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Image of tumor metastasis and inflammatory lymph node enlargement by contrast-enhanced ultrasonography

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World Journal of Radiology 2011年第12期3卷 298-305页

作者： Takaya Aoki Fuminori Moriyasu Kei Yamamoto Masafumi Shimizu masahiko yamada Yasuharu Imai Department of Gastroenterology and Hepatology Tokyo Medical University 6-7-1NishishinjukuShinjyuku-kuTokyo 160-0023Japan

AIM:To compare the difference between tumorinduced lymph node enlargement and inflammation-induced lymph node enlargement by contrast-enhanced ultrasonography and pathological findings. METHODS:A model of tumor-induced lymph node metastasis was prepared by embedding a VX2 tumor into the hind paws of white rabbits.A model of inflammation-induced enlargement was prepared by injecting a suspension of Escherichia coli into separate hind paws of white ***,a solution of SonazoidTM(GE Healthcare,Oslo,Norway)was injected subcutaneously in the proximity of the lesion followed by contrast-enhanced ultrasonography of the enlarged popliteal lymph nodes. RESULTS:In the contrast-enhanced ultrasonography of the tumor-induced metastasis model,the sentinel lymph node was *** area of filling defect was observed in that enlarged lymph *** the histology examination,the area of filling defect corresponded to the metastatic lesion of the ***-enhanced ultrasonography of the model on inflammation-induced lymph node enlargement,and that of the acute inflam-mation model performed 3-7 d later,revealed dense staining that was comparatively *** pathological findings showed acute lymphadenitis mainly due to infiltration of inflammatory ***-enhanced ultrasonography that was performed 28 d post-infection in the acute inflammation model showed speckled ***-induced cell infiltration and fiberization,which are findings of chronic lymphadenitis, were seen in the pathological findings. CONCLUSION:Sentinel lymph node imaging was made possible by subcutaneous injection of ***-enhanced ultrasonography was suggested to be useful in differentiating tumor-induced enlargement and inflammation-induced enlargement of lymph nodes.

关键词： Lymph node enlargement Sentinel lymph node Contrast-enhanced ultrasonography Subcutaneous injection Sonazoid^(TM)

Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

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World Journal of Gastroenterology 2012年第38期18卷 5360-5368页

作者： Kunihiro Hosono Eiji yamada Hiroki Endo Hirokazu Takahashi masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima Division of Gas-troenterology Yokohama City University School of Medicine Yokohama 2360004 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 1040045 Japan

AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis.

关键词： Tumor necrosis factor-α Tumor necrosis factor receptor 1 c-Jun N-terminal kinase Colorectal adenoma Biomarker

The stay coefficient: a novel quantification of the relationship between stay time and travel time for urban shopping behavior analysis

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Geo-Spatial Information Science 2023年第1期26卷 44-57页

作者： Takashi yamada Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityWakayamaJapan

Shoppers typically want to spend an amount of time at a destination that is proportional to the travel time required to arrive there;thus,the travel time can be considered the cost of their *** is likely to be the case across regions with different urban structures and *** purpose of this study was therefore to analyze the shopping behaviors contained in travel survey data from three metropolitan areas in Japan to identify common patterns and indicators based on travel time and stay time,thereby obtaining an understanding to inform future trade area *** the travel time and stay time associated with shopping behavior were found to be log-normally distributed regardless of metropolitan area,and four shopping behavior patterns common among the metropolitan areas were ***“stay coeffi-cient”was then defined to express the elasticity of stay time according to travel time,and its values were similar according to shopping behavior pattern regardless of metropolitan *** stay coefficient proposed in this study can therefore be applied to identify shopping behavior patterns in any urban area based on the relationship between travel time and stay time,realizing a novel approach to the analysis of and marketing for trade areas when planning the construction or renovation of commercial *** approach can help inform the decisions of urban policy makers,marketing advisors,and commercial facility operators,and should be of interest to researchers and practitioners working with geospatial,shopping,and other human behavioral characteristics.

关键词： Travel survey shopping behavior travel time stay time stay coefficient trade area analysis

An Inverse Laplace Transform on Lattice Spacing

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Chinese Physics Letters 2013年第3期30卷 32-35页

作者： Hirofumi yamada Division of Mathematics and Science Chiba Institute of TechnologyShibazono 2-1-1NarashinoChiba 275-0023Japan

An inverse Laplace transform on lattice spacing is introduced as a computational framework of the extrapolation of the strong coupling expansion to the scaling *** apply the transform to the two-dimensional nonlinear O(N)model at N≥3 and show that the approximation of the continuum limit of the susceptibility agrees with the existing theoretical and Monte Carlo data.

关键词： apply spacing susceptibility

Intestinal anisakiasis can cause intussusception in adults:An extremely rare condition

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World Journal of Gastroenterology 2010年第14期16卷 1804-1807页

作者： Tomofumi Miura Akira Iwaya Takao Shimizu Junpei Tsuchiya Junichiro Nakamura Satoshi yamada Tsutomu Miura masahiko Yanagi Hiroyuki Usuda Iwao Emura Toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital 2-297-1 Senshu Nagaoka Niigata 940-2085 Japan Division of Digestive and General Surgery Nagaoka Red Cross Hospital 2-297-1 Senshu Nagaoka Niigata 940-2085 Japan Division of Medical Technology Nagaoka Red Cross Hospital 2-297-1 Senshu Nagaoka Niigata 940-2085 Japan Division of Pathology Nagaoka Red Cross Hospital 2-297-1 Senshu Nagaoka Niigata 940-2085 Japan

We report an extremely rare case of adult intussusception caused by anisakiasis. A 41-year-old man was admitted into our hospital for right lower abdominal colicky pain. Ultrasonography and computed tomography revealed the presence of intussusception. As pneumodynamic resolution by colonoscopy failed, surgery was performed. The anisakis body was found in the submucosal layer of the resection specimen. The patient was discharged 9 d after the operation. Anisakiasis may cause intussusception in any country where sushi or sashimi now exists as a popular food. If suspicious, detailed clinical interview as to food intake prior to symptom development is crucial.

