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World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito Mori Hideki Kobara Noriko Nishiyama Tsutomu masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

Improvement in bias current redistribution in superconducting strip ion detectors with parallel configuration

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Chinese Physics B 2015年第9期24卷 562-565页

作者： Nobuyuki Zen Go Fujii Shigetomo Shiki Masahiro Ukibe masaki Koike Masataka Ohkubo National Institute of Advanced Industrial Science and Technology (AIST)

In time-of-flight mass spectrometry（TOF MS）, superconducting strip ion detectors（SSIDs） in the parallel configuration are promising for ideal ion detection with a nanosecond-scale time response and a practical large sensitive area. In the parallel configuration, the bias current in one strip is diverted into other parallel strips after each detection event. Under high bias current conditions, the diverted bias current induces cascade switching of all parallel strips. Studies show that cascade switching degrades the ion count rate of SSIDs made from niobium and hence is disliked in TOF MS applications. To suppress the bias current redistribution, we connected resistors in a series with the individual parallel strips using aluminum-bonding wires. Their effect was studied by measuring the pulse height distributions.

关键词： superconducting devices time-of-flight mass spectrometry ion-surface impact

Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe:In vivo mouse pancreatic ductal adenocarcinoma model

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 478-485页

作者： Nana Shimamoto masaki Ito Masafumi Chiba Sadamu Honma Hiroo Imazu Kazuki Sumiyama Department of Endoscopy The Jikei University School of Medicine3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Oncology Research Center for Medical Science3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine30-1 Oyaguchikami-choItabashi-kuTokyo 173-8610Japan

Background:Ultrasound-targeted microbubble destruction(UTMD)induces cellular inflow of drugs at low intensity,while high intensity eradicates tumor *** vascular endothelial growth factor receptor 2(VEGFR2)is highly expressed in pancreatic ductal adenocarcinoma(PDAC),VEGFR2-targeted microbubble(MB)might additionally increase the tissue specificity of drugs and thus improve antitumor *** addition,fixing the dual pulse intensity could maximize MB *** study evaluated the one-off(experiment 1)and cumulative(experiment 2)treatment effect of UTMD by regulating the dual pulse output applied to PDAC using VEGFR2-targeted ***:C57BL/6 mice inoculated with Pan-02 cells were allocated to five groups:VEGFR2-targeted MB+gemcitabine(GEM),VEGFR2-targeted MB,non-targeted MB+GEM,GEM,and control *** injection of GEM or GEM and either VEGFR2-targeted or non-targeted MB,UTMD was applied for several minutes at low intensity followed by high intensity *** experiment 1,mice were treated by the protocol described above and then euthanized immediately or at the tumor diameter doubling time(TDT).In experiment 2,the same protocol was repeated weekly and mice were euthanized at TDT regardless of protocol *** analysis by CD31 and VEGFR2 staining provided microvascular density(MVD)and VEGFR2 expression along vessels(VEGFR2v)or intra/peripheral cells(VEGFR2c).Results:In experiment 1,TDT was significantly longer in the VEGFR2-targeted MB+GEM group compared to the non-targeted MB+GEM,GEM,and control groups,while the VEGFR2-targeted MB group showed no statistical *** and VEGFR2v in the immediate euthanasia was significantly lower in the VEGFR2-targeted MB+GEM and VEGFR2-targeted MB groups than other *** experiment 2,the VEGFR2-targeted MB+GEM group produced significantly longer TDT than the GEM or control groups,whereas the VEGFR2-targeted MB group showed no significant *** revealed sign

关键词： Ultrasound-targeted microbubble destruction VEGFR2-targeted microbubble Pancreatic ductal adenocarcinoma Gemcitabine

High-throughput Three-dimensional Gel Electrophoresis for Versatile Utilities: A Stacked Slice-gel System for Separation and Reactions (4SR)

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Genomics, Proteomics & Bioinformatics 2006年第1期4卷 26-33页

作者： Md. Salimullah masaki Mori Koichi Nishigaki Department of Functional Materials Science Saitama University Saitama 338-8570 Japan Rational Evo-lutionary Design of Advanced Biomolecules (REDS) Group Saitama Small Enterprise Promotion CorporationSKIP City Kawaguchi 333-0844 Japan.

