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Candidates for liver transplantation with alcoholic liver disease: Psychosocial aspects

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World Journal of Gastroenterology 2015年第39期21卷 11027-11033页

作者： Diogo Telles-Correia Inês mega Deparment of Psychiatry Faculty of Medicine University of Lisbon Curry Cabral Liver Transplantation Center

In Europe, 30% to 50% of liver transplantations are currently due to alcoholic liver disease(ALD). In the United States, this percentage is 17.2%. Post-transplantsurvival and other predictors of clinical course do not differ significantly from those in other types of transplanted patients, as long as there is no relapse of drinking. However, 20%-25% of these patients lapse or relapse to heavy drinking post-operatively, which has been associated with an increased risk of liver damage and mortality. It is therefore crucial to design specific selection and follow-up strategies aimed at this particular type of patient. Several good and poor prognosis factors that could help to predict a relapse have been suggested, among them the duration of abstinence, social support, a family history of alcoholism, abuse diagnosis versus alcohol dependence, non-acceptance of diagnosis related to alcohol use, presence of severe mental illness, nonadherence in a broad sense, number of years of alcoholism, and daily quantity of alcohol consumption. In this article, we discuss these and other, more controversial factors in selecting ALD patients for liver transplantation. Abstinence should be the main goal after transplantation in an ALD patient. In this article, we review the several definitions of post-transplant relapse, its monitoring and the psychopharmacological and psychotherapeutic treatment.

关键词： Liver transplantation Alcoholic liver disease Psyc

Ionic liquid/tetraglyme hybrid Mg[TFSI]_2 electrolytes for rechargeable Mg batteries

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Green Energy & Environment 2019年第2期4卷 146-153页

作者： Zheng Ma Maria Forsyth Douglas R.MacFarlane mega Kar School of Chemistry Faculty of Science Monash University ARC Centre of Excellence for Electromaterials Science IFM – Institute for Frontier Materials Deakin University

The electrochemical reversibility of Mg in hybrid electrolytes based on mixtures of ionic liquid and glyme based organic solvents was investigated for applications in rechargeable magnesium batteries(RMBs). The electrolytes demonstrate reversible reduction and oxidation of Mg only after being pre-treated with the dehydrating agent, magnesium borohydride, Mg[BH_4]_2, highlighting the importance of removing water in Mg based electrolytes. The addition magnesium di[bis(trifluoromethanesulfonyl)imide](Mg[TFSI]_2)(0.3 M) to N-butyl-n-methyl-pyrrolidinium bis(trifluoromethanesulfonyl)imide [C4 mpyr][TFSI]/tetraglyme at a mole ratio of 1:2 showed stable CV cycling over almost 300 cycles while scanning electron microscopy(SEM) and X-ray diffraction(XRD) confirmed Mg deposition, showing non-dendritic morphology and a well-aligned growth. Further thermogravimetric analysis(TGA) demonstrated a mass retention of 79% at 250℃ for this electrolyte suggesting that the presence of the ionic liquid increases thermal stability substantially making these hybrid electrolytes compatible for RMBs.

关键词： Mg[TFSI]2 Ionic liquids Tetraglyme Rechargeable Mg battery Mg[BH4]2 dehydrate reagent

Sono-Transesterification of Kapok Seed Oil with CaO:BaO-(x:y)/Active Natural Zeolite Catalyst

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Journal of Renewable Materials 2022年第12期10卷 3659-3670页

作者： Sumari Sumari mega Murti Aman Santoso Muhammad Roy Asrori Department of Chemistry Faculty of Mathematics and Natural SciencesUniversitas Negeri MalangMalang65145Indonesia

Kapok seed oil is an environmentally friendly biodiesel *** problem of the best catalyst for transester-ification of Kapok seed oil still continues *** research developed a base-heterogeneous catalyst with the effect of ultrasonic waves during ***,the study aims:(1)to determine the type of natural zeolite used,(2)to determine the characteristics of the synthesized CaO:BaO/ANZ catalyst,and(3)to determine the effectiveness of the CaO:BaO/ANZ catalyst in the biodiesel production process through sono-transeste rification of kapok seed *** research stages consisted of:(1)activation of natural zeolite and its characterization,(2)preparation of CaO:BaO/ANZ catalyst,(3)characterization of CaO:BaO/ANZ catalyst,(4)esterification and uti-lization of catalyst in the transesterification,(5)analysis of transesterified *** results showed that the natural zeolite type from the southerm area of Malang is mordenite(MOR)***,after the natural zeolite was impregnated,the obtained catalyst compositions were CaO:BaO-9:9/ANZ,CaO:BaO-14:9/ANZ,and CaO:BaO-4:11/ANZ with a surface area of 129.7;124.6;128.5 m^(2)/g,and acidity of 1.037;0.254;and 0.685 mmol/g,*** best catalyst for transesterification of kapok seed oil was CaO:BaO-9:9/ANZ,which resulted in a biodiesel yield of 73.6%with a density of 889.6 kg/m^(3) and kinematic viscosity of 2.987 *** characteristics of the produced biodiesel meet requirement of SNI 7182:2015.

