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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an Elderly Population

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World Journal of Vaccines 2022年第2期12卷 11-19页

作者： Satoko Kitamura Naoki Komatsu masahide matsushita Hiromi Seo Seisho Takeuchi Department of General Medicine Kochi Medical School Hospital Nankoku Japan Kochi General Rehabilitation Hospital Kochi Japan

Annual vaccination is necessary to maintain humoral immunity in the elderly population. However, the factors influencing the response to influenza vaccination have not been completely identified. The aim of this study was to explore the factors that influenced antibody responses to repeated vaccination using measures that were both objective and quantitative. A total of 111 volunteers aged > 61 years were vaccinated subcutaneously with one dose of influenza vaccine from the 2005-2006 season through the 2009-2010 season. The factors that influenced antibody responses after vaccination were evaluated. The seroprotection rates (PRs) were significantly higher in responders (subjects with a higher antibody titer in the 2005-2006 season) than in nonresponders only in the 2006-2007 and 2007-2008 seasons. PRs after vaccination were significantly higher in seropositive individuals (subjects with a higher prevaccination antibody titer in the 2006-2007 season) than in seronegative individuals for all three virus strains in almost all of the 5 years. Age, gender, and vaccination in the 2004-2005 season did not influence the response. These results suggest that an immune response at a certain time point would predict immune responses only in the near future. However, prevaccination antibody titer in the following season is the ideal predictor for future responses that last over several influenza seasons.

关键词： Influenza Vaccine Elderly Persons Repeated Vaccination Seroprotection Rate

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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an Elderly Population

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World Journal of Vaccines（疫苗） 2022年第2期

作者： satoko kitamura naoki komatsu masahide matsushita hiromi seo seisho takeuchi

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Feasibility of a Direct-Conversion Method from Magnetic Susceptibility to Relative Electron Density for Radiation Therapy Treatment Planning

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第3期6卷 252-265页

作者： Kengo Ito Noriyuki Kadoya Yujiro Nakajima masahide Saito Kiyokazu Sato Tatsuo Nagasaka Kazuomi Yamanaka Suguru Dobashi Ken Takeda Haruo matsushita Keiichi Jingu Department of Radiation Oncology Tohoku University Graduate School of Medicine Sendai Japan Department of Radiology Tokyo Metropolitan Komagome Hospital Tokyo Japan Department of Radiology University of Yamanashi Chuo-shi Japan Department of Radiology Tohoku University Hospital Sendai Japan Department of Therapeutic Radiology Tohoku University School of Medicine Sendai Japan

Recently, several institutions have been developing magnetic resonance imaging (MRI)-guided radiotherapy treatment systems. In this study, we examine whether it is possible to perform radiation therapy planning (RTP) using a magnetic susceptibility map obtained using MRI. The head of a healthy volunteer was scanned using dual-energy computed tomography (CT) and MRI. A T2-star-weighted 3D gradient echo-based sequence (GRE) with images taken at four different echo times was acquired using the MRI scanner. The CT images were converted to relative electron density (rED) using a predefined ΔCT-rED conversion table. ΔCT was derived using the energy-subtraction method. The rED map was obtained from a single-linear relationship with the ΔCT-rED conversion table, whereas the magnetic susceptibility map was obtained from quantitative susceptibility mapping (QSM) via MRI. Subsequently, to obtain the relationship between the magnetic susceptibility and the rED, the rED map was rigidly aligned to the susceptibility map and resampled at the susceptibility map’s resolution. Finally, the magnetic susceptibility rED conversion table was obtained via voxel-by-voxel mapping between the two maps. No strong relationship between magnetic susceptibility and rED was obtained in the healthy volunteer’s head or in this study. The coefficient correlation between these parameters was 0.0145. Magnetic susceptibility values may be not able to convert to rED using our proposed method in healthy volunteer’s head. In contrast to the magnetic-susceptibility values obtained from the QSM algorithm, which were strongly affected by calcification and iron content, the rED or CT number was not considerably affected by such materials.

关键词： Magnetic Susceptibility Quantitative Susceptibility Mapping MRI-Based Radiation Therapy Planning

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True left-sided gallbladder with variations of bile duct and cholecystic vein

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World Journal of Gastroenterology 2015年第21期21卷 6754-6758页

作者： Hiromichi Ishii Akinori Noguchi Mie Onishi Koji Takao Takahiro Maruyama Hiroaki Taiyoh Yasunobu Araki Takeshi Shimizu Hiroyuki Izumi Naoki Tani masahide Yamaguchi Tetsuro Yamane Department of Surgery Matsushita Memorial Hospital

A left-sided gallbladder without a right-sided round ligament,which is called a true left-sided gallbladder,is extremely rare.A 71-year-old woman was referred to our hospital due to a gallbladder *** tomography(CT) revealed not only a gallbladder polyp but also the gallbladder located to the left of the round ligament connected to the left umbilical *** portography revealed that the main portal vein diverged into the right posterior portal vein and the common trunk of the left portal vein and right anterior portal *** cholangiography revealed that the infraportal bile duct of segment 2 joined the common bile *** cholecystectomy was performed for a gallbladder polyp,and the intraoperative finding showed that the cholecystic veins joined the round ligament.A true left-sided gallbladder is closely associated with several anomalies; therefore,surgeons encountering a true left-sided gallbladder should be aware of the potential for these anomalies.

关键词： True left-sided gallbladder Infraportal bileduct of segment 2 Anomaly of the cholecystic vein Anomaly of the portal vein Laparoscopic cholecystectomy

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