A novel high-throughput system, called the stacked slice-gel system for separation and reactions （4SR）, was developed for the analysis of DNA/RNA and protein/peptide. The system provides a novel three-dimensional gel electrophoresis approach that exploits the property of stacked slice gels. It allows multiple samples simultaneously to react as well as to be separated, offering a two-dimensional （m×n） sample loading system. For this purpose, high-throughput multi-micro vessels （MMVs） containing variable numbers of wells （100 wells in this paper） have been used, which are made of 25 mm square-size polyacrylamide gels. Furthermore, after electrophoretic separation, a slice gel containing a desired sample can be easily removed and proceeded to the next step. Different biological reactions as well as successive separation of products were effectively carried out dealing with DNA/RNA and protein/peptide. It shows that this system has a diversity of potentials to be developed.

关键词： three-dimensional polyacrylamide gel electrophoresis (3D-PAGE) high-throughput screening three-dlmensional separation microarray technology

Fabrication of iron disilicide from multilayer by helicon plasma sputtering

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中国有色金属学会会刊：英文版 2005年第S3期15卷 434-438页

作者：沈鸿烈杨颖 SAKAMOTO Isao KOIKE masaki MAKITA Yunosuke College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China National Institute of Advanced Industrial Science and Technology Photonics Research Institute Tsukuba Ibaraki 305-8568 Japan

Helicon plasma sputtering of Fe/Si multilayer followed by thermal annealing in Ar atmosphere was used to fabricate β-FeSi2 films. [Fe 0.5nm/Si 1.6nm] 120 multilayer was deposited on Si（100） substrate and then the samples were annealed at 900℃ for 2h or at 9001000℃ for 10s. Annealed samples were characterized by X-ray diffractometry（XRD）, Rutherford backscattering spectroscopy, scanning electron microscopy and optical absorption measurement. （202）/（220） oriented β-FeSi2 films are fabricated from the multilayer according to XRD patterns. It is found that there is a very small redistribution of Fe and Si components in the films during the thermal annealing, so that a good stoichiometry of FeSi2 can be obtained. It is also revealed by scanning electron microscopy that multilayer technology can result in a smooth surface for β-FeSi2 films. Optical absorption spectra demonstrate that the films have a direct band gap of 0.9eV at room temperature.

关键词： iron disilicide sputtering multilayer thermal annealing

Recent Progress of Neutral Beam Injector and Bearn Emission Diagnosis in LHD

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Plasma Science and Technology 2009年第4期11卷 452-455页

作者： Katsunori IKEDA Kenichi NAGAOKA Yasuhiko TAKEIRI masaki OSAKABE Katsuyoshi TSUMORI Osamu KANEKO 无 National Institute for Fusion Science LHD Experimental Group

Large size hydrogen neutral beam injectors （NBI） used a negative ion source （NNBI） as well as a proton source （PNBI） were developed for the large helical device （LHD）. The injected power from NNBI and PNBI have reached 16 MW and 6.8 MW, respectively, These injected powers have outstripped the nominal beam powers. A diagnostic system of beam-emitted hydrogen visible spectrum has been installed along the beam injection axis to estimate the energy fraction on PNBI. The full energy beam component is about half which is equivalent to 70% of injected beam power. The attenuation of high energy neutral beam is also observed on NNBI. The peak density distribution is effective to increase beam deposition power.

关键词： NBI spectroscopy LHD

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bZ3纯电动轿车的空气动力性能开发

汽车工程学报 2024年第1期14卷 72-82页

作者：唐丽君曹亚飞王虎久保恒典张风利罗秋丽铃木雅贵陆博比亚迪丰田电动车科技有限公司广东深圳518000 比亚迪汽车工业有限公司广东深圳518000

作为比亚迪丰田电动车科技有限公司第1款纯电动轿车,bZ3的能耗要求极高,也给空气动力学性能开发带来了很大的挑战。为实现这一目标,通过采用计算流体力学(Computational Fluid Dynamics,CFD)仿真和风洞试验相结合的方法,对车身造型、车... 详细信息

作为比亚迪丰田电动车科技有限公司第1款纯电动轿车,bZ3的能耗要求极高,也给空气动力学性能开发带来了很大的挑战。为实现这一目标,通过采用计算流体力学(Computational Fluid Dynamics,CFD)仿真和风洞试验相结合的方法,对车身造型、车底、前舱进气管理、车轮、密封等部位进行了持续的优化验证。最终bZ3在风洞中进行实车试验验收,空气阻力系数达到0.218,在同级别车型中处于领先水平。通过两种不同仿真方法对比研究发现格子玻尔兹曼(Lattice Boltzmann Method,LBM)方法整体精度较高,但对于底部气流的模拟精度还有待提升。

