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SYNTHESES AND PROPERTIES OF POLYMERIZABLE METALLOPHTHALOCYANINE DERIVATIVES

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Chinese Journal of Polymer Science 1988年第4期6卷 289-298页

作者：刘云圻山田瑛重原淳孝原正彦 Institute of Chemistry Academia Sinica The Institute of Physical and Chemical Research Wako Saitama 351—01 Japan Saitama 351—01 Japan Beijing China

Metallophthalocyanine derivatives with polymerizable vinyl groups were synthesized, characterized and polymerized. Preliminary results on their Langmuir-Blodgett (LB) film formation and the electronic properties of (I... 详细信息

关键词： Metallophthalocyanine Vinyl monomer Langmuir-Blodgett film Schottky device

Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1082-1088页

作者： Naoto Tokuda Yasushi Kitaoka Ayaka Tsukamoto Yasuhiro Toyoda Yusuke yamada Kana Sase Hitoshi Takagi Department of Ophthalmology St Marianna University School of Medicine2-16-1 Sugao Miyamae-ku Kawasaki-shiKanagawa 216-8851Japan

AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook(μLOT) or a single i Stent? trabecular bypass implantation(i Stent) in eyes with cataract and mild-tomoderate glaucoma. METHODS: This study enrolled subjects with mild-tomoderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90 y of age. Patients underwent cataract surgery cooperated with either implantation of an i Stent(i Stent-phaco) or excisional goniotomy with the μLOT(μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while i Stent-phaco was carried out on the other eye. Intraocular pressure(IOP) pre-and post-surgery, alterations in anterior chamber flare(ACF), and corneal endothelial cell density(ECD) were ***: Twenty subjects were enrolled(mean age: 73.6±7.3 y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the i Stent eyes. The mean final IOP at 12 mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the i Stent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30 d postoperatively, with a value of 11.4 pc/ms. In the i Stent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7 d postoperatively(11.2 pc/ms atday 7), demonstrating that postoperative inflammation was less in the i Stent eyes. The corneal ECD in both groups was not significantly ***: In this study, i Stent and μLOT are both effective through 12 mo of follow-up. Safety is more favorable in the i Stent eyes, based on early anterior chamber inflammation.

关键词： minimally invasive glaucoma surgery iStent ab interno trabeculotomy

Computed tomography attenuation values of ascites are helpful to predict perforation site

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World Journal of Gastroenterology 2015年第5期21卷 1573-1579页

作者： Ryo Seishima Koji Okabayashi Hirotoshi Hasegawa Masashi Tsuruta Hiroki Hoshino Toru yamada Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 1608582Japan

AIM:To evaluate the effect of computed tomography(CT) attenuation values of ascites on gastrointestinal(GI) perforation site ***:The CT attenuation values of the ascites from 51 patients with GI perforations were measured by volume rendering to calculate the mean *** effect of the CT attenuation values of the ascites on perforation site prediction and postoperative complications was ***:Of 24 patients with colorectal perforations,the CT attenuation values of ascites were significantly higher than those in patients with perforations at other sites [22.5 Hounsfield units(HU) vs 16.5 HU,respectively,P = 0.006].Colorectal perforation was significantly associated with postoperative complications(P = 0.038).The prediction rate of colorectal perforation using attenuation values as an auxiliary diagnosis improved by 9.8% compared to that of CT findings alone(92.2% vs 82.4%).CONCLUSION:The CT attenuation values of ascites could facilitate the prediction of perforation sites and postoperative complications in GI perforations,particularly in cases in which the perforation sites are difficult to predict by CT findings alone.

