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Control Theory and Technology 2022年第2期20卷 248-262页

作者： Ryota Nakahara Kazuma Sekiguchi Kenichiro Nonaka masahiro Takasugi Hiroki Hasebe Kenichi Matsubara Graduate School of Integrative Science and Engineering Tokyo City UniversityTamazutsumiSetagaya-kuTokyo 1588557Japan Nabtesco Automotive Co. Ltd.HirakawachoChiyoda-kuTokyo 1020093Japan

When heavy-duty commercial vehicles(HDCVs)must engage in emergency braking,uncertain conditions such as the brake pressure and road profile variations will inevitably affect braking *** minimize these uncertainties,we propose a combined longitudinal and lateral controller method based on stochastic model predictive control(SMPC)that is achieved via Chebyshev–Cantelli *** our method,SMPC calculates braking control inputs based on a finite time prediction that is achieved by solving stochastic programming elements,including chance *** accomplish this,SMPC explicitly describes the probabilistic uncertainties to be used when designing a robust control *** main contribution of this paper is the proposal of a braking control formulation that is robust against probabilistic friction circle uncertainty *** specifically,the use of Chebyshev–Cantelli inequality suppresses road profile influences,which have characteristics that are different from the Gaussian distribution,thereby improving both braking robustness and control performance against statistical ***,since the Kalman filtering(KF)algorithm is used to obtain the expectation and covariance used for calculating deterministic transformed chance constraints,the SMPC is reformulated as a KF embedded deterministic ***,the effectiveness of our proposed method is verified via a MATLAB/Simulink and TruckSim co-simulation.

关键词： Heavy-duty commercial vehicle Brake system Stochastic model predictive control Road profile

S100A7 Co-localization and Up-regulation of Filaggrin in Human Sinonasal Epithelial Cells

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Current Medical Science 2021年第5期41卷 863-868页

作者： masahiro Nakamura Kazusaku Kamiya Atsushi Furuhata Katsuhisa Ikeda Frangois Niyonsaba Department of Otorhinolaryngology Juntendo University School of MedicineTokyo 113-8421Japan Atopy(Allergy)Research Center Junlendo University School of MedicineTokyol 13-8421Japan Biomedical Research Center Graduate School of MedicineJuntendo UniversityTokyo 113-8421Japan Faculty of International Liberal Arts Laboratory of Morphology and Image AnalysisGraduate School of MedicineJuntendo UniversityTokyo 113-8421Japan

Objective:Filaggrin(FLG)is a protein expressed in the epidermis and involved in the maintenance of the epidermal ***,the expression and localization of FLG in the upper airway remain *** present study aimed to determine the significance of FLG and the effect of S100A7 on FLG expression in the upper respiratory ***:Human nasal epithelial cells(HNECs)were cultured and examined for FLG expression and S100A7 effects by real-time polymerase chain reaction and Western *** localization and distribution of FLG were assessed using sinonasal ***:A significant expression of FLG was detected at the mRNA and protein levels in HNECs.A moderate FLG immunoreactivity was observed in the epithelial cells,but no staining was seen in epithelial goblet cells.S100A7 increased the FLG mRNA level in HNECs in a dose-dependent manner and also up-regulated the FLG protein in a dose-dependent ***:This study significantly contributes to a better understanding of the role of FLG in the pathogenesis of airway inflammation from the viewpoint of the epithelial barrier ***-related events in response to S100A7 protein may represent novel therapeutic targets for the treatment of upper airway inflammation.

关键词： nasal epithelial cell filaggrin S100A7 keratinocyte

A plant growth chamber system equipped with aerosol generators for studying aerosol-vegetation interactions

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Particuology 2024年第2期85卷 122-132页

作者： Masao Gen Seiji Ikawa masahiro Yamaguchi Fong Zyin Lim Takeshi Izuta I.Wuled Lenggoro Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan Faculty of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509 Japan Department of Applied Physics and Chemical Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan

Understanding aerosol-vegetation interactions is vital in ***,the interactions remain elusive partly due to the lack of suitable plant growth chamber ***,deposition of submicron particles on leaf surfaces is challenging due to its low deposition velocities compared to larger *** this work,we present a plant-growth chamber that was used to study the effect of sub-micron black carbon(BC)particles on the growth and photosynthesis of *** chamber system simultaneously enables the growth of multiple plants in pots and the deposition of submicron particles onto *** spraying methods assisted by ultrasonic and electrostatic forces were employed as aerosol generators to realize the particle *** flow regime inside the chamber was numeri-cally calculated to predict the transportation of aerosol particles,suggesting the optimal operating conditions of the *** gas-phase particle size distribution measurements showed that gener-ated BC particles were suspended in submicron diameter *** aerosol generators were examined in the chamber using three conductor and insulator substrates as a model of plant *** observations and spectroscopic analysis ascertained that submicron BC particles generated from our generators were deposited on all substrate *** the developed chamber system,systematic studies can be performed to advance the fundamental understanding of aerosol-vegetation interactions.

