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The roles and relations of calpastatin,calmodulin and an undefined cytoplasmic factor in the regulation of cardiac L-type Ca^(2+) channels

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沈阳药科大学学报 2008年第S1期25卷 94-95页

作者： tsuko Minobe masaki Kameyama Department of Physiology Graduate School of Medical and Dental SciencesKagoshima University

Objective To explore the mechanism that cytoplasmic factors could recover L-type Ca2+ channel activity after "run-down".The factors include ATP,calpastatin and H fraction(a high molecular fraction of bovine cardiac cytoplasm).Methods Single Ca2+ channel activities were recorded with patch clamp technique in guinea-pig cardiac ***-down was induced by the inside-out patch ***(CS),calmodulin(CaM)and three GST-fusion fragment peptides derived from the C-terminal tail of guinea-pig Cav1.2,CT-1(amino acids number 1509-1791),CT-2(1777-2003)and CT-3(1944-2169)were produced as GST fusion ***(1)CaM + ATP or CS + ATP restored the channels after run-down;however,the CaM or CS's effects became smaller with the longer run-down time.(2)After run down,CaM-dependent protein kinase(CaMKII)produced Ca2+ channel activity to only 2-10% of the basal activity,however,in the presence of CaMKII,the time-dependent nature of the CaM effect was abolished.(3)In pull-down assay,CT-1 treated with CaMKII showed a higher affinity for CaM than that treated with phosphatase.(4)CaMKII was detected in the H fraction of bovine cardiac *** The results show that CS,CaM and CaMKII are all involved in the maintenance of the basal activity of L-type Ca2+ channels,and that there might be cross talks among the four factors(CS,CaM,CaMKII and the undefined cytoplasmic factor).

关键词： calpastatin calmodulin calcium channel regulation

Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

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World Journal of Gastroenterology 2014年第10期20卷 2653-2663页

作者： Kosuke Tanaka Yuko masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan Department of Clinical Pharmacology Faculty of Pharmaceutical Science Fukuoka University Fukuoka 814-0180 Japan Department of Gastroenterology Kyushu Medical Center National Hospital Organization Fukuoka 810-8563 Japan Innovation Center for Medical Redox Navigation Kyushu University Fukuoka 812-8582 Japan

AIM: To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease (NAFLD).

关键词： Adipose tissue Energy expenditure Exenatide Glucagon-like peptide-1 Hepatic steatosis Lipolysis Nonalcoholic fatty liver disease

Current status of function-preserving surgery for gastric cancer

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World Journal of Gastroenterology 2014年第46期20卷 17297-17304页

作者： Takuro Saito Yukinori Kurokawa Shuji Takiguchi masaki Mori Yuichiro Doki Department of Gastroenterological Surgery Osaka University Graduate School of MedicineOsaka 565-0871Japan

Recent advances in diagnostic techniques have allowed the diagnosis of gastric cancer(GC)at an early *** to the low incidence of lymph node metastasis and favorable prognosis in early GC,function-preserving surgery which improves postoperative quality of life may be ***-preserving gastrectomy(PPG)is one such function-preserving procedure,which is expected to offer advantages with regards to dumping syndrome,bile reflux gastritis,and the frequency of flatus,although PPG may induce delayed gastric *** gastrectomy(PG)is another functionpreserving procedure,which is thought to be advantageous in terms of decreased duodenogastric reflux and good food reservoir function in the remnant stomach,although the incidence of heartburn or gastric fullness associated with this procedure is ***,these disadvantages may be overcome by the reconstruction method *** other important problem after PG is remnant GC,which was reported to occur in approximately 5%of ***,the reconstruction technique used with PG should facilitate postoperativeendoscopic examinations for early detection and treatment of remnant gastric *** safety seems to be assured in both procedures,if the preoperative diagnosis is *** selection should be carefully *** many retrospective studies have demonstrated the utility of function-preserving surgery,no consensus on whether to adopt functionpreserving surgery as the standard of care has been *** prospective randomized controlled trials are necessary to evaluate survival and postoperative quality of life associated with function-preserving surgery.

关键词： Gastric cancer Function preserving surgery Quality of life Pylorus preserving surgery Proximal gastrectomy

Automated crystal structure analysis based on blackbox optimisation

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npj Computational Materials 2020年第1期6卷 1022-1028页

作者： Yoshihiko Ozaki Yuta Suzuki Takafumi Hawai Kotaro Saito masaki Onishi Kanta Ono Artificial Intelligence Research Center(AIRC) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan GREE Inc.TokyoJapan Institute of Materials Structure Science(IMSS) High Energy Accelerator Research Organization(KEK)IbarakiJapan SOKENDAI(The Graduate University for Advanced Studies) IbarakiJapan Paul Scherrer Institute VilligenSwitzerland Medley IncTokyoJapan

In the present study,we show that time-consuming manual tuning of parameters in the Rietveld method,one of the most frequently used crystal structure analysis methods in materials science,can be automated by considering the entire trial-and-error process as a blackbox optimisation *** automation is successfully achieved using Bayesian optimisation,which outperforms both a human expert and an expert-system type automation despite the absence of *** approach stabilises the analysis quality by eliminating human-origin variance and bias,and can be applied to various analysis methods in other areas which also suffer from similar tiresome and unsystematic manual tuning of extrinsic parameters and human-origin variance and bias.