关键词： Anisakis Intussusception Eosinophilic gran- uloma Multiplanar reconstruction

Analysis of shopping behavior characteristics in the Keihanshin metropolitan area in Japan based on a person trip survey

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Geo-Spatial Information Science 2020年第4期23卷 305-315页

作者： Takashi yamada Takumi Hayashida Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityKinokawaWakayamaJapan

This study analyzed weekday shopping behavior from a home base to a destination using data from the 4th Keihanshin metropolitan area person trip *** first analyzed the relationships between occupation and transportation means,transportation means and travel time,and transportation means and duration of time at the *** of a chi-square test,residual analysis,and correspondence analysis confirmed that employed persons tend to travel by cars while unemployed persons tend to travel by bus or *** relationship between travel time and duration of time at the destination was also revealed according to transportation *** of a cluster analysis then classified shopping behaviors to expose four ***,multiple regression analyzed the degree to which certain variables were related to duration of time at the *** confirmed a strong relationship between duration of time at the destination and travel *** degree of this factor’s influence on other variables was also *** value of these findings is that the relationship between travel time by means of transportation and the duration of time at the destination was clarified using statistical *** then found a highly accurate equation that estimates the duration of time at a destination from the travel *** the duration of time at a destination can be estimated,it may be possible to more accurately develop the structure of rest facilities,the number of parking lots,the degree of congestion,and so on,which can be associated with the customer’s usage behavior in a shopping *** research in this paper contributes to the field of urban analysis and marketing by presenting a new effective method for person trip survey and analysis.

关键词： Person trip survey shopping behavior transportation means travel time duration of time at a destination

Antibunching and blinking from a single colloidal CdSe quantum dot

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Science China(Physics,Mechanics & Astronomy) 2010年第9期53卷 1619-1625页

作者： yamada Toshiki Kobe Advanced Research Center National Institute of Information and Communications Technology

We have investigated the optical properties of single CdSe/ZnS nanocrystals by conducting combinations of experiments on antibunching and photoluminescence intermittence under different experimental *** on photoluminescence in an antibunching experiment,we analyzed the emission lifetime of QDs by using stretched *** difference between the parameters obtained from average lifetimes and stretched exponents were analyzed by considering the effect of nonradiative *** Auger-assisted tunneling model was used to explain the power law exponents of off time *** power law exponent under high excitation power was correlated with a higher Auger ionization *** the parameters obtained from stretched exponential function and power law,the antibunching phenomena at different time and under different excitation intensity were analyzed.

关键词： single photon source quantum dot lifetime

Supra-angular biopsy is more reliable for atrophy recognization:analysis of 1598 cases for gastric mucosal histological examination

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World Journal of Gastroenterology 2000年第6期6卷 893-897页

作者： Nobutaka yamada Department of Pathology First Hospital of Nippon Medical SchoolTokyoJapan

INTRODUCTIONChronic gastritis might be a disease of the highestmorbidity in the *** Warren and Marshallsuccessfully isolated and cultured Helicobacter pylori(***)from a gastric antrum biopsy,intensive researches produ... 详细信息

关键词： Helicobacter pylori gastric mucosa/pathology biopsy gastroscopy gastritis atrophic/pathology metaplasia

TTF-1 is useful for primary site determination in duodenal metastasis

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 360-363页

作者： Tomofumi Miura Yuichi Shimaoka Junichiro Nakamura Satoshi yamada Tsutomu Miura masahiko Yanagi Kazuhiro Sato Hiroyuki Usuda Iwao Emura Toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Respiratory Medicine Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

We report here on a case of duodenal metastasis from primary lung adenocarcinoma. A 69-year old man was diagnosed with primary lung adenocarcinoma. Four courses of combined chemotherapy with carboplatin and paclitaxel associated with irradiation of 60 Gy shrunk the lung tumor. However, soon after,the para-aortic lymph node became swollen. Esophagogastroduodenoscopy revealed three duodenal tumors. Differential diagnosis between malignant lymphoma and metastatic duodenal cancer was endoscopically difficult. The histology of biopsied specimens was poorly differentiated adenocarcinoma. Immunohistochemical analysis revealed a positive reaction for thyroid transcription factor-1 (TTF-1). Thus, we concluded that these were metastatic duodenal tumors from lung adenocarcinoma. Two courses of gemcitabine led to a complete remission in this duodenal metastasisand para-aortic lymph node swelling with only scarring remaining in computed tomography. He is now on the continuous generalized chemotherapy. In conclusion, duodenal metastasis from primary lung adenocarcinoma is rare and hard to diagnose. In such an instance, TTF-1 immunostaining is crucial to obtain the correct diagnosis.

关键词： Lung adenocarcinoma Duodenal metastasis Thyroid transcription factor-1