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Physical multimorbidity patterns and depressive symptoms:a nationwide cross-sectional study in Japan

Family Medicine and Community Health 2020年第1期8卷 14-19页

作者： Takuya Aoki Yosuke yamamoto Sayaka Shimizu Shunichi Fukuhara Department of Healthcare Epidemiology Kyoto UniversityKyotoJapan Institute for Health Outcomes and Process Evaluation Research(iHope International) KyotoJapan Department of General Medicine Fukushima Medical UniversityFukushimaJapan Center for Innovative Research for Communities and Clinical Excellence(CIRC2LE) Fukushima Medical UniversityFukushimaJapan

Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of ***,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains *** study aimed to investigate the associations of physical multimorbidity patterns with depressive *** This study was designed as a nationwide cross-sectional survey in *** General sample of the Japanese *** Adult Japanese residents were selected by a quota sampling *** were analysed from 1788 residents who reported one or more chronic health *** Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive *** these patterns,patients with the RDE pattern may be at a higher risk for developing depressive *** study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients.

关键词： pattern nationwide sectional

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Effect of Catch Cup Geometry on 3D Boundary Layer Flow over the Wafer Surface in a Spin Coating

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Journal of Thermal Science 2008年第1期17卷 56-60页

作者： Mizue MUNEKATA Seiichi KIMURA Hiroaki KURISHIMA Jinsuke TANAKA Sohei yamamoto Hiroyuki YOSHIKAWA Kazuyoshi MATSUZAKI Hideki OHBA Department of Mechanical System Engineering 2-39-1 KurokamiKumamoto860-8555 Japan Assistant Professor Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto860-8555 Japan Tokyo Electron Kyushu LTD. 1-1 FukuharaKoushi-shiKumamoto861-1116 Japan Department of Mechanical System Engineering 2-39-1 KurokamiKumamoto860-8555 Japan Tokyo Electron LTD. 650 MitsuzawaHosaka-choNirasaki-shiYamanashi407-0192 Japan

Recently, development of high technology has been required for the formation of thin uniform film in manufacturing processes of semiconductor as the semiconductor instruments become more sophisticated. Spin coating is usually used for spreading photoresist on a wafer surface. However, since rotating speed of the disk is very high in spin coating, the dropped photoresist scarers outward and reattaches on the film surface. A catch cup is set up outside the wafer in spin coating, and scattered photoresist mist is removed from the wafer edge by the exhaust flow generated at the gap between the wafer edge and the catch cup. In the dry process of a spin coating, it is a serious concern that the film thickness increases near the wafer edge in the case of low rotating speed. The purpose of this study is to make clear the effect of the catch cup geometry on the 3D boundary layer flow over the wafer surface and the drying rate of liquid film.

关键词： Rotating disk Spin coating Boundary layer flow Laser Doppler velocimeter Infrared camera

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Radiation Temperature Measurement of an Imploded X-Ray Source with a Filtered-Multi-Channel Pinhole Camera

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Chinese Physics Letters 2010年第12期27卷 136-138页

作者：王首钧董全力张翼李玉同张蕾 Shinsuke Fujioka Norimasa yamamoto Hiroaki Nishimura 张杰 Beijing National Laboratoiy of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 Institute of Laser Engineering Osaka University Osaka 565-0871 Japan Department of Physics Shanghai Jiaotong University Shanghai 200240

The Plankian radiation temperature of an intense x-ray source driven by imploding spherical CH plastic shell is measured with a filtered-multi-channel pinhole camera. With all the twelve laser beams of the GEKKO-XII laser facility applied, the average radiation temperature is measured to be around 465 eV while the temperature at the core is as high as 818eV. This value is confirmed by other instruments applied.

关键词： Plasma physics

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Rheumatic manifestations of inflammatory bowel disease

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World Journal of Gastroenterology 2009年第44期15卷 5517-5524页

作者： Tatiana Sofía Rodríguez-Reyna Cynthia Martínez-Reyes Jesús Kazúo yamamoto-Furusho Department of Immunology and Rheumatology National Institute of Medical Sciences and Nutrition Salvador ZubiránVasco de Quiroga 15Col Sección XVI. DelTlalpanMexico City 14000Mexico Department of Gastro-enterology National Institute of Medical Sciences and Nutrition Salvador ZubiránVasco de Quiroga 15Col Sección XVI. DelTlalpanMexico City 14000Mexico

