检索结果-南通市图书馆

Prolonged survival in patients with hand-foot skin reaction secondary to cooperative sorafenib treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第32期27卷 5424-5437页

作者： Masanori Ochi Toshiro Kamoshida masahiro Araki Tadashi Ikegami Department of Gastroenterology Hitachi General HospitalIbaraki 317–0077Japan Department of Gastroenterology and Hepatology Ibaraki Prefectural Central HospitalIbaraki Cancer CenterIbaraki 309-1793Japan Division of Gastroenterology and Hepatology Tokyo Medical University Ibaraki Medical CenterIbaraki 309-1793Japan

BACKGROUND Sorafenib is an oral drug that prolongs overall survival(OS)in patients with hepatocellular *** events,including hand-foot skin reaction(HFSR),lead to permanent sorafenib *** To clarify the association between interventions for adverse events and patient *** We performed a retrospective,multicenter study of patients treated with sorafenib monotherapy between May 2009 and March *** developed a mutual cooperation system that was initiated at the start of sorafenib treatment to effectively manage adverse *** mutual cooperation system entailed patients receiving consultations during which pharmacists provided accurate information about sorafenib to alleviate the fear and anxiety related to adverse *** stratified the patients into three groups:Group A,patients without HFSR but with pharmacist intervention;Group B,patients with HFSR and pharmacist interventions unreported to oncologists(nonmutual cooperation system);and Group C,patients with HFSR and pharmacist interventions known to oncologists(mutual cooperation system).OS and time to treatment failure(TTF)were evaluated using the Kaplan-Meier *** We enrolled 134 patients(Group A,n=41;Group B,n=30;Group C,n=63).The median OS was significantly different between Groups A and C(6.2 vs 13.9 mo,p<0.01)but not between Groups A and B(6.2 vs 7.7 mo,P=0.62).Group A vs Group C was an independent OS predictor(HR,0.41;95%CI:0.25-0.66;P<0.01).In Group B alone,TTF was significantly lower and the nonadherence rate was higher(P<0.01).In addition,the Spearman’s rank correlation coefficients between OS and TTF in each group were 0.41(Group A;P<0.01),0.13(Group B;P=0.51),and 0.58(Group C;P<0.01).There was a highly significant correlation between OS and TTF in Group ***,there was no correlation between OS and TTF in Group *** The mutual cooperation system increased treatment duration and improved prognosis in patients with *** prospect

关键词： Hepatocellular carcinoma Sorafenib Pharmacists Oncologists Prognosis Duration of therapy

The Monotone Robin-Robin Domain Decomposition Methods for the Elliptic Problems with Stefan-Boltzmann Conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2010年第8期8卷 642-662页

作者： Wenbin Chen Jin Cheng masahiro Yamamoto Weili Zhang School of Mathematical Sciences and Key Laboratory of Computational Physics(MOE) Fudan UniversityShanghai200433China Shanghai Key Laboratory of Intelligent Information Processing Fudan UniversityShanghai200433China Department of Mathematical Sciences University of TokyoTokyo153-8914Japan

This paper is concerned with the elliptic problems with nonlinear StefanBoltzmann boundary *** combining with the monotone method,the RobinRobin domain decomposition methods are proposed to decouple the nonlinear interface and boundary *** monotone properties are verified for both the multiplicative and the additive domain decomposition *** numerical results confirm the theoretical analysis.

关键词： Nonlinear Stefan-Boltzmann condition monotone methods Robin-Robin domain decomposition method

Synthetic Hexaploid Wheat： Yesterday, Today, and Tomorrow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2018年第4期4卷 552-558页

作者： Aili Li Dengcai Liu Wuyun Yang masahiro Kishii Long Mao Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China Triticeae Research Institute Sichuan Agricultural University Chengdu 611130 China Crop Research Institute Sichuan Academy of Agricultural Sciences Chengdu 610066 China International Maize and Wheat Improvement Center Yexcoco 56237 Mexico

In recent years, wheat yield per hectare appears to have reached a plateau, leading to concerns for future food security with an increasing world population. Since its invention, synthetic hexaploid wheat （SHW） has been shown to be an effective genetic resource for transferring agronomically important genes from wild relatives to common wheat. It provides new sources for yield potential, drought tolerance, disease resistance, and nutrient-use efficiency when bred conventionally with modern wheat varieties. SHW is becoming more and more important for modern wheat breeding. Here, we review the current status of SHW generation, study, and application, with a particular focus on its contribution to wheat breeding. We also briefly introduce the most recent progress in our understanding of the molecular mechanisms for growth vigor in SHW. Advances in new technologies have made the complete wheat reference genome available, which offers a promising future for the study and applications of SHW in wheat improvement that are essential to meet global food demand.

