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Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer

World Journal of Gastrointestinal Oncology 2010年第2期2卷 85-97页

作者： Yutaka Yonemura Ayman Elnemr Yoshio Endou Mitsumasa Hirano Akiyoshi Mizumoto Nobuyuki Takao Masumi Ichinose masahiro miura NPO Organization to Support Peritoneal Dissemination Treatment KishiwadaOsaka 596-0032Japan Department of Experimental Therapeutics Cancer Research InstituteKanazawa University Department of Surgery Kusatsu General Hospital Department of Anatomy School of Medicine Ooita University

There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer.A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)],peritonectomy,hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been *** this article,we assess the indications,safety and eff icacy of this treatment,review the relevant studies and introduce our *** aims of NIPS are stage reduction,the eradication of peritoneal free cancer cells,and an increased incidence of complete cytoreduction (CC-0) for PC.A complete response after NIPS was ob-tained in 15 (50%) out of 30 patients with ***,a signif icantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ *** a multivariate analysis to examine the survival benef it,CC-0 and NIPS are identified as significant indicators of a good ***,the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection *** best indications for multidisciplinary therapy are localized PC (PCI≤6) from resectable gastric cancer that can be completely removed during a *** and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer.

关键词： Gastric cancer Peritoneal carcinomatosis Chemotherapy

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Zn Dissolution-Passivation Behavior with ZnO Formation via In Situ Characterizations

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Energy & Environmental Materials 2024年第1期7卷 193-200页

作者： Tanyanyu Wang masahiro Kunimoto masahiro Yanagisawa Masayuki Morita Takeshi Abe Takayuki Homma Graduate School of Advanced Science and Engineering Waseda University1-104 TotsukamachiShinjuku-kuTokyo 169-8050Japan Office of Society-Academia Collaboration for Innovation Kyoto UniversityGokashoUji 611-0011Japan Graduate School of Engineering Kyoto UniversityKyoto daigaku-katsuraNishikyo-kuKyoto 615-8510Japan

In this study,ZnO formation during the dissolution-passivation process of Zn anodes is observed via in situ Raman and optical *** Zn passivation during galvanostatic anodization merely follows the dissolution-precipitation model,whereas that of potentiodynamic polarization exhibits different behaviors in different potential ***,the Zn electrode is gradually covered by a ZnO precipitation film and then undergoes solid-state oxidation at~255 *** starting point of solid-state oxidation is well indicated by the abrupt current drop and yellow coloration of the electrode *** the pseudo passivation,an intense current oscillation is ***,blink-like color changes between yellow and dark blue are revealed for the first time,implying that the oscillation is caused by the dynamic adsorption and desorption of OH *** as-formed ZnOs then experience a dissolution-reformation evolution,during which the crystallinity of the primary ZnO film is improved but the solid-state-formed ZnO layer becomes rich in oxygen ***,oxide densification is realized,contributing to the Zn *** study provides new insights into the Zn dissolution-passivation behavior,which is critical for the future optimization of Zn batteries.

关键词： in situ characterization Zn dissolution and passivation ZnO formation

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Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： Masato Kanazawa Itaru Ninomiya Yutaka Otsu masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

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Preoperative assessment of liver function and perioperative management of posthepatectomy liver failure

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 527-529页

作者： masahiro Shiihara Mitsugi Shimoda Shuji Suzuki Department of Gastroenterological Surgery Ibaraki Medical CenterTokyo Medical UniversityIbarakiJapan

PHLF is the status of disfunction in synthesis,excretion and *** to International Study Group of Liver Surgery(ISGLS),PHLF is defined by an increased bilirubin level and international normalized ratio(INR)on or after postoperative 5 days,and is graded by clinical severity from grades A to C(1,2).Grade A is the condition without any *** B deviates from normal postoperative management and requires blood products,diuretics,oxygen administration,and so *** C is the status with multiple organ failure which requires intensive management including respirator,dialysis,and liver transplantation,*** mortality rates in A,B and C were estimated 0%,12%,and 54%,respectively(1).Although PHLF has decreased due to extensive studies of risk factors for PHLF and improvements in surgical techniques,it remains high for several types of *** to a nationwide survey of board-certified training institutions by the Japanese Society of Hepato-Biliary-Pancreatic Surgery,90-day mortality rates is 10.3%and 6.7%after left trisectionectomy and hepatopancreatectomy,respectively(3).Further,the mortality rates after associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)was reported over 5%(4).

