** is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine release.A 54-year-old woman was diagnosed with rheumatic arthritis and initiated salazosulfapyridine by *** 10 d later,she had a high fever,skin rash and liver *** was admitted to hospital and diagnosed with a drug *** was treated with oral prednisolone 30 mg/d;however,she developed high fever again and her blood tests showed acute liver failure and cytopenia associated with *** was diagnosed with acute liver failure and hemophagocytosis caused by *** was transferred to the Department of Medicine and Bioregulatory Science,Kyushu University,where she was treated with arterial steroid injection *** this treatment,her liver function improved and serum ferritin immediately *** hypothesized that an immune-mediated reaction in DIHS may have generated over-activation of macrophages and T-lymphocytes,followed by a cytokine storm that affected various *** measurement of serum ferritin might be a useful marker of the severity of DIHS.

关键词： Acute liver failure Drug-induced hypersensitivity syndrome Ferritin Human herpes virus 6 Macrophage

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Antithrombin Ⅲ injection via the portal vein suppresses liver damage

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World Journal of Gastroenterology 2012年第16期18卷 1884-1891页

作者： Masayuki Miyazaki masaki kato Masatake Tanaka Kosuke Tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide Ito Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-0065Japan Department of Clinical Pharmacology Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-0180Japan

AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver ***:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal *** Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and *** levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were ***:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control *** vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin *** treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme ***:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities.

关键词： Antithrombin Ⅲ Acute liver failure Intravascular coagulation Portal vein

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Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virusinfected liver

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World Journal of Gastroenterology 2015年第11期21卷 3291-3299页

作者： Motoyuki Kohjima Tsuyoshi Yoshimoto Munechika Enjoji Nobuyoshi Fukushima Kunitaka Fukuizumi Tsukasa Nakamura Miho Kurokawa Nao Fujimori Yusuke Sasaki Yasushi Shimonaka Yusuke Murata Susumu Koyama Ken Kawabe Kazuhiro Haraguchi Yorinobu Sumida Naohiko Harada masaki kato Kazuhiro Kotoh Makoto Nakamuta Department of Gastroenterology and Clinical Research Center National Hospital Organization Kyushu Medical Center Health Care Center Fukuoka University Product Research Department Chugai Pharmaceutical Co.Ltd. Department of Medicine and Bioregulatory Science Kyushu University

AIM:To investigate the relationship between the ironmetabolism-related gene expression profiles and efficacy of antiviral therapy in chronic hepatitis C ***:The hepatic expression profile of ironmetabolism-related genes was analyzed and its association with virological response to pegylated-interferon plus ribavirin combination therapy was evaluated.A hundred patients with chronic hepatitis C(genotype1b,n = 50; genotype 2,n = 50) were enrolled and retrospectively *** biopsy samples were subjected to quantitative polymerase chain reaction for iron-metabolismrelated genes and protein expression(Western blotting analysis) for *** a control,normal liver tissue was obtained from 18 living donors of liver *** hepcidin level was measured by sensitive liquid chromatography/electrospray ionization tandem mass ***:Iron overload is associated with liver damage by increasing oxidative stress and hepatitis C virus(HCV)is reported to induce iron accumulation in hepatocytes in ***,iron administration suppresses HCV replication in ***,the association between HCV infection and iron metabolism remains *** with controls,patients had significantly higher gene expression for transferrin,iron-regulatoryproteins 1 and 2,divalent metal transporter 1,and ferroportin,but similar for transferrin receptors 1 and2,and *** the expression profiles were compared between sustained virological response(SVR)and non-SVR patients,the former showed significantly lower transcription and protein expression of hepcidin and *** of hepcidin-regulating genes,BMPR1,BMPR2,and hemojuvelin,was significantly increased,whereas BMP2 was decreased in HCV-infected ***2 and hemojuvelin expression was significantly lower in the SVR than non-SVR *** infection affects the expression of iron-metabolism-related genes,leading to iron accumulation in ***:Decrea

关键词： Chronic hepatitis C Iron-metabolism Hepcidin Ferro

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