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Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature

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World Journal of Gastroenterology 2021年第1期27卷 129-142页

作者： Takeshi okamoto Takaaki Yoshimoto Nobuyuki Ohike Aoi Fujikawa Takayoshi Kanie Katsuyuki Fukuda Department of Gastroenterology St.Luke's International HospitalTokyo 104-8560Japan Department of Pathology Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Surgery St.Luke’s International HospitalTokyo 104-8560Japan Department of Cardiology St.Luke’s International HospitalTokyo 104-8560Japan

BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely *** report the first case of spontaneous regression of gastric *** SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed *** tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle *** esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 *** removal of the abdominal mass confirmed it to be a metastatic gastrinoma *** gastric lesion was subsequently diagnosed as primary gastric *** months later,the gastric lesion had disappeared without *** patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of *** Gastric gastrinoma may arise as a polypoid lesion in the gastric *** regression can rarely occur after biopsy.

关键词： Neuroendocrine neoplasm Functional tumor Biopsy Gastrin Stomach Case report

Efficacy of Japanese traditional(Kampo) medicine for treating chemotherapy-induced peripheral neuropathy: A retrospective case series study

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World Journal of Clinical Cases 2016年第10期4卷 310-317页

作者： Yumiko Kimata Keiko Ogawa Hideki okamoto Atsushi Chino Takao Namiki Department of Japanese-Oriental(Kampo)Medicine Chiba University School of Medicine Department of Japanese-Traditional(Kampo)Medicine Kanazawa University Hospital Department of Japanese-Oriental(Kampo)Medicine Chiba Central Medical Center

AIM To investigate Japanese traditional(Kampo) medicine's effectiveness on cancer chemotherapy-induced peripheral neuropathy(CIPN), we carried out this retrospective *** By searching our outpatient database of 3154 patients who consulted our outpatient clinic of Japanese-Oriental(Kampo) Medicine at Chiba University Hospital from November 2005 to December 2010, a total of 281 patients diagnosed with cancer were identified. Twentyfour patients out of the 281 patients identified met the following three conditions and were eligible for further investigation of the effectiveness of Kampo treatment: At least one course of cancer chemotherapy had been administered; numbness and pain appeared after the chemotherapy; and CIPN was diagnosed before they were given Kampo *** The 24 patients included 6 males and 18 females and ranged in age from 39 to 86(mean 61.2 ± 11.5) years old. Kampo formulas were individually chosen by Kampo expert doctors based on Kampo-specific diagnostics. Beneficial outcomes were obtained by Kampo treatment in 20 out of the 24 cases(83.3%). Nine out 20 cases had a major response(the numbness and pain showed improvement or reduction by 50% or more), with 7 of 9 cases showing a more than 70% symptom reduction. Eleven out of 20 cases showed a minor response(less than 50% symptom reduction), and 4 out of the 24 cases had no beneficial response. The most frequently used formula was goshajinkigan(GJG), followed by hachimijiogan(HJG) and keishibukuryogan. Thirteen of the 24 cases(54.2%) were prescribed aconite rootcontaining formulas including GJG and HJG. Aconite root has "warming" effects and ameliorates pain and numbness; 21 out of 24 cases(87.5%) in total used warming formulas such as aconite root-containing formulas to reduce *** Our current study suggested that Kampo formulas chosen based on Kampo-specific diagnostics could be for treating CIPN that is refractory to conventional medicine.

关键词： Asian medicine Traditional Chinese medicine Goshajinkigan Keishibukuryogan Hachimijiogan

Non-ossifying fibromas: Case series, including in uncommon upper extremity sites

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World Journal of Orthopedics 2017年第7期8卷 561-566页

作者： Akio Sakamoto Ryuzo Arai Takeshi okamoto Shuichi Matsuda Department of Orthopaedic Surgery Graduate School of Medicine Kyoto University

AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower *** We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow *** NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress.

