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World Journal of Gastroenterology 2016年第48期22卷 10523-10531页

作者： masaki miyazawa Mitsuru Matsuda Masaaki Yano Yasumasa Hara Fumitaka Arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital

Gastric adenocarcinoma of the fundic gland(chief cellpredominant type, GA-FG-CCP) is a rare variant of welldifferentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis.

关键词： Narrow-band imaging Pepsinogen-I Fundic gland Gastric adenocarcinoma Chief cell

Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection

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World Journal of Gastroenterology 2015年第26期21卷 8208-8214页

Recently,a new disease entity termed gastric adenocarcinoma of fundic gland type(GA-FG) was *** treated five cases of GA-FG with endoscopic submucosal *** tumors were small and located in the upper third of the *** tumors were macroscopically identified as 0-IIa and one was identified as 0-Ⅱ***-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the *** tumors arose from the deep layer of the lamina propria mucosae and showed submucosal *** invasion was seen only in one case,while no venous invasion was *** tumors were positive for pepsinogen-Ⅰ and MUC6 by *** showed p53 overexpression,and the labeling index of Ki-67 was low in all *** cases have been free from recurrence or ***,we discussed the clinicopathological features of GA-FG in comparison with past reports.

关键词： Gastric adenocarcinoma of fundic glandtype Pepsinogen-Ⅰ Chief cell Endoscopic diagnosis Narrow-band imaging with magnifying endoscopy Endoscopic submucosal dissection

Aggregation-induced emission and thermally activated delayed fluorescence of 2,6-diaminobenzophenones

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Science China Chemistry 2018年第8期61卷 925-931页

作者： masaki Shimizu masaki Nakatani Kenta Nishimura Faculty of Molecular Chemistry and Engineering Kyoto Institute of Technology

Exploration of novel organic luminophores that exhibit thermally activated delayed fluorescence(TADF) in the aggregated state is very crucial for advance of delayed luminescence-based applications such as time-gated bio-sensing and temperature *** report herein that synthesis, photophysical properties, molecular and crystal structures, and theoretical calculations of 2,6-bis(diarylamino)benzophenones. Absorption spectra in solution and calculations using density functional theory(DFT) method revealed that the optical excitation took place through intramolecular charge-transfer from one diarylamino moiety to an aroyl group. While the benzophenones did not luminesce in solution, the solids of the benzophenones emitted green light with moderate-to-good quantum yields. Thus, the benzophenones exhibit aggregation-induced emission. Based on the lifetime measurement, the green emission of the solids was found to include TADF. The emergence of the TADF is supported by the small energy gap between the excited singlet and triplet states, which was estimated by time-dependent DFT calculations. Thin films of poly(methyl methacrylate) doped by the benzophenones also showed green prompt and delayed fluorescence whose lifetimes were in the order of microseconds. Linear correlation between logarithm value of TADF lifetime and temperature was observed with the benzophenone in powder, suggesting that the benzophenones can serve as molecular thermometers workable under aqueous conditions.

关键词： donor-acceptor system delayed fluorescence temperature sensor

Resourceability on nuclear fuel cycle by transmutation approach

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Science China Chemistry 2012年第9期55卷 1746-1751页

作者： OZAWA masaki SAITO masaki Research Laboratory for Nuclear Reactors Tokyo Institute of Technology2-12-1-N1-1 OokayamaMeguro-kuTokyo 152-8550Japan

A resourceability on nuclear fuel cycle by transmutation of fission products in the spent fuel of nuclear reactors is discussed in this paper to investigate the feasibility of ＂creation and utilization＂ of Apr6s ORIENT from Adv.-ORIENT cycle, in which chemical ＂separation and utilization＂ of nuclear rare metals （platinum group metals, Mo, Tc, rare earth, etc.） has been proposed since FY2006. Apr6s ORIENT research program was newly initiated in FY2011 for nuclear transmutation of fission products into stable or short-lived highly-valuable elements. In the resourceability of rare earth metals from fission products, non-radioactive Nd and Dy can be created from Pr and Tb, respectively, by transmutation. Especially, the Dy creation has relatively high feasibility of about 10-20 %/y in creation rate. A proper moderation of neutrons in blanket of fast reactors may be required to provide a high creation rate of La from Ba. In light platinum group metals, non-radioactive Ru can be created from Tc by transmutation, of which creation rate is about 4-5 %/y in blanket of fast reactors. Pd created from Rh is almost non-radioactively depending on the isotope fraction of 107pd. Rh creation from Ru is not feasible under the neutron irradiation of typical nuclear reactors.

