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Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures

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Biomedical Engineering Frontiers 2021年第1期2卷 89-102页

作者： Wubin Bai masahiro irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers Department of Materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering University of Texas at ArlingtonArlingtonTX 76019USA Department of Mechanical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Chemistry Northwestern UniversityEvanstonIllinois 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA The Center for Developmental Therapeutics Northwestern UniversityEvanstonIllinois 60208USA Center for Advanced Molecular Imaging Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Neurobiology Northwestern UniversityEvanstonIllinois 60208USA Department of Chemical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonIllinois 60208USA Northwestern Medicine Feinberg School of MedicineNorthwestern UniversityEvanstonIllinois 60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIllinois 60208USA

Objective and Impact ***-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and *** thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body *** at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the ***,surgical extraction procedures after a period of need can introduce additional risks and ***,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body *** designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical *** with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo *** results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.

关键词： signature constraints multilayer

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Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse

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World Journal of Gastroenterology 2007年第16期13卷 2289-2297页

作者： Miho Kato Atsushi Ishige Naoko Anjiki masahiro Yamamoto Yoshifumi irie Mitsue Taniyama Ryoko Kibe Junichiro Oka Yoshimi Benno Kenji Watanabe Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Department of Kampo Medicine Keio University School of Medicine 35 Shinano-machi Shinjuku-ku Tokyo 160-8582 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Pharmacology Research Department Tsumura Research Institute Research Division 3586 Yoshiwara Ami-machi Inashiki-gun Ibaraki 300-1192 Japan Japan Collection of Microorganisms Riken 2-1 Hirosawa Wako-shi Saitama 351-0198 Japan Faculty of Pharmaceutical Science Tokyo University of Science 264 Yamazaki Noda City Chiba 278-8519 Japan

AIM： To evaluate the role of intestinal microflora in the effects of multi-herbal medicine on gene expression in the gut and liver. METHODS： The multi-herbal medicine Juzentaihoto （JTX） was administered to five germ-free mice and regular mice for 2 wk. Among the results of the comprehensive gene chip analysis of the intestine and liver, we featured heat shock proteins （HSPs） 70 and 105 because their gene expression changed only in the presence of microflora. Real-time RT-PCR was performed to confirm the expression levels of these HSP genes. To determine whether JTX acts directly on the HSP genes, sodium arsenite （SA） was used to induce the heat shock proteins directly. To examine the change of the intestinal microflora with administration of JTX, the terminal restriction fragment polymorphism （T-RFLP） method was used. To identify the changed bacteria, DNA sequencing was *** by gene chip and real-time RT-PCR, changed with the administration of JTX in the regular mice but not in the germ-free mice. JTX did not suppress the direct induction of the HSPs by SA. T-RFLP suggested that JTX decreased unculturable bacteria and increased Lactobacillus johnsoni. These data suggested that JTX changed the intestinal microflora which, in turn, changed HSP gene ***： Intestinal microflora affects multi-herbal product JTX on the gene expression in the gut and liver.

关键词： Herbal medicine Juzentaihoto Intestinal microflora Terminal restriction fragment length polymorphism Heat shock protein

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The hemodynamic study for growth factor evaluation of rupture cerebral aneurysm followed up for five years

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Journal of Biomedical Science and Engineering 2012年第12期5卷 884-891页

作者： masahiro Kojima Keiko irie Seiichi Ikeda Toshio Fukuda Fumihito Arai Yuichi Hirose Makoto Negoro Department of Mechanical Engineering Nagoya University Nagoya Japan Department of Micro-Nano System Mechatronics Nagoya University Nagoya Japan Department of Neurosurgery Fujita Health University Toyoake Japan

Computer-based simulations are essential for clarifying the hemodynamics of brain aneurysms. Since cerebrovascular disease is often fatal, it is strongly desirable to predict its progression. While previous studies have clarified the initiation mechanism of aneurysms, their growth mechanism remains unclear. Consequently, it is difficult to develop a diagnostic system for predicting aneurysm rupture. This study seeks to clarify the mechanism of aneurysm growth by identifying significant hydrodynamic factors. We focus on a single ruptured aneurysm that was followed up for five years. Computer simulations and fluid dynamic experiments with silicone vessel models were performed. To confirm the reliability of data in the computer simulations, we conducted particle image velocimetry measurements in steady flow. We then performed computer simulations for pulsatile conditions to determine an effective index for aneurysm growth. We obtained good agreement between the trends in the obtained computer simulation and experimental data. Numerical simulations for pulsatile flow in three models revealed that aneurysms grew in regions having a low wall shear stress, a low aneurysm formation indicator, and a high oscillatory shear index.

关键词： Simulation Aneurysm PIV

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