关键词： Perforation site prediction Gastrointestinal perfo

PI-3 kinase pathway can mediate the effect of TGF-β1 in inducing the expression of SHARP-2 in LLC-PK1 cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第9期10卷 702-706页

作者： Zhang-fei SHOU Qin ZHOU Jie-ru CAI Jiang-hua CHEN Kazuya yamada Kaoru MIYAMOTO Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Key Laboratory of Multi-organ Combined Transplantation Ministry of Health Hangzhou 310003 China Department of Biochemistry Faculty of Medical Sciences University of Fukui Eiheiji-cho Fukui 910-1193 Japan

We aim to investigate the effect of transforming growth factor （TGF）-β1 on the expression of enhancer of split- and hairy-related protein-2 （SHARP-2） messenger RNA （mRNA） and its signaling pathway. In this study, several cell lines including LLC-PK1 （a porcine kidney tubular epithelial cell line）, MDCK （Madin-Darby canine kidney） and CTLL-2 （cytotoxic T-lymphocyte line） were treated with recombinant human TGF-131, and a series of experiments were carried out, involving Northern blot analysis of total RNA from these cells. Further, several specific chemical inhibitors were applied before TGF-β1 treatment to probe the signaling pathway. The results showed that TGF-β1 can significadtly up-regulate SHARP-2 mRNA expression in the LLC-PK1 cell line. The peak level of induction was found 2 h after TGF-β1 stimulation. While one phospho- inositide 3-kinases （PI-3） kinase inhibitor, LY294002, completely blocked the effect of TGF-131 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect. The effect of LY294002 was dose-dependent. We conclude that, in LLC-PK1 cells at least, TGF-β1 can effectively induce the SHARP-2 mRNA expression and that the PI-3 kinase pathway can mediate this effect.

关键词： Transforming growth factor (TGF)-β1 Split- and hairy-related protein-2 (SHARP-2) Phosphoinositide 3-kinases (PI-3)kinase pathway LY294002

Delayed immune-related sclerosing cholangitis after discontinuation of pembrolizumab:A case report

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World Journal of Gastroenterology 2022年第28期28卷 3732-3738页

作者： Takeshi Tanaka Arata Sakai Masahiro Tsujimae Yasutaka yamada Takashi Kobayashi Atsuhiro Masuda Yuzo Kodama Division of Gastroenterology Department of Internal MedicineKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Secondary sclerosing cholangitis,characterized by biliary obstruction,can be caused by drugs such as immune checkpoint inhibitors(ICIs).While there a few reports of sclerosing cholangitis after immune checkpoint inhibitor administration,no case has been reported after discontinuation of such *** SUMMARY A 68-year-old man who underwent chemotherapy for lung adenocarcinoma with bone metastasis presented with abdominal pain and fever 4 mo after the final administration of *** tomography revealed thickening of the gallbladder wall and dilatation of the common bile *** retrograde cholangiopancreatography revealed an irregularly narrowed intrahepatic bile *** of the bile duct demonstrated that CD8+T cells were predominant over CD4+T *** biopsy showed dominant infiltration of CD8+T in the portal tract,but onion-skin lesions were not *** patient was diagnosed with immune-related sclerosing cholangitis induced by *** of methylprednisolone and endoscopic nasobiliary drainage were performed,but the cholangiography and laboratory test findings did not *** further treatment was administered due to disease progression,and the patient was referred for palliative *** Immune-related sclerosing cholangitis may have a late onset,and such cases occurring after discontinuation of ICIs should be carefully managed.

关键词： Immune-related adverse events Sclerosing cholangitis Delayed immunerelated events Case report

Japanese Mythology From Ethnological Perspectives

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History Research 2013年第5期3卷 309-316页

作者： Hitoshi yamada Tohoku University Sendai Japan

Comparative studies of Japanese mythology have developed since the 1920s above all through eftbrts of Japanese ethnologists. They have paid attention to the possible ethno-cultural complexes that brought mythological motifs into the archipelago. In the present paper the theories set forth by Nobuhiro Matsumoto, Akihide Mishina, and Masao Oka are examined in terms of retrospect. The result shows that they shared the view that at least three different complexes, based in ancient Yamato, Izumo, and Kyushu respectively, contributed to the formation of Japanese mythology compiled in the 8th century CE （Common Era）. Their assumptions were synthesized by Taryo Obayashi in 1961, the hypothesis which has survived until today. In future we should cooperate with other disciplines and address the formation process of Japanese mythology.

