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Photoactivated adenylyl cyclase （PAC）, a microaigal photoreceptor with intrinsic effector function

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Photoactivated adenylyl cyclase （PAC）, a microaigal photor...

Failed Completion Pneumonectomy for Early Recurrent Pleomorphic Carcinoma: A Case Report

The 3rd Asian and Oceanian Conference on Photobiology

作者： masakatsu Watanabe Mineo Iseki Sigeru Matsunaga Takeshi Suzuki Shinya Yoshikawa Shinji Ito School of Advanced Sciences and Center for Advanced Research Graduate University for Advanced Studies（SOKENDAI）Shonan VillageHayarmKanagawa240-0193JAPAN Center for Advanced Research Graduate University for Advanced Studies（SOKENDAI）Shonan VillageHayamaKanagawa240-0193JAPAN Center for Advanced Research Graduate University for Advanced Studies（SOKENDAI）Shonan VillageHayamaKanagawa240-0193JAPAN Center for Advanced Research Graduate University for Advanced Studies（SOKENDAI）Shonan VillageHayamaKanagawa240-0193JAPAN Department of Marine Bioscience Fukui Prefectural UniversityGakuenchoObamaFukui917-0003JAPAN National Institutes of Health RBBCCRNCIBldg.10Rm B3-B699000 Rockville PikeBethesdaMD 20892-1002U.S.A.

＜正＞Photoactivated adenylyl cyclase （PAC） is the blue-light receptor flavoprotein recently identified as a sensor for photomovements in the unicellular flagellate alga, Euglena gracilis （Iseki et al. 2002, Nature 415, 1047-1051）. PAC is consisted of α-and β-subunits, which are similar to each other and contain two FAD-binding domains （BLUF;sensor of Blue-light-Light Using FAD） each followed by a class Ⅲ adenylyl cyclase catalytic domain. Adanylyl cyclase activity of purified PAC is elevated by UVA/blue-light irradiation in a fluence-dependent manner with a wavelength dependency consistent with the absporption spectrum of FAD （Yoshikawa et al. 2005, Photochem. Photobiol. Sci.727-731） . Heterologously expressed FAD-binding domain of PACaaaaa exhibits sperctral red shift upon blue-light irradiation, which indicates that the primary mechanism of photoactivation is similar to that seen with other BLUF proteins of prokaryotic origin （Ito et al. 2005, Photochem. Photobiol. Sci. 4, 762-769）. Phylogenetic analysis of the adenylyl cyclase catalytic domains revealed that they belong to a bacterial cluster, not to a trypanosomal one. Consideration together with the phylogeny of euglenoids suggests that PAC might have been transferred to euglenoids on the occasion of secondary endosymbiosis （Koumura et al. 2004, Photochem. Photobiol. Sci. 3, 580-586）. Since PAC is directly activated by light without any other intervening components, it is expected to serve as a biotechnological tool for controlling intracellular camp levels using blue-light （Watanabe and Iseki 2005, Handbook of Photosensory Receptors, W. R. Briggs and J. L. Spudich eds., Wiley-VCH, pp. 447-460;Iseki et al. 2006, Flavins:Photochemistry and Photobiology, E. Silva and A. M. Edwards eds., RSC Publishing, pp. 271-286）.

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Open Journal of Thoracic Surgery 2013年第1期3卷 1-3页

作者： Mayuko Uehara Atsushi Watanabe Junji Nakazawa Ryo Harada Masahiro miyajima Shinji Nakashima Takuro Obama Tetsuya Higami Department of Thoracic and Cardiovascular Surgery Sapporo Medical University Sapporo Japan.

We report a patient with a large pulmonary pleomorphic carcinoma (PPC) in the left upper lobe greater than 10 cm in diameter. She underwent left upper lobectomy with mediastinal lymph node dissection and concomitant resection of the left phrenic nerve, vagus nerve and pericardium. She received adjuvant chemotherapy, but had tumor recurrence. We then performed left completion pneumonectomy, but could not remove the tumor completely because of rapid tumor invasion to the left atrium. Urgent surgery should be considered for recurrent resectable PPC.

关键词： Pulmonary Pleomorphic Carcinoma Completion Pneumonectomy Reoperation Tumor Recurrence

Copper Accumulates in Hemosiderins in Livers of Patients with Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2015年第2期3卷 85-92页