关键词： Hepatectomy posthepatectomy liver failure posthepatectomy liver failure(PHLF)

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A plant growth chamber system equipped with aerosol generators for studying aerosol-vegetation interactions

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Particuology 2024年第2期85卷 122-132页

作者： Masao Gen Seiji Ikawa masahiro Yamaguchi Fong Zyin Lim Takeshi Izuta I.Wuled Lenggoro Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan Faculty of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509 Japan Department of Applied Physics and Chemical Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan

Understanding aerosol-vegetation interactions is vital in ***,the interactions remain elusive partly due to the lack of suitable plant growth chamber ***,deposition of submicron particles on leaf surfaces is challenging due to its low deposition velocities compared to larger *** this work,we present a plant-growth chamber that was used to study the effect of sub-micron black carbon(BC)particles on the growth and photosynthesis of *** chamber system simultaneously enables the growth of multiple plants in pots and the deposition of submicron particles onto *** spraying methods assisted by ultrasonic and electrostatic forces were employed as aerosol generators to realize the particle *** flow regime inside the chamber was numeri-cally calculated to predict the transportation of aerosol particles,suggesting the optimal operating conditions of the *** gas-phase particle size distribution measurements showed that gener-ated BC particles were suspended in submicron diameter *** aerosol generators were examined in the chamber using three conductor and insulator substrates as a model of plant *** observations and spectroscopic analysis ascertained that submicron BC particles generated from our generators were deposited on all substrate *** the developed chamber system,systematic studies can be performed to advance the fundamental understanding of aerosol-vegetation interactions.

关键词： Aerosol Exposure chamber Spray drying Black carbon

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Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： Takeshi Ogura Yuki Uba masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

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Controlling Three-Step and Five-Step Spin Transitions by Polymorphism in an Fe^(Ⅲ) Spin Crossover Complex

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Chinese Journal of Chemistry 2024年第8期42卷 879-886页

作者： Yingying Wu Shuang Peng Ziyi Zhang Yue Gao Guangyan Xu Jingwei Dai Zhao-Yang Li masahiro Yamashita School of Materials Science and Engineering Nankai University38 Tongyan RoadHaihe Educational ParkTianjin300350 China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin300071 China Department of Chemistry Graduate School of ScienceTohoku UniversitySendai980-8578 Japan

Comprehensive Summary,Regulating spin crossover(SCO)behavior,especially controlling the spin transition steps,is an important scientific issue,mainly because people aim to control spin bistability and ***,SCO bistability can be regulated by changing the ligand-modifying species,non-coordinated anions,guest molecules,and metal-ion ***,the control of multistability is extremely challenging,especially in Fe(III)SCO ***,we report that[FeIII(H-5-Br-thsa)(5-Br-thsa)]·H2O(5-Br-thsa=(5-bromo-2-hydroxybenzylidene)hydrazinecarbothioamide),a compound we have reported before,exists in two polymorphic forms:polymorph 1 exhibits three-step SCO,and polymorph 2 shows five-step SCO,with multi-step SCO behavior effectively regulated by *** to single-crystal and powder X-ray diffractometry,polymorphs 1 and 2 crystallize in different space groups during their spin transitions,with two-step symmetry breaking observed(Pbcn→Pnc2→Pbcn for polymorph 1;P21/n→Pn→P21/n for polymorph 2).We realized that the behavior of these two polymorphs depends significantly on the structure,including(i)the average Fe—N bond distance,(ii)deformation of octahedral FeIII atoms,and(iii)distinct crystal packing,which account for the large differences observed in magnetic properties.

关键词： Spin crossover Multi-step spin transition Symmetry breaking Polymorphism Magnetic property

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The mediatory role of water quality on the association between extreme precipitation events and infectious diarrhea in the Yangtze River Basin,China

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Fundamental Research 2024年第3期4卷 495-504页

作者： Junfeng Yu Liang Zhao Xin-Zhong Liang Hung Chak Ho masahiro Hashizume Cunrui Huang School of Public Health Sun Yat-sen UniversityGuangzhou 510080China The State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Atmospheric and Oceanic Science University of MarylandCollege ParkMD 20740USA Department of Public and International Affairs City University of Hong KongHong Kong 999077China Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Healthy China Tsinghua UniversityBeijing 100084China