关键词： Japanese mythology retrospect ethnology ethnogenesis diffusion

Static Stability Analysis of a Single Planar Object Grasped by *** Hand

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Journal of Mechanics Engineering and Automation 2012年第10期2卷 606-627页

作者： Takayoshi yamada Manabu yamada Hidehiko Yamamoto Department of Human and Information Systems Faculty of Engineering Gifu University Gifu 501-1193 Japan Department of Mechanical Engineering Faculty of Engineering Nagoya Institute of Technology Nagoya 466-8555 Japan

In this study, the static stability of the grasp of a single planar object is analyzed using the potential energy method. In previous papers, we considered cases in which individual fingers were replaced by a multidimensional translational spring model, in which each finger is constructed with prismatic joints. Human hands and the most developed mechanical hands are constructed with revolute joints. In this paper, the effects of fingertip rotation and a revolute joint spring model are investigated. A grasp stiffness matrix is analytically derived by considering not only frictional rolling contact but also frictionless sliding contact. The difl＇erence between the frictional stiffness matrix and the frictionless one is analytically obtained. The effect of local curvature at contact points is analytically derived. The grasp displacement directions affected by the change in curvature and the contact condition are also obtained. The derived stiffness matrix of the revolute joint model is compared with that of the prismatic joint model, and then the stiffness relation is clarified. The gravity effect of the object is also considered. The effectiveness of our method is demonstrated through numerical examples. The stability is evaluated by the eigenvalues of the grasp stiffness matrix, and the grasp displacement direction is obtained by the corresponding eigenvectors. The effect of joint angle is also discussed.

关键词： Grasping multifingered hands static grasp stability revolute joint stiffness model.

Treatment strategy for gastric non-invasive intraepithelial neoplasia diagnosed by endoscopic biopsy

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 93-99页

作者： Tsutomu Nishida Shusaku Tsutsui Motohiko Kato Takuya Inoue Shunsuke Yamamoto Yoshito Hayashi Tomofumi Akasaka Takuya yamada Shinichiro Shinzaki Hideki Iijima masahiko Tsujii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan

Treatment strategies,whether as follow-up or"total incisional biopsy"for gastric noninvasive intraepithelial neoplasia diagnosed by examination of an endoscopic forceps biopsy specimen,are controversial due to problems associated with the diagnostic accuracy of endoscopic forceps biopsy and questions about the safety and efficacy of endoscopic *** on the histological findings of the biopsy specimen,it is difficult to differentiate between reactive or regenerative changes,inflammation and neoplastic changes,intraepithelial and invasive ***,gastric neoplasia diagnosed as noninvasive intraepithelial often develop into invasive carcinoma during *** advances in endoscopic modalities and treatment devices,such as image-enhanced endoscopy and highfrequency generators,may make endoscopic treatment,such as endoscopic submucosal dissection(ESD),a therapeutic option for gastric intraepithelial neoplasia,including low-grade *** studies are required to evaluate whether ESD is a valid strategy for gastric intraepithelial neoplasm with regard to safety and cost effectiveness.

关键词： Gastric intraepithelial neoplasia Adenoma Dysplasia Endoscopic submucosal dissection Endoscopic mucosal resection Endoscopic resection Adenocarcinoma

Some Comments on the Real Meaning of Schrodinger’s Equation Revealed by the Fact that Electron Is Always a Particle

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Journal of Quantum Information Science 2012年第4期2卷 112-118页

作者： Hironari yamada Faculty of Science and Engineering Ritsumeikan UniversityKusatsuJapan

We all physicist have long been believed that an elementary particle is a wave as well as a particle, but we discuss in this paper that an electron (probably all fermions) is always a particle. Author claim that quantum mechanics (QM) is not such mysterious as Bohr stated that the wave turn to the particle by observation. We can understand QM by natural human sense. The wave nature of electrons is only an appearance or a phenomena but not intrinsic or substantial. An electron is an individual body, which interferes with other individual electrons. Interference is the key word instead of the wave to understand the quantum mechanics. Interference produces the wave nature and the uncertainty. When we determine that an electron is nothing but a particle, we will see the true meaning of wave function and the Schr?dinger’s equation.

关键词： Quantum Mechanics Interference Uncertainty Principle Pauli Exclusive Principle Schrodinger’s Equation