关键词： Natural zeolite heterogeneous catalyst biodiesel kapok seed oil transesterification ultrasonication

Is osteoporosis a peculiar association with primary biliary cirrhosis?

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World Journal of Gastroenterology 2005年第34期11卷 5347-5350页

作者： Annarosa Floreani Andrea mega Valentina Camozzi Vincenzo Baldo Mario Plebani Patrizia Burra Giovanni Luisetto Department of Surgical and Gastroenterological Sciences University of Padova Italy Department of Medical and Surgical Sciences University of Padova Italy Department of Public Health University of Padova Italy Department of Clinical Chemistry University of Padova Italy

AIM：（1） To compare the prevalence of osteoporosis （t-score ≤-2.5 SD） between stage IV PBC patients, and two groups of age- and sex-matched controls： one with hepatitis C virus （HCV）-related cirrhosis, and the other one consisting of a group of healthy subjects from the general population, （2） to identify the main risk factors for the development of bone loss. METHODS： Thirty-five stage IV PBC patients （mean age 52.5±10 years）, 49 females with HCV-related cirrhosis （mean age 52.9±5.8 years） and 33 healthy females （mean age 51.8±2.22 years） were enrolled in the study. Bone metabolism was evaluated by measuring serum calcium corrected for serum albumin （Ca corr.）, 25-hydroxy vitamin D （25-OH vit D）, parathyroid hormone, osteocaldn. Bone mineral density （BMD） was assessed at the lumbar spine by dual-photon X-ray absorptiometry. RESULTS： Osteoporosis was present in 5/35 PBC patients （14.2%） and in 7/49 HCV-related drrhotic patients （14.3%）, without any statistical difference between the two groups. Among healthy control subjects, none had osteoporosis. No difference was found between the three groups in serum parameters of bone metabolism. Univariate analysis showed that menopausal state and low BMI were significantly correlated with osteoporosis. Multivariate regression analysis showed that menopausal status, BMI〈23, and old age were independent variables significantly correlated with osteoporosis. CONCLUSION： PBC in itself has no negative influence on BMD. End-stage liver disease patients carry a disease-specific risk for osteoporosis, but have an effective risk of bone loss in relation to individual potential risk for each patient. A practical message should be taken into account, that is, every effort should be made to prevent osteoporosis when a patient has simple osteopenia, or if it is a woman in or near menopausal age.

关键词： Osteoporosis Primary biliary cirrhosis HCV infection

Macroalgae-derived rare sugars: Applications and catalytic synthesis

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Carbon Resources Conversion 2021年第1期4卷 150-163页

作者： Asep Bayu mega F.Warsito Masteria Y.Putra Surachai Karnjanakom Guoqing Guan Research Center for Biotechnology Indonesian Institute of Sciences(LIPI)Jalan Raya Jakarta-Bogor KM.46CibinongBogorWest JavaIndonesia Department of Chemistry Faculty of ScienceRangsit UniversityPathumthani 12000Thailand Energy Conversion Engineering Group Institute of Regional Innovation(IRI)Hirosaki University2-1-3MatsubaraAomori 030-0813Japan

Rare sugars have attracted much attention since they are highly beneficial for health as alternative sweeteners and full of potential economic value in *** limited availability of rare sugars in nature has promoted efforts on the conversion of sugars obtained from terrestrial plants into rare sugars,either via biological or chemo-catalytic ***,the processes are generally complicated and consist of multiple *** or seaweeds have been industrially used as a natural source of *** water-soluble polysaccharides contain monomeric sugars with unique chemical structures and are categorized as *** this review,the potency of macroalgae as a sustainable source of rare sugars and the recent progress on their catalytic conversion,either via biological or chemo-catalytical process,are summarized and ***,the depolymerization of macroalgae for the production of rare sugars is *** is expected to enrich our knowledge in the development of sustainable production of rare sugars from macroalgae.

关键词： Rare sugars Carbohydrates Macroalgae Seaweeds Phycocolloids

Nutraceutical health benefit and safety utility of Portulaca oleracea: A review focus on neuroendocrine function

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 83-95页

作者： Oyowvi mega Obukohwo Department of Physiology Adeleke UniversityEdeOsun State PMB 250Nigeria

Background:Portulaca oleracea L.,a traditional medicine with bioactive compounds like flavonoids and omega-3 fatty acids,has gained interest in its neuroendocrine and toxicological ***:The aim of this review is to provide a comprehensive summary of the current knowledge on the neuroendocrine and toxicological activities of Portulaca *** review also highlights the potential mechanisms of action of these ***:A literature search was conducted using various databases such as PubMed,ScienceDirect,and Google *** such as’Portulaca oleracea’,’purslane’,’neuroendocrine activity’,and’toxicological activity’were used to identify relevant *** studies published in English were included in this ***:Portulaca oleracea has been found to improve testicular and cognitive function as well as memory in animal models of Alzheimer’s disease and cerebral ischemia due to its antioxidant,anti-inflammatory properties,anti-anxiety and anti-depressant *** the other hand,Portulaca oleracea has also been reported to possess toxicological *** have shown that high doses of Portulaca oleracea extract can cause liver and kidney damage in animal *** toxic effects of Portulaca oleracea are thought to be due to the presence of oxalates and nitrates in the ***,these toxic effects have not been observed in human studies,where Portulaca oleracea was found to be safe for ***:In conclusion,Portulaca oleracea,a medicinal plant with potential health benefits,has neuroendocrine effects like neuroprotective,anxiolytic,and anti-depressant ***,high doses should be used cautiously due to potential toxicological effects.

