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小鼠腭发育过程中腭皱褶细胞的特点

中华口腔医学杂志 2009年第Z1期44卷 97-97页

作者： Hitoshi Yamamoto Takashi Muramatsu Yoshiyuki Shibukawa masakazu Tazaki DepartmentofHistology CytologyandDevelopmentalAnatomy NihonUniversitySchoolofDentistryatMatsudo DepartmentofPathology TokyoDentalCollege DepartmentofPhysiology TokyoDentalCollege Tokyo Japan DepartmentofPhysiology TokyoDentalColle DepartmentofHistology CytologyandDevelopmentalAnatomy NihonUniversitySchoolofDentistryatMatsudo DepartmentofPathology TokyoDentalCollege DepartmentofPhysiology TokyoDentalCollege Tokyo Japan DepartmentofPhysiology TokyoDentalColle DepartmentofHistology CytologyandDevelopmentalAnatomy NihonUniversitySchoolofDentistryatMatsudo DepartmentofPathology TokyoDentalCollege DepartmentofPhysiology TokyoDentalCollege Tokyo Japan DepartmentofPhysiology TokyoDentalColle DepartmentofHistology CytologyandDevelopmentalAnatomy NihonUniversitySchoolofDentistryatMatsudo DepartmentofPathology TokyoDentalCollege DepartmentofPhysiology TokyoDentalCollege Tokyo Japan DepartmentofPhysiology TokyoDentalColle

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Clipping Method. a Modified Procedure of Transanal Endoscopic Microsurgery （TEM）

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Clipping Method. a Modified Procedure of Transanal Endoscopi...

Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Kazuto Sasaya Takenori Hada Toshio lino Michiaki Watanabe Masaichi Ogawa Yasushi Kaneko Eiichiro Miura Kenji lkeuchi masakazu Iwamoto Sadao Anazawa Yoji Yamazaki Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine Department of surgery. Daisan hospital the Jikei university school of medicine

＜正＞Transanal Endoscopic Microsurgery（TEM） has been reported to be a better operating method for resecting a rectal mucosal lesion than any other conventional transanal or transsacral procedure. One of the greatest advantage of TEM is en bloc resection with safety margin even of large sized lesion. Nevertheless. according to our clinical experiences, an enough safety margin could not be secured in more than 30％ of cases in our series, including cases in which local recurrence occurred, requiring additional surgery. To perform en bloc resection completely with a safety margin, we modified TEM by using hemoclips and proved to be useful clinical practice.

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World Journal of Diabetes 2013年第5期4卷 227-230页

作者： Eiji Kawasaki Jun-ichi Yasui Masako Tsurumaru Haruko Takashima Toshiyuki Ikeoka Fumi Mori Satoru Akazawa Ikuko Ueki masakazu Kobayashi Hironaga Kuwahara Norio Abiru Hironori Yamasaki Atsushi Kawakami Department of Metabolism/Diabetes and Clinical Nutrition Nagasaki University Hospital First Department of Internal Medicine Nagasaki University Graduates School of Biomedical Sciences Clinical Research Center Nagasaki University Hospital Center for Health and Community Medicine Nagasaki University

We have previously reported the high levels of glutamic acid decarboxylase 65 autoantibodies(GAD65A)in patients with type 1 diabetes and autoimmune thyroid *** we describe a 32-year-old Japanese female with a thirteen-year history of type 1 diabetes whose levels of GAD65A were elevated just after the emergence of anti-thyroid *** 19 years of age,she developed diabetic ketoacidosis and was diagnosed with type 1 *** had GAD65A,insulinoma-associated antigen-2 autoantibodies(IA-2A),and zinc transporter-8 autoantibodies(ZnT8A),but was negative for antibodies to thyroid peroxidase(TPOAb)and thyroglobulin(TGAb)at disease ***8A and IA-2A turned negative 2-3 years after the onset,whereas GAD65A were persistently positive at lower level(approximately 40 U/mL).However,just after the emergence of TGAb at disease duration of 12.5 years,GAD65A levels were reelevated up to5717 U/mL in the absence of ZnT8A and *** thyroid function was normal and TPOAb were consistently *** has a HLA-DRB1*03:01/*04:01-DQB1*02:01/*03:02 *** positivity for GAD65A might be associated with increased risk to develop anti-thyroid autoimmunity.