关键词： Aerosol Exposure chamber Spray drying Black carbon

Adaptive design of an X-ray magnetic circular dichroism spectroscopy experiment with Gaussian process modelling

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npj Computational Materials 2018年第1期4卷 639-646页

作者： Tetsuro Ueno Hideitsu Hino Ai Hashimoto Yasuo Takeichi masahiro Sawada Kanta Ono Quantum Beam Science Research Directorate National Institutes for Quantum and Radiological Science and Technology1-1-1 KotoSayoHyogo 679-5148Japan Institute of Materials Structure Science High Energy Accelerator Research Organization1-1 OhoTsukubaIbaraki 305-0801Japan Elements Strategy Initiative Center for Magnetic Materials Research Center for Magnetic and Spintronic MaterialsNational Institute for Materials Science1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Computer Science University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8573Japan Hiroshima Synchrotron Radiation Center Hiroshima University2-313 KagamiyamaHigashihiroshimaHiroshima 739-0046Japan Center for Materials Research by Information Integration(CMI2) Research and Services Division of Materials Data and Integrated System(MaDIS)National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki 305-0047Japan

Spectroscopy is a widely used experimental technique,and enhancing its efficiency can have a strong impact on materials *** propose an adaptive design for spectroscopy experiments that uses a machine learning technique to improve *** examined X-ray magnetic circular dichroism(XMCD)spectroscopy for the applicability of a machine learning technique to *** XMCD spectrum was predicted by Gaussian process modelling with learning of an experimental spectrum using a limited number of observed data *** sampling of data points with maximum variance of the predicted spectrum successfully reduced the total data points for the evaluation of magnetic moments while providing the required *** present method reduces the time and cost for XMCD spectroscopy and has potential applicability to various spectroscopies.

关键词： spectroscopy circular spectroscopy

High-solids anaerobic mono-digestion of riverbank grass under thermophilic conditions

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Journal of Environmental Sciences 2017年第2期29卷 29-38页

作者： Fetra J.Andriamanohiarisoamanana Nobuyuki Matsunami Takaki Yamashiro masahiro Iwasaki Ikko Ihara Kazutaka Umetsu Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Graduate School of Agriculture Science Kobe University

The purpose of this study was to investigate the potential of high-solids anaerobic mono-digestion of riverbank grass under thermophilic conditions, focusing on the effects of the strength and the amount of inoculum. Ensiled grass was inoculated with three different inocula; inoculum from liquid anaerobic digester（LI）, inoculum from dry anaerobic digester（DI）, and mixture of LI and DI（MI）, at feedstock-to-inoculum ratio（FIR） of 1, 2 and 4. The ensiling process of riverbank grass reduced moisture content（p 〉 0.05）, while the hemicellulose content was significantly increased from 30.88% to 35.15%（p 〈 0.05）, on dry matter basis. The highest methane production was at an FIR of 2 with MI（167 L/kg VSadded）,which was significantly higher（p 〈 0.05） than with DI, but not significant compared to LI（p 〉 0.05）. At an FIR of 4, digesters inoculated with LI and DI failed to produce methane,whereas 135 LCH4/kg VSaddedwas obtained with MI. The kinetic studies showed that at an FIR of 1 with LI and MI, the inoculum had less of effects on the hydrolysis rate constant（0.269 day-1and 0.245 day-1） and methane production（135 versus 149 L/kg VSadded）; rather,it affected the lag phase. In a thermophilic HS-AD of riverbank grass, the mixture of inoculum with low and high total solids content（TS） helps increase the TS of inoculum and digestion process. An FIR of 2 was deducted to be the limit for a better startup time and higher volumetric productivity of methane.

关键词： Riverbank grass High-solids anaerobic digestion Inoculum Feedstock-to-inoculum ratio Thermophilic temperature

High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis

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World Journal of Gastroenterology 2016年第26期22卷 6083-6088页

作者： Kazuhiro Shimazu Koji Fukuda Taichi Yoshida masahiro Inoue Hiroyuki Shibata Department of Clinical Oncology Graduate School of Medicine Akita University

AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at ***: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome.