关键词： Non-ossifying fibroma Humerus Radius Fibula Upper extremity

Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

Segmental gastrectomy with radical lymph node dissection for early gastric cancer

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World Journal of Gastroenterology 2010年第41期16卷 5247-5251页

作者： Takeru Matsuda Kunihiko Kaneda Manabu Takamatsu Keishi Aishin Masahide Awazu Akiko okamoto Katsunori Kawaguchi Department of Surgery Kobe Kaisei HospitalKobe 657-0078 Japan

AIM: To describe a new surgical technique and evaluate the early results of segmental gastrectomy (SG) with modified D2 lymph node (LN) dissection for early gastric cancer (EGC). METHODS: Fourteen patients with EGC underwent SG with modified D2 dissection from 2006 to 2008. Their operative results and postoperative courses were compared with those of 17 patients who had distal gastrectomy (DG) for EGC during the same period. RESULTS: Operating time, blood loss, and hospital stay were similar between the 2 groups. Postoperative complications developed significantly more frequently in the DG group than in the SG group. Mean number of dissected LNs per each station in the SG group was comparable with that in the DG group. Postoperative recovery of body weight was significantly better in the SG group than in the DG group. The incidence of reflux esophagitis and gastritis after surgery was less frequent in the SG group than in the DG ***: SG with modified D2 LN dissection may be a new function-preserving gastrectomy that is feasible for treatment of EGC with possible LN involvement.

关键词： Gastrectomy Early diagnosis Gastric can-cer Lymph node Metastasis Gastrointestinal surgical procedures

Electric Field Enhancement of Nano Gap of Silver Prisms

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Chinese Physics Letters 2007年第10期24卷 2934-2937页

作者： KENZO Yamaguchi TOMOHIRO Inoue MASAMITSU Fujii MASANOBU Haraguchi TOSHIHIRO okamoto MASUO Fukui SHU Seki SEIICHI Tagawa Department of Optical Science and Engineering Faculty and School of Engineering The University of Tokushima 2-1 Minamijosanjima-cho Tokushima-city Tokushima 770-8506 Japan Department of Electronics and Mechanics Toba National College of Maritime Technology 1-1 Ikegami-cho Toba-city Mie 517-8501 Japan Institute of Scientific and Industrial Research Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Using numerical calculation, we examine the effects of gap distance of a pair of nano gap silver prisms with rounded corners on the local light intensity enhancement. Two peaks due to localized surface plasmon （LSP） excitation are observed in a wavelength range from 900nm to 300nm. The results demonstrate that peaks at a longer and a shorter wavelength corresponded to dipole-like and quadrupole-like LSP resonances, respectively. It is found that a gap distance up to 20 nm provides larger light intensity enhancement than that of a single silver nano prism with rounded corners. Furthermore, nano gap silver prisms are fabricated by direct focused ion beam processing, and we measure the scattering light spectrum of a pair of nano prisms by a confocal optical system. However, the two LSP peaks are not observed in visible range because the sizes of the nano gap and prisms are too large.

关键词： SURFACE-PLASMON RESONANCE AG NANOPARTICLES NEAR-FIELD NANOANTENNAS SCATTERING

Sclerosing cholecystitis associated with autoimmune pancreatitis

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World Journal of Gastroenterology 2006年第23期12卷 3736-3739页

作者： Terumi Kamisawa Yuyang Tu Hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake okamoto Shinichirou Horiguchi Hitoshi Nakajima NaotoEgawa Department of Internal Medicine Tokyo MetropolitanKomagome Hospital 3-18-22 Honkomagome Bunkyo-ku TokyoJapan Department of Surgery Tokyo Metropolitan Komagome Hospital 3-18-22 HonkomagomeBunkyo-ku Tokyo Japan Department of Pathology TokyoMetropolitan Komagome Hospital 3-18-22 HonkomagomeBunkyo-ku Tokyo Japan