关键词： Apres ORIENT Advanced ORIENT cycle nuclear rare metal transmutation nuclear fuel cycle

Photophysical properties of heteroaromatic ring-fused(di)benzosiloles

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Science China Chemistry 2011年第12期54卷 1937-1947页

作者： SHIMIZU masaki MOCHIDA Kenji KATOH masaki HIYAMA Tamejiro Department of Material Chemistry Graduate School of EngineeringKyoto University Kyoto University Katsura Current address:Research & Development Initiative Chuo University

Benzosiloles fused to heterocycles such as thiophene, benzothiophene, and benzofuran, and indole- and benzosilole-fused dibenzosiloles were prepared by palladium-catalyzed intramolecular coupling of the corresponding 2-（arylsilyl）aryl triflates in good to high yields. Molecular and crystal structures of 5,7-dihydro-5,5,7,7-tetrakis（1-methylethyl）bis[1]benzosilolo-[2,3-b：3＇, 2＇-d]thiophene, 6-methyl-12,12-diisopropyl-12H-indololo[3,2-b][1]silafluorene, and 5,5,11,11-tetraisopropyl-5,11H-benzosilolo[3,2-c]silafluorene were determined by X-ray diffraction analysis. The UV absorption spectra of the （di）benzosilole derivafives in cyclohexane red-shifted when compared to 1,1-diisopropyldibenzosilole, indicating that replacing a benzene ring of dibenzosilole by the heterocycles as well as fusion of indole and benzosilole moieties onto dibenzosilole narrowed the HOMO- LUMO gaps of the n-conjugation system. The thiophene-fused benzosiloles were faintly fluorescent in solution and in the solid state, whereas the dibenzosiloles exhibited luminescence with moderate and high quantum yields in cyclohexane and in microcrystals, respectively. In other words, aggregation-induced emission was observed for the dibenzosiloles. Notably, 5,5,11,1 1- tetraisopropyl-5,11H-benzosilolo[3,2-c]silafluorene in microcrystals exhibited violet fluorescence （λmax = 396 nm） with a quantum yield of 0.70. Density functional theory （DFT） calculations of the prepared （di）benzosiloles were also performed.

关键词： absorption benzosflole fluorescence silicon solid-state emission

Design and strategy for manufacturing kidney organoids

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Bio-Design and Manufacturing 2020年第1期3卷 7-14页

作者： masaki Nishikawa Yasuyuki Sakai Norimoto Yanagawa Department of Chemical System Engineering School of EngineeringUniversity of TokyoRm.5A01Engineering Bldg.3Hongo 7‑3‑1BunkyoTokyo 113‑8656Japan Medical and Research Services Greater Los Angeles Veterans Affairs Healthcare System at SepulvedaNorth HillsCAUSA David Geffen School of Medicine University of California at Los AngelesLos AngelesCAUSA

Despite a continuing increase in the number of patients suffering from chronic kidney disease,currently available treatments for these patients,such as dialysis and kidney transplantation,are *** kidney is also a critical target organ vulnerable to the toxicity of various new drugs,and the lack of a reliable in vitro culture model imposes a severe limitation on drug *** the development of induced pluripotent stem cells(iPSCs)revolutionized strategies in biomedical fields,the complexity of the kidney imposed additional challenge to the application of this technology in kidney ***,the recent advancement in our understanding on the developmental origin of kidney progenitor cells and the mechanisms of their reciprocal induction and self-organization has boosted research in kidney *** since then has demonstrated that kidney organoids derived from iPSCs can serve as a useful model for drug discovery and toxicity screening,as well as for disease modeling,especially in combination with gene editing ***,attempts at kidney organoid implantation in animals have suggested their potential as an alternative source of kidney *** this review,we summarize recent progress on the generation of kidney organoids,as well as the obstacles that remain.

关键词： Kidney organoid Kidney development iPSC Progenitor cell Self-organization Regenerative medicine

Numerical analysis on element creation by nuclear transmutation of fission products

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Nuclear Science and Techniques 2015年第1期26卷 113-120页

作者： Atsunori Terashima masaki Ozawa Department of Nuclear Engineering Graduate School of Science and EngineeringTokyo Institute of Technology Research Laboratory for Nuclear Reactors Tokyo Institute of Technology

A burnup calculation was performed to analyze the Apr`es ORIENT process, which aims to create highlyvaluable elements from fission products separated from spent nuclear fuels. The basic idea is to use nuclear transmutation induced by a neutron capture reaction followed by a β-decay, thus changing the atomic number Z of a target element in fission products by 1 unit. LWR(PWR) and FBR(MONJU) were considered as the transmutation devices. High rates of creation were obtained in some cases of platinum group metals(44Ru by FBR,46 Pd by LWR) and rare earth(64Gd by LWR,66 Dy by FBR). Therefore, systems based on LWR and FBR have their own advantages depending on target elements. Furthermore, it was found that creation rates of even Z(= Z + 1) elements from odd Z ones were higher than the opposite cases. This creation rate of an element was interpreted in terms of "average 1-group neutron capture cross section of the corresponding target element σc Z defined in this work. General trends of the creation rate of an even(odd) Z element from the corresponding odd(even) Z one were found to be proportional to the 0.78th(0.63th) power of σc Z, however with noticeable dispersion. The difference in the powers in the above analysis was explained by the difference in the number of stable isotopes caused by the even-odd effect of Z.