作者： Yukiya Ono Masatoshi Ishigami Kazuhiko Hayashi Shinya Wakusawa Hisao Hayashi Kotaro Kumagai Natsuko Morotomi Tetsuji Yamashita Miwa Kawanaka Minemori Watanabe Hiroaki Ozawa Mayumi Tai Hiroaki miyajima Kentarou Yoshioka Yoshiki Hirooka Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of Medicine Nagoya Japan Department of Medical Laboratory Sciences Nagoya University Graduate School of Medicine Nagoya Japan Department of Medicine Aichi Gakuin University School of Pharmacy Nagoya Japan Digestive Disease and Lifestyle Related Disease Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Department of Internal Medicine Moji Hospital Kitakyushu Japan Department of Medicine Yoshida Hospital Matsuyama Japan General Internal Medicine 2 Kawasaki Hospital Kawasaki Medical School Okayama Japan Department of Endocrinology and Diabetes Okazaki City Hospital Okazaki Japan Department of Pathology Okazaki City Hospital Okazaki Japan Department of Gastroenterology Fukushima Rohsai Hospital Fukushima Japan First Department of Medicine Hamamatsu University School of Medicine Hamamatsu Japan Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University Toyoake Japan

In biology,redox reactions are essential and sometimes harmful,and therefore,iron metabolism is tightly regulated by *** the state of copper in iron overload syndromes remains unclear,we investigated whether copper metabolism is altered in these *** patients with iron overload syndromes participated in this *** clinical diagnoses were aceruloplasminemia (n=2),hemochromatosis (n=5),ferroportin disease (n=2),and receiving excess intravenous iron supplementation (n=2).Liver specimens were analyzed using a light microscope and transmission electron microscope equipped with an X-ray *** addition to a large amount of iron associated with oxygen and phosphorus,the iron-rich hemosiderins of hepatocytes and Kupffer cells contained small amounts of copper and sulfur,regardless of disease ***-dimensional imaging clearly showed that cuproproteins were distributed homogenously with iron complexes within *** stasis was unlikely in noncirrhotic *** enhanced induction of cuproproteins by excess iron may contribute to copper accumulation in *** conclusion,we have demonstrated that copper accumulates in hemosiderins in iron overload conditions,perhaps due to alterations in copper metabolism.

关键词： Aceruloplasminemia Cuproprotein induction Ferroportin disease Hemochromatosis Hemosiderin Iron copper interaction Iron overload syndromes

Combined Effects of Blood Pressure and Aldosterone on Cardiac Left Ventricular Mass Index—Ethnic Differences between Kazakh, Uygur and Han Subjects

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World Journal of Cardiovascular Diseases 2014年第3期4卷 99-105页

作者： masakatsu Ohta Yuji Kasamaki Yukio Ozawa Atsushi Hirayama Tomohiro Nakayama Hiroshi Kawamura Dilxat Himit Masayoshi Soma Yoichi Izumi Department of Cardiology Kanazawa Medical University Himi Municipal Hospital Himi Japan Department of Internal Medicine Nippon Dental University Tokyo Japan Department of Science and Research Xinjiang Medical University Urumqi China Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan Division of Laboratory Medicine Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

Previous Background: Hemodynamic factors, like blood pressure, have been established to be major determinants of cardiac left ventricular structure. However, several factors other than blood pressure to influence cardiac mass have been implicated. When we did medical survey, cardiac left ventricular mass index (LVMI) of one ethnic group that had higher blood pressure was found to be smaller than that of the other ethnic groups with a lower blood pressure. Such contradicted data from the present study were analyzed combining blood pressure, LVMI and chemical parameters obtained from blood and urine. Methods: In a medical survey conducted in Xinjiang, China, 279 people (65 - 70 years old) from three ethnic groups (Kazakh, Uygur and Han) from two separated regions provided blood and urine samples and underwent echocardiography and 24-h ambulatory blood pressure monitoring (ABPM). Results: Systolic and diastolic blood pressure obtained from ABPM and urinary sodium excretion values were significantly higher in Kazakh than that in Uygur and Han. However, LVMI in Kazakh was lower than that in other 2 groups. Plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were significantly lowest in Kazakh. The values of LVMI in all ethnic groups were positively related to both blood pressure and PAC. An inverse correlation was identified between PAC and urinary sodium excretion value. Conclusion: Although higher blood pressure in Kazakh subjects, their LVMI was lower than those of Uygur and Han, whose blood pressure was lower than that in Kazakh. These results suggest that blood pressure is not always a determinant for LVMI value. There is a possibility that relatively lower PAC resulted from higher sodium intake suppressed the rise in LVMI caused by higher blood pressure in Kazakh.