关键词： Autoimmune thyroid disease Case report Glutamic acid decarboxylase autoantibodies Type 1diabetes

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具有广泛回弹性和硬度的泡沫的聚醚

具有广泛回弹性和硬度的泡沫的聚醚

Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand

中国聚氨酯工业协会第十次年会

作者： masakazu Kageoka Masaki Kuwagaki Hideaki Ootsuka Yasuhiko Sato Takashi Kumaki 武田药品工业株式会社

介绍如何选择最佳聚醚而生产最理想的泡沫。特别注意分析其与泡沫物性(硬度和回弹性)的关系。同时介绍一些聚醚(ACTCOL),包括新开发的聚醚。

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 21-33页

作者： Gyokukou You Lu Zeng Hideaki Tanaka Emi Ohta Takahiro Fujii Kazuhiko Ohshima masakazu Tanaka Nobuyuki Hamajima Chutiwan Viwatthanasittiphong Mantana Muangphot Dhiraphol Chenvidhya Adisorn Jedpiyawongse Banchob Sripa Masanao Miwa Satoshi Honjo Department of Bioscience Nagahama Institute of Bio-Science and TechnologyNagahama 526-0829ShigaJapan Division of Neuroimmunology Joint Research Center for Human Retrovirus InfectionKagoshima UniversityKagoshima 890-8544KagoshimaJapan Department of Healthcare Administration Nagoya University Graduate School of MedicineNagoya 466-8550AichiJapan Department of Diagnostic and Interventional Radiology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of Pathology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of Surgery Ubon Cancer CentreUbon Ratchathani 34000Thailand Research Division National Cancer InstituteBangkok 10400Thailand Department of Pathology Khon Kaen UniversityKhon Kaen 40002Thailand Department of Paediatirics National Hospital OrganizationFukuoka National HospitalFukuoka 811-1394FukuokaJapan

BACKGROUND Cholangiocarcinoma(CCA)is an intractable cancer,and its incidence in north eastern Thailand is the highest *** with the liver fluke Opisthorchis viverrini(OV)has been associated with CCA ***,animal experiments have suggested that OV alone does not induce CCA,but its combination with a chemical carcinogen like nitrosamine can cause experimentally induced CCA in ***,in humans,other environmental and genetic factors may also be *** To examine relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related *** This hospital-based case-control study enrolled 95 case-control pairs matched by age(±5 years)and *** examined relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related genes,serum anti-OV,alcohol consumption,and *** of CYP2E1,IL-6(-174 and-634),IL-10(-819),and NF-κB(-94)and their cooccurrence with polymorphisms in the drug-metabolizing enzyme gene GSTT1 or GSTM1 were also *** Although CCA risk was not significantly associated with any single polymorphism,persons with the GSTT1 wild-type and CYP2E1 c1/c2+c2/c2 genotype had an increased risk(OR=3.33,95%CI:1.23-9.00)as compared with persons having the GSTT1 wild-type and CYP2E1 c1/c1 wild *** presence of anti-OV in serum was associated with a 7-to 11-fold increased risk,and smoking level was related to an OR of 1.5-1.8 in multivariable analyses adjusted for each of the seven genetic *** In addition to infection with OV,gene-gene interactions may be considered as one of the risk factors for CCA development.

关键词： Opisthorchis Glutathione transferase Cytochrome P-450 CYP2E1 Case-control study

Effects of Beam Startup Characteristics on Dose Delivery Accuracy at Low Monitor Units in Step-and-Shoot Intensity Modulated Radiation Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2013年第1期2卷 1-5页

作者： Kazunori Fujimoto Kunihiko Tateoka Yuji Yaegashi Katsumi Shima Junji Suzuki Yuichi Saito Akihiro Nakata Takuya Nakazawa Tadanori Abe Masaki Yano Masanori Someya Kensei Nakata masakazu Hori Masato Hareyama Koichi Sakata Department of Medical Physics Graduate School of Medicine Sapporo Medical University Sapporo Japan Department of Radiology Sapporo Medical University Sapporo Japan Radiation Therapy Research Institute Social Medical Corporation Teishinkai Sapporo Japan

Intensity modulated radiation therapy (IMRT) is a highly accurate technique that is usually implemented in either dynamic or step-and-shoot fashion with many segments each having low monitor units (MUs). The present study evaluated the effects of beam startup characteristics on the dose delivery accuracy for each segment at low MUs for step-and-shoot IMRT with an Elekta Precise accelerator at the highest dose rates. We used a two-dimensional semi-conductor detector for the dose measurements. The field size of each segment was assumed to be 20 ×20 cm2 and each segment was set to deliver 1 - 10 MUs. Our results show a variation in dose delivery accuracy between segments for the same IMRT beam, which can be attributed to the beam startup characteristics. This variability is attributed to the changes in the transient changes in the temperatures of the electron gun filament and the magnetron. That is, the transient increase in the temperature of the filament leads to increasing doses with time and that of the magnetron leads to decreasing doses with time during the first few MUs.