This article reviews the literature concerning rheu-matic manifestations of inflammatory bowel disease (IBD),including common immune-mediated pathways,frequency,clinical course and therapy. Musculoskel-etal complications are frequent and well-recognized manifestations in IBD,and affect up to 33% of pa-tients with IBD. The strong link between the bowel and the osteo-articular system is suggested by many clinical and experimental observations,notably in HLA-B27 transgenic rats. The autoimmune pathogenic mechanisms shared by IBD and spondyloarthropathies include genetic susceptibility to abnormal antigen pre-sentation,aberrant recognition of self,the presence of autoantibodies against specific antigens shared by the colon and other extra-colonic tissues,and increased intestinal permeability. The response against microor-ganisms may have an important role through molecular mimicry and other mechanisms. Rheumatic mani-festations of IBD have been divided into peripheral arthritis,and axial involvement,including sacroiliitis,with or without spondylitis,similar to idiopathic anky-losing spondylitis. Other periarticular features can oc-cur,including enthesopathy,tendonitis,clubbing,peri-ostitis,and granulomatous lesions of joints and *** and osteomalacia secondary to IBD and iatrogenic complications can also occur. The manage-ment of the rheumatic manifestations of IBD consists of physical therapy in combination with local injection of corticosteroids and nonsteroidal anti-inflammatory drugs; caution is in order however,because of their possible harmful effects on intestinal integrity,perme-ability,and even on gut inflammation. Sulfasalazine,methotrexate,azathioprine,cyclosporine and lefluno-mide should be used for selected indications. In some cases,tumor necrosis factor-α blocking agents should be considered as first-line therapy.

关键词： Inflammatory bowel disease Spondylitis Rheumatic diseases

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A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers

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World Journal of Gastroenterology 2010年第46期16卷 5779-5789页

作者： Yasushi Adachi Hiroyuki yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University Department of Internal Medicine Sapporo Shirakabadai Hospital Vanderbilt-Ingram Cancer Center and Departments of Medicine and Cell Biology Vanderbilt University

Advances in molecular research in cancer have brought new therapeutic strategies into clinical *** new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) *** concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new *** I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human *** this review,we focus on this promising therapeutic target,*** IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI *** studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer *** results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and *** also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical *** mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single *** summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug ***,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcino

关键词： Dominant negative Gastrointestinal cancer Insulin like growth factor-I receptor Monoclonal anti-body Tyrosine kinase inhibitor

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New tomographic reconstruction technique based on Laplacian eigenfunction

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Plasma Science and Technology 2020年第10期22卷 5-9页

作者： Yasuhiro SUZUKI Shishir PUROHIT Satoshi OHDACHI Satoshi yamamoto Kazunobu NAGASAKI National Institute for Fusion Science Toki 509-5292Japan The Graduate University for Advanced Studies SOKENDAIToki 509-5292Japan Institute for Plasma Research Gandhinagar 382428India Graduate School of Frontier Science The University of TokyoKashiwa 277-8561.Japan Naka Fusion Institute National Institutes for Quantum and Radiological Science and TechnologyNaka 311-0193Japan Institute of Advanced Energy Kyoto UniversityUji 611-0011Japan

This letter proposes a new tomographic reconstruction procedure based on the Laplacian eigenfunction(LEF) patterns, which are independent of the plasma cross-section and do not require the flux surface information. The process is benchmarked for the experimental data of Heliotron J plasma and the results are compared with the least-squares approximation by a Phillips–Tikhonov(PT)-type regularization, which is widely used as the standard technique for tomographic reconstruction. The reconstruction based on the LEF is found to be capable of determining the magnetic axis at different time locations efficiently in comparison with the PT-type regularization.

关键词： tomography Laplacian eigenfunction Heliotron J soft x-ray

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Perceptions of Collaboration and Satisfaction with Collaboration Regarding Care Decision-Making in Intensive Care Units in Japan: A National Survey

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Open Journal of Nursing 2020年第8期10卷 731-744页

作者： Kanako yamamoto Graduate School of Nursing St. Luke’s International University Department of Critical Care Tokyo Japan

Multi-professional collaboration is being promoted worldwide as a response to the need for sophisticated medical care and for catering to patients’ diverse needs. Patients in Intensive Care Units (ICUs) are seriously ill, and their families may be at risk depending on the patient’s situation. Considering these characteristics of patients and families, there is a strong need for multi-professional collaboration within ICUs. The purpose of this descriptive study was to examine recognition and other factors related to collaboration and satisfaction involving care decisions in Japanese ICUs. A mail survey about collaboration of activities and systems was sent to physicians, clinical engineers, and nurses working in ICUs in Japan, 387 consented to participate in this study. Results showed that satisfaction scores were generally high among the three aforementioned professions, but collaboration scores on deciding care for patients showed significant differences (p < 0.05). The total collaboration score was the highest among physicians (36.7 ± 6.7 points), followed by nurses (32.8 ± 7.4 points), and CEs (32.8 ± 7.4 points). The factors that commonly affected collaboration scores were the satisfaction score and the ability to collaborate with other professionals and set team medical care as a goal. Moreover, it is worth noting that the degree of difficulty in collaboration negatively affected this factor. On the other hand, other factors differed among the three professions, suggesting that the purpose and need for collaboration differ depending on the profession.

