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A case of a patient positive for anti-cardiolipin antibodies with recurrent fetal wastage and cerebral infarction who was successfully treated with Sairei-to, low dose aspirin, and heparin

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 398-401页

作者： Taro Nonaka Makoto Chihara Izumi Ooki masaki tamura Takumi Kurabayashi Koichi Takakuwa Department of Obstetrics and Gynecology Niigata City General Hospital Niigata Japan Department of Obstetrics and Gynecology Niigata University General Hospital of Medical and Dental Sciences Niigata Japan

We report a successful case of a pregnant female positive for anti-cardiolipin antibodies who experienced two abnormal pregnancies with postpartum cerebral hemispheric infarctions. A 38-year-old female diagnosed as being positive for anti-cardiolipin antibodies was referred to our hospital due to her strong desire to have a baby. The administration of Japanese herbal medicine, Sairei-to, as immunosuppressive therapy, and low dose aspirin, as anti-coagulation therapy, were initiated prior to the patient’s pregnancy. Five months after beginning the treatment, the patient conceived spontaneously. At 34 weeks of gestation, emergency cesarean section was performed due to increasing genital bleeding resulting from coincidental placenta previa and the patient delivered an appropriate-for-date female infant (1970 g). Treatment with Japanese herbal medicine (Sairei-to) and low-dose aspirin is considered to be an effective treatment option for patients positive for anti-phospholipid antibodies with past histories of abnormal pregnancies.

关键词： Anti-Cardiolipin Antibody Postpartum Cerebral Hemispheric Infarction Abnormal Pregnancy Sairei-to Low Dose Aspirin

資源環境の保全をめざした二次副産材を導入するコンクリ一ト材料の発展的利用に関する研究

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青岛理工大学学报 2009年第4期30卷 43-50页

作者：田村雅紀依田和久大島正記藤順一工学院大学鹿島技術研究所 BASFポゾリス八洋コンサルタント

日本では,21世紀半ばに人工の固体物質の代表である解体コンクリ一ト塊の排出量がピ一クを迎えると同時に,最終処分が困難になる状況が想定されていることから,コンクリ一ト材料の完全資源型の利活用要求はより一層高まるといえる.本研... 详细信息

日本では,21世紀半ばに人工の固体物質の代表である解体コンクリ一ト塊の排出量がピ一クを迎えると同時に,最終処分が困難になる状況が想定されていることから,コンクリ一ト材料の完全資源型の利活用要求はより一層高まるといえる.本研究は,副産微粉,再生骨材などの二次副産材を積極的に混和し,同一産地.種類型の調合条件のもとで,コンクリ一トの物性改善,資源有効利活用を目的としたコンクリ一トを製造し,その基礎的物性の評価と環境影響評価を行い,環境保全に資するコンクリ一ト材料の発展的利用のあり方を検討した.

关键词：资源保存二次副产材再生骨材微粉

原因不明习惯性流产患者封闭抗体活性与肿瘤坏死因子-α的关系

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上海医学 2005年第9期28卷 741-743页

作者：朱洁萍高桑好一横尾朋和大木泉菊池朗田村正毅田中宪一上海交通大学附属第六人民医院妇产科 200233 日本新泻大学大学院产妇人科

目的观察原因不明习惯性流产(RSA)患者的封闭抗体效应与辅助性T细胞(Th)1型免疫之间的关系。方法以20例连续发生过3次以上早期自然流产的患者作为观察对象。采用比重离心法从外周血中提取淋巴细胞,以1×106/ml浓度加入含有1%小牛血清的R... 详细信息

目的观察原因不明习惯性流产(RSA)患者的封闭抗体效应与辅助性T细胞(Th)1型免疫之间的关系。方法以20例连续发生过3次以上早期自然流产的患者作为观察对象。采用比重离心法从外周血中提取淋巴细胞,以1×106/ml浓度加入含有1%小牛血清的RPMI中。每毫升淋巴细胞悬浮液中加入植物血凝素(PHA)2μg培养72 h。采用酶联免疫吸附试验(ELISA法)检测培养液中肿瘤坏死因子(TNF)-α的水平。采用混合淋巴细胞培养方法检测研究对象的封闭抗体效应(MLR-BE),>22%为阳性,≤22%为阴性。分析TNF-α水平与MLR-BE的关系。结果20例患者TNF-α的平均浓度为(561.0±522.9)pg/ml,平均MLR-BE为(-6.5±37.6)%(阴性14例、阳性6例)。MLR-BE阴性患者的TNF-α水平为(676.1±585.0)pg/ml,显著高于MLR-BE阳性患者的(292.5±159.5)pg/ml(P0.05)。结论MLR-BE可能影响母体Th1/Th2的平衡,从而导致习惯性流产的发生。