关键词： Startup Performance Step-and-Shoot IMRT Low Monitor Units

Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2006年第2期12卷 322-326页

作者： Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa masakazu Haneda Masashi Yoneda Second Department of Medicine Asahikawa Medical CollegeAsahikawaJapan Department of Surgical Pathology Asahikawa Medical CollegeAsahikawaJapan Health Care Administration Center Obihiro University of Agriculture and Veterinary MedicineObihiroJapan Department of Gastroenterology Dokkyo University School of MedicineMibuJapan

AIM： To investigate the efficacy of angiotensin Ⅱ receptor antagonist on hepatic stellate cells （HSCs） activation in the patients with non-alcoholic steatohepatitis （NASH）. METHODS： Seven patients with NASH were prescribed Iosartan, a selective angiotensin Ⅱ type 1 receptor antagonist （50 mg/d） for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 and α-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver （NAFL） were also examined as controls. RESULTS： In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk Iosartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION： Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensin Ⅱ receptor antagonist on patients with NASH.

关键词： NASH NAFLD Hepatic fibrosis HSC Losartan

区域大气CO2浓度实时测量及分析——以江苏大学校区为例

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复旦学报（自然科学版） 2020年第4期59卷 505-510页

作者：杨晨徐朔夏涛毛静郑敏学伊藤雅一江苏大学环境与安全工程学院江苏镇江212013 日本名古屋产业大学日本爱知县488-8711

二氧化碳(CO2)浓度是研究大气温室效应最重要的参数,目前国内CO2监测点少,实时监测数据缺乏,已成为CO2相关研究的瓶颈.本研究采用日本先进的便携式CO2测量仪,从2018年3月—2019年9月对江苏大学校园30个不同观测点的CO2浓度变化进行监测... 详细信息

二氧化碳(CO2)浓度是研究大气温室效应最重要的参数,目前国内CO2监测点少,实时监测数据缺乏,已成为CO2相关研究的瓶颈.本研究采用日本先进的便携式CO2测量仪,从2018年3月—2019年9月对江苏大学校园30个不同观测点的CO2浓度变化进行监测,期间共获得6 300组有效数据.监测结果表明:(1)监测期间CO2平均浓度为397.9mL/m^3,低于2018年全球CO2平均浓度(407.8mL/m^3);(2)月平均浓度变化大体呈"M"型,浓度差最大为35.7mL/m^3;日平均浓度变化呈"V"型,早、晚高,中午低;(3)研究区域内CO2浓度空间分布特征为西北部、中部、东北部偏高(398.7~401.7mL/m^3),北部、东南部、西南部偏低(394.2~396.5mL/m^3);(4)CO2浓度与湿度呈正相关,与温度及风速呈负相关;(5)研究区域风向在正北方向、东北方向和东南方向具有较高重现率;(6)周边工业生产和居民生活对CO2浓度变化有较大的影响.

关键词：二氧化碳浓度地理信息系统实时测量时空变化镇江市

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Potential of a COX-2 inhibitor in lowering chemotherapy-induced neutropenia

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中华乳腺病杂志（电子版） 2010年第5期4卷 8-13页

作者： Louis Wing-Cheong Chow Adrian Yun-San Yip Eleanor Yuen-Yuen Ong Chi-Kei Lam masakazu Toi Clinical Trials Centre Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Organisation for Oncology and Translational Research Comprehensive Centre for Breast Diseases UNI MED Medical Institute Department of Surgery Kyoto UniversityJapan

Objective This study was initially designed to evaluate the effect of celecoxib on the regimen of 5-fluorouracil,epirubicin,and cyclophosphamide(FEC)combination,followed by docetaxel(T)in neoadjuvant *** unplanned preliminary review on safety was conducted after a halt of the study due to the concerned potential cardiovascular risk of using COX-2 *** We studied 23 consecutive cases of operable breast cancer having received four cycles of FEC(500 mg/m2,100 mg/m2,500 mg/m2)followed by four cycles of T(100 mg/m2)with concurrent celecoxib(400 mg twice daily)(group A)or same chemotherapy regimen but without concurrent celecoxib(group B).These combined chemotherapies were administered every 3 *** Chi-square test or Fisher's exact test were used to assess the difference in incidence of limiting hematological toxicites between *** 23 patients(group A:n=12;group B,n=11)received a total of 183 out of 184 planned treatment cycles;one(4%,1/23)of them omitted the fourth cycle of FEC owing to repeated incidences of febrile *** dose intensity(RDI)for FEC in group A(90%±11%)was higher than that in group B(80%±8%)while RDI for T was similar between group A(93%±8%)and group B(96%±9%).Of the first 91 treatment cycles of FEC,limiting hematological toxicity,severe neutropenia including febrile neutropenia,was significantly different between group A and B [(10.4%,5/48)vs.(32.6%,14/43),P=0.009].Other toxicities commonly observed in chemotherapy receiving patients were *** Neoadjuvant use of FEC followed by T with concurrent celecoxib appeared to be safe for treatment of operable invasive breast *** observed lower incidence of chemotherapy-induced neutropenia is possibly contributed by the administration of *** believe that further investigation might provide more evidence on the use of COX-2 inhibitors in breast cancer.

关键词：血疗法乳腺癌治疗临床

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