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Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men:a preliminary report

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Asian Journal of Andrology 2023年第5期25卷 587-590页

作者： Nobuyuki Kondoh Yohei Kaizuka Seiji Nagasawa Yoshikazu Togo Shingo yamamoto Department of Urology Kawanishi City Medical CenterKawanishiHyogo 6660017Japan Department of Urology Hyogo Medical UniversityNishinomiyaHyog 6638501Japan

Although testosterone replacement therapy(TRT)is the first-choice method used worldwide for late-onset hypogonadism(LOH),clinical benefits are not seen in all *** study was conducted to determine the predictors of TRT efficacy for ***-six patients who visited our Men’s Health Clinic(Kawanishi City Medical Center,Kawanishi and Hyogo Medical University,Nishinomiya,Hyogo,Japan)between November 2003 and June 2021 with data available before and after TRT were *** were divided into responders(Group 1;n=45,accounting for 80.4%)and nonresponders(Group 2;n=11,accounting for 19.6%)based on the clinical response to TRT,including patient *** noted before TRT included age,body mass index,aging males’symptoms score,sexual health inventory for men,luteinizing hormone,follicular-stimulating hormone,testosterone,free testosterone,prolactin(PRL),estradiol(E2),and testosterone/estradiol(T/E2)ratio in *** statistical analysis,a multivariable logistic regression model was *** analysis revealed PRL(odds ratio TORI:0.9624;95%confidence interval[Cl]:0.9316-0.9943,P<0.05),E2(OR:0.8692;95%Cl:0.7745-0.9754,P<0.05),and T/E2 ratio(OR:1.1312;95%Cl:1.0106-1.2661,P<0.05)to be predictive *** analyses showed that T/E2 ratio was an independent predictive factor(OR:1.1593;95%Cl:1.0438-1.2875,P<0.01).The present results suggest that a low value for T/E2 ratio may predict a reduced response to *** T/E2 ratio threshold to predict nonresponders based on receiver-operating characteristics(ROC)curve analysis was shown to be *** additional studies with larger number of patients are necessary,we propose the determination of serum E2 level and testosterone level prior to performing TRT.

关键词： estradiol late-onset hypogonadism predictive factor testosterone treatment

Analysis of Motor Synergies Utilization for Optimal Movement Generation for a Human-like Robotic Arm

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International Journal of Automation and computing 2013年第6期10卷 515-524页

作者： Kin Chung Denny Fu Yutaka Nakamura Tomoyuki yamamoto Hiroshi Ishiguro Graduate School of Engineering Science Osaka University

Controlling human-like robots with musculoskeletal structure has been a challenging problem in engineering. In biological studies, motor synergy hypothesis has been proposed as a solution in order to control high degree-of-freedom and complex human body. In this paper, we focus on exploring the applicability of motor synergies in generating goal-directed movements by optimal control in a human-like robotic arm. We focus on three problems： 1） Can motor synergies facilitate the solving of optimal control problem？ 2） What properties should motor synergies have in order to achieve tasks？ 3） How should motor synergies be utilized better？ For the first problem we show that goal-directed movements can be achieved by utilizing motor synergies which have properties of achieving the goals. For the second problem, we testify motor synergies which have different properties and discover that energy efficiency is an important aspect in motor synergies which can also be utilized to achieve goal-directed movements. This discovery also implies that we can obtain motor synergies by other ways rather than from goal-directed optimal control signals. For the third problem, we show that the control complexity can be further reduced by utilizing a subset of motor synergies which are effective to achieve goals.

关键词： Motor synergies optimal control dimension reduction bio-inspired control biomimetics.

Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide

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World Journal of Gastroenterology 1999年第6期5卷 477-482页

作者： H yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi Kyoto Phamaceutical University 日本

AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins.

关键词： irsogladine rebamipide monochloramine gastric mucosal lesions rats comparative study

An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

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Precision Chemistry 2023年第2期1卷 100-106页

作者： An Wu Hirotaka Ikeda Hisashi yamamoto Peptide Research Center Chubu UniversityKasugaiAichi 487-8501Japan Materials Science Department MOLSIS Inc.Chuo-kuTokyo 104-0032Japan

Peptide bond formation has drawn more and more attention due to its importance in medicinal chemistry and drug *** active esters to construct peptide bonds is an indispensable strategy in this *** herein report a fast and efficient amination reaction to synthesize peptides from catechol *** monoesters are good active esters in peptide synthesis due to the anchimeric assistance *** previously reported work,the amination reaction was inactivated if the 2-hydroxyl group in the catechol esters was ***,we found an unusual acceleration of the amination reactivity when the 2-hydroxyl group was functionalized as an ester *** reaction can be complete in 2−3 min in some *** acceleration was found through experimental studies to not result from the anchimeric assistance *** proposed aπ*−π*interaction pathway between the two proximal ester *** computational studies were made to support this assumption.

关键词： catechol diesters peptide synthesis amination π*−π*interaction proximal ester groups

Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

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World Journal of Gastroenterology 2017年第21期23卷 3928-3933页

作者： Hiromi Tamura Hirotsugu Saiki Takahiro Amano Masashi yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu Nishida Katsumi yamamoto Shiro Adachi Department of Pathology City Hospital of Toyonaka Department of Gastroenterology JCHO Osaka Hospital Department of Gastroenterology City Hospital of Toyonaka

A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.