关键词： Bone metastasis Circulating tumor cell Gastric cancer Predictive biomarker Prognostic biomarker

Actuation and blocking force of stacked nanocarbon polymer actuators

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International Journal of Smart and Nano Materials 2018年第3期9卷 184-198,I0003页

作者： Ken Mukai masahiro Yamamura Junko Kamata Hirosato Monobe Kinji Asaka Inorganic Functional Material Research institute National Institute of Advanced Industrial Science and Technology(AIST)OsakaJapan

We have developed stacked nanocarbon polymer actuators that are composed of several nanocarbon polymer actuator films using nonwoven fabric as insulation *** nonwoven fabric prepared through electrospinning methods has extremely-low-density structures,which do not significantly prevent the motions of each nanocarbon actuator ***,stacking several thin nanocarbon polymer actuators using nonwoven fabric as insulation layers is expected to increase generated force without decreasing the displacement of a one-layer *** have prepared stacked actuators with one,two,three,four,and seven layers using this *** displacement and blocking force of these actuators are measured and compared with those of one-layer actuators of different *** is weakly dependent on the thickness of the actuator films of the stacked *** the contrary,it decreases considerably as the thickness of the actuator film of the one-layer actuator *** both cases,blocking force is proportional to the thickness of actuator *** have developed a stacked actuator model based on a trilayer actuator model and confirmed the experimental results using the model.

关键词： Nanocarbon actuator polymer stacking model

Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： Takeshi Ogura Yuki Uba masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

Bis(phthalocyaninato)yttrium Grown on Au(111): Electronic Structure of a Single Molecule and the Stability of Two- dimensional Films Investigated by Scanning Tunneling Microscopy/Spectroscopy at 4.8 K

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Nano Research 2010年第8期3卷 604-611页

作者： Yanfeng Zhang Pengfei Guan Hironari Isshiki Mingwei Chen masahiro Yamashita Tadahiro Komeda Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-0877Japan Center for Nanochemistry Academy for Advanced Interdisciplinary StudiesDepartment of Advanced Materials and NanotechnologyCollege of EngineeringBeijing UniversityBeijing 100871China WPI-Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Department of Chemistry Graduate School of ScienceTohoku UniversitySendai 980-8578Japan CREST Japan Science and Technology Agency(JST)Saitama 332-0012Japan

Scanning tunneling microscopy/spectroscopy(STM/STS)at 4.8 K has been used to examine the growth of a double-decker bis(phthalocyaninato)yttrium(YP_(c2))molecule on a reconstructed Au(111)*** differential conductance spectra(dI/dV)of a single YPc2 molecule allow the characteristics of the highest occupied molecular orbital(HOMO)and the lowest unoccupied molecular orbital(LUMO)to be ***,lateral distributions of the local density of states(LDOS)have also been obtained by dI/dV mapping and confirmed by first principles *** electronic feature mappings and theoretical calculations provide a basis for understanding the unique STM morphology of YPc2,which is usually imaged as an eight-lobed *** addition,we demonstrate that bias-dependent STM morphologies and simultaneous dI/dV maps can provide a way of understanding the stability of two-dimensional YP_(c2) films.

关键词： Scanning tunneling microscopy/spectroscopy(STM/STS) phthalocyanine electronic structure

MIXED MODES INTERLAMINAR FRACTURE TOUGHNESS OF CFRP LAMINATES TOUGHENED WITH CNF INTERLAYER

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Acta Mechanica Solida Sinica 2012年第3期25卷 321-330页

作者： masahiro Arai Tatsuya Sasaki Satoshi Hirota Hiroaki Ito Ning Hu Marino Quaresimin Shinshu University 4-17-1 Wakasato Nagano-shi Nagano 380-8553 Japan Chiba University 1-33 Yayoi-cho Inage-ku Chiba-shi Chiba 263-8522 Japan University of Padova Stradella San Nicola 3 36100 Vicenza Italy

In the present paper, the influence of carbon nanofiber on interlaminar fracture toughness of CFRP investigated using MMB（Mixed Mode Bending） tests. Vapor grown carbon fiber VGCF and VGCF-S, and multi-walled carbon nanotube MWNT-7 has been employed for the toughener of the interlayer on the CFRP laminates. In order to evaluate the fracture toughness and mixed mode ratio of it, double cantilever beam （DCB） tests, end notched fracture （ENF） tests and mixed mode bending （MMB） tests have been carried out. Boundary element analysis was applied to the CFRP model to compute the interlaminar fracture toughness, where extrapolation method was used to determine the fracture toughness and mixed mode ratio. The interlaminar fracture toughness and mixed mode ratio can be extrapolated by stress distribution in the vicinity of the crack tip of the CFRP laminate. It was found that the interlaminar fracture toughness of the CFRP laminates was improved inserting the interlayer made by carbon nanofiber especially in the region where shear mode deformation is dominant.

关键词： CFRP laminate fracture toughness interlaminar crack boundary element method,interlayer