关键词： Intensive Care Unit Interprofessional Collaboration Decision-Making Quantitative Method

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Pancreatolithiasis with an anatomic variant of Wirsung duct:a case report

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Gastroenterology Report 2023年第1期11卷 585-587页

作者： Satoshi yamamoto Kazuo Inui Yoshiaki Katano Senju Hashimoto Hironao Miyoshi Takashi Kobayashi Yoshihiko Tachi Department of Gastroenterology Fujita Health University Bantane HospitalOtoubashiNakagawa-kuNagoyaAichiJapan Department of Gastroenterology Yamashita HospitalNakamachiIchinomiyaAichiJapan Board Chairman Geriatric Health Services Facility YukiMizuhomachiHandaAichiJapan Department of Gastroenterology Fujita Health University Okazaki Medical CenterHarisakichoOkazakiAichiJapan

Introduction In contrast to familiar developmental anomalies,such as pancreatobiliary maljunction and pancreas divisum,a double orifice of the ampulla of Vater is a much more rare congenital *** encountered a patient with pancreatolithiasis associated with anatomic variation of Wirsung duct showing a single major duodenal papilla with a double orifice and no minor papilla.

关键词： Vater orifice congenital

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Classification of rectal cancer according to recurrence types-comparison of Japanese guidelines and Western guidelines

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World Journal of Clinical Cases 2022年第36期10卷 13284-13292页

作者： Hiroshi Miyakita Yutaro Kamei Lin Fung Chan Kazutake Okada Hajime Kayano Seiichiro yamamoto Department of Digestive System Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Rectal cancer is characterized by more local recurrence(LR)and lung metastasis than colon ***,the diagnosis of rectal cancer is not standardized as there is no global consensus on its definition and *** classification of rectal cancer differs between Japanese and Western *** To clarify the characteristics of rectal cancer by comparing the tumor location and characteristics of rectal cancer with those of colon cancer according to each set of *** A total of 958 patients with Stage II and III colorectal cancer were included in the analysis:607 with colon cancer and 351 with rectal *** of rectal cancers was assessed by enema examination and rigid *** to Japan guidelines,rectal cancer is classified as Rb(below the peritoneal inversion),Ra(between the inferior margin of second sacral vertebrae and Rb)or RS(between Ra and sacral promontory).RESULTS There were no significant differences between RS rectal cancer and colon cancer in the rates of liver and lung metastasis or *** metastasis and LR were significantly more common among Rb rectal cancer(in Japan)than in colon cancer(P=0.0043 and P=0.0002,respectively).Lung metastases and LR occurred at significantly higher rates in rectal cancer measuring≤12 cm and≤10 cm than in colon cancers(P=0.0117,P=0.0467,P=0.0036,P=0.0010).Finally,the rates of liver metastasis,lung metastasis,and LR in rectal cancers measuring 11 cm to 15 cm were 6.9%,2.8%,and 5.7%,*** were equivalent to the rates in colon *** High rectal cancer may be treated with the same treatment strategies as colon *** was no difference in the classification of colorectal cancer between Japan and Western countries.

关键词： Colon cancer Metastasis Local recurrence Classification of rectal cancer Western guidelines Japanese guideline

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丝氨酸331是蛋白激酶C诱导血栓素α受体磷酰化和脱敏的主要部位(英文)

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Acta Pharmacologica Sinica 2002年第10期23卷 90-98页

作者：严奉祥,yamamoto Shuichi,TAIHsin-Hsiung,廖端芳南华大学药物药理研究所 Department of Pediatrics Saga Medical School Saga Japan College of Pharmacy University of Kentucky Lexington KY 40536-0082 USA 南华大学药物药理研究所衡阳中国 421001 衡阳中国 421001

目的:检测人类血栓素α受体（TPα）C端丝氨酸/苏氨酸残基的各种两氨酸诱变体作为PKC底物的能力,以确定被PKC磷酸化和脱敏的特异的丝氨酸/苏氨酸残基.方法:为了易于鉴定被磷酰化的细胞内区段,使用甘胱甘肽S-转移酶（GST）-细胞内区段融... 详细信息

目的:检测人类血栓素α受体（TPα）C端丝氨酸/苏氨酸残基的各种两氨酸诱变体作为PKC底物的能力,以确定被PKC磷酸化和脱敏的特异的丝氨酸/苏氨酸残基.方法:为了易于鉴定被磷酰化的细胞内区段,使用甘胱甘肽S-转移酶（GST）-细胞内区段融合蛋白作纯化的PKC底物,然后突变磷酰化蛋白的cDNA,以找出TPα被PKC磷酰化的主要部位,并将有组氨酸尾野生型或诱变型血栓素受体α稳定地转移到人类胚胎肾（HEK）293细胞,以研究该受体的磷酸化和脱敏.结果:仅C-端能充当纯化PKC底物.丝氨酸-331（mP4）被显示强的磷酰化,丝氨酸-324（mP1）则轻微磷酰化,丝氨酸-329（mP3）则微弱磷酰化,而其它丝氨酸/苏氨酸残基没被发现磷酰化.佛被醇-12-肉豆蔻酸酯-13-乙酸盐（PMA）诱导表达野生型TPα的HEK 293细胞磷酰化.然而不能显示触发表达丝氨酸331丙氨酸诱变受体的HEK 293受体磷酸化.用PMA预处理表达野生型受体的HEK 293细胞能抑制I-B0P诱导Ca2+释放,然而用PMA预处理表达诱变受体的细胞不能中止I-BOP抑制Ca2+释放.结论:丝氨酸331是TPαa磷酰化和脱敏的主要和关键部位.

关键词：血栓素受体定点诱变丝氨酸蛋白激酶C 磷酰化

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