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Clinical Utility of Procalcitonin for Differentiating between Cryptogenic Organizing Pneumonia and Community-Acquired Pneumonia

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International Journal of Clinical Medicine 2015年第6期6卷 372-376页

作者： Satoshi Takeda Nobuhiko Nagata Hiroyuki Miyazaki Takanori Akagi Taishi Harada Masaru Kodama Shinichiro Ushijima Takashi Aoyama Kentaro Wakamatsu masaki fujita Kentaro Watanabe Department of Respiratory Medicine Fukuoka University Chikushi Hospital Chikushino Japan Department of Respiratory Medicine National Hospital Organization Omuta Hospital Omuta Japan Department of Respiratory Medicine Faculty of Medicine Fukuoka University Fukuoka Japan

Background: Differentiating cryptogenic organizing pneumonia (COP) from community-acquired pneumonia (CAP) can be difficult in some cases. Objective: To clarify the clinical utility of procalcitonin (PCT) levels for differentiating between COP and CAP. Methods: Blood PCT levels, leukocyte count, C-reactive protein concentration, number of segments involved on computed tomography (CT) images, and pneumonia severity assessment scale were retrospectively investigated from clinical charts and chest CT images of COP and CAP patients who were admitted to our hospital from 2012 to 2014. The clinical characteristics of COP patients were compared to those of CAP patients for whom causative organisms were not detected. Results: There were 16 COP and 94 CAP patients for whom causative organisms were not detected. Blood PCT levels of all COP patients were less than 0.16 ng/dL, and significantly lower than those of CAP patients (p = 0.0004), while the number of involved segments was significantly higher than that of CAP patients (p = 0.0001). Blood PCT levels and the number of involved segments remained independently significant for differentiating between COP and CAP by multivariate analysis. Receiver operating characteristics curve analysis revealed that 7 was the best cut-off number for involved segments to differentiate between COP and CAP patients with low PCT levels (sensitivity 85.7%, specificity 94.7%). Conclusion: A combination of PCT levels and number of involved segments on CT images is useful for differentiation between COP and CAP.

关键词： Cryptogenic Organizing Pneumonia Procalcitonin Community-Acquired Pneumonia Computed Tomography

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伊藤町零碳酒店

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世界建筑导报 2024年第1期39卷 114-117页

作者： Minoru Yokoo Takumi Saikawa masaki Hamada(kkpo)(摄影) 不详

我们设计了一家零能耗酒店,作为西条市的社区中心。西条市是著名的“Uchinuki”井水产地,水源来自被视为圣山的石锤山。2016年,东京大学隈研吾实验室开始与各地的合作伙伴密切合作,以水为主题制定名为“伊藤町项目”的新型环保城市总体... 详细信息

我们设计了一家零能耗酒店,作为西条市的社区中心。西条市是著名的“Uchinuki”井水产地,水源来自被视为圣山的石锤山。2016年,东京大学隈研吾实验室开始与各地的合作伙伴密切合作,以水为主题制定名为“伊藤町项目”的新型环保城市总体规划。与当地居民举办了研讨会,为年轻建筑师举办了个人建筑竞赛,并在此基础上建立了“伊藤町”网络。

关键词：城市总体规划东京大学零能耗隈研吾酒店零碳当地居民建筑师

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Organic fluorophores that emit ultraviolet light in the aggregated state

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Aggregate 2022年第2期3卷 22-32页

作者： masaki Shimizu Tsuneaki Sakurai Faculty of Molecular Chemistry and Engineering Kyoto Institute of TechnologyKyotoJapan

Ultraviolet(UV)-emissive organic light-emitting diodes(OLEDs)have attracted growing attention as future UV-lighting sources following *** design and development of highly efficient UV-emissive organic solids are essential for the advancement of *** herein are organic small molecules and polymers that exhibit UV emission in the aggregated state such as crystal,powder,and amorphous *** UV-emissive molecules are in principle limited to those whose photoluminescence(PL)maxima are less than 400 nm and whose PL quantum yields in the aggregated state,which are useful for evaluating the potential of solid-state emitters,are *** cases that electroluminescence(EL)studies are demonstrated,the emission maxima and external quantum efficiencies with the device structures are also *** exceptions are also included whose PL quantum yields are not reported,but UV-EL with an emission maximum of less than 400 nm is demonstrated.