关键词： Left Ventricular Mass Aldosterone Blood Pressure Salt Intake

喷管面积比为300:1的液氢/液氧发动机性能研究

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导弹与航天运载技术 1986年第1期 23-31页

作者： H.miyajima 朱庆林

本文简要地介绍一种制造燃烧室的新工艺——管壁铸焊技术。用喷管面积比为300:1、燃烧室压力为3.5MPa、推力为4200N的液氢/液氧发动机进行高空模拟试验。测定的比推力和计算预估的相当一致。混合比为5.0,燃烧效率为98％,比推力为458秒。

关键词：比推力冷却剂混合比薄膜冷却液氧比冲燃气轮机性能参数气膜冷却喷注器燃烧室效率喷管壁推力室燃烧室压力喷管面积比液化气体液氢

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家蚕传染性软化病的蚕座内感染

广东蚕业 1965年第2期 31-32页

作者： Yoshifumi Ishikawa Shigetoshi miyajima 金伟

调查了在健康蚕儿和罹病蚕儿混育中有关罹病蚕儿混育数和混育时间长短的传染性软化病的发病率。越多的罹病蚕儿混入,其传染性软化病的发病率就变得越高。当混育的时间越长,其传染性软化病的发病率越增高。

关键词：蚕儿发病率蚕座软化病

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LE-5氢/氧发动机的比推力分析

导弹与航天运载技术 1985年第3期 1-10页

作者： H.miyajima 孙国庆

用测得的LE-5发动机的真空比推力来评定具有现代技术的喷管性能预计法。LE-5发动机是一台燃气发生器循环式的氢氧发动机。该发动机的推力为103千牛顿、燃烧室压力为3.6兆帕、喷管面积比为140:1。涡轮排气喷入超音速主流。涡轮排气的有... 详细信息

用测得的LE-5发动机的真空比推力来评定具有现代技术的喷管性能预计法。LE-5发动机是一台燃气发生器循环式的氢氧发动机。该发动机的推力为103千牛顿、燃烧室压力为3.6兆帕、喷管面积比为140:1。涡轮排气喷入超音速主流。涡轮排气的有效比推力是用一个简单方法计算的。然后,再乘一个由缩尺模型热试验决定的系数。主流比推力由类似于JANNAF喷管分析法计算。该法假定,能量释放效率等于测得的c;效率。测量的和预计的比推力是相当一致的。文中指出了在某些情况下c;效率与能量释放效率之间的差别和不一致程度。

关键词：比推力主流二次流混合比比冲燃气轮机性能参数 LE-5 喷管面积比喷注器发动机

TiO2-Coated TCO (SnO2:F) Films Prepared by AP-CVD with High Durability against Hydrogen Radicals

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TiO2-Coated TCO (SnO2:F) Films Prepared by AP-CVD with High ...

Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions

第十五届国际光伏科学与工程大会

作者： Mika Kambe Kazuo Sato Yasuyoshi Kurokawa Shinsuke miyajima Makoto Fukawa Naoki Taneda Makoto Konagai Research Center Asahi Glass Co. Ltd. 1150 Hazawa-cho Kanagawa-ku Yokohama 221-8755 Japan Department of Physical Electronics Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8552 Japan

Durability of textured transparent conductive oxide (TCO) film against hydrogen radicals was investgated. An ultra thin TiO film of 2 nm in thickness was deposited on textured fluorine-doped tin oxide (SnO:F) film, successively by atmospheric pressure chemical vapor deposition (AP-CVD). TCO films with and without TiO layer were exposed to hydrogen radicals generated by VHF exited plasma. TCO films with TiO layer showed higher optical transmittatice and lower resistivity after exposure to hydrogen radicals, while TCO films without TiO layer showed lower optical transmittance and higher resistivity after the exposure. These TCO films were characterized by X-ray photoelectron spectroscopy (XPS) and secondary ion mass spectroscopy (SIMS) before and after the exposure to hydrogen radicals.

关键词： transparent conductive oxide TiO2 SnO2 hydrogen radical

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Health 2010年第7期2卷 781-788页

作者： Mayumi Watanabe Kenya miyajima Ittoku Matsui Chikako Tomiyama-Miyaji Eisuke Kainuma Masashi Inoue Hiroaki Matsumoto Yuh Kuwano Toru Abo 不详

In a series of our recent studies, stress was found to induce simultaneously hypothermia and hyperglycemia. These conditions are beneficial to obtain prompt force which depends on the glycolysis pathway and to escape emergency. Since we have noticed that such conditions resemble the internal environment seen in some cancer patients, it was investigated whe- ther such conditions were accompanied with other patients. We selected patients with early and advanced cancer. Body temperature and other parameters including blood gas contents were examined. A difference was seen in body temperature, namely, many patients showed hypothermia, irrespective of cancer stages. Fur- ther characterization of other parameters show- ed that hypothermia and hyperglycemia existed in many patients. They had immunosuppressive state and anemia. Blood gas analysis showed that oxygen contents were low and carbon dioxide contents were high in patients. These results suggest a possibility that the internal environment seen in patients is responsible to induce onset of disease and to maintain their cell growth, because cancer cells have an energy system of predominant glycolysis. Although hypothermia, hypoxia and hyperglycemia are important to activate the glycolysis pathway and to escape from emergency, such responses suppress the mitochondrial pathway for long span and may result in carcinogenesis.

关键词： Cancer Hypothermia Hypoxia Hyperglycemia Glycolysis Mitochondria