关键词：习惯性流产封闭抗体肿瘤坏死因子-α 辅助性T细胞1型/2型阴性患者原因不明抗体活性封闭酶联免疫吸附试验 TNF-α

Hybrid Operation of Fault Current Limiter and Thyristor Controlled Braking Resistor

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Journal of Energy and Power Engineering 2012年第4期6卷 601-608页

作者： masaki Yagami Junji tamura Department of Electrical and Digital Systems Engineering Hokkaido Institute of Technology Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

The effectiveness of a combination of fault current limiter and thyristor controlled braking resistor on power system stability enhancement and damping turbine shaft torsional oscillations has been studied. If both devices operate at the same bus, the stabilization control scheme can be carried out continuously and with flexibility. As a result, the fault currents are limited, and the generator disturbances and the turbine shaft torsional oscillations are converged quickly. In this paper, the effectiveness of the combination of both devices has been demonstrated by considering 3LG （three-lines-to-ground） fault in a two-machine infinite bus system. Also, temperature rise effect of both devices with various resistance values and weights has been demonstrated. Simulation results indicate a significant power system stability enhancement and damping turbine shaft torsional oscillations as well as with allowable temperature rise.

关键词： Fault current limiter thyristor controlled braking resistor fault current power system stability turbine shaft torsional oscillation temperature rise effect.

Transient Stability Assessment of Synchronous Generator in Power System with High-Penetration Photovoltaics

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Journal of Mechanics Engineering and Automation 2012年第12期2卷 762-768页

作者： masaki Yagami Takahiko Hasegawa Junji tamura Department of Electrical and Digital Systems Engineering Hokkaido Institute of Technology Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

As photovoltaic （PV） capacity in power system increases, the capacity of synchronous generator needs to be reduced relatively. This leads to the lower system inertia and the higher generator reactance, and hence the generator transient stability may negatively be affected. In particular, the impact on the transient stability may become more serious when the considerable amounts of PV systems are disconnected simultaneously during voltage sag. In this work, the generator transient stability in the power system with significant PV penetration is assessed by a numerical simulation. In order to assess the impact from various angles, simulation parameters such as levels of PV penetration, variety of power sources （inverter or rotational machine）, and existence of LVRT capability are considered. The simulation is performed by using PSCAD/EMTDC software.

关键词： High-penetration photovoltaics low-voltage ride-through (LVRT) synchronous generator transient stability.

Transient Stability Analysis of Power System with Photovoltaic Systems Installed

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Journal of Energy and Power Engineering 2015年第10期9卷 896-904页

作者： masaki Yagami Seiichiro Ishikawa Yoshihiro Ichinohe Kenji Misawa Junji tamura Department of Electrical and Electronic Engineering Hokkaido University of Science Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

The impact of large-scale grid-connected PV （photovoltaics） on power system transient stability is discussed in this paper. In response to an increase of PV capacity, the capacity of conventional synchronous generator needs to be reduced relatively. This leads to the lower system inertia and the higher generator reactance, and hence, the power system transient stability may negatively be affected. In particular, the impact on the transient stability may become more serious when the considerable amounts of PV systems are disconnected simultaneously during voltage sag. In this work, the potential impact of significant PV penetration on the transient stability is assessed by a numerical simulation using PSCAD/EMTDC.

关键词： Photovoltaic LVRT (low-voltage ride-through) synchronous generator infinite bus transient stability.