关键词： conjugation light-emitting materials molecular design solid-state emission UV OLEDs

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Prediction of Photosynthetic Carbon Assimilation Rate of Individual Rice Leaves under Changes in Light Environment Using BLSTM-Augmented LSTM

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 557-577页

作者： Masayuki Honda Kenichi Tatsumi masaki Nakagawa Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchu City183-0054Japan Institute of Engineering Tokyo University of Agriculture and TechnologyKoganei City184-8588Japan

A model to predict photosynthetic carbon assimilation rate(A)with high accuracy is important for forecasting crop yield and *** short-term memory(LSTM),a neural network suitable for time-series data,enables prediction with high accuracy but requires mesophyll *** addition,for practical use,it is desirable to have a technique that can predict A from easily available *** this study,we propose a BLSTM augmented LSTM(BALSTM)model,which utilizes bi-directional LSTM(BLSTM)to indirectly reproduce the mesophyll variables required for *** most significant feature of the proposed model is that its hybrid architecture uses only three relatively easy-to-collect external environmental variables—photosynthetic photon flux density(Q_(in)),ambient CO_(2) concentration(C_(a)),and temperature(T_(air))—to generate mesophyll CO_(2) concentration(C_(i))and stomatal conductance to water vapor(g_(sw))as intermediate ***,A is predicted by applying the obtained intermediate outputs to the learning ***,in this study,1)BALSTM(Q_(in),C_(a),T_(air))had a significantly higher A prediction accuracy than LSTM(Q_(in),C_(a),T_(air))in case of using only Q_(in),C_(a),and T_(air);2)BALSTMC_(i),g_(sw),which had C_(i) and g_(sw) as intermediate products,had the highest A prediction accuracy compared with other candidates;and 3)for samples where LSTM(Q_(in),C_(a),T_(air))had poor prediction accuracy,BALSTMC_(i),g_(sw)(Q_(in),C_(a),T_(air))clearly improved the ***,it was found that incorrect predictions may be formed when certain factors are not reflected in the data(e.g.,timing,cultivar,and growth stage)or when the training data distribution that accounts for these factors differs from the predicted data ***,a robust model should be constructed in the future to improve the prediction accuracy of A by conducting gasexchange measurements(including a wide range of external environmental values)and by increasing the

关键词： Hybrid prediction model assimilation rate leaf internal variables recurrent neural network fluctuating light environments rice

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Generation of micro/nano hybrid surface structures on copper by femtosecond pulsed laser irradiation

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Nanomanufacturing and Metrology 2022年第3期5卷 274-282页

作者： Ayumi Nakajima masaki Omiya Jiwang Yan School of Integrated Design Engineering Graduate School of Science and TechnologyKeio UniversityYokohama 223-8522Japan Department of Mechanical Engineering School of Science and TechnologyKeio UniversityYokohama 223-8522Japan

The delamination of copper lead frames from epoxy molding compounds(EMC)is a severe problem for microelectronic devices,as it leads to reduced heat dissipation or circuit *** micro/nanoscale surface structuring of copper is a promising method to improve the copper-EMC interfacial *** this study,the generation of micro/nano hybrid structures on copper surfaces through femtosecond pulsed laser irradiation is proposed to improve interfacial *** micro/nano hybrid structures were realized by generating nanoscale laser-induced periodic surface structures(LIPSS)on microscale parallel *** types of hybrid surface structures were generated by changing the laser polarization direction,fluence,and scanning *** a specific aspect ratio of microgrooves,a latticed structure was generated on the sides of microgrooves by combining LIPSS formation and direct laser interference *** study provides an efficient method for the micro/nanoscale hybrid surface structure formation for interfacial adhesion improvement between copperand EMC.