关键词：计算流体力学仿真风洞试验空气阻力系数格子玻尔兹曼

The roles and relations of calpastatin,calmodulin and an undefined cytoplasmic factor in the regulation of cardiac L-type Ca^(2+) channels

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沈阳药科大学学报 2008年第S1期25卷 94-95页

作者： tsuko Minobe masaki Kameyama Department of Physiology Graduate School of Medical and Dental SciencesKagoshima University

Objective To explore the mechanism that cytoplasmic factors could recover L-type Ca2+ channel activity after "run-down".The factors include ATP,calpastatin and H fraction(a high molecular fraction of bovine cardiac cytoplasm).Methods Single Ca2+ channel activities were recorded with patch clamp technique in guinea-pig cardiac ***-down was induced by the inside-out patch ***(CS),calmodulin(CaM)and three GST-fusion fragment peptides derived from the C-terminal tail of guinea-pig Cav1.2,CT-1(amino acids number 1509-1791),CT-2(1777-2003)and CT-3(1944-2169)were produced as GST fusion ***(1)CaM + ATP or CS + ATP restored the channels after run-down;however,the CaM or CS's effects became smaller with the longer run-down time.(2)After run down,CaM-dependent protein kinase(CaMKII)produced Ca2+ channel activity to only 2-10% of the basal activity,however,in the presence of CaMKII,the time-dependent nature of the CaM effect was abolished.(3)In pull-down assay,CT-1 treated with CaMKII showed a higher affinity for CaM than that treated with phosphatase.(4)CaMKII was detected in the H fraction of bovine cardiac *** The results show that CS,CaM and CaMKII are all involved in the maintenance of the basal activity of L-type Ca2+ channels,and that there might be cross talks among the four factors(CS,CaM,CaMKII and the undefined cytoplasmic factor).

关键词： calpastatin calmodulin calcium channel regulation

Automated crystal structure analysis based on blackbox optimisation

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npj Computational Materials 2020年第1期6卷 1022-1028页

作者： Yoshihiko Ozaki Yuta Suzuki Takafumi Hawai Kotaro Saito masaki Onishi Kanta Ono Artificial Intelligence Research Center(AIRC) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan GREE Inc.TokyoJapan Institute of Materials Structure Science(IMSS) High Energy Accelerator Research Organization(KEK)IbarakiJapan SOKENDAI(The Graduate University for Advanced Studies) IbarakiJapan Paul Scherrer Institute VilligenSwitzerland Medley IncTokyoJapan

In the present study,we show that time-consuming manual tuning of parameters in the Rietveld method,one of the most frequently used crystal structure analysis methods in materials science,can be automated by considering the entire trial-and-error process as a blackbox optimisation *** automation is successfully achieved using Bayesian optimisation,which outperforms both a human expert and an expert-system type automation despite the absence of *** approach stabilises the analysis quality by eliminating human-origin variance and bias,and can be applied to various analysis methods in other areas which also suffer from similar tiresome and unsystematic manual tuning of extrinsic parameters and human-origin variance and bias.

关键词： analysis black structure

Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports

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World Journal of Clinical Cases 2020年第21期8卷 5320-5325页

作者： masaki Okajima Yoshinori Takahashi Takaaki Kaji Naohiko Ogawa Hideyuki Mouri Intensive Care Unit Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Rheumatology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Nephrology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Respiratory Medicine Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Nafamostat mesylate(NM)may prove to be one of the key drugs effective against coronavirus disease 2019(COVID-19)because of its anti-viral properties and the potential to manage ***,NM tends to increase serum potassium *** SUMMARY We observed hyperkalemia immediately after NM administration(200 mg/d)in four consecutive patients who were admitted to the Kanazawa University Hospital with severe COVID-19 *** potassium excretion decreased after NM administration in three patients who underwent *** NM is likely to produce hyperkalemia in patients with ***,it is necessary to monitor serum potassium values closely after NM initiation in COVID-19 patients who need respiratory support.

关键词： COVID-19 Nafamostat Hyperkalemia Disseminated intravascular coagulation Respiratory insufficiency Case report