关键词： Esophageal adenocarcinoma Bilayered structure Esophageal gland duct

Emerging therapeutic options in inflammatory bowel disease

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World Journal of Gastroenterology 2021年第48期27卷 8242-8261页

作者： Jesus K yamamoto-Furusho Norma N Parra-Holguín Gastroenterology Unit Inflammatory Bowel Disease ClinicInstituto Nacional de Ciencias Medicas y NutricionMexico City 14080Mexico

Inflammatory bowel disease(IBD)is a chronic disease that requires chronic treatment throughout the evolution of the disease,with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn's *** anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment,so there is a need to develop new therapies and markers of treatment *** pathways involved in the development of the disease are known and the new therapies have focused on blocking the inflammatory process at the gastrointestinal level by oral,intravenous,subcutaneous,and topical *** these new therapies can lead to more personalized treatments with higher success rates and fewer *** treatments have not only focused on clinical remission,but also on achieving macroscopic changes at the endoscopic level and microscopic changes by achieving mucosal *** treatments are mainly based on modifying signaling pathways,by blocking receptors or ligands,reducing cell migration and maintaining the integrity of the epithelial ***,this review presents the efficacy and safety of the new treatments that are currently under study and the advances that have been made in this area in recent years.

关键词： Inflammatory bowel disease Review Emerging Treatment Ulcerative colitis Crohn's disease

A sustainable way of agricultural livelihood:edible bird’s nests in Indonesia

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Ecosystem Health and Sustainability 2021年第1期7卷 332-341页

作者： Yutaka Ito Ken’ichi Matsumoto Aswin Usup Yuki yamamoto Faculty of Regional Policy The University of ShimaneMatsueJapan Faculty of Economics Toyo UniversityTokyoJapan Faculty of Agriculture University of Palangka RayaPalangkarayaIndonesia Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasakiJapan

Edible birds’nests(EBNs)have traditionally been produced in Southeast *** farmers construct buildings for swiftlets and harvest their *** farming does not directly degrade forest resources and is therefore considered a sustainable means of production,whereas the expansion of other agricultural activities often relies on the degradation of natural *** study examines the relationship between natural resources and agricultural livelihoods,focusing on Indonesian EBN *** survey data that we collected in 2017,combined with satellite information on the extent of the forest in Central Kalimantan,Indonesia,we measured production efficiency and identified the natural and social factors that enhance production *** results show that a forest extent ranging between 2,000 and 6,000 meters from nesting building is positively associated with the production efficiency of EBN farming,perhaps because extensive forest could help swiftlets to collect food and build ***,while EBN farming is a sustainable and profitable option,the initial costs of constructing buildings to house swiftlets may deter farmers from participating in the process.

关键词： Edible bird’s nest swiftlet Indonesia forest natural habitat ecosystem services satellite data

Establishment of a surveillance program for anal cancer in Crohn's disease

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World Journal of Gastroenterology 2024年第45期30卷 4844-4849页

作者： Hajime Kayano Ken-Ichi Okada Seiichiro yamamoto Kazuo Koyanagi Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

This letter discusses the incidence of anal cancer among Crohn's disease(CD)-related *** with CD have been demonstrated to be at a higher risk of developing small bowel and colorectal cancers than healthy *** CD-associated anal cancer is relatively rare,patients with CD accom-panied by anal or perianal lesions are at increased risk of anal ***-tionally,compared to ulcerative colitis,which is also an inflammatory disease,CD-related anal cancer is often detected at an advanced stage owing to the complexity of CD and is associated with a poor prognosis with frequent local ***,the detection of early-stage cancer is crucial for improving the ***,the surveillance methods recommended for CD-related malignancies in the United States and Europe are similar to those for ulcerative *** are not appropriate for detecting CD-related malignancies in the recto-anal ***,there is an urgent need for surveillance programs aimed at the early detection of malignant anorectal lesions in patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Colorectal cancer Perianal disease Anal cancer surveillance

Numerical Simulation of Ice Accretion Phenomena on Rotor Blade of Axial Blower

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Journal of Thermal Science 2012年第4期21卷 322-326页

作者： Taiki Matsuura Masaya Suzuki Makoto yamamoto Shinichiro Shishido Takeshi Murooka Hiroshi Miyagawa Graduate School of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Department of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Research and Engineering Division IHI Corporation 229 Tonogaya Mizuho-cho Nishitama-gun

Ice accretion is the phenomenon that super-cooled water droplets impinge and accrete on a body. It is well known that ice accretion on blades and airfoils leads to performance degradation and severe accidents. For this reason, experimental investigations have been carried out using flight tests or icing tunnels. However, it is too expensive, dangerous, and difficult to set actual icing conditions. Hence, computational fluid dynamics is useful to predict ice accretion. A rotor blade is one of jet engine components where ice accretes. Therefore, the authors focus on the ice accretion on a rotor blade in this study. Three-dimensional icing phenomena on the rotor blade of a commercial axial blower are computed here, and ice accretion on the rotor blade is numerically investigated.

关键词： Icing Computational Fluid Dynamics Euler-Lagrangian Coupling Rotor Blade Axial Blower