Transient Stability Assessment of Synchronous Generator in Power System with High-Penetration Photovoltaics （Part 2）

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Journal of Mechanics Engineering and Automation 2015年第7期5卷 401-406页

作者： masaki Yagami Seiichiro lshikawa Yoshihiro Ichinohe Kenji Misawa Junji tamura Department of Electrical and Electronic Engineering Hokkaido University of Science Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

In the previous paper [1], the transient stability of synchronous generator in power system with high-penetration PV （photovoltaic） was assessed by simulation analysis of a single-machine infinite-bus system model. Through the simulation analysis, we have obtained some conclusions in terms of the impact of high-penetration PV on the stability. However, for more accurate assessment of the transient stability, it is necessary to analyze various simulation models considering many other power system conditions. This paper presents the results of the analysis for the transient stability simulation performed for IEEE 9-bus system model, in which the effects of various conditions, such as variety of power sources （inverter or rotational machine）, load characteristics, existence of LVRT （low-voltage ride-through） capability and fault locations, on the transient stability are investigated.

关键词： High-penetration photovoltaics LVRT (low-voltage ride-through) synchronous generator transient stability

Transient Stability Analysis of Synchronous Generator in Power System with Renewable Power Sources Installed

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Journal of Mechanics Engineering and Automation 2016年第8期6卷 400-407页

作者： masaki Yagami Yoshihiro Ichinohe Yohichiro Kojima Kenji Misawa Junji tamura Department of Electrical and Electronic Engineering Hokkaido University of Science Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

The impact of large-scale grid-connected renewable power sources, such as wind generators and solar photovoitaic systems, on transient stability of synchronous generators is discussed in this paper. The permanent magnet synchronous generator with variable speed wind turbine is used in the simulation analysis as a wind generator model. The transient stability analysis is performed for IEEE 9-bus system model with high-penetration renewable power sources. The effect of FRT （fault ride-through） capability implemented for each power source on the transient stability is investigated.

关键词： Fault ride-through variable speed wind generator photovoltaic synchronous generator transient stability.

Harnessing a T1 Phage-Derived Spanin for Developing Phage-Based Antimicrobial Development

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BioDesign Research 2024年第1期6卷 28-38页

作者： Wakana Yamashita Shinjiro Ojima Azumi tamura Aa Haeruman Azam Kohei Kondo Zhang Yuancheng Longzhu Cui masaki Shintani Masato Suzuki Yoshimasa Takahashi Koichi Watashi Satoshi Tsuneda Kotaro Kiga Research Center for Drug and Vaccine Development National Institute of Infectious DiseasesTokyo 162-8640Japan Department of Life Science and Medical Bioscience Waseda University2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan Division of Infectious Diseases Advanced Clinical Research CenterThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan Antimicrobial Resistance Research Center National Institute of Infectious DiseasesTokyoJapan Division of Bacteriology Department of Infection and ImmunitySchool of MedicineJichi Medical UniversityShimotsuke-shiTochigi 329-0498Japan Department of Engineering Graduate School of Integrated Science and TechnologyShizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Phage Therapy Institute Comprehensive Research OrganizationWaseda University2-2 Wakamatsu-choShinjuku-kuTokyo 162-8480Japan

The global increase in the prevalence of drug-resistant bacteria has necessitated the development of alternative treatments that do not rely on conventional antimicrobial *** bacteriophage-derived lytic enzymes in antibacterial therapy shows promise;however,a thorough comparison and evaluation of their bactericidal efficacy are *** study aimed to compare and investigate the bactericidal activity and spectrum of such lytic enzymes,with the goal of harnessing them for antibacterial ***,we examined the bactericidal activity of spanins,endolysins,and holins derived from 2 Escherichia coli model phages,T1 and *** these,T1-spanin exhibited the highest bactericidal activity against ***,we expressed T1-spanin within bacterial cells and assessed its bactericidal activity.T1-spanin showed potent bactericidal activity against all clinical isolates tested,including bacterial strains of 111 ***,2 Acinetobacter spp.,3 Klebsiella spp.,and 3 Pseudomonas *** contrast,T1 phage-derived endolysin showed bactericidal activity against *** and ***,yet its efficacy against other bacteria was inferior to that of ***,we developed a phage-based technology to introduce the T1-spanin gene into target *** synthesized non-proliferative phage exhibited strong antibacterial activity against the targeted *** potent bactericidal activity exhibited by spanins,combined with the novel phage synthetic technology,holds promise for the development of innovative antimicrobial agents.

关键词： development antimicrobial developing harnessing phage-based phage-derived spanin