关键词： Portulaca oleracea Purslane Neuronal activity Endocrine activity Toxicological activity

Evolution of health law in Turkey

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History & Philosophy of Medicine 2022年第1期4卷 21-29页

作者： Serenay Agin Ertunc mega Izmir Bar Association Sante LegalBayrakli/Izmir 35535Turkey University of Health Sciences Fatih Sultan Mehmet Education and Research Hospital Bayrakli/Izmir 35535Turkey

Turkey has always been one of the leading countries in the field of health and fundamental *** Turkey is a member of many international organizations and a candidate state for the European Union,had some regulations on fundamental rights,patients rights and right to health,even before the international papers,such as the Universal Declaration of Human Rights,did not come into *** always follows closely to the new developments in health care technologies,that is why Turkey continues to be one of the most chosen countries in international health *** improvements in health care drive Turkey to adjust its regulations related to patients'fundamental rights and right to access to *** the 2000s,health law postgraduate programs were founded in some universities in *** these programs,research in health law has been *** will be one of the leading countries in health law too in the next few *** this study,we started with the fundamental sources of the right to health in Turkey;then we continued with current objects at issue in Turkish health law;then we gave place to the current problems of Turkish health law such as reproductive rights,problems related to organ and tissue transplantations,increasing numbers of legal cases against health care professionals,their possible solutions and the future expectations.

关键词： health law medical law fundamental rights right to health right to access to health improvements in healthcare technologies Turkish medical law Turkish health law reproductive rights malpractice cases

Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring

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Neural Regeneration Research 2019年第3期14卷 491-500页

作者： Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo Programa de Pos-Graduacao em Neurociencias Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Laboratorio de Histofisiologia Comparada Departamento de Ciencias Morfologicas Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Programa de Pos-Graduacao em Biociências e Reabilitacao Centro Universitario Metodista-IPA

It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear.

关键词： epigenetics preconception methylation learning treadmill running fetal programming inheritance sperm nerve regeneration

Protein kinase inhibitors affect spermatogenic functions and blood testis barrier remodelling:A scoping review

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Asian pacific Journal of Reproduction 2023年第3期12卷 97-108页

作者： Oyovwi mega Obukohwo Onome Bright Oghenetega Falajiki Yewande Faith Emojevwe Victor Rotu Arientare Rume Joseph Gregory Uchechukwu Oyeleke Abiodun Abioye Department of Physiology Faculty of Basic Medical SciencesAdeleke UniversityEdeOsun StateNigeria Department of Physiology School of Basic Medical ScienceBabcock UniversityIllisan-RomoOgun StateNigeria Department of Physiology University of Medical SciencesOndo StateNigeria Department of Physiology University of IbadanIbadanOyo StateNigeria Department of Medical Laboratory Science Adeleke UniversityEdeOsun StateNigeria Department of Physiology Federal University Oye-EkitiNigeria

Objective:To identify the role of protein kinase in male reproduction in animal models and human spermatogenic ***:This study assessed the protein kinase of male reproduction in animal models and human using different reviewed paper indexed in PubMed,Science Direct,EBSCO,Scopus,Cochrane Library,Sage Journals,and Google *** were charted based on author,year of publication published between 1893 and 2023,country,purpose,data collection,key findings,and research focus/***:The MAPK pathway contributed to the growth,maturation,and functionality of male germ *** also found out that certain influencing factors categorized into hormonal/non hormonal factors and chemotoxicant,as well as heat stress expressed an inhibitory mechanism on protein kinase,thus affecting spermatogenic functions and maintenance/remodeling of the blood testis barrier,as well as the physiology of the Sertoli cells necessary for nutritional support of ***,activating protein kinases pathway like the mTOR pathway as well as increased expression of peroxiredoxin-4 and L-carnitine mediated protein kinases may be useful for treating or managing male reproductive ***:Protein kinase plays an important role in spermatogenic functions and blood testis remodeling in animal and *** assessment provides essential information that can guide treatment strategies aimed at improving male reproductive *** together,these recent advances highlight a future therapeutic intervention in assessing male reproductive *** might also be possible to look at potential targets for male contraceptives in the MAPK pathway.

关键词： Spermatogenesis Protein kinase Inhibitors Sertoli cells Capacitation mTOR