Extreme precipitation is exacerbating the burden of infectious diarrhea in the context of climate change,it is necessary to identify the critical and easy-to-intervene intermediate factors for public health *** quality may be the most important mediator,while relevant empirical evidence is *** study aimed to examine the role of water quality in the process of infectious diarrhea caused by extreme *** infectious diarrhea cases,meteorological factors and water quality data in Yangtze River Basin in China between October 29,2007 to February 19,2017 were ***-stage statistical models were used to estimate city-specific extreme precipitation,water quality and infectious diarrhea relationships that were pooled to derive regional estimates.A causal mediation analysis was used to assess the mediation effect of water *** Yangtze River Basin,extreme precipitation events had a significant impact on infectious diarrhea(Incidence Rate Ratios[IRR]:1.027,95%Confidence Interval[CI]:1.013~1.041).After extreme precipitation events,the dissolved oxygen(DO)in surface water decreased(-0.123 mg/L,95%CI:-0.159 mg/L~-0.086 mg/L),while the un-ionized ammonia(NH(3)-N)increased(0.004 mg/L,95%CI:0.001 mg/L~0.006 mg/L).The combined overall effect of DO and NH(3)-N on infectious diarrhea showed that both low and high concentrations were associated with an increased risk of infectious *** causal mediation analysis showed that the mediation proportion of the two water quality indexes(DO and NH(3)-N)is 70.54%(P<0.001).To reduce the health effects of extreme precipitation,in contrast to current population-oriented health strategies,those that take into account more direct and easy-to-intervene water quality indicators should be encouraged by future policies.

关键词： Extreme precipitation Infectious diarrhea Water quality Dissolved oxygen Un-ionized ammonia Mediation analysis

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腹膜毛细淋巴管网的形态结构特征

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解剖学报 2001年第3期32卷 233-237,T007,T008页

作者：纪瑞成三浦真弘下田浩加藤征治大分医科大学解剖学讲座大分8795593

目的　探讨腹膜淋巴管的形态特征 ,为研究内皮和间皮细胞的物质转运机理提供必要的依据。　方法　用酶组织化学染色法观察了猴腹膜毛细淋巴管网的分布及其内皮细胞的超微结构。　结果　腹膜毛细淋巴管有丰富的网状连接、显著的瓣样结构... 详细信息

目的　探讨腹膜淋巴管的形态特征 ,为研究内皮和间皮细胞的物质转运机理提供必要的依据。　方法　用酶组织化学染色法观察了猴腹膜毛细淋巴管网的分布及其内皮细胞的超微结构。　结果　腹膜毛细淋巴管有丰富的网状连接、显著的瓣样结构和大量盲端 ,管径变化较大 (约 40～ 12 0 μm)、管腔极不规则。淋巴管周围结缔组织稀疏 ,并常见到内皮细胞与覆盖其表面的间皮细胞直接相贴。网膜和系膜内可见由大量巨噬细胞及淋巴细胞构成的圆形或椭圆形的乳斑 ,起于乳斑的淋巴管与间皮细胞之间缺乏基底膜。膈腹膜小孔的边缘附着有大量的细纤维成分 ,形成小孔的间皮细胞与其深面的淋巴管窦均有较强的 5’ Nase酶活性。　结论　腹膜毛细淋巴管的形态及结构显示出明显的部位性差异。

关键词：酶组织化学染色 5'-核苷酸酶毛细淋巴管腹膜猴

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Spectrally resolved Franson interference

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 11-17页

作者： Rui-Bo Jin Zi-Qi Zeng Dan Xu Chen-Zhi Yuan Bai-Hong Li You Wang Ryosuke Shimizu masahiro Takeoka Mikio Fujiwara Masahide Sasaki Pei-Xiang Lu Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China School of Physics and Information Science Shaanxi University of Science and TechnologyXi'an 710021China Southwest Institute of Technical Physics Chengdu 610041China Graduate School of Informatics and Engineering University of Electro-CommunicationsTokyo 182-8585Japan Department of Electronics and Electrical Engineering Keio UniversityKanagawa 223-8522Japan National Institute of Information and Communications Technology Tokyo 184-8795Japan

Franson interference can be used to test the nonlocal features of energy-time entanglement and has become a standard in quantum ***,most of the previous Franson interference experiments were demonstrated in the time domain,and the spectral properties of Franson interference have not been fully ***,we theoretically and experimentally demonstrate spectrally resolved Franson interference using biphotons with different correlations,including positive correlation,negative correlation,and *** is found that the joint spectral intensities of the biphotons can be modulated along both the signal and idler directions,which has potential applications in generating high-dimensional frequency entanglement and time-frequency grid *** work may provide a new perspective for understanding the spectral-temporal properties of the Franson interferometer.

关键词： resolved correlation spectral

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