AIM： TO evaluate the histopathological and radiological findings of the gallbladder in patients with autoimmune pancreatitis （AIP）. METHODS： The radiological findings of the gallbladder of 19 AIP patients were retrospectively reviewed. Resected gallbladders of 8 AIP patients were examined histologically and were immunostained with anti- IgG4 antibody. Controls consisted of gallbladders resected for symptomatic gallstones （n = 10） and those removed during pancreatoduodenectomy for pancreatic carcinoma （n = 10）, as well as extrahepatic bile ducts and pancreases removed by pancreatoduodenectomy for pancreatic carcinoma （n = 10）. RESULTS： Thickening of the gallbladder wall was detected by ultrasound and/or computed tomography in 10 patients with AIP （3 severe and 7 moderate）; in these patients severe stenosis of the extrahepatic bile duct was also noted. Histologically, thickening of the gallbladder was detected in 6 of 8 （75%） patients with AIP; 4 cases had transmural lymphoplasmacytic infiltration with fibrosis, and 2 cases had mucosal-based lymphoplasmacytic infiltration. Considerable transmural thickening of the extrahepatic bile duct wall with dense fibrosis and diffuse ly,mphoplasmacytic infiltration was detected in 7 patients. Immunohistochemically, severeor moderate infiltration of IgG4-positive plasma cells was detected in the gallbladder, bile duct, and pancreas of all 8 patients, but was not detected in controls. CONCLUSION： Gallbladder wall thickening with fibrosis and abundant infiltration of IgG4-positive plasma cells is frequently detected in patients with AIP. We propose the use of a new term, sclerosing cholecystitis, for these cases that are induced by the same mechanism as sclerosing pancreatitis or sclerosing cholangitis in AIP.

关键词： Autoimmune pancreatitis Sclerosing cholecystitis IgG4

Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients

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World Journal of Gastroenterology 2006年第9期12卷 1412-1415页

作者： Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki Department of Tumor Surgery Kochi Medical School KohasuOko-choNankoku 783-8505Japan Department of Epidemiological & Clinical Research Information Management Kyoto University Graduate School of Medicine Yoshida Hon-machiSakyo-ku 606-8317Japan Department of Tumor Surgery Kochi Medical School Kohasu Oko-cho Nankoku 783-8505 Japan

AIM： To examine the paclitaxel concentrations in plasma and ascites after its intravenous administration in patients with ascites due to peritonitis carcinomatosa resulting from advanced gastric cancer. METHODS： Two patients with ascites due to peritonitis carcinomatosa resulting from gastric cancer were included in this study. The paclitaxel concentrations in plasma and ascites were investigated for 72 h in case 1 and 168 h in case 2 after intravenous administration. RESULTS： The paclitaxel concentration in plasma peaked immediately after administration, followed by rapid decrease below the threshold value of 0.1 μmol （85 ng/mL） within 24 h. In contrast, the paclitaxel concentration in ascites increased gradually for 24 h after administration to a level consistent with the level found in plasma. After 24 h the level of paclitaxel in ascites and plasma became similar, with the optimal level being maintained up to 72 h following administration. CONCLUSION： The concentration of paclitaxel in ascites is maintained within the optimal level for the treatment of cancer cells for up to 72 h after intravenous administration. Paclitaxel is a promising drug for the treatment of malignant ascites of gastric cancer.

关键词： Paclitaxel Chemotherapy Gastric cancer Peritoneal carcinomatosis Pharmacokinetic study Ascites

Possible role of human cytomegalovirus in pouchitis after proctocolectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis

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World Journal of Gastroenterology 2007年第7期13卷 1085-1089页

作者： Damian Casadesus Tatsuo Tani Toshifumi Wakai Satoshi Maruyama Tsuneo iiai Haruhiko okamoto Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

AIM: To detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (iPAA). METHODS: immunohistochemistry, polymerase chain reaction (PCR) and PCR sequencing methods were utilized to test the presence of HCMV in pouch specimens taken from 34 patients in 86 endoscopies. RESULTS: HCMV genes and proteins were detected in samples from 12 (35.2%) patients. The rate of detection was significant in the endoscopies from patients diagnosed with pouchitis (5 of 12, 41.6%), according to the Japanese classification of pouchitis, in comparison to patients with normal pouch (7 of 62, 11.2%; P = 0.021). in all patients with pouchitis in which the HCMV was detected, it was the first episode of pouchitis. The virus was not detected in previous biopsies taken in normal endoscopies of these patients. During the follow- up, HCMV was detected in one patient with recurrent pouchitis and in 3 patients whose pouchitis episodes improved but whose positive endoscopic findings persisted. CONCLUSION: HCMV can take part in the inflammatory process of the pouch in some patients with ulcerative colitis who have undergone proctocolectomy with iPAA.

关键词： Human cytomegalovJrus Pouchitis Inflammatory bowel disease Ileal pouch-analanastomosis