关键词：裂变产物元素数值分析嬗变快中子增殖反应堆轻水反应堆稳定同位素 LWR

Plate and plume tectonics:Numerical simulation and seismic tomography

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Geoscience Frontiers 2015年第1期6卷 1-2页

作者： masaki Yoshida Department of Deep Earth Structure and Dynamics Research Jaan Agency for Marine-Earth Science and Technology(JAMSTEC)

About three decades after the establishment of the plate tec- tonics theory in the late 1960s, Maruyama （1994） proposed the ＂plume tectonics＂ theory based on whole-mantle seismic tomogra- phy image （Fukao, 1992; Fukao et al., 1994）. According to this the- ory, the earth＇s interior is divided into three regimes： the earth＇s surface region governed by lateral motions of tectonic plates, the mantle governed by vertical motions of ＂superplumes＂（i.e., large- scale mantle upwelling/downwelling plumes）, and the core, whose convection style is probably controlled by superplumes in the mantle. With the rapid progress in earth science after the birth of the plume tectonics theory, it is now widely accepted that various geological phenomena observed in the earth＇s surface are closely linked to the fluid motion in the deep mantle （e.g., Davies, 2011）.

关键词： Plate and plume tectonics UHT deep LVL

Diagonal reflection symmetries and universal four-zero texture

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Chinese Physics C 2021年第4期45卷 87-97页

作者： masaki J.S.Yang Department of Physics Saitama UniversityShimo-okuboSakura-kuSaitama338-8570Japan

In this paper,we consider a set of new symmetries in the SM:diagonal reflection symmetries Rm_(u,v)^(*),R=m_(u,v),m_(d,e)^(*)=mde with R=diag(-1,1,1).These generalized CP symmetries predict the Majorana phases to beα_(2.3)/2-0π/*** of diagonal reflection symmetries implies a broken chiral U(1)po symmetry only for the first *** axion scale is suggested to be(θ_(u,d))~△GuT√m_(u,dm_(c,s))/v-10^(12)[GeV].By combining the symmetries with the four-zero texture,the mass eigenvalues and mixing matrices of quarks and leptons are reproduced *** scheme predicts the normal hierarchy,the Dirac phase ocp≈203°,and|ml|≈2.5 or 6.2[meV].In this scheme,the type-I seesaw mechanism and a given neutrino Yukawa matrix Y_(y)completely determine the structure of the right-handed neutrino mass M_(R).A u-y unification predicts the mass eigenvalues to be(M_(RI),M_(R2),M_(R3))=(O(10^(5)).O(10^(9)),O(10^(14))[Gev].

关键词： μ-t reflection symmetry four-zero texture generalized CP symmetry

Dynamic robust optimal reorder point with uncertain lead time and changeable demand distribution

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 938-945页

作者： masaki TAMURA Kazuko MORIZAWA Hiroyuki NAGASAWA Department of Electrical and Information Systems Engineering Graduate School of EngineeringOsaka Prefecture University Osaka Prefectural College of Technology

In fixed order quantity systems,uncertainty in lead time is expressed as a set of scenarios with occurrence probabilities,and the mean and variance in demand distribution are supposed to be changeable according to a known pattern.A new concept of "dynamic robust optimal reorder point" is proposed in this paper and its value is calculated as a "robust optimal reorder point function with respect to reorder time".Two approaches were employed in determining the dynamic optimal reorder *** first is a shortage rate satisfaction approach and the second is a backorder cost minimization *** former aims at finding the minimum value of reorder point at each reorder time which satisfies the condition that the cumulative distribution function (CDF) of shortage rate under a given set of scenarios in lead time is greater than or equal to a basic CDF of shortage rate predetermined by a *** the latter approach,the CDF of closeness of reorder point is defined at each reorder time to express how close to the optimal reorder points under the set of scenarios,and the dynamic optimal reorder point is defined according to stochastic *** numerical examples demonstrate the features of these dynamic robust optimal reorder points.

关键词： Reorder point Lead time Robust optimum Uncertainty Scenario