关键词： Synthetic wheat Wheat Polyploidization Disease resistance Stress tolerance Yield

Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第12期9卷 2751-2758页

作者： Atsushi Masamune masahiro Satoh Kazuhiro Kikuta Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendaiJapan A.M.and M.S.equally contributed to this work

AIM: Activated pancreatic stellate cells (PSCs) have been implicated in the pathogenesis of pancreatic fibrosis and inflammation. Primary PSCs can be subcultured only several times because of their limited growth potential. A continuous cell line may therefore be valuable in studying molecular mechanisms of these pancreatic disorders. The aim of this study was to establish a cell line of rat PSCs by spontaneous ***: PSCs were isolated from the pancreas of male Wistar rats, and conventional subcultivation was performed repeatedly. Telomerase activity was measured using the telomere repeat amplification protocol. Activation of transcription factors was assessed by electrophoretic mobility shift *** of mitogen-activated protein (MAP) kinases was examined by Western blotting using anti-phosphospecific antibodies. Expression of cytokine-induced neutrophil chemoattractant-1 was determined by enzyme ***: Conventional subcultivation yielded actively growing cells. One clone was obtained after limiting dilution,and designated as SIPS. This cell line has been passaged repeatedly more than 2 years, and is thus likely *** cells retained morphological characteristics of primary,culture-activated PSCs. SIPS expressed α-smooth muscle actin, glial acidic fibrillary protein, vimentin, desmin, type Ⅰ collagen, fibronectin, and prolyl hydroxylases. Telomerase activity and p53 expression were negative. Proliferation of SIPS cells was serum-dependent, and stimulated with platelet-derived growth factor-BB through the activation of extracellular signal-regulated kinase. Interleukin-1β activated nuclear factor-κB, activator protein-1, and MAP ***-1β induced cytokine-induced neutrophil chemoattractant-1 expression through the activation of nuclear factor-κB and MAP ***: SIPS cells can be useful for in vitro studies of cell biology and signal transduction of PSCs.

关键词： Animals Base Sequence Cell Culture Techniques Cell Line, Transformed Cells, Cultured Cystic Fibrosis Cytoskeletal Proteins Extracellular Matrix Proteins Immunohistochemistry NF-kappa B Oligonucleotide Probes Pancreas Rats Research Support, Non-U.S. Gov't Transcription Factor AP-1

Three Dimensional Separation with Spiral-Focus in a Decelerating Duct Flow (Effect of Asymmetric Inlet Boundary Layer Thickness)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2003年第1期12卷 27-32页

作者： Yoichi Kinoue Toshiaki Setoguchi Kenji Kaneko Mamun Mohammad masahiro Inoue Department of Mechanical Engineering Saga University 1Department of Mechanical Engineering Saga University 1Department of Mechanical Engineering Saga University 1Department of Mechanical Engineering Saga University 1Department Honjo Saga 840-8502 Japan Honjo Saga 840-8502 Japan Honjo Saga 840-8502 Japan Honjo Saga 840-8502 Japanof Mechanical Engineering Science Kyushu University 6-10-1Hakozaki Higashi-ku Fukuoka 812-8581Japan

An experimental apparatus was developed to study the three dimensional separated flow with spiral-foci. The internal decelerating flow was generated by the air suction from a side wall to produce the separation on an opposite-side wall. The relation between the upstream boundary layer and the generation of spiral-foci in the separation region was observed by a tuft method. As a result, it was clarified that the spiral-focus type separation could be produced on the side wall and its behavior was closely related to the vortices supplied into the separation region from the boundary layer developing along top wall or bottom one.

关键词： three dimensional separation spiral-focus decelerating duct flow.

Does a combined intervention program of repetitive transcranial magnetic stimulation and intensive occupational therapy affect cognitive function in patients with post-stroke upper limb hemiparesis?

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第12期11卷 1932-1939页

作者： Takatoshi Hara masahiro Abo Kiyohito Kakita Takeshi Masuda Ryunosuke Yamazaki Department of Rehabilitation Medicine The Jikei University School of Medicine Department of Rehabilitation Medicine Kyoto Ohara Memorial Hospital

Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.