关键词： analysis black structure

Treatment for superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2014年第35期20卷 12501-12508页

作者： Naomi Kakushima Hideyuki Kanemoto masaki Tanaka Kohei Takizawa Hiroyuki Ono Division of Endoscopy Shizuoka Cancer Center Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer CenterShizuoka Cancer Center

Because of the low prevalence of non-ampullary duodenal epithelial tumors(NADETs),standardized clinical management of sporadic superficial NADETs,including diagnosis,treatment,and follow-up,has not yet been *** studies have revealed certain endoscopic findings suggestive of *** adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive *** use of endoscopic treatment including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),for the treatment for superficial NADETs is *** requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after *** provides an excellent complete resection rate,however it remains a challenging method,considering the high risk of intraoperative or delayed *** invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic *** remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion,which presents a risk of lymph node *** or surgical treatment outcomes of superficial NADETs without submucosal invasion are *** an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment.

关键词： Duodenal neoplasms Duodenal cancer Pancreaticoduodenectomy Endoscopic surgery Esophagogastroduodenoscopy

Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports

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World Journal of Clinical Cases 2020年第21期8卷 5320-5325页

作者： masaki Okajima Yoshinori Takahashi Takaaki Kaji Naohiko Ogawa Hideyuki Mouri Intensive Care Unit Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Rheumatology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Nephrology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Respiratory Medicine Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Nafamostat mesylate(NM)may prove to be one of the key drugs effective against coronavirus disease 2019(COVID-19)because of its anti-viral properties and the potential to manage ***,NM tends to increase serum potassium *** SUMMARY We observed hyperkalemia immediately after NM administration(200 mg/d)in four consecutive patients who were admitted to the Kanazawa University Hospital with severe COVID-19 *** potassium excretion decreased after NM administration in three patients who underwent *** NM is likely to produce hyperkalemia in patients with ***,it is necessary to monitor serum potassium values closely after NM initiation in COVID-19 patients who need respiratory support.

关键词： COVID-19 Nafamostat Hyperkalemia Disseminated intravascular coagulation Respiratory insufficiency Case report

Infrasound observations at Syowa Station,East Antarctica:Implications for detecting the surface environmental variations in the polar regions

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Geoscience Frontiers 2015年第2期6卷 285-296页

作者： Yoshiaki Ishihara masaki Kanao Masa-yuki Yamamoto Shigeru Toda Takeshi Matsushima Takahiko Murayama National Institute of Advanced Industrial Science and Technology National Institute of Polar Research Research Organization of Information and Systems Kochi University of Technology Faculty of Education Aichi Education University Faculty of Sciences Kyushu University Japan Weather Association

Characteristic infrasound waves observed at Antarctic stations demonstrate physical interaction involving environmental changes in the Antarctic continent and the surrounding oceans. A Chaparraltype infrasound sensor was installed at Syowa Station （SYO; 39°E, 69°S）, East Antarctica, as one of the projects of the International Polar Year （IPY2007-2008）. Data continuously recorded during the three seasons in 2008-2010 clearly indicate a contamination of the background oceanic signals （microbaroms） with peaks between 4 and 10 s observed during a whole season. The peak amplitudes of the microbaroms have relatively lower values during austral winters, caused by a larger amount of sea-ice extending around the Lutzow-Holm Bay near SYO, with decreasing ocean wave loading effects. Micro- baroms measurements are useful tool for characterizing ocean wave climate, complementing other oceanographic and geophysical data. A continuous monitoring by infrasound sensors in the Antarctic firmly contributes to the Comprehensive Nuclear-Test-Ban Treaty （CTBT） in the southern high latitude, together with the Pan-Antarctic Observations System （PAntOS） under the Scientific Committee on Antarctic Research （SCAR）. Detailed measurements of the infrasound waves in Antarctica, consequently, could be a new proxy for monitoring regional environmental change as well as the temporal climate variations in the polar regions.

关键词： lnfrasound Antarctica Microbaroms Environment Global network

Guest Editorial:Special Section on the Second China-Japan Academic Symposium on Nuclear Fuel Cycle(ASNFC-2013)

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Nuclear Science and Techniques 2015年第1期 3-4页

作者： Yuezhou WEI masaki OZAWA School of Nuclear Science and Engineering Shanghai Jiao Tong University Research Laboratory for Nuclear Reactors Tokyo Institute of Technology

Shanghai,China,November 27-30,2013As a high-density energy with almost no discharge of greenhouse gas,nuclear energy plays an important role in long-term energy security and global warming ***,to realize a sustainable development of nuclear energy for the future,it is necessary to save uranium resource and minimize radioactive *** nuclear fuel

关键词： ASNFC-2013 Guest Editorial CAS

Pyrochemical treatment of spent nitride fuels for MA transmutation

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Science China Chemistry 2014年第11期57卷 1427-1431页

作者： HAYASHI Hirokazu SATO Takumi SHIBATA Hiroki KURATA masaki IWAI Takashi ARAI Yasuo Nuclear Science and Engineering Center Sector of Nuclear Science Research Japan Atomic Energy Agency2-4 Shirakata-shiraneTokai-muraNaka-gun Ibaraki-ken 319-1195 Japan

Nitride fuels have several advantages including high thermal conductivity and high metal density(like metallic fuels) and high melting point and isotropic crystal structure(like oxide fuels). Since the late 1990 s, the partitioning and transmutation of minor actinides(MA) has been studied to decrease the long-term radio-toxicity of high-level waste and to mitigate the burden of final disposal. Japan Atomic Energy Agency(JAEA) has proposed a dedicated transmutation cycle using an accelerator-driven system(ADS) with nitride fuels containing MA. The nitride fuel cycle we have developed includes a pyrochemical process. Our focus is on the electrolysis of nitride fuels and their refabrication from the recovered actinides; other processes are similar to the technology for metal fuel treatment and have been studied elsewhere. Here, we summarize our activity on the development of the pyrochemical treatment of spent nitride fuels.

关键词： nitride fuels minor actinides pyrochemical process