关键词： Femtosecond pulsed laser Copper Metal surface LIPSS Direct laser interference patterning-Micro/nano hybrid structures

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Effect of fiber-reinforcement on the mechanical behavior of sand approaching the critical state

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1241-1252页

作者： Jakhongirbek Ganiev Shotaro Yamada masaki Nakano Takayuki Sakai Department of Civil Engineering Nagoya UniversityNagoya464-8603Japan Department of Civil Engineering Tohoku UniversitySendai980-8579Japan

Several types of ground improvement methods that employ fiber-reinforcement have been developed in recent years.A series of consolidated drained triaxial compression tests has been conducted here to examine the effect of short fibers on the mechanical properties of Toyoura *** with 0%,0.2%,0.4%,and 1%fiber contents,prepared to yield random distribution,was sheared under several confining pressures and controlled via their initial relative *** test results showed that the maximum and residual deviatoric stresses increased,whereas the volumetric expansion decreased with an increase in fiber *** the stress ratio h(=q/p′)and specific volume changed depending on the fiber content and confining pressure with shear progression,they each reached the same values for a definite fiber content at the end of shearing,independent of initial relative *** other words,the unique critical state line can be found for a definite fiber ***,the greater the fiber content,the larger the slope of the critical state line at the end of ***,as the length of fibers shortened with the same percentage of fiber inclusions in sand,the deviatoric stress and the stress ratio decreased,approaching the shear-strain-volumetric response of unreinforced sand.

关键词： Fiber-reinforced sand Triaxial compression Stress ratio Critical state Relative density

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Change in microstructural characteristics of laser powder bed fused Al–Fe binary alloy at elevated temperature

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Journal of Materials Science & Technology 2022年第2期97卷 38-53页

作者： Xing Qi Naoki Takata Asuka Suzuki Makoto Kobashi masaki Kato Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Aichi Center for Industry and Science Technology 1267-1 AkiaiYakusa-choToyota 470-0356Japan

The present study addressed the change in the microstructure of Al-2.5 wt%Fe binary alloy produced using laser powder bed fusion(L-PBF)technique by thermal exposure at 300℃,and the associated mechanical and thermal properties were systematically examined as ***-semi-cylindrical patterns corresponding to melt pools in the microstructure were macroscopically observed for the asmanufactured *** change in the melt-pool morphology was observed after thermal exposure for1000 *** the melt pools,a large number of the nanoscale metastable Al6 Fe phase particles were uniformly distributed inside columnar grains of theα-Al matrix containing concentrated solute Fe in *** sequential formation and coarsening of stableθ-Al13 Fe4 phases were observed upon exposure to a 300℃ environment,but a considerable amount of nano-sized metastable Al6 Fe phases remained even after 1000 ***,the thermal exposure continuously reduced the concentration of solute Fe atoms in theα-Al *** significant grain growth was found inα-Al matrix after 1000 h owing to the pinning effect of the dispersed fine particles on grain boundary *** results demonstrate a sluggish change in microstructural morphologies of the Al-2.5 wt%Fe *** quantified microstructural parameters addressed dominant strengthening contributions by the solid solution of Fe element and Orowan strengthening mechanism by fine Al-Fe intermetallics in the L-PBF-produced *** high strength level was sustained even after being exposed to 300℃ for long *** superior balance of mechanical properties and thermal conductivity can be achieved in the experimental alloys by taking advantage of the various microstructural parameters related to the Al-Fe intermetallic phases andα-Al matrix.

关键词： Al-Fe alloy Laser powder bed fusion Phase transformation Microstructure Tensile properties

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Assessment of delayed bleeding after endoscopic submucosal dissection of early-stage gastrointestinal tumors in patients receiving direct oral anticoagulants

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World Journal of Gastroenterology 2023年第19期29卷 2916-2931页

作者： Mitsushige Sugimoto masaki Murata Takashi Kawai Department of Gastroenterological Endoscopy Tokyo Medical University HospitalTokyo 160-0023Japan Department of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 612-8555Japan

Delayed bleeding is a major and serious adverse event of endoscopic submucosal dissection(ESD)for early-stage gastrointestinal *** rate of post-ESD bleeding for gastric cancer is higher(around 5%-8%)than that for esophagus,duodenum and colon cancer(around 2%-4%).Although investigations into the risk factors for post-ESD bleeding have identified several procedure-,lesion-,physician-and patient-related factors,use of antithrombotic drugs,especially anticoagulants[direct oral anticoagulants(DOACs)and warfarin],is thought to be the biggest risk factor for post-ESD *** fact,the post-ESD bleeding rate in patients receiving DOACs is 8.7%-20.8%,which is higher than that in patients not receiving ***,because clinical guidelines for management of ESD in patients receiving DOACs differ among countries,it is necessary for endoscopists to identify ways to prevent post-ESD delayed bleeding in clinical *** that the pharmacokinetics(e.g.,plasma DOAC level at both trough and T_(max))and pharmacodynamics(e.g.,anti-factor Xa activity)of DOACs are related to risk of major bleeding,plasma DOAC level and anti-FXa activity may be useful parameters for monitoring the anti-coagulate effect and identifying DOAC patients at higher risk of post-ESD bleeding.

关键词： Direct oral anticoagulants Gastrointestinal tumors Endoscopic submucosal dissection Delayed bleeding Adverse events Anticoagulants

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Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients

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World Journal of Gastroenterology 2023年第15期29卷 2283-2293页

作者： Weijie Xue masaki Honda Taizo Hibi Department of Transplantation and Pediatric Surgery Kumamoto UniversityKumamoto 860-8556Japan

Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a major global public health event,resulting in a significant social and economic *** COVID-19 was initially characterized as an upper respiratory and pulmonary infection,recent evidence suggests that it is a complex disease including gastrointestinal symptoms,such as diarrhea,nausea,and ***,it remains unclear whether the gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or are the result of systemic immune activation and subsequent dysregulation of homeostatic *** review provides a brief overview of the mechanisms by which SARS-CoV-2 disrupts the integrity of the gastrointestinal barrier including the mechanical barrier,chemical barrier,microbial barrier,and immune barrier.

关键词： Gastrointestinal barrier dysfunction SARS-CoV-2 COVID-19 Angiotensinconverting enzyme 2 Microbiome Immune cells

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Autonomous Dual Active Power-frequency Control in Power System with Small-scale Photovoltaic Power Generation

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 941-953页

作者： Noha Harag masaki Imanaka Muneaki Kurimoto Shigeyuki Sugimoto Hassan Bevrani Takeyoshi Kato Electrical Engineering Department of Nagoya University NagoyaJapan University of Kurdistan SanandajIran Institute of Materials and Systems for Sustainability of Nagoya University NagoyaJapan

Active power control of the photovoltaic(PV)power generation system is a promising solution to regulate frequency fluctuation in a power system with high penetration of renewable *** paper proposes an autonomous active power control of a small-scale PV system for supporting the inertial response of synchronous generators and power-frequency *** the proposed control approach,an effective grid frequency regulation scheme is realized using slow-and fast-frequency responses.A low-pass filter based frequency measurement is used for slow-frequency response,while direct frequency measurement is used for fast-frequency *** designed dual droop characteristic-based control is shaped to achieve a smooth transition between slow-and fast-frequency *** performance of the proposed control approach is demonstrated for serious disturbance scenarios,i.e.,considerable power-load imbalance and generation *** the powerload imbalance test scenario,the proposed control approach works properly within the normal frequency deviation region even when the frequency deviation exceeds that region *** the generation trip test,the frequency deviation is mitigated quickly,and the employed droop control is smoothly transferred from the slow-to fast-frequency responses.

关键词： Dual droop control fast-frequency response slow-frequency response inertial response power-frequency control regulation support

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