关键词： nerve regeneration stroke repetitive transcranial magnetic stimulation Trail-Making Test cognitive function occupational therapy neural regeneration

Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第22期11卷 3385-3391页

作者： Atsushi Masamune masahiro Satoh Kazuhiro Kikuta Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan

AM: To clarify the role of Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway in platelet-derived growth factor (PDGF) induced proliferation in activated pancreatic stellate cells (PSCs). METHODS: PSCs were isolated from rat pancreas tissue, and used in their culture-activated, myofibroblast-like phenotype. STAT-specific binding activity was assessed by electrophoretic mobility shift assay. Activation of Src, JAK2, STAT1, STAT3, and ERK was determined by Western blotting using anti-phosphospecific antibodies. Cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxyuridine. RESULTS: PDGF-BB induced STAT-specific binding activity, and activation of Src, JAK2, STAT1, STAB, and ERK. Ethanol and acetaldehyde at clinically relevant concentrations decreased basal activation of JAK2 and STAT3. PDGF-induced activation of STAT1 and STAT3 was inhibited by a Src inhibitor PP1 and a JAK2 inhibitor AG490, whereas PDGF-induced activation of ERK was inhibited by PP1, and not by AG490. PDGF-induced proliferation was inhibited by PP1 and AG490 as well as by STAT3 antisense oligonucleotide. CONCLUSION: PDGF-BB activated JAK2-STAT pathway via Src-dependent mechanism. Activation of 3AK2-STAT3 pathway, in addition to ERK, may play a role in PDGF-induced proliferation of PSCs.

关键词： Pancreatitis Pancreatic fibrosis Pancreatic stellate cells Platelet-derived growth factor Janus kinase Signal transducers and activators of transcription

The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2011年第9期2卷 755-763页

作者： Kentaro Ito Akinori Takahashi masahiro Morita Toru Suzuki Tadashi Yamamoto Division of Oncology Department of Cancer BiologyInstitute of Medical ScienceUniversity of TokyoTokyo 108-8639Japan Cell Signal Unit Okinawa Institute of Science and Technology1919-1Okinawa 904-0412Japan

The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic *** evidence suggests that the non-enzymatic subunits are involved in the regulation of mRNA deadenylation,although their precise roles remain to be *** this study,we addressed the function of the CNOT1 subunit by depleting its expression in HeLa *** cytometric analysis revealed that the sub G1 fraction was increased in CNOT1-depleted ***,the same level of the sub G1 fraction was seen when cells were treated with a mixture of siRNAs targeted against all enzymatic subunits,suggesting that CNOT1 depletion induces apoptosis by destroying the CCR4-NOT-associated deadenylase *** analysis revealed that CNOT1 depletion leads to a reduction in the amount of other CCR4-NOT ***,the specific activity of the CNOT6L immunoprecipitates-associated deadenylase from CNOT1-depleted cells was less than that from control *** formation of P-bodies,where mRNA decay is reported to take place,was largely suppressed in CNOT1-depleted ***,CNOT1 has an important role in exhibiting enzymatic activity of the CCR4-NOT complex,and thus is critical in control of mRNA deadenylation and mRNA *** further showed that CNOT1 depletion enhanced CHOP mRNA levels and activated caspase-4,which is associated with endoplasmic reticulum ER stress-induced *** together,CNOT1 depletion structurally and functionally deteriorates the CCR4-NOTcomplex and induces stabilization of mRNAs,which results in the increment of translation causing ER stress-mediated *** conclude that CNOT1 contributes to cell viability by securing the activity of the CCR4-NOT deadenylase.

关键词： deadenylation CCR4-NOT small interfering RNA P-bodies apoptosis

Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第22期11卷 3368-3374页

作者： Atsushi Masamune Kazuhiro Kikuta masahiro Satoh Noriaki Suzuki Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan

AIM: To clarify the effects of epigallocatechin-3-gallate (EGCG) on the platelet-derived growth factor (PDGF)-BB-induced proliferation and migration of pancreatic stellate cells (PSCs). METHODS: PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype. Cell proliferation was assessed by measuring the incorporation of 5-bromo-2'-deoxyuridine. Cell migration was assessed using modified Boyden chambers. Cyclin D1, p21waf1, and p27kip1 expression and phosphorylation of PDGF β-receptor, extracellular signal-regulated kinase, and Akt were examined by Western blotting. Activation of phospha-tidylinositol 3-kinase was examined by kinase assay using phosphatidylinositol as a substrate. Cell cycle was assessed by flow cytometry after staining with propidium iodide. RESULTS: EGCG at non-cytotoxic concentrations inhibited PDGF-induced proliferation and migration. This effect was associated with the inhibition of cell cycle progression beyond the G1 phase, decreased cyclin Dl and increased p27kip1 expression. EGCG inhibited tyrosine phosphorylation of PDGF p-receptor and downstream activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/ Akt pathways. CONCLUSION: EGCG inhibited PDGFBB-induced proliferation and migration of PSCs through the inhibition of PDGFmediated signaling pathways.

关键词： Pancreatitis Pancreatic fibrosis Pancreatic stellate cells Epigallocatechin-3-gallate Green tea Platelet-